Table of Contents

• Joseph L. Evans,
• Ira D. Goldfine,
• Betty A. Maddux,
• and Gerold M. Grodsky

Are Oxidative Stress−Activated Signaling Pathways Mediators of Insulin Resistance and β-Cell Dysfunction?

• Reza Halse,
• Lee G.D. Fryer,
• James G. McCormack,
• David Carling,
• and Stephen J. Yeaman

Regulation of Glycogen Synthase by Glucose and Glycogen: A Possible Role for AMP-Activated Protein Kinase

• Georg Schaller,
• Adele Schmidt,
• Johannes Pleiner,
• Wolfgang Woloszczuk,
• Michael Wolzt,
• and Anton Luger

Plasma Ghrelin Concentrations Are Not Regulated by Glucose or Insulin: A Double-Blind, Placebo-Controlled Crossover Clamp Study

• Rebecca J. Gum,
• Lori L. Gaede,
• Sandra L. Koterski,
• Matthew Heindel,
• Jill E. Clampit,
• Bradley A. Zinker,
• James M. Trevillyan,
• Roger G. Ulrich,
• Michael R. Jirousek,
• and Cristina M. Rondinone

Reduction of Protein Tyrosine Phosphatase 1B Increases Insulin-Dependent Signaling in ob/ob Mice

• Frédéric Tremblay,
• Charles Lavigne,
• Hélène Jacques,
• and André Marette

Dietary Cod Protein Restores Insulin-Induced Activation of Phosphatidylinositol 3-Kinase/Akt and GLUT4 Translocation to the T-Tubules in Skeletal Muscle of High-Fat-Fed Obese Rats

• Pankaj Shah,
• Adrian Vella,
• Ananda Basu,
• Rita Basu,
• Aron Adkins,
• W. Frederick Schwenk,
• C. Michael Johnson,
• K. Sreekumaran Nair,
• Michael D. Jensen,
• and Robert A. Rizza

Elevated Free Fatty Acids Impair Glucose Metabolism in Women: Decreased Stimulation of Muscle Glucose Uptake and Suppression of Splanchnic Glucose Production During Combined Hyperinsulinemia and Hyperglycemia

• Nayan G. Patel,
• Julie C. Holder,
• Stephen A. Smith,
• Sudesh Kumar,
• and Margaret C. Eggo

Differential Regulation of Lipogenesis and Leptin Production by Independent Signaling Pathways and Rosiglitazone During Human Adipocyte Differentiation

• David R. Garris and
• Bryan L. Garris

Diabetes-Induced, Progressive Endometrial Involution Characterization of Periluminal Epithelial Lipoatrophy

• Georg F. Beilhack,
• Yolanda C. Scheffold,
• Irving L. Weissman,
• Cariel Taylor,
• Libuse Jerabek,
• Matthew J. Burge,
• Marilyn A. Masek,
• and Judith A. Shizuru

Purified Allogeneic Hematopoietic Stem Cell Transplantation Blocks Diabetes Pathogenesis in NOD Mice

• Abdulkadir Omer,
• Valérie F. Duvivier-Kali,
• Nitin Trivedi,
• Karen Wilmot,
• Susan Bonner-Weir,
• and Gordon C. Weir

Survival and Maturation of Microencapsulated Porcine Neonatal Pancreatic Cell Clusters Transplanted into Immunocompetent Diabetic Mice

• Sidhartha Singh Tulachan,
• Ryuichiro Doi,
• Yoshiya Kawaguchi,
• Shoichiro Tsuji,
• Sanae Nakajima,
• Toshihiko Masui,
• Masayuki Koizumi,
• Eiji Toyoda,
• Tomohiko Mori,
• Daisuke Ito,
• Kazuhiro Kami,
• Koji Fujimoto,
• and Masayuki Imamura

All-Trans Retinoic Acid Induces Differentiation of Ducts and Endocrine Cells by Mesenchymal/Epithelial Interactions in Embryonic Pancreas

• Latif Rachdi,
• Jean-Claude Marie,
• and Raphael Scharfmann

Role for VPAC2 Receptor-Mediated Signals in Pancreas Development

• Anna Karenina Azevedo-Martins,
• Stephan Lortz,
• Sigurd Lenzen,
• Rui Curi,
• Decio L. Eizirik,
• and Markus Tiedge

Improvement of the Mitochondrial Antioxidant Defense Status Prevents Cytokine-Induced Nuclear Factor-κB Activation in Insulin-Producing Cells

• Alexandra E. Butler,
• Juliette Janson,
• Susan Bonner-Weir,
• Robert Ritzel,
• Robert A. Rizza,
• and Peter C. Butler

β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

• Raogo Ouedraogo,
• Erik Näslund,
• and Annette L. Kirchgessner

Glucose Regulates the Release of Orexin-A From the Endocrine Pancreas

• Marianne O. Larsen,
• Bidda Rolin,
• Michael Wilken,
• Richard D. Carr,
• and Carsten F. Gotfredsen

Measurements of Insulin Secretory Capacity and Glucose Tolerance to Predict Pancreatic β-Cell Mass In Vivo in the Nicotinamide/Streptozotocin Göttingen Minipig, a Model of Moderate Insulin Deficiency and Diabetes

• Jean Buteau,
• Sylvain Foisy,
• Erik Joly,
• and Marc Prentki

Glucagon-Like Peptide 1 Induces Pancreatic β-Cell Proliferation Via Transactivation of the Epidermal Growth Factor Receptor

• Guenther Boden,
• Peter Cheung,
• and Carol Homko

Effects of Acute Insulin Excess and Deficiency on Gluconeogenesis and Glycogenolysis in Type 1 Diabetes

• Johanna Kuhlmann,
• Claudia Neumann-Haefelin,
• Ulrich Belz,
• Jürgen Kalisch,
• Hans-Paul Juretschke,
• Marion Stein,
• Elke Kleinschmidt,
• Werner Kramer,
• and Andreas W. Herling

Intramyocellular Lipid and Insulin Resistance: A Longitudinal In Vivo ¹H-Spectroscopic Study in Zucker Diabetic Fatty Rats

• Stewart C. Ferguson,
• Ian J. Deary,
• Julie C. Evans,
• Sian Ellard,
• Andrew T. Hattersley,
• and Brian M. Frier

Apolipoprotein-E Influences Aspects of Intellectual Ability in Type 1 Diabetes

• Stewart C. Ferguson,
• Annette Blane,
• Petros Perros,
• Rory J. McCrimmon,
• Jonathan J.K. Best,
• Joanna Wardlaw,
• Ian J. Deary,
• and Brian M. Frier

Cognitive Ability and Brain Structure in Type 1 Diabetes: Relation to Microangiopathy and Preceding Severe Hypoglycemia

• Hannah R. Shotton,
• Simon Clarke,
• and Jill Lincoln

The Effectiveness of Treatments of Diabetic Autonomic Neuropathy Is Not the Same in Autonomic Nerves Supplying Different Organs

• Ann M. Schmeichel,
• James D. Schmelzer,
• and Phillip A. Low

Oxidative Injury and Apoptosis of Dorsal Root Ganglion Neurons in Chronic Experimental Diabetic Neuropathy

• Delma J. Nieves,
• Miriam Cnop,
• Barbara Retzlaff,
• Carolyn E. Walden,
• John D. Brunzell,
• Robert H. Knopp,
• and Steven E. Kahn

The Atherogenic Lipoprotein Profile Associated With Obesity and Insulin Resistance Is Largely Attributable to Intra-Abdominal Fat

• Misato Kobayashi,
• Tamio Ohno,
• Atsushi Tsuji,
• Masahiko Nishimura,
• and Fumihiko Horio

Combinations of Nondiabetic Parental Genomes Elicit Impaired Glucose Tolerance in Mouse SMXA Recombinant Inbred Strains

• Robert S. Lindsay,
• Robert L. Hanson,
• Chris Wiedrich,
• William C. Knowler,
• Peter H. Bennett,
• and Leslie J. Baier

The Insulin Gene Variable Number Tandem Repeat Class I/III Polymorphism Is in Linkage Disequilibrium With Birth Weight but Not Type 2 Diabetes in the Pima Population

• Pernille Poulsen,
• Gitte Andersen,
• Mogens Fenger,
• Torben Hansen,
• Søren M. Echwald,
• Aage Vølund,
• Henning Beck-Nielsen,
• Oluf Pedersen,
• and Allan Vaag

Impact of Two Common Polymorphisms in the PPARγ Gene on Glucose Tolerance and Plasma Insulin Profiles in Monozygotic and Dizygotic Twins: Thrifty Genotype, Thrifty Phenotype, or Both?

• Timo Otonkoski,
• Nina Kaminen,
• Jarkko Ustinov,
• Risto Lapatto,
• Thomas Meissner,
• Ertan Mayatepek,
• Juha Kere,
• and Ilkka Sipilä

Physical Exercise-Induced Hyperinsulinemic Hypoglycemia Is an Autosomal-Dominant Trait Characterized by Abnormal Pyruvate-Induced Insulin Release

• Frances A. Brook,
• Edward P. Evans,
• Christopher J. Lord,
• Paul A. Lyons,
• Daniel B. Rainbow,
• Sarah K. Howlett,
• Linda S. Wicker,
• John A. Todd,
• and Richard L. Gardner

The Derivation of Highly Germline-Competent Embryonic Stem Cells Containing NOD-Derived Genome

• Naoko Iwasaki,
• Nancy J. Cox,
• Yan-Qing Wang,
• Peter E.H. Schwarz,
• Graeme I. Bell,
• Masashi Honda,
• Mitsuo Imura,
• Makiko Ogata,
• Masayuki Saito,
• Naoyuki Kamatani,
• and Yasuhiko Iwamoto

Mapping Genes Influencing Type 2 Diabetes Risk and BMI in Japanese Subjects

• Margrit Urbanek,
• Yangzhu Du,
• Kaisa Silander,
• Francis S. Collins,
• Claire M. Steppan,
• Jerome F. Strauss III,
• Andrea Dunaif,
• Richard S. Spielman,
• and Richard S. Legro

Variation in Resistin Gene Promoter Not Associated With Polycystic Ovary Syndrome

• Thomas C. Brodnicki,
• Fiona Quirk,
• and Grant Morahan

A Susceptibility Allele From a Non-Diabetes-Prone Mouse Strain Accelerates Diabetes in NOD Congenic Mice

Errata