Increased Insulin Sensitivity and Hypoinsulinemia in APS Knockout Mice

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FIG. 5.
FIG. 5.

Effects of APS on insulin receptor signaling in isolated adipocyte of APS−/− mice. The effect on phosphorylations of insulin signaling molecules (insulin receptor and Akt, MAP kinase) in isolated adipocytes of APS+/+ and APS−/− mice. Isolated adipocytes were serum starved and then stimulated with (+) or without (−) 100 nmol/l insulin for 5 min and lysed. The total lysates were measured by immunoprecipitation (IP) and immunoblotting (IB) using indicated antibodies.

This Article

  1. Diabetes vol. 52 no. 11 2657-2665