Preservation of Pancreatic β-Cell Function and Prevention of Type 2 Diabetes by Pharmacological Treatment of Insulin Resistance in High-Risk Hispanic Women

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FIG. 3.
FIG. 3.

A and B: OGTT plasma glucose concentrations at baseline and 8 months posttrial in women who participated in posttrial testing after completing the blinded trial without diabetes. The change in total glucose area between baseline and posttrial testing was significantly different between groups (P = 0.03). C and D: IVGTT AIRg plotted against SI at baseline and 8 months posttrial. Curved lines are y = k/x, where “k” is product of AIRg and SI, representing β-cell compensation for insulin resistance. β-cell compensation decreased 39% in the placebo group and 3% in the troglitazone group (P = 0.01 between groups).

This Article

  1. Diabetes vol. 51 no. 9 2796-2803