Intracellular Targeting of Protein Kinases and Phosphatases
Abstract
Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger-mediated signaling events. Localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase anchoring proteins (AKAPs). This study focused on recent advances that further our understanding of AKAPs, with particular emphasis on the bidirectional regulation of signaling events by AKAP signaling complexes and their contribution to the control of actin reorganization events.
Footnotes
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Address correspondence and reprint requests to John D. Scott, Howard Hughes Medical Institute, Vollum Institute, 3181 SW Sam Jackson Park Rd., Portland, OR 97201-3098. E-mail: scott{at}ohsu.edu.
Received for publication 28 February 2002 and accepted in revised form 2 May 2002.
Abl, Abelson tyrosine kinase; AKAP, A-kinase anchoring protein; mAKAP, muscle-specific AKAP; NMDA, N-methyl-d-aspartic acid; PDE4D3, cAMP-specific type 4 phosphodiesterase; PK, protein kinase; PKA, cAMP-dependent protein kinase; PP, protein phosphatase; RyR, ryanodine receptor; SSeCKS, Src-suppressed C kinase substrate; WASP, Wiskott-Aldrich syndrome gene.
The symposium and the publication of this article have been made possible by an unrestricted educational grant from Servier, Paris.
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