Table of Contents

Editorial

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- Suad Efendic,
- Christian Boitard,
- Erol Cerasi,
- Ele Ferrannini,
- Jean-Claude Henquin,
- and Donald F. Steiner
Regulation of Insulin Production: In Search of Therapeutic Targets
Diabetes December 2002 51:S285-S287; doi:10.2337/diabetes.51.2007.S285

Section 1: In Search of Diabetes Genes

Select this article
- Stephen S. Rich and
- Patrick Concannon
Challenges and Strategies for Investigating the Genetic Complexity of Common Human Diseases
Diabetes December 2002 51:S288-S294; doi:10.2337/diabetes.51.2007.S288
Select this article
- Pierre Bougnères
Genetics of Obesity and Type 2 Diabetes: Tracking Pathogenic Traits During the Predisease Period
Diabetes December 2002 51:S295-S303; doi:10.2337/diabetes.51.2007.S295
Select this article
- Sophie Le Fur,
- Catherine Le Stunff,
- and Pierre Bougnères
Increased Insulin Resistance in Obese Children Who Have Both 972 IRS-1 and 1057 IRS-2 Polymorphisms
Diabetes December 2002 51:S304-S307; doi:10.2337/diabetes.51.2007.S304
Select this article
- Marshall Alan Permutt,
- Jonathan Wasson,
- Latisha Love-Gregory,
- Jiyan Ma,
- Gary Skolnick,
- Brian Suarez,
- Jennifer Lin,
- and Benjamin Glaser
Searching for Type 2 Diabetes Genes on Chromosome 20
Diabetes December 2002 51:S308-S315; doi:10.2337/diabetes.51.2007.S308
Select this article
- Michèle M. Sale,
- Liesel M. FitzGerald,
- Jacinta C. Charlesworth,
- Donald W. Bowden,
- and Stephen S. Rich
Evidence for a Novel Type 1 Diabetes Susceptibility Locus on Chromosome 8
Diabetes December 2002 51:S316-S319; doi:10.2337/diabetes.51.2007.S316

Section 2: Beta-Cell Genes: Functional Aspects

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- Danielle Melloul,
- Sonya Marshak,
- and Erol Cerasi
Regulation of pdx-1 Gene Expression
Diabetes December 2002 51:S320-S325; doi:10.2337/diabetes.51.2007.S320
Select this article
- Frans Schuit,
- Daisy Flamez,
- Anick De Vos,
- and Daniel Pipeleers
Glucose-Regulated Gene Expression Maintaining the Glucose-Responsive State of β-Cells
Diabetes December 2002 51:S326-S332; doi:10.2337/diabetes.51.2007.S326
Select this article
- Haiyan Wang,
- Kerstin Hagenfeldt-Johansson,
- Luc A. Otten,
- Benoit R. Gauthier,
- Pedro L. Herrera,
- and Claes B. Wollheim
Experimental Models of Transcription Factor-Associated Maturity-Onset Diabetes of the Young
Diabetes December 2002 51:S333-S342; doi:10.2337/diabetes.51.2007.S333
Select this article
- Pascal Boileau,
- Christian Wolfrum,
- David Q. Shih,
- Tien-An Yang,
- Allan W. Wolkoff,
- and Markus Stoffel
Decreased Glibenclamide Uptake in Hepatocytes of Hepatocyte Nuclear Factor-1α-Deficient Mice: A Mechanism for Hypersensitivity to Sulfonylurea Therapy in Patients With Maturity-Onset Diabetes of the Young, Type 3 (MODY3)
Diabetes December 2002 51:S343-S348; doi:10.2337/diabetes.51.2007.S343

Section 3: Beta-Cell Stimulus-Secretion Coupling: K+ ATP Channels and CA2+

Select this article
- Jose M. Cancela and
- Ole H. Petersen
Regulation of Intracellular Ca²⁺ Stores by Multiple Ca²⁺-Releasing Messengers
Diabetes December 2002 51:S349-S357; doi:10.2337/diabetes.51.2007.S349
Select this article
- Christina Schwanstecher and
- Mathias Schwanstecher
Nucleotide Sensitivity of Pancreatic ATP-Sensitive Potassium Channels and Type 2 Diabetes
Diabetes December 2002 51:S358-S362; doi:10.2337/diabetes.51.2007.S358
Select this article
- Christina Schwanstecher,
- Bettina Neugebauer,
- Miriam Schulz,
- and Mathias Schwanstecher
The Common Single Nucleotide Polymorphism E23K in K_IR6.2 Sensitizes Pancreatic β-Cell ATP-Sensitive Potassium Channels Toward Activation Through Nucleoside Diphosphates
Diabetes December 2002 51:S363-S367; doi:10.2337/diabetes.51.2007.S363
Select this article
- Peter Proks,
- Frank Reimann,
- Nick Green,
- Fiona Gribble,
- and Frances Ashcroft
Sulfonylurea Stimulation of Insulin Secretion
Diabetes December 2002 51:S368-S376; doi:10.2337/diabetes.51.2007.S368
Select this article
- Jonathan D. Lippiat,
- Sophie L. Albinson,
- and Frances M. Ashcroft
Interaction of the Cytosolic Domains of the Kir6.2 Subunit of the K_ATP Channel Is Modulated by Sulfonylureas
Diabetes December 2002 51:S377-S380; doi:10.2337/diabetes.51.2007.S377
Select this article
- Kenan Cejvan,
- David H. Coy,
- Jens Juul Holst,
- Erol Cerasi,
- and Suad Efendic
Gliclazide Directly Inhibits Arginine-Induced Glucagon Release
Diabetes December 2002 51:S381-S384; doi:10.2337/diabetes.51.2007.S381

Section 4: Beta-Cell Stimulus-Secretion Coupling: Metabolic Factors

Select this article
- Neal Alto,
- Jennifer J. Carlisle Michel,
- Kimberly L. Dodge,
- Lorene K. Langeberg,
- and John D. Scott
Intracellular Targeting of Protein Kinases and Phosphatases
Diabetes December 2002 51:S385-S388; doi:10.2337/diabetes.51.2007.S385
Select this article
- Christopher B. Newgard,
- Danhong Lu,
- Mette Valentin Jensen,
- Jonathan Schissler,
- Anne Boucher,
- Shawn Burgess,
- and A. Dean Sherry
Stimulus/Secretion Coupling Factors in Glucose-Stimulated Insulin Secretion: Insights Gained From a Multidisciplinary Approach
Diabetes December 2002 51:S389-S393; doi:10.2337/diabetes.51.2007.S389
Select this article
- Franz M. Matschinsky
Regulation of Pancreatic β-Cell Glucokinase: From Basics to Therapeutics
Diabetes December 2002 51:S394-S404; doi:10.2337/diabetes.51.2007.S394
Select this article
- Marc Prentki,
- Erik Joly,
- Wissal El-Assaad,
- and Raphaël Roduit
Malonyl-CoA Signaling, Lipid Partitioning, and Glucolipotoxicity: Role in β-Cell Adaptation and Failure in the Etiology of Diabetes
Diabetes December 2002 51:S405-S413; doi:10.2337/diabetes.51.2007.S405
Select this article
- Kazuhiro Eto,
- Tokuyuki Yamashita,
- Junji Matsui,
- Yasuo Terauchi,
- Mitsuhiko Noda,
- and Takashi Kadowaki
Genetic Manipulations of Fatty Acid Metabolism in β-Cells Are Associated With Dysregulated Insulin Secretion
Diabetes December 2002 51:S414-S420; doi:10.2337/diabetes.51.2007.S414
Select this article
- Andrea Kelly,
- Changhong Li,
- Zhiyong Gao,
- Charles A. Stanley,
- and Franz M. Matschinsky
Glutaminolysis and Insulin Secretion: From Bedside to Bench and Back
Diabetes December 2002 51:S421-S426; doi:10.2337/diabetes.51.2007.S421

Section 5: Beta-Cell Stimulus-Secretion Coupling: Hormonal and Pharmacological Modulators

Select this article
- Prabakhar D. Borge,
- Jacob Moibi,
- Scott R. Greene,
- Matteo Trucco,
- Robert A. Young,
- Zhiyong Gao,
- and Bryan A. Wolf
Insulin Receptor Signaling and Sarco/Endoplasmic Reticulum Calcium ATPase in β-Cells
Diabetes December 2002 51:S427-S433; doi:10.2337/diabetes.51.2007.S427
Select this article
- Patrick E. MacDonald,
- Wasim El-kholy,
- Michael J. Riedel,
- Anne Marie F. Salapatek,
- Peter E. Light,
- and Michael B. Wheeler
The Multiple Actions of GLP-1 on the Process of Glucose-Stimulated Insulin Secretion
Diabetes December 2002 51:S434-S442; doi:10.2337/diabetes.51.2007.S434
Select this article
- Patrick E. MacDonald,
- Anne Marie F. Salapatek,
- and Michael B. Wheeler
Glucagon-Like Peptide-1 Receptor Activation Antagonizes Voltage-Dependent Repolarizing K⁺ Currents in β-Cells: A Possible Glucose-Dependent Insulinotropic Mechanism
Diabetes December 2002 51:S443-S447; doi:10.2337/diabetes.51.2007.S443
Select this article
- Suad Efendic,
- Alexander M. Efanov,
- Per-Olof Berggren,
- and Sergei V. Zaitsev
Two Generations of Insulinotropic Imidazoline Compounds
Diabetes December 2002 51:S448-S454; doi:10.2337/diabetes.51.2007.S448

Section 6: Beta-Cell Survival

Select this article
- Heather P. Harding and
- David Ron
Endoplasmic Reticulum Stress and the Development of Diabetes: A Review
Diabetes December 2002 51:S455-S461; doi:10.2337/diabetes.51.2007.S455
Select this article
- Hiroshi Okamoto and
- Shin Takasawa
Recent Advances in the Okamoto Model: The CD38-Cyclic ADP-Ribose Signal System and the Regenerating Gene Protein (Reg)-Reg Receptor System in β-Cells
Diabetes December 2002 51:S462-S473; doi:10.2337/diabetes.51.2007.S462
Select this article
- Piero Marchetti,
- Alessandro Antonelli,
- Roberto Lupi,
- Lorella Marselli,
- Poupak Fallahi,
- Claudia Nesti,
- Germano Baj,
- and Ele Ferrannini
Prolonged In Vitro Exposure to Autoantibodies Against CD38 Impairs the Function and Survival of Human Pancreatic Islets
Diabetes December 2002 51:S474-S477; doi:10.2337/diabetes.51.2007.S474
Select this article
- Michiaki Unno,
- Koji Nata,
- Naoya Noguchi,
- Yoichi Narushima,
- Takako Akiyama,
- Takayuki Ikeda,
- Kei Nakagawa,
- Shin Takasawa,
- and Hiroshi Okamoto
Production and Characterization of Reg Knockout Mice: Reduced Proliferation of Pancreatic β-Cells in Reg Knockout Mice
Diabetes December 2002 51:S478-S483; doi:10.2337/diabetes.51.2007.S478
Select this article
- Ernesto Bernal-Mizrachi,
- Wu Wen,
- Michael Shornick,
- and M. Alan Permutt
Activation of Nuclear Factor-κB by Depolarization and Ca²⁺ Influx in MIN6 Insulinoma Cells
Diabetes December 2002 51:S484-S488; doi:10.2337/diabetes.51.2007.S484
Select this article
- Danièle Dubois-Lafforgue,
- Laurent Mogenet,
- Karine Thébault,
- Jacques Jami,
- Patricia Krief,
- and Christian Boitard
Proinsulin 2 Knockout NOD Mice: A Model for Genetic Variation of Insulin Gene Expression in Type 1 Diabetes
Diabetes December 2002 51:S489-S493; doi:10.2337/diabetes.51.2007.S489

Editorial

Regulation of Insulin Production: In Search of Therapeutic Targets

Section 1: In Search of Diabetes Genes

Challenges and Strategies for Investigating the Genetic Complexity of Common Human Diseases

Genetics of Obesity and Type 2 Diabetes: Tracking Pathogenic Traits During the Predisease Period

Increased Insulin Resistance in Obese Children Who Have Both 972 IRS-1 and 1057 IRS-2 Polymorphisms

Searching for Type 2 Diabetes Genes on Chromosome 20

Evidence for a Novel Type 1 Diabetes Susceptibility Locus on Chromosome 8

Section 2: Beta-Cell Genes: Functional Aspects

Regulation of pdx-1 Gene Expression

Glucose-Regulated Gene Expression Maintaining the Glucose-Responsive State of β-Cells

Experimental Models of Transcription Factor-Associated Maturity-Onset Diabetes of the Young

Decreased Glibenclamide Uptake in Hepatocytes of Hepatocyte Nuclear Factor-1α-Deficient Mice: A Mechanism for Hypersensitivity to Sulfonylurea Therapy in Patients With Maturity-Onset Diabetes of the Young, Type 3 (MODY3)

Section 3: Beta-Cell Stimulus-Secretion Coupling: K+ ATP Channels and CA2+

Regulation of Intracellular Ca2+ Stores by Multiple Ca2+-Releasing Messengers

Nucleotide Sensitivity of Pancreatic ATP-Sensitive Potassium Channels and Type 2 Diabetes

The Common Single Nucleotide Polymorphism E23K in KIR6.2 Sensitizes Pancreatic β-Cell ATP-Sensitive Potassium Channels Toward Activation Through Nucleoside Diphosphates

Sulfonylurea Stimulation of Insulin Secretion

Interaction of the Cytosolic Domains of the Kir6.2 Subunit of the KATP Channel Is Modulated by Sulfonylureas

Gliclazide Directly Inhibits Arginine-Induced Glucagon Release

Section 4: Beta-Cell Stimulus-Secretion Coupling: Metabolic Factors

Intracellular Targeting of Protein Kinases and Phosphatases

Stimulus/Secretion Coupling Factors in Glucose-Stimulated Insulin Secretion: Insights Gained From a Multidisciplinary Approach

Regulation of Pancreatic β-Cell Glucokinase: From Basics to Therapeutics

Malonyl-CoA Signaling, Lipid Partitioning, and Glucolipotoxicity: Role in β-Cell Adaptation and Failure in the Etiology of Diabetes

Genetic Manipulations of Fatty Acid Metabolism in β-Cells Are Associated With Dysregulated Insulin Secretion

Glutaminolysis and Insulin Secretion: From Bedside to Bench and Back

Section 5: Beta-Cell Stimulus-Secretion Coupling: Hormonal and Pharmacological Modulators

Insulin Receptor Signaling and Sarco/Endoplasmic Reticulum Calcium ATPase in β-Cells

The Multiple Actions of GLP-1 on the Process of Glucose-Stimulated Insulin Secretion

Glucagon-Like Peptide-1 Receptor Activation Antagonizes Voltage-Dependent Repolarizing K+ Currents in β-Cells: A Possible Glucose-Dependent Insulinotropic Mechanism

Two Generations of Insulinotropic Imidazoline Compounds

Section 6: Beta-Cell Survival

Endoplasmic Reticulum Stress and the Development of Diabetes: A Review

Recent Advances in the Okamoto Model: The CD38-Cyclic ADP-Ribose Signal System and the Regenerating Gene Protein (Reg)-Reg Receptor System in β-Cells

Prolonged In Vitro Exposure to Autoantibodies Against CD38 Impairs the Function and Survival of Human Pancreatic Islets

Production and Characterization of Reg Knockout Mice: Reduced Proliferation of Pancreatic β-Cells in Reg Knockout Mice

Activation of Nuclear Factor-κB by Depolarization and Ca2+ Influx in MIN6 Insulinoma Cells

Proinsulin 2 Knockout NOD Mice: A Model for Genetic Variation of Insulin Gene Expression in Type 1 Diabetes

This Issue

Current Issue

Regulation of Intracellular Ca²⁺ Stores by Multiple Ca²⁺-Releasing Messengers

The Common Single Nucleotide Polymorphism E23K in K_IR6.2 Sensitizes Pancreatic β-Cell ATP-Sensitive Potassium Channels Toward Activation Through Nucleoside Diphosphates

Interaction of the Cytosolic Domains of the Kir6.2 Subunit of the K_ATP Channel Is Modulated by Sulfonylureas

Glucagon-Like Peptide-1 Receptor Activation Antagonizes Voltage-Dependent Repolarizing K⁺ Currents in β-Cells: A Possible Glucose-Dependent Insulinotropic Mechanism

Activation of Nuclear Factor-κB by Depolarization and Ca²⁺ Influx in MIN6 Insulinoma Cells