Increased Insulin Sensitivity and Hypoinsulinemia in APS Knockout Mice
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Insulin actions in isolated tissues of APS−/− mice. A and B: Insulin-stimulated glucose uptake into isolated adipocytes (A) and skeletal muscle (B) from APS+/+ and APS−/− mice. Adipocytes and skeletal muscle were isolated and stimulated with (shaded bars) or without (open bar) insulin at 37°C
for 30 min, then 2-deoxyglucose uptake was measured. All values are expressed as the means ± SD (n = 5–9); P < 0.05 vs. APS+/+ mice. C: Glycogen contents in liver from APS+/+ and APS−/− mice. Data are expressed as the means ± SD (n = 6–8).