Table of Contents

Metabolism

Select this article
- Stella P. Kim,
- Martin Ellmerer,
- Gregg W. Van Citters,
- and Richard N. Bergman
Primacy of Hepatic Insulin Resistance in the Development of the Metabolic Syndrome Induced by an Isocaloric Moderate-Fat Diet in the Dog
Diabetes October 2003 52:2453-2460; doi:10.2337/diabetes.52.10.2453
Select this article
- Sangeeta Kashyap,
- Renata Belfort,
- Amalia Gastaldelli,
- Thongchai Pratipanawatr,
- Rachele Berria,
- Wilailak Pratipanawatr,
- Mandeep Bajaj,
- Lawrence Mandarino,
- Ralph DeFronzo,
- and Kenneth Cusi
A Sustained Increase in Plasma Free Fatty Acids Impairs Insulin Secretion in Nondiabetic Subjects Genetically Predisposed to Develop Type 2 Diabetes
Diabetes October 2003 52:2461-2474; doi:10.2337/diabetes.52.10.2461
Select this article
- O. Kunert,
- H. Stingl,
- E. Rosian,
- M. Krššák,
- E. Bernroider,
- W. Seebacher,
- K. Zangger,
- P. Staehr,
- V. Chandramouli,
- B.R. Landau,
- P. Nowotny,
- W. Waldhäusl,
- E. Haslinger,
- and M. Roden
Measurement of Fractional Whole-Body Gluconeogenesis in Humans From Blood Samples Using ²H Nuclear Magnetic Resonance Spectroscopy
Diabetes October 2003 52:2475-2482; doi:10.2337/diabetes.52.10.2475

Signal Transduction

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- Martin Haluzik,
- Shoshana Yakar,
- Oksana Gavrilova,
- Jennifer Setser,
- Yves Boisclair,
- and Derek LeRoith
Insulin Resistance in the Liver-Specific IGF-1 Gene-Deleted Mouse Is Abrogated by Deletion of the Acid-Labile Subunit of the IGF-Binding Protein-3 Complex: Relative Roles of Growth Hormone and IGF-1 in Insulin Resistance
Diabetes October 2003 52:2483-2489; doi:10.2337/diabetes.52.10.2483

Obesity Studies

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- Lynne E. Wagenknecht,
- Carl D. Langefeld,
- Ann L. Scherzinger,
- Jill M. Norris,
- Steven M. Haffner,
- Mohammed F. Saad,
- and Richard N. Bergman
Insulin Sensitivity, Insulin Secretion, and Abdominal Fat: The Insulin Resistance Atherosclerosis Study (IRAS) Family Study
Diabetes October 2003 52:2490-2496; doi:10.2337/diabetes.52.10.2490

Immunology and Transplantation

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- Zhidong Ling,
- Mark Van de Casteele,
- Jing Dong,
- Harry Heimberg,
- Jacques-Antoine Haefliger,
- Gérard Waeber,
- Frans Schuit,
- and Daniel Pipeleers
Variations in IB1/JIP1 Expression Regulate Susceptibility of β-Cells to Cytokine-Induced Apoptosis Irrespective of C-Jun NH₂-Terminal Kinase Signaling
Diabetes October 2003 52:2497-2502; doi:10.2337/diabetes.52.10.2497

Islet Studies

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- Mary Kay Treutelaar,
- Jennifer M. Skidmore,
- Claudia L. Dias-Leme,
- Manami Hara,
- Lizhi Zhang,
- Diane Simeone,
- Donna M. Martin,
- and Charles F. Burant
Nestin-Lineage Cells Contribute to the Microvasculature but Not Endocrine Cells of the Islet
Diabetes October 2003 52:2503-2512; doi:10.2337/diabetes.52.10.2503
Select this article
- Richard D. Carr,
- Christian L. Brand,
- Thora B. Bodvarsdottir,
- John B. Hansen,
- and Jeppe Sturis
NN414, a SUR1/Kir6.2-Selective Potassium Channel Opener, Reduces Blood Glucose and Improves Glucose Tolerance in the VDF Zucker Rat
Diabetes October 2003 52:2513-2518; doi:10.2337/diabetes.52.10.2513
Select this article
- Rohan K. Humphrey,
- Nathan Bucay,
- Gillian M. Beattie,
- Ana Lopez,
- Conrad A. Messam,
- Vincenzo Cirulli,
- and Alberto Hayek
Characterization and Isolation of Promoter-Defined Nestin-Positive Cells from the Human Fetal Pancreas
Diabetes October 2003 52:2519-2525; doi:10.2337/diabetes.52.10.2519
Select this article
- Frits Kamp,
- Nadeem Kizilbash,
- Barbara E. Corkey,
- Per-Olof Berggren,
- and James A. Hamilton
Sulfonylureas Rapidly Cross Phospholipid Bilayer Membranes by a Free-Diffusion Mechanism
Diabetes October 2003 52:2526-2531; doi:10.2337/diabetes.52.10.2526

Pathophysiology

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- Matti Uusitupa,
- Virpi Lindi,
- Anne Louheranta,
- Titta Salopuro,
- Jaana Lindström,
- and Jaakko Tuomilehto
Long-Term Improvement in Insulin Sensitivity by Changing Lifestyles of People with Impaired Glucose Tolerance: 4-Year Results From the Finnish Diabetes Prevention Study
Diabetes October 2003 52:2532-2538; doi:10.2337/diabetes.52.10.2532
Select this article
- Monika Zoltowska,
- Ehud Ziv,
- Edgard Delvin,
- Daniel Sinnett,
- Ronny Kalman,
- Carole Garofalo,
- Ernest Seidman,
- and Emile Levy
Cellular Aspects of Intestinal Lipoprotein Assembly in Psammomys Obesus: A Model of Insulin Resistance and Type 2 Diabetes
Diabetes October 2003 52:2539-2545; doi:10.2337/diabetes.52.10.2539
Select this article
- Seppo M. Pöykkö,
- Eija Kellokoski,
- Sohvi Hörkkö,
- Heikki Kauma,
- Y. Antero Kesäniemi,
- and Olavi Ukkola
Low Plasma Ghrelin Is Associated With Insulin Resistance, Hypertension, and the Prevalence of Type 2 Diabetes
Diabetes October 2003 52:2546-2553; doi:10.2337/diabetes.52.10.2546

Complications

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- Nica M. Borradaile,
- Linda E. de Dreu,
- and Murray W. Huff
Inhibition of Net HepG2 Cell Apolipoprotein B Secretion by the Citrus Flavonoid Naringenin Involves Activation of Phosphatidylinositol 3-Kinase, Independent of Insulin Receptor Substrate-1 Phosphorylation
Diabetes October 2003 52:2554-2561; doi:10.2337/diabetes.52.10.2554
Select this article
- Cecilia C. Low Wang,
- Inga Gurevich,
- and Boris Draznin
Insulin Affects Vascular Smooth Muscle Cell Phenotype and Migration Via Distinct Signaling Pathways
Diabetes October 2003 52:2562-2569; doi:10.2337/diabetes.52.10.2562
Select this article
- Shinsuke Kiritoshi,
- Takeshi Nishikawa,
- Kazuhiro Sonoda,
- Daisuke Kukidome,
- Takahumi Senokuchi,
- Tomoko Matsuo,
- Takeshi Matsumura,
- Hiroshi Tokunaga,
- Michael Brownlee,
- and Eiichi Araki
Reactive Oxygen Species from Mitochondria Induce Cyclooxygenase-2 Gene Expression in Human Mesangial Cells: Potential Role in Diabetic Nephropathy
Diabetes October 2003 52:2570-2577; doi:10.2337/diabetes.52.10.2570
Select this article
- Thierry C. Coste,
- Alain Gerbi,
- Philippe Vague,
- Gérard Pieroni,
- and Denis Raccah
Neuroprotective Effect of Docosahexaenoic Acid-Enriched Phospholipids in Experimental Diabetic Neuropathy
Diabetes October 2003 52:2578-2585; doi:10.2337/diabetes.52.10.2578
Select this article
- Shinichi Okada,
- Kenichi Shikata,
- Mitsuhiro Matsuda,
- Daisuke Ogawa,
- Hitomi Usui,
- Yuichi Kido,
- Ryo Nagase,
- Jun Wada,
- Yasushi Shikata,
- and Hirofumi Makino
Intercellular Adhesion Molecule-1–Deficient Mice Are Resistant Against Renal Injury After Induction of Diabetes
Diabetes October 2003 52:2586-2593; doi:10.2337/diabetes.52.10.2586
Select this article
- Alessia Fornoni,
- Oliver Lenz,
- Liliane J. Striker,
- and Gary E. Striker
Glucose Induces Clonal Selection and Reversible Dinucleotide Repeat Expansion in Mesangial Cells Isolated from Glomerulosclerosis-Prone Mice
Diabetes October 2003 52:2594-2602; doi:10.2337/diabetes.52.10.2594
Select this article
- Munehiro Kitada,
- Daisuke Koya,
- Toshiro Sugimoto,
- Motohide Isono,
- Shin-ichi Araki,
- Atsunori Kashiwagi,
- and Masakazu Haneda
Translocation of Glomerular p47phox and p67phox by Protein Kinase C-β Activation Is Required for Oxidative Stress in Diabetic Nephropathy
Diabetes October 2003 52:2603-2614; doi:10.2337/diabetes.52.10.2603
Select this article
- Soley Thrainsdottir,
- Rayez A. Malik,
- Lars B. Dahlin,
- Peter Wiksell,
- Karl F. Eriksson,
- Ingmar Rosén,
- Jesper Petersson,
- Douglas A. Greene,
- and Göran Sundkvist
Endoneurial Capillary Abnormalities Presage Deterioration of Glucose Tolerance and Accompany Peripheral Neuropathy in Man
Diabetes October 2003 52:2615-2622; doi:10.2337/diabetes.52.10.2615
Select this article
- Jonathan Q. Purnell,
- Raj K. Dev,
- Michael W. Steffes,
- Patricia A. Cleary,
- Jerry P. Palmer,
- Irl B. Hirsch,
- John E. Hokanson,
- and John D. Brunzell
Relationship of Family History of Type 2 Diabetes, Hypoglycemia, and Autoantibodies to Weight Gain and Lipids With Intensive and Conventional Therapy in the Diabetes Control and Complications Trial
Diabetes October 2003 52:2623-2629; doi:10.2337/diabetes.52.10.2623

Brief Genetics Reports

Select this article
- Michael J. Riedel,
- Parveen Boora,
- Diana Steckley,
- Gerda de Vries,
- and Peter E. Light
Kir6.2 Polymorphisms Sensitize β-Cell ATP-Sensitive Potassium Channels to Activation by Acyl CoAs: A Possible Cellular Mechanism for Increased Susceptibility to Type 2 Diabetes?
Diabetes October 2003 52:2630-2635; doi:10.2337/diabetes.52.10.2630
Select this article
- Gabrielle S. Sellick,
- Christine Garrett,
- and Richard S. Houlston
A Novel Gene for Neonatal Diabetes Maps to Chromosome 10p12.1-p13
Diabetes October 2003 52:2636-2638; doi:10.2337/diabetes.52.10.2636
Select this article
- Arno R. van der Slik,
- Bobby P.C. Koeleman,
- Willem Verduijn,
- G. Jan Bruining,
- Bart O. Roep,
- and Marius J. Giphart
KIR in Type 1 Diabetes: Disparate Distribution of Activating and Inhibitory Natural Killer Cell Receptors in Patients Versus HLA-Matched Control Subjects
Diabetes October 2003 52:2639-2642; doi:10.2337/diabetes.52.10.2639

Erratum

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Erratum
Diabetes October 2003 52:2643; doi:10.2337/diabetes.52.10.2643

Diabetes

Metabolism

Primacy of Hepatic Insulin Resistance in the Development of the Metabolic Syndrome Induced by an Isocaloric Moderate-Fat Diet in the Dog

A Sustained Increase in Plasma Free Fatty Acids Impairs Insulin Secretion in Nondiabetic Subjects Genetically Predisposed to Develop Type 2 Diabetes

Measurement of Fractional Whole-Body Gluconeogenesis in Humans From Blood Samples Using ²H Nuclear Magnetic Resonance Spectroscopy

Signal Transduction

Insulin Resistance in the Liver-Specific IGF-1 Gene-Deleted Mouse Is Abrogated by Deletion of the Acid-Labile Subunit of the IGF-Binding Protein-3 Complex: Relative Roles of Growth Hormone and IGF-1 in Insulin Resistance

Obesity Studies

Insulin Sensitivity, Insulin Secretion, and Abdominal Fat: The Insulin Resistance Atherosclerosis Study (IRAS) Family Study

Immunology and Transplantation

Variations in IB1/JIP1 Expression Regulate Susceptibility of β-Cells to Cytokine-Induced Apoptosis Irrespective of C-Jun NH₂-Terminal Kinase Signaling

Islet Studies

Nestin-Lineage Cells Contribute to the Microvasculature but Not Endocrine Cells of the Islet

NN414, a SUR1/Kir6.2-Selective Potassium Channel Opener, Reduces Blood Glucose and Improves Glucose Tolerance in the VDF Zucker Rat

Characterization and Isolation of Promoter-Defined Nestin-Positive Cells from the Human Fetal Pancreas

Sulfonylureas Rapidly Cross Phospholipid Bilayer Membranes by a Free-Diffusion Mechanism

Pathophysiology

Long-Term Improvement in Insulin Sensitivity by Changing Lifestyles of People with Impaired Glucose Tolerance: 4-Year Results From the Finnish Diabetes Prevention Study

Cellular Aspects of Intestinal Lipoprotein Assembly in Psammomys Obesus: A Model of Insulin Resistance and Type 2 Diabetes

Low Plasma Ghrelin Is Associated With Insulin Resistance, Hypertension, and the Prevalence of Type 2 Diabetes

Complications

Inhibition of Net HepG2 Cell Apolipoprotein B Secretion by the Citrus Flavonoid Naringenin Involves Activation of Phosphatidylinositol 3-Kinase, Independent of Insulin Receptor Substrate-1 Phosphorylation

Insulin Affects Vascular Smooth Muscle Cell Phenotype and Migration Via Distinct Signaling Pathways

Reactive Oxygen Species from Mitochondria Induce Cyclooxygenase-2 Gene Expression in Human Mesangial Cells: Potential Role in Diabetic Nephropathy

Neuroprotective Effect of Docosahexaenoic Acid-Enriched Phospholipids in Experimental Diabetic Neuropathy

Intercellular Adhesion Molecule-1–Deficient Mice Are Resistant Against Renal Injury After Induction of Diabetes

Glucose Induces Clonal Selection and Reversible Dinucleotide Repeat Expansion in Mesangial Cells Isolated from Glomerulosclerosis-Prone Mice

Translocation of Glomerular p47phox and p67phox by Protein Kinase C-β Activation Is Required for Oxidative Stress in Diabetic Nephropathy

Endoneurial Capillary Abnormalities Presage Deterioration of Glucose Tolerance and Accompany Peripheral Neuropathy in Man

Relationship of Family History of Type 2 Diabetes, Hypoglycemia, and Autoantibodies to Weight Gain and Lipids With Intensive and Conventional Therapy in the Diabetes Control and Complications Trial

Brief Genetics Reports

Kir6.2 Polymorphisms Sensitize β-Cell ATP-Sensitive Potassium Channels to Activation by Acyl CoAs: A Possible Cellular Mechanism for Increased Susceptibility to Type 2 Diabetes?

A Novel Gene for Neonatal Diabetes Maps to Chromosome 10p12.1-p13

KIR in Type 1 Diabetes: Disparate Distribution of Activating and Inhibitory Natural Killer Cell Receptors in Patients Versus HLA-Matched Control Subjects

Erratum

Erratum

This Issue

Current Issue

Diabetes

Table of Contents

Metabolism

Primacy of Hepatic Insulin Resistance in the Development of the Metabolic Syndrome Induced by an Isocaloric Moderate-Fat Diet in the Dog

A Sustained Increase in Plasma Free Fatty Acids Impairs Insulin Secretion in Nondiabetic Subjects Genetically Predisposed to Develop Type 2 Diabetes

Measurement of Fractional Whole-Body Gluconeogenesis in Humans From Blood Samples Using 2H Nuclear Magnetic Resonance Spectroscopy

Signal Transduction

Insulin Resistance in the Liver-Specific IGF-1 Gene-Deleted Mouse Is Abrogated by Deletion of the Acid-Labile Subunit of the IGF-Binding Protein-3 Complex: Relative Roles of Growth Hormone and IGF-1 in Insulin Resistance

Obesity Studies

Insulin Sensitivity, Insulin Secretion, and Abdominal Fat: The Insulin Resistance Atherosclerosis Study (IRAS) Family Study

Immunology and Transplantation

Variations in IB1/JIP1 Expression Regulate Susceptibility of β-Cells to Cytokine-Induced Apoptosis Irrespective of C-Jun NH2-Terminal Kinase Signaling

Islet Studies

Nestin-Lineage Cells Contribute to the Microvasculature but Not Endocrine Cells of the Islet

NN414, a SUR1/Kir6.2-Selective Potassium Channel Opener, Reduces Blood Glucose and Improves Glucose Tolerance in the VDF Zucker Rat

Characterization and Isolation of Promoter-Defined Nestin-Positive Cells from the Human Fetal Pancreas

Sulfonylureas Rapidly Cross Phospholipid Bilayer Membranes by a Free-Diffusion Mechanism

Pathophysiology

Long-Term Improvement in Insulin Sensitivity by Changing Lifestyles of People with Impaired Glucose Tolerance: 4-Year Results From the Finnish Diabetes Prevention Study

Cellular Aspects of Intestinal Lipoprotein Assembly in Psammomys Obesus: A Model of Insulin Resistance and Type 2 Diabetes

Low Plasma Ghrelin Is Associated With Insulin Resistance, Hypertension, and the Prevalence of Type 2 Diabetes

Complications

Inhibition of Net HepG2 Cell Apolipoprotein B Secretion by the Citrus Flavonoid Naringenin Involves Activation of Phosphatidylinositol 3-Kinase, Independent of Insulin Receptor Substrate-1 Phosphorylation

Insulin Affects Vascular Smooth Muscle Cell Phenotype and Migration Via Distinct Signaling Pathways

Reactive Oxygen Species from Mitochondria Induce Cyclooxygenase-2 Gene Expression in Human Mesangial Cells: Potential Role in Diabetic Nephropathy

Neuroprotective Effect of Docosahexaenoic Acid-Enriched Phospholipids in Experimental Diabetic Neuropathy

Intercellular Adhesion Molecule-1–Deficient Mice Are Resistant Against Renal Injury After Induction of Diabetes

Glucose Induces Clonal Selection and Reversible Dinucleotide Repeat Expansion in Mesangial Cells Isolated from Glomerulosclerosis-Prone Mice

Translocation of Glomerular p47phox and p67phox by Protein Kinase C-β Activation Is Required for Oxidative Stress in Diabetic Nephropathy

Endoneurial Capillary Abnormalities Presage Deterioration of Glucose Tolerance and Accompany Peripheral Neuropathy in Man

Relationship of Family History of Type 2 Diabetes, Hypoglycemia, and Autoantibodies to Weight Gain and Lipids With Intensive and Conventional Therapy in the Diabetes Control and Complications Trial

Brief Genetics Reports

Kir6.2 Polymorphisms Sensitize β-Cell ATP-Sensitive Potassium Channels to Activation by Acyl CoAs: A Possible Cellular Mechanism for Increased Susceptibility to Type 2 Diabetes?

A Novel Gene for Neonatal Diabetes Maps to Chromosome 10p12.1-p13

KIR in Type 1 Diabetes: Disparate Distribution of Activating and Inhibitory Natural Killer Cell Receptors in Patients Versus HLA-Matched Control Subjects

Erratum

Erratum

This Issue

Current Issue

Measurement of Fractional Whole-Body Gluconeogenesis in Humans From Blood Samples Using ²H Nuclear Magnetic Resonance Spectroscopy

Variations in IB1/JIP1 Expression Regulate Susceptibility of β-Cells to Cytokine-Induced Apoptosis Irrespective of C-Jun NH₂-Terminal Kinase Signaling