Increased Insulin Sensitivity and Hypoinsulinemia in APS Knockout Mice

TABLE 1

Metabolic parameters in APS−/− mice

APS+/+ APS−/−
Body weight (g) 25.28 ± 3.33 27.77 ± 2.39 NS
Epididymal fat weight (g) 0.24 ± 0.31 0.31 ± 0.14 NS
Food intake (g/day) 2.79 ± 0.02 2.68 ± 0.23 NS
Fasted glucose (mmol/l) 3.60 ± 0.50 3.21 ± 0.53 NS
Fasted insulin (pmol/l) 141 ± 48 100 ± 16 *
Fasted glucagon (ng/l) 32.1 ± 12.0 41.7 ± 14.7 NS
Triglycerides (mmol/l) 1.17 ± 0.24 1.10 ± 0.23 NS
Total cholesterol (mmol/l) 3.01 ± 1.23 2.72 ± 1.07 NS
FFAs (mEq/l) 0.468 ± 0.120 0.551 ± 0.147 NS
  • Data are means ± SD (n = 8–16). Weights of body and epididymal fat removed surgically were measured after a 14 h fast. Blood samples from mice aged 8–11 weeks were collected from the inferior vena cava for biochemical analysis, as described in research design and methods.

  • *

    * P < 0.05 vs. APS+/+ mice.

This Article

  1. Diabetes vol. 52 no. 11 2657-2665