Table of Contents

Rapid Publication

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- Constadina Panagiotopoulos,
- Huilian Qin,
- Rusung Tan,
- and C. Bruce Verchere
Identification of a β-Cell-Specific HLA Class I Restricted Epitope in Type 1 Diabetes
Diabetes November 2003 52:2647-2651; published ahead of print September 5, 2003, doi:10.2337/diabetes.52.11.2647

Perspectives in Diabetes

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- Felix Kreier,
- Ajda Yilmaz,
- Andries Kalsbeek,
- Johannes A. Romijn,
- Hans P. Sauerwein,
- Eric Fliers,
- and Ruud M. Buijs
Hypothesis: Shifting the Equilibrium From Activity to Food Leads to Autonomic Unbalance and the Metabolic Syndrome
Diabetes November 2003 52:2652-2656; doi:10.2337/diabetes.52.11.2652

Signal Transduction

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- Asako Minami,
- Masanori Iseki,
- Kazuhiro Kishi,
- Miao Wang,
- Makoto Ogura,
- Noboru Furukawa,
- Sanae Hayashi,
- Mizuki Yamada,
- Toshiyuki Obata,
- Yukari Takeshita,
- Yutaka Nakaya,
- Yoshimi Bando,
- Keisuke Izumi,
- Shonna A. Moodie,
- Fumiko Kajiura,
- Mitsuru Matsumoto,
- Kiyoshi Takatsu,
- Satoshi Takaki,
- and Yousuke Ebina
Increased Insulin Sensitivity and Hypoinsulinemia in APS Knockout Mice
Diabetes November 2003 52:2657-2665; doi:10.2337/diabetes.52.11.2657

Obesity Study

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- Fernando Castro-Chavez,
- Vijay K. Yechoor,
- Pradip K. Saha,
- Javier Martinez-Botas,
- Eric C. Wooten,
- Saumya Sharma,
- Peter O’Connell,
- Heinrich Taegtmeyer,
- and Lawrence Chan
Coordinated Upregulation of Oxidative Pathways and Downregulation of Lipid Biosynthesis Underlie Obesity Resistance in Perilipin Knockout Mice: A Microarray Gene Expression Profile
Diabetes November 2003 52:2666-2674; doi:10.2337/diabetes.52.11.2666
Select this article
- Tooru M. Mizuno,
- Kevin A. Kelley,
- Giulio M. Pasinetti,
- James L. Roberts,
- and Charles V. Mobbs
Transgenic Neuronal Expression of Proopiomelanocortin Attenuates Hyperphagic Response to Fasting and Reverses Metabolic Impairments in Leptin-Deficient Obese Mice
Diabetes November 2003 52:2675-2683; doi:10.2337/diabetes.52.11.2675
Select this article
- Stephen C. Benoit,
- Deborah J. Clegg,
- Jason G. Barrera,
- Randy J. Seeley,
- and Stephen C. Woods
Learned Meal Initiation Attenuates the Anorexic Effects of the Melanocortin Agonist MTII
Diabetes November 2003 52:2684-2688; doi:10.2337/diabetes.52.11.2684

Immunology and Transplantation

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- Carolyn J. Padoa,
- J. Paul Banga,
- Anne-Marie Madec,
- Manfred Ziegler,
- Michael Schlosser,
- Eva Ortqvist,
- Ingrid Kockum,
- Jerry Palmer,
- Olov Rolandsson,
- Katherine A. Binder,
- Jefferson Foote,
- Dong Luo,
- and Christiane S. Hampe
Recombinant Fabs of Human Monoclonal Antibodies Specific to the Middle Epitope of GAD65 Inhibit Type 1 Diabetes–Specific GAD65Abs
Diabetes November 2003 52:2689-2695; doi:10.2337/diabetes.52.11.2689
Select this article
- Malin Flodström-Tullberg,
- Deepak Yadav,
- Robert Hägerkvist,
- Devin Tsai,
- Patrick Secrest,
- Alexandr Stotland,
- and Nora Sarvetnick
Target Cell Expression of Suppressor of Cytokine Signaling-1 Prevents Diabetes in the NOD Mouse
Diabetes November 2003 52:2696-2700; doi:10.2337/diabetes.52.11.2696
Select this article
- Burak Kutlu,
- Alessandra K. Cardozo,
- Martine I. Darville,
- Mogens Kruhøffer,
- Nils Magnusson,
- Torben Ørntoft,
- and Décio L. Eizirik
Discovery of Gene Networks Regulating Cytokine-Induced Dysfunction and Apoptosis in Insulin-Producing INS-1 Cells
Diabetes November 2003 52:2701-2719; doi:10.2337/diabetes.52.11.2701

Islet Study

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- Bin Zhang,
- Masahiro Hosaka,
- Yoshie Sawada,
- Seiji Torii,
- Shin Mizutani,
- Masato Ogata,
- Tetsuro Izumi,
- and Toshiyuki Takeuchi
Parathyroid Hormone–Related Protein Induces Insulin Expression Through Activation of MAP Kinase–Specific Phosphatase-1 That Dephosphorylates c-Jun NH₂-Terminal Kinase in Pancreatic β-Cells
Diabetes November 2003 52:2720-2730; doi:10.2337/diabetes.52.11.2720
Select this article
- Ewan Bell,
- Xiaopei Cao,
- Jacob A. Moibi,
- Scott R. Greene,
- Robert Young,
- Matteo Trucco,
- Zhiyong Gao,
- Franz M. Matschinsky,
- Shaoping Deng,
- James F. Markman,
- Ali Naji,
- and Bryan A. Wolf
Rapamycin Has a Deleterious Effect on MIN-6 Cells and Rat and Human Islets
Diabetes November 2003 52:2731-2739; doi:10.2337/diabetes.52.11.2731

Pathophysiology

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- Anthony J.G. Hanley,
- Lynne E. Wagenknecht,
- Ralph B. D’Agostino, Jr.,
- Bernard Zinman,
- and Steven M. Haffner
Identification of Subjects with Insulin Resistance and β-Cell Dysfunction Using Alternative Definitions of the Metabolic Syndrome
Diabetes November 2003 52:2740-2747; doi:10.2337/diabetes.52.11.2740
Select this article
- Meredith Hawkins,
- Julia Tonelli,
- Preeti Kishore,
- Daniel Stein,
- Enzo Ragucci,
- Alon Gitig,
- and Kalpana Reddy
Contribution of Elevated Free Fatty Acid Levels to the Lack of Glucose Effectiveness in Type 2 Diabetes
Diabetes November 2003 52:2748-2758; doi:10.2337/diabetes.52.11.2748
Select this article
- Hai-Lu Zhao,
- Fernand M.M. Lai,
- Peter C.Y. Tong,
- Ding-Rong Zhong,
- Di Yang,
- Brian Tomlinson,
- and Juliana C.N. Chan
Prevalence and Clinicopathological Characteristics of Islet Amyloid in Chinese Patients With Type 2 Diabetes
Diabetes November 2003 52:2759-2766; doi:10.2337/diabetes.52.11.2759
Select this article
- Martin G. de Vries,
- Linda M. Arseneau,
- Marcus E. Lawson,
- and Joseph L. Beverly
Extracellular Glucose in Rat Ventromedial Hypothalamus During Acute and Recurrent Hypoglycemia
Diabetes November 2003 52:2767-2773; doi:10.2337/diabetes.52.11.2767
Select this article
- Francesca Porcellati,
- Simone Pampanelli,
- Paolo Rossetti,
- Cristina Cordoni,
- Stefania Marzotti,
- Luciano Scionti,
- Geremia B. Bolli,
- and Carmine G. Fanelli
Counterregulatory Hormone and Symptom Responses to Insulin-Induced Hypoglycemia in the Postprandial State in Humans
Diabetes November 2003 52:2774-2783; doi:10.2337/diabetes.52.11.2774
Select this article
- Peter J. Klover,
- Teresa A. Zimmers,
- Leonidas G. Koniaris,
- and Robert A. Mooney
Chronic Exposure to Interleukin-6 Causes Hepatic Insulin Resistance in Mice
Diabetes November 2003 52:2784-2789; doi:10.2337/diabetes.52.11.2784
Select this article
- Michael S. Boyne,
- David M. Silver,
- Joy Kaplan,
- and Christopher D. Saudek
Timing of Changes in Interstitial and Venous Blood Glucose Measured With a Continuous Subcutaneous Glucose Sensor
Diabetes November 2003 52:2790-2794; doi:10.2337/diabetes.52.11.2790

Complications

Select this article
- Lisa Quagliaro,
- Ludovica Piconi,
- Roberta Assaloni,
- Lucia Martinelli,
- Enrico Motz,
- and Antonio Ceriello
Intermittent High Glucose Enhances Apoptosis Related to Oxidative Stress in Human Umbilical Vein Endothelial Cells: The Role of Protein Kinase C and NAD(P)H-Oxidase Activation
Diabetes November 2003 52:2795-2804; doi:10.2337/diabetes.52.11.2795
Select this article
- Melpomeni Peppa,
- Harold Brem,
- Paul Ehrlich,
- Jian-Gang Zhang,
- Weijing Cai,
- Zhu Li,
- Anca Croitoru,
- Swan Thung,
- and Helen Vlassara
Adverse Effects of Dietary Glycotoxins on Wound Healing in Genetically Diabetic Mice
Diabetes November 2003 52:2805-2813; doi:10.2337/diabetes.52.11.2805
Select this article
- Roberto Lorusso,
- Samuele Pentiricci,
- Riccardo Raddino,
- Tiziano M. Scarabelli,
- Claudia Zambelli,
- Vincenzo Villanacci,
- Anna Burattin,
- Giuseppe Romanelli,
- Salvatore Casari,
- Roberto Scelsi,
- and Andrea Giustina
Influence of Type 2 Diabetes on Functional and Structural Properties of Coronary Artery Bypass Conduits
Diabetes November 2003 52:2814-2820; doi:10.2337/diabetes.52.11.2814
Select this article
- Itamar Goren,
- Heiko Kämpfer,
- Maurizio Podda,
- Josef Pfeilschifter,
- and Stefan Frank
Leptin and Wound Inflammation in Diabetic ob/ob Mice: Differential Regulation of Neutrophil and Macrophage Influx and a Potential Role for the Scab as a Sink for Inflammatory Cells and Mediators
Diabetes November 2003 52:2821-2832; doi:10.2337/diabetes.52.11.2821
Select this article
- Dana Dabelea,
- Gregory Kinney,
- Janet K. Snell-Bergeon,
- John E. Hokanson,
- Robert H. Eckel,
- James Ehrlich,
- Satish Garg,
- Richard F. Hamman,
- and Marian Rewers
Effect of Type 1 Diabetes on the Gender Difference in Coronary Artery Calcification: a Role for Insulin Resistance?: The Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study
Diabetes November 2003 52:2833-2839; doi:10.2337/diabetes.52.11.2833

Genetics

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- Weihong Tang,
- Michael B. Miller,
- Stephen S. Rich,
- Kari E. North,
- James S. Pankow,
- Ingrid B. Borecki,
- Richard H. Myers,
- Paul N. Hopkins,
- Mark Leppert,
- and Donna K. Arnett
Linkage Analysis of a Composite Factor for the Multiple Metabolic Syndrome: The National Heart, Lung, and Blood Institute Family Heart Study
Diabetes November 2003 52:2840-2847; doi:10.2337/diabetes.52.11.2840
Select this article
- Nobue Tanaka,
- Tetsuya Babazono,
- Susumu Saito,
- Akihiro Sekine,
- Tatsuhiko Tsunoda,
- Masakazu Haneda,
- Yasushi Tanaka,
- Tomoaki Fujioka,
- Kohei Kaku,
- Ryuzou Kawamori,
- Ryuichi Kikkawa,
- Yasuhiko Iwamoto,
- Yusuke Nakamura,
- and Shiro Maeda
Association of Solute Carrier Family 12 (Sodium/Chloride) Member 3 With Diabetic Nephropathy, Identified by Genome-Wide Analyses of Single Nucleotide Polymorphisms
Diabetes November 2003 52:2848-2853; doi:10.2337/diabetes.52.11.2848
Select this article
- Pål R. Njølstad,
- Jørn V. Sagen,
- Lise Bjørkhaug,
- Stella Odili,
- Naim Shehadeh,
- Doua Bakry,
- S. Umit Sarici,
- Faruk Alpay,
- Janne Molnes,
- Anders Molven,
- Oddmund Søvik,
- and Franz M. Matschinsky
Permanent Neonatal Diabetes Caused by Glucokinase Deficiency: Inborn Error of the Glucose-Insulin Signaling Pathway
Diabetes November 2003 52:2854-2860; doi:10.2337/diabetes.52.11.2854

Brief Genetics Report

Select this article
- Thomas Illig,
- Friedhelm Bongardt,
- Andreas Schöpfer,
- Rolf Holle,
- Sylvia Müller,
- Wolfgang Rathmann,
- Wolfgang Koenig,
- Christa Meisinger,
- H.-Erich Wichmann,
- and Hubert Kolb
The Endotoxin Receptor TLR4 Polymorphism Is Not Associated With Diabetes or Components of the Metabolic Syndrome
Diabetes November 2003 52:2861-2864; doi:10.2337/diabetes.52.11.2861

Diabetes

Rapid Publication

Identification of a β-Cell-Specific HLA Class I Restricted Epitope in Type 1 Diabetes

Perspectives in Diabetes

Hypothesis: Shifting the Equilibrium From Activity to Food Leads to Autonomic Unbalance and the Metabolic Syndrome

Signal Transduction

Increased Insulin Sensitivity and Hypoinsulinemia in APS Knockout Mice

Obesity Study

Coordinated Upregulation of Oxidative Pathways and Downregulation of Lipid Biosynthesis Underlie Obesity Resistance in Perilipin Knockout Mice: A Microarray Gene Expression Profile

Transgenic Neuronal Expression of Proopiomelanocortin Attenuates Hyperphagic Response to Fasting and Reverses Metabolic Impairments in Leptin-Deficient Obese Mice

Learned Meal Initiation Attenuates the Anorexic Effects of the Melanocortin Agonist MTII

Immunology and Transplantation

Recombinant Fabs of Human Monoclonal Antibodies Specific to the Middle Epitope of GAD65 Inhibit Type 1 Diabetes–Specific GAD65Abs

Target Cell Expression of Suppressor of Cytokine Signaling-1 Prevents Diabetes in the NOD Mouse

Discovery of Gene Networks Regulating Cytokine-Induced Dysfunction and Apoptosis in Insulin-Producing INS-1 Cells

Islet Study

Parathyroid Hormone–Related Protein Induces Insulin Expression Through Activation of MAP Kinase–Specific Phosphatase-1 That Dephosphorylates c-Jun NH2-Terminal Kinase in Pancreatic β-Cells

Rapamycin Has a Deleterious Effect on MIN-6 Cells and Rat and Human Islets

Pathophysiology

Identification of Subjects with Insulin Resistance and β-Cell Dysfunction Using Alternative Definitions of the Metabolic Syndrome

Contribution of Elevated Free Fatty Acid Levels to the Lack of Glucose Effectiveness in Type 2 Diabetes

Prevalence and Clinicopathological Characteristics of Islet Amyloid in Chinese Patients With Type 2 Diabetes

Extracellular Glucose in Rat Ventromedial Hypothalamus During Acute and Recurrent Hypoglycemia

Counterregulatory Hormone and Symptom Responses to Insulin-Induced Hypoglycemia in the Postprandial State in Humans

Chronic Exposure to Interleukin-6 Causes Hepatic Insulin Resistance in Mice

Timing of Changes in Interstitial and Venous Blood Glucose Measured With a Continuous Subcutaneous Glucose Sensor

Complications

Intermittent High Glucose Enhances Apoptosis Related to Oxidative Stress in Human Umbilical Vein Endothelial Cells: The Role of Protein Kinase C and NAD(P)H-Oxidase Activation

Adverse Effects of Dietary Glycotoxins on Wound Healing in Genetically Diabetic Mice

Influence of Type 2 Diabetes on Functional and Structural Properties of Coronary Artery Bypass Conduits

Leptin and Wound Inflammation in Diabetic ob/ob Mice: Differential Regulation of Neutrophil and Macrophage Influx and a Potential Role for the Scab as a Sink for Inflammatory Cells and Mediators

Effect of Type 1 Diabetes on the Gender Difference in Coronary Artery Calcification: a Role for Insulin Resistance?: The Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study

Genetics

Linkage Analysis of a Composite Factor for the Multiple Metabolic Syndrome: The National Heart, Lung, and Blood Institute Family Heart Study

Association of Solute Carrier Family 12 (Sodium/Chloride) Member 3 With Diabetic Nephropathy, Identified by Genome-Wide Analyses of Single Nucleotide Polymorphisms

Permanent Neonatal Diabetes Caused by Glucokinase Deficiency: Inborn Error of the Glucose-Insulin Signaling Pathway

Brief Genetics Report

The Endotoxin Receptor TLR4 Polymorphism Is Not Associated With Diabetes or Components of the Metabolic Syndrome

This Issue

Current Issue

Parathyroid Hormone–Related Protein Induces Insulin Expression Through Activation of MAP Kinase–Specific Phosphatase-1 That Dephosphorylates c-Jun NH₂-Terminal Kinase in Pancreatic β-Cells