Preservation of Pancreatic β-Cell Function and Prevention of Type 2 Diabetes by Pharmacological Treatment of Insulin Resistance in High-Risk Hispanic Women

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

FIG. 2.
FIG. 2.

A: Schematic diagram of mechanism for protection from diabetes tested under question 2. Curved line is hyperbolic relationship between insulin output and SI at baseline. Arrow no. 1 represents an intervention-induced increase in SI. Arrow no. 2 represents a reciprocal reduction in total insulin output, as seen in a previous short-term study of women with recent GDM (11). B: SI and total insulin output (IVGTT insulin area) at baseline in each of 73 troglitazone-treated women who increased SI into the protective range after 3 months on trial. •, women destined to have a small decrease in IVGTT insulin area 3 months after randomization (i.e., women in tertiles 1 and 2 for change in insulin area, Table 3). ○, women destined to have a large decrease in insulin area (women in tertile 3 for change in insulin area). ——, hyperbola y = k/x, where “k” is the mean of the products of SI and insulin area for each of the 73 women (11,18,19). ——, 95% CIs. C and D: Means of SI and IVGTT insulin area at baseline and 3 months later in each of the two subgroups.

This Article

  1. Diabetes vol. 51 no. 9 2796-2803