Increased insulin sensitivity in APS−/− mice. A: Blood glucose levels during the IPITT in APS+/+ (•) and APS−/− mice (○) at age 8–9 weeks (+/+, n = 10; −/−, n = 13). B and C: Blood glucose levels (B) and plasma insulin levels (C) during the IPGTT at age 8–9 weeks (+/+, n = 12; −/−, n = 10). D: Glucose infusion rate measured using an euglycemic-hyperinsulinemic glucose clamp test as described in research design and methods. Insulin-mediated whole-body glucose uptake was determined in anesthetized mice aged 9–11 weeks (+/+, n = 10; −/−, n = 12). The averages of body weight of APS+/+ and APS−/− mice were 25 and 27 g, respectively. No correlation between body weight and glucose infusion rate was evident. All values
are expressed as means ± SD. *P < 0.05 vs. APS+/+ mice.