Table of Contents

Select this article
- Jean-Claude Henquin,
- Christian Boitard,
- Suad Efendic,
- Ele Ferrannini,
- Donald F. Steiner,
- and Erol Cerasi
Insulin Secretion: Movement at All Levels
Diabetes February 2002 51:S1-S2; doi:10.2337/diabetes.51.2007.S1

Section 1: Insulin Release: Some Molecular Requisites

Select this article
- Stefan H. Gerber and
- Thomas C. Südhof
Molecular Determinants of Regulated Exocytosis
Diabetes February 2002 51:S3-S11; doi:10.2337/diabetes.51.2007.S3
Select this article
- Stefan H. Gerber,
- Josep Rizo,
- and Thomas C. Südhof
Role of Electrostatic and Hydrophobic Interactions in Ca²⁺-Dependent Phospholipid Binding by the C₂A-Domain From Synaptotagmin I
Diabetes February 2002 51:S12-S18; doi:10.2337/diabetes.51.2007.S12
Select this article
- Haruo Kasai,
- Tomoyuki Suzuki,
- Ting-Ting Liu,
- Takuya Kishimoto,
- and Noriko Takahashi
Fast and cAMP-Sensitive Mode of Ca²⁺-Dependent Exocytosis in Pancreatic β-Cells
Diabetes February 2002 51:S19-S24; doi:10.2337/diabetes.51.2007.S19
Select this article
- Noriko Takahashi,
- Tomomi Nemoto,
- Ryoichi Kimura,
- Akira Tachikawa,
- Akiko Miwa,
- Haruo Okado,
- Yasushi Miyashita,
- Masamitsu Iino,
- Takashi Kadowaki,
- and Haruo Kasai
Two-Photon Excitation Imaging of Pancreatic Islets With Various Fluorescent Probes
Diabetes February 2002 51:S25-S28; doi:10.2337/diabetes.51.2007.S25
Select this article
- Mitsuhisa Komatsu,
- Yoshihiko Sato,
- Satoko Yamada,
- Keishi Yamauchi,
- Kiyoshi Hashizume,
- and Toru Aizawa
Triggering of Insulin Release by a Combination of cAMP Signal and Nutrients: An ATP-Sensitive K⁺ Channel–Independent Phenomenon
Diabetes February 2002 51:S29-S32; doi:10.2337/diabetes.51.2007.S29
Select this article
- Erik Renström,
- Sebastian Barg,
- Frank Thévenod,
- and Patrik Rorsman
Sulfonylurea-Mediated Stimulation of Insulin Exocytosis via an ATP-Sensitive K⁺ Channel–Independent Action
Diabetes February 2002 51:S33-S36; doi:10.2337/diabetes.51.2007.S33
Select this article
- Claes B. Wollheim and
- Pierre Maechler
β-Cell Mitochondria and Insulin Secretion: Messenger Role of Nucleotides and Metabolites
Diabetes February 2002 51:S37-S42; doi:10.2337/diabetes.51.2007.S37
Select this article
- Michael G. Roper,
- Wei-jun Qian,
- Bei B. Zhang,
- Rohit N. Kulkarni,
- C. Ronald Kahn,
- and Robert T. Kennedy
Effect of the Insulin Mimetic L-783,281 on Intracellular [Ca²⁺] and Insulin Secretion From Pancreatic β-Cells
Diabetes February 2002 51:S43-S49; doi:10.2337/diabetes.51.2007.S43
Select this article
- Johanna Westerlund,
- Bryan A. Wolf,
- and Peter Bergsten
Glucose-Dependent Promotion of Insulin Release From Mouse Pancreatic Islets by the Insulin-Mimetic Compound L-783,281
Diabetes February 2002 51:S50-S52; doi:10.2337/diabetes.51.2007.S50

Section 2: Biphasic Insulin Release: Pools and Signal Modulation

Select this article
- Rafael Nesher and
- Erol Cerasi
Modeling Phasic Insulin Release: Immediate and Time-Dependent Effects of Glucose
Diabetes February 2002 51:S53-S59; doi:10.2337/diabetes.51.2007.S53
Select this article
- Jean-Claude Henquin,
- Nobuyoshi Ishiyama,
- Myriam Nenquin,
- Magalie A. Ravier,
- and Jean-Christophe Jonas
Signals and Pools Underlying Biphasic Insulin Secretion
Diabetes February 2002 51:S60-S67; doi:10.2337/diabetes.51.2007.S60
Select this article
- Rafael Nesher,
- Eyal Anteby,
- Michael Yedovizky,
- Nasim Warwar,
- Nurit Kaiser,
- and Erol Cerasi
β-Cell Protein Kinases and the Dynamics of the Insulin Response to Glucose
Diabetes February 2002 51:S68-S73; doi:10.2337/diabetes.51.2007.S68
Select this article
- Sebastian Barg,
- Lena Eliasson,
- Erik Renström,
- and Patrik Rorsman
A Subset of 50 Secretory Granules in Close Contact With l-Type Ca²⁺ Channels Accounts for First-Phase Insulin Secretion in Mouse β-Cells
Diabetes February 2002 51:S74-S82; doi:10.2337/diabetes.51.2007.S74
Select this article
- Troitza K. Bratanova-Tochkova,
- Haiying Cheng,
- Samira Daniel,
- Subhadra Gunawardana,
- Yi-Jia Liu,
- Jennifer Mulvaney-Musa,
- Thomas Schermerhorn,
- Susanne G. Straub,
- Hiroki Yajima,
- and Geoffrey W.G. Sharp
Triggering and Augmentation Mechanisms, Granule Pools, and Biphasic Insulin Secretion
Diabetes February 2002 51:S83-S90; doi:10.2337/diabetes.51.2007.S83
Select this article
- Susanne G. Straub,
- Hiroki Yajima,
- Mitsuhisa Komatsu,
- Toru Aizawa,
- and Geoffrey W.G. Sharp
The Effects of Cerulenin, an Inhibitor of Protein Acylation, on the Two Phases of Glucose-Stimulated Insulin Secretion
Diabetes February 2002 51:S91-S95; doi:10.2337/diabetes.51.2007.S91
Select this article
- Toru Aizawa,
- Yoshihiko Sato,
- and Mitsuhisa Komatsu
Importance of Nonionic Signals for Glucose-Induced Biphasic Insulin Secretion
Diabetes February 2002 51:S96-S98; doi:10.2337/diabetes.51.2007.S96
Select this article
- Pierre Maechler,
- Asllan Gjinovci,
- and Claes B. Wollheim
Implication of Glutamate in the Kinetics of Insulin Secretion in Rat and Mouse Perfused Pancreas
Diabetes February 2002 51:S99-S102; doi:10.2337/diabetes.51.2007.S99

Section 3: Phasic Insulin Release and Metabolic Control

Select this article
- Alan D. Cherrington,
- Dana Sindelar,
- Dale Edgerton,
- Kurt Steiner,
- and Owen P. McGuinness
Physiological Consequences of Phasic Insulin Release in the Normal Animal
Diabetes February 2002 51:S103-S108; doi:10.2337/diabetes.51.2007.S103
Select this article
- Stefano Del Prato,
- Piero Marchetti,
- and Riccardo C. Bonadonna
Phasic Insulin Release and Metabolic Regulation in Type 2 Diabetes
Diabetes February 2002 51:S109-S116; doi:10.2337/diabetes.51.2007.S109
Select this article
- John E. Gerich
Is Reduced First-Phase Insulin Release the Earliest Detectable Abnormality in Individuals Destined to Develop Type 2 Diabetes?
Diabetes February 2002 51:S117-S121; doi:10.2337/diabetes.51.2007.S117
Select this article
- Michael Stumvoll,
- Andreas Fritsche,
- and Hans-Ulrich Häring
Clinical Characterization of Insulin Secretion as the Basis for Genetic Analyses
Diabetes February 2002 51:S122-S129; doi:10.2337/diabetes.51.2007.S122
Select this article
- Elena Toschi,
- Stefania Camastra,
- Anna Maria Sironi,
- Antonio Masoni,
- Amalia Gastaldelli,
- Andrea Mari,
- Ele Ferrannini,
- and Andrea Natali
Effect of Acute Hyperglycemia on Insulin Secretion in Humans
Diabetes February 2002 51:S130-S133; doi:10.2337/diabetes.51.2007.S130
Select this article
- Roberto Lupi,
- Silvia Del Guerra,
- Vanna Fierabracci,
- Lorella Marselli,
- Michela Novelli,
- Giovanni Patanè,
- Ugo Boggi,
- Franco Mosca,
- Salvatore Piro,
- Stefano Del Prato,
- and Piero Marchetti
Lipotoxicity in Human Pancreatic Islets and the Protective Effect of Metformin
Diabetes February 2002 51:S134-S137; doi:10.2337/diabetes.51.2007.S134
Select this article
- Martina Kvist Reimer and
- Bo Ahrén
Altered β-Cell Distribution of pdx-1 and GLUT-2 After a Short-Term Challenge With a High-Fat Diet in C57BL/6J Mice
Diabetes February 2002 51:S138-S143; doi:10.2337/diabetes.51.2007.S138

Section 4: Oscillations in β-Cells

Select this article
- Patrick Gilon,
- Magalie A. Ravier,
- Jean-Christophe Jonas,
- and Jean-Claude Henquin
Control Mechanisms of the Oscillations of Insulin Secretion In Vitro and In Vivo
Diabetes February 2002 51:S144-S151; doi:10.2337/diabetes.51.2007.S144
Select this article
- Robert T. Kennedy,
- Lisa M. Kauri,
- Gabriella M. Dahlgren,
- and Sung-Kwon Jung
Metabolic Oscillations in β-Cells
Diabetes February 2002 51:S152-S161; doi:10.2337/diabetes.51.2007.S152
Select this article
- Edward K. Ainscow and
- Guy A. Rutter
Glucose-Stimulated Oscillations in Free Cytosolic ATP Concentration Imaged in Single Islet β-Cells: Evidence for a Ca²⁺-Dependent Mechanism
Diabetes February 2002 51:S162-S170; doi:10.2337/diabetes.51.2007.S162
Select this article
- Peter Bergsten
Role of Oscillations in Membrane Potential, Cytoplasmic Ca²⁺, and Metabolism for Plasma Insulin Oscillations
Diabetes February 2002 51:S171-S176; doi:10.2337/diabetes.51.2007.S171
Select this article
- Lise L. Kjems,
- Magalie A. Ravier,
- Jean-Christophe Jonas,
- and Jean-Claude Henquin
Do Oscillations of Insulin Secretion Occur in the Absence of Cytoplasmic Ca²⁺ Oscillations in β-Cells?
Diabetes February 2002 51:S177-S182; doi:10.2337/diabetes.51.2007.S177
Select this article
- Feng Qian,
- Ping Huang,
- Li Ma,
- Andrey Kuznetsov,
- Natalia Tamarina,
- and Louis H. Philipson
TRP Genes: Candidates for Nonselective Cation Channels and Store-Operated Channels in Insulin-Secreting Cells
Diabetes February 2002 51:S183-S189; doi:10.2337/diabetes.51.2007.S183
Select this article
- Aniko Varadi and
- Guy A. Rutter
Dynamic Imaging of Endoplasmic Reticulum Ca²⁺ Concentration in Insulin-Secreting MIN6 Cells Using Recombinant Targeted Cameleons: Roles of Sarco(endo)plasmic Reticulum Ca²⁺-ATPase (SERCA)-2 and Ryanodine Receptors
Diabetes February 2002 51:S190-S201; doi:10.2337/diabetes.51.2007.S190

Section 5: Methodology for Quantifying Insulin Release in Man

Select this article
- Bo Ahrén and
- Hillevi Larsson
Quantification of Insulin Secretion in Relation to Insulin Sensitivity in Nondiabetic Postmenopausal Women
Diabetes February 2002 51:S202-S211; doi:10.2337/diabetes.51.2007.S202
Select this article
- Richard N. Bergman,
- Marilyn Ader,
- Katrin Huecking,
- and Gregg Van Citters
Accurate Assessment of β-Cell Function: The Hyperbolic Correction
Diabetes February 2002 51:S212-S220; doi:10.2337/diabetes.51.2007.S212
Select this article
- Andrea Mari,
- Andrea Tura,
- Amalia Gastaldelli,
- and Ele Ferrannini
Assessing Insulin Secretion by Modeling in Multiple-Meal Tests: Role of Potentiation
Diabetes February 2002 51:S221-S226; doi:10.2337/diabetes.51.2007.S221
Select this article
- Elena Breda,
- Gianna Toffolo,
- Kenneth S. Polonsky,
- and Claudio Cobelli
Insulin Release in Impaired Glucose Tolerance: Oral Minimal Model Predicts Normal Sensitivity to Glucose but Defective Response Times
Diabetes February 2002 51:S227-S233; doi:10.2337/diabetes.51.2007.S227
Select this article
- Andreas Fritsche,
- Alexander Madaus,
- Norbert Stefan,
- Otto Tschritter,
- Elke Maerker,
- Anna Teigeler,
- Hans Häring,
- and Michael Stumvoll
Relationships Among Age, Proinsulin Conversion, and β-Cell Function in Nondiabetic Humans
Diabetes February 2002 51:S234-S239; doi:10.2337/diabetes.51.2007.S234
Select this article
- Philippe Vague and
- Loan Nguyen
Rationale and Methods for the Estimation of Insulin Secretion in a Given Patient: From Research to Clinical Practice
Diabetes February 2002 51:S240-S244; doi:10.2337/diabetes.51.2007.S240

Section 6: Pusatile and Phasic Insulin Release in Normal and Diabetic Men

Select this article
- Niels Pørksen,
- Malene Hollingdal,
- Claus Juhl,
- Peter Butler,
- Johannes D. Veldhuis,
- and Ole Schmitz
Pulsatile Insulin Secretion: Detection, Regulation, and Role in Diabetes
Diabetes February 2002 51:S245-S254; doi:10.2337/diabetes.51.2007.S245
Select this article
- Claus Juhl,
- Thorbjørn Grøfte,
- Peter C. Butler,
- Johannes D. Veldhuis,
- Ole Schmitz,
- and Niels Pørksen
Effects of Fasting on Physiologically Pulsatile Insulin Release in Healthy Humans
Diabetes February 2002 51:S255-S257; doi:10.2337/diabetes.51.2007.S255
Select this article
- Chantal Simon and
- Gabrielle Brandenberger
Ultradian Oscillations of Insulin Secretion in Humans
Diabetes February 2002 51:S258-S261; doi:10.2337/diabetes.51.2007.S258
Select this article
- Clifton Bogardus and
- P. Antonio Tataranni
Reduced Early Insulin Secretion in the Etiology of Type 2 Diabetes Mellitus in Pima Indians
Diabetes February 2002 51:S262-S264; doi:10.2337/diabetes.51.2007.S262
Select this article
- Timon W. van Haeften,
- Walkyria Pimenta,
- Asimina Mitrakou,
- Mary Korytkowski,
- Trond Jenssen,
- Hannele Yki-Jarvinen,
- and John E. Gerich
Disturbances in β-Cell Function in Impaired Fasting Glycemia
Diabetes February 2002 51:S265-S270; doi:10.2337/diabetes.51.2007.S265
Select this article
- Errol B. Marliss and
- Mladen Vranic
Intense Exercise Has Unique Effects on Both Insulin Release and Its Roles in Glucoregulation: Implications for Diabetes
Diabetes February 2002 51:S271-S283; doi:10.2337/diabetes.51.2007.S271

Diabetes

Insulin Secretion: Movement at All Levels

Section 1: Insulin Release: Some Molecular Requisites

Molecular Determinants of Regulated Exocytosis

Role of Electrostatic and Hydrophobic Interactions in Ca2+-Dependent Phospholipid Binding by the C2A-Domain From Synaptotagmin I

Fast and cAMP-Sensitive Mode of Ca2+-Dependent Exocytosis in Pancreatic β-Cells

Two-Photon Excitation Imaging of Pancreatic Islets With Various Fluorescent Probes

Triggering of Insulin Release by a Combination of cAMP Signal and Nutrients: An ATP-Sensitive K+ Channel–Independent Phenomenon

Sulfonylurea-Mediated Stimulation of Insulin Exocytosis via an ATP-Sensitive K+ Channel–Independent Action

β-Cell Mitochondria and Insulin Secretion: Messenger Role of Nucleotides and Metabolites

Effect of the Insulin Mimetic L-783,281 on Intracellular [Ca2+] and Insulin Secretion From Pancreatic β-Cells

Glucose-Dependent Promotion of Insulin Release From Mouse Pancreatic Islets by the Insulin-Mimetic Compound L-783,281

Section 2: Biphasic Insulin Release: Pools and Signal Modulation

Modeling Phasic Insulin Release: Immediate and Time-Dependent Effects of Glucose

Signals and Pools Underlying Biphasic Insulin Secretion

β-Cell Protein Kinases and the Dynamics of the Insulin Response to Glucose

A Subset of 50 Secretory Granules in Close Contact With l-Type Ca2+ Channels Accounts for First-Phase Insulin Secretion in Mouse β-Cells

Triggering and Augmentation Mechanisms, Granule Pools, and Biphasic Insulin Secretion

The Effects of Cerulenin, an Inhibitor of Protein Acylation, on the Two Phases of Glucose-Stimulated Insulin Secretion

Importance of Nonionic Signals for Glucose-Induced Biphasic Insulin Secretion

Implication of Glutamate in the Kinetics of Insulin Secretion in Rat and Mouse Perfused Pancreas

Section 3: Phasic Insulin Release and Metabolic Control

Physiological Consequences of Phasic Insulin Release in the Normal Animal

Phasic Insulin Release and Metabolic Regulation in Type 2 Diabetes

Is Reduced First-Phase Insulin Release the Earliest Detectable Abnormality in Individuals Destined to Develop Type 2 Diabetes?

Clinical Characterization of Insulin Secretion as the Basis for Genetic Analyses

Effect of Acute Hyperglycemia on Insulin Secretion in Humans

Lipotoxicity in Human Pancreatic Islets and the Protective Effect of Metformin

Altered β-Cell Distribution of pdx-1 and GLUT-2 After a Short-Term Challenge With a High-Fat Diet in C57BL/6J Mice

Section 4: Oscillations in β-Cells

Control Mechanisms of the Oscillations of Insulin Secretion In Vitro and In Vivo

Metabolic Oscillations in β-Cells

Glucose-Stimulated Oscillations in Free Cytosolic ATP Concentration Imaged in Single Islet β-Cells: Evidence for a Ca2+-Dependent Mechanism

Role of Oscillations in Membrane Potential, Cytoplasmic Ca2+, and Metabolism for Plasma Insulin Oscillations

Do Oscillations of Insulin Secretion Occur in the Absence of Cytoplasmic Ca2+ Oscillations in β-Cells?

TRP Genes: Candidates for Nonselective Cation Channels and Store-Operated Channels in Insulin-Secreting Cells

Dynamic Imaging of Endoplasmic Reticulum Ca2+ Concentration in Insulin-Secreting MIN6 Cells Using Recombinant Targeted Cameleons: Roles of Sarco(endo)plasmic Reticulum Ca2+-ATPase (SERCA)-2 and Ryanodine Receptors

Section 5: Methodology for Quantifying Insulin Release in Man

Quantification of Insulin Secretion in Relation to Insulin Sensitivity in Nondiabetic Postmenopausal Women

Accurate Assessment of β-Cell Function: The Hyperbolic Correction

Assessing Insulin Secretion by Modeling in Multiple-Meal Tests: Role of Potentiation

Insulin Release in Impaired Glucose Tolerance: Oral Minimal Model Predicts Normal Sensitivity to Glucose but Defective Response Times

Relationships Among Age, Proinsulin Conversion, and β-Cell Function in Nondiabetic Humans

Rationale and Methods for the Estimation of Insulin Secretion in a Given Patient: From Research to Clinical Practice

Section 6: Pusatile and Phasic Insulin Release in Normal and Diabetic Men

Pulsatile Insulin Secretion: Detection, Regulation, and Role in Diabetes

Effects of Fasting on Physiologically Pulsatile Insulin Release in Healthy Humans

Ultradian Oscillations of Insulin Secretion in Humans

Reduced Early Insulin Secretion in the Etiology of Type 2 Diabetes Mellitus in Pima Indians

Disturbances in β-Cell Function in Impaired Fasting Glycemia

Intense Exercise Has Unique Effects on Both Insulin Release and Its Roles in Glucoregulation: Implications for Diabetes

This Issue

Current Issue

Role of Electrostatic and Hydrophobic Interactions in Ca²⁺-Dependent Phospholipid Binding by the C₂A-Domain From Synaptotagmin I

Fast and cAMP-Sensitive Mode of Ca²⁺-Dependent Exocytosis in Pancreatic β-Cells

Triggering of Insulin Release by a Combination of cAMP Signal and Nutrients: An ATP-Sensitive K⁺ Channel–Independent Phenomenon

Sulfonylurea-Mediated Stimulation of Insulin Exocytosis via an ATP-Sensitive K⁺ Channel–Independent Action

Effect of the Insulin Mimetic L-783,281 on Intracellular [Ca²⁺] and Insulin Secretion From Pancreatic β-Cells

A Subset of 50 Secretory Granules in Close Contact With l-Type Ca²⁺ Channels Accounts for First-Phase Insulin Secretion in Mouse β-Cells

Glucose-Stimulated Oscillations in Free Cytosolic ATP Concentration Imaged in Single Islet β-Cells: Evidence for a Ca²⁺-Dependent Mechanism

Role of Oscillations in Membrane Potential, Cytoplasmic Ca²⁺, and Metabolism for Plasma Insulin Oscillations

Do Oscillations of Insulin Secretion Occur in the Absence of Cytoplasmic Ca²⁺ Oscillations in β-Cells?

Dynamic Imaging of Endoplasmic Reticulum Ca²⁺ Concentration in Insulin-Secreting MIN6 Cells Using Recombinant Targeted Cameleons: Roles of Sarco(endo)plasmic Reticulum Ca²⁺-ATPase (SERCA)-2 and Ryanodine Receptors