Table of Contents

Perspectives in Diabetes

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- J. Robinson Singleton,
- A. Gordon Smith,
- James W. Russell,
- and Eva L. Feldman
Microvascular Complications of Impaired Glucose Tolerance
Diabetes December 2003 52:2867-2873; doi:10.2337/diabetes.52.12.2867

Metabolism

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- Aaron P. Russell,
- Jonas Feilchenfeldt,
- Sylvia Schreiber,
- Manu Praz,
- Antoinette Crettenand,
- Charles Gobelet,
- Christoph A. Meier,
- David R. Bell,
- Anastasia Kralli,
- Jean-Paul Giacobino,
- and Olivier Dériaz
Endurance Training in Humans Leads to Fiber Type-Specific Increases in Levels of Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 and Peroxisome Proliferator-Activated Receptor-α in Skeletal Muscle
Diabetes December 2003 52:2874-2881; doi:10.2337/diabetes.52.12.2874
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- Devjit Tripathy,
- Priya Mohanty,
- Sandeep Dhindsa,
- Tufail Syed,
- Husam Ghanim,
- Ahmad Aljada,
- and Paresh Dandona
Elevation of Free Fatty Acids Induces Inflammation and Impairs Vascular Reactivity in Healthy Subjects
Diabetes December 2003 52:2882-2887; doi:10.2337/diabetes.52.12.2882
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- François Collard,
- Ghislain Delpierre,
- Vincent Stroobant,
- Gert Matthijs,
- and Emile Van Schaftingen
A Mammalian Protein Homologous to Fructosamine-3-Kinase Is a Ketosamine-3-Kinase Acting on Psicosamines and Ribulosamines but not on Fructosamines
Diabetes December 2003 52:2888-2895; doi:10.2337/diabetes.52.12.2888

Signal Transduction

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- Dan Kawamori,
- Yoshitaka Kajimoto,
- Hideaki Kaneto,
- Yutaka Umayahara,
- Yoshio Fujitani,
- Takeshi Miyatsuka,
- Hirotaka Watada,
- Ingo B. Leibiger,
- Yoshimitsu Yamasaki,
- and Masatsugu Hori
Oxidative Stress Induces Nucleo-Cytoplasmic Translocation of Pancreatic Transcription Factor PDX-1 Through Activation of c-Jun NH₂-terminal Kinase
Diabetes December 2003 52:2896-2904; doi:10.2337/diabetes.52.12.2896
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- Hiraku Ono,
- Hitoshi Shimano,
- Hideki Katagiri,
- Naoya Yahagi,
- Hideyuki Sakoda,
- Yukiko Onishi,
- Motonobu Anai,
- Takehide Ogihara,
- Midori Fujishiro,
- Amelia Y.I. Viana,
- Yasushi Fukushima,
- Miho Abe,
- Nobuhiro Shojima,
- Masatoshi Kikuchi,
- Nobuhiro Yamada,
- Yoshitomo Oka,
- and Tomoichiro Asano
Hepatic Akt Activation Induces Marked Hypoglycemia, Hepatomegaly, and Hypertriglyceridemia With Sterol Regulatory Element Binding Protein Involvement
Diabetes December 2003 52:2905-2913; doi:10.2337/diabetes.52.12.2905

Obesity Study

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- Steven R. Smith,
- Barbara Gawronska-Kozak,
- Lenka Janderová,
- Taylor Nguyen,
- Angela Murrell,
- Jacqueline M. Stephens,
- and Randall L. Mynatt
Agouti Expression in Human Adipose Tissue: Functional Consequences and Increased Expression in Type 2 Diabetes
Diabetes December 2003 52:2914-2922; doi:10.2337/diabetes.52.12.2914
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- Giuseppe Murdolo,
- Paola Lucidi,
- Chiara Di Loreto,
- Natascia Parlanti,
- Arianna De Cicco,
- Cristina Fatone,
- Carmine G. Fanelli,
- Geremia B. Bolli,
- Fausto Santeusanio,
- and Pierpaolo De Feo
Insulin is Required for Prandial Ghrelin Suppression in Humans
Diabetes December 2003 52:2923-2927; doi:10.2337/diabetes.52.12.2923
Select this article
- Deborah L. Drazen,
- Matthew D. Wortman,
- Michael W. Schwartz,
- Deborah J. Clegg,
- Gertjan van Dijk,
- Stephen C. Woods,
- and Randy J. Seeley
Adrenalectomy Alters the Sensitivity of the Central Nervous System Melanocortin System
Diabetes December 2003 52:2928-2934; doi:10.2337/diabetes.52.12.2928

Immunology and Transplantation

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- Juan L. Contreras,
- Christopher Eckstein,
- Cheryl A. Smyth,
- Marty T. Sellers,
- Mario Vilatoba,
- Guadalupe Bilbao,
- Firoz G. Rahemtulla,
- Carlton J. Young,
- J. Anthony Thompson,
- Irshad H. Chaudry,
- and Devin E. Eckhoff
Brain Death Significantly Reduces Isolated Pancreatic Islet Yields and Functionality In Vitro and In Vivo After Transplantation in Rats
Diabetes December 2003 52:2935-2942; doi:10.2337/diabetes.52.12.2935

Islet Study

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- Martin Köhler,
- Sergei V. Zaitsev,
- Irina I. Zaitseva,
- Barbara Leibiger,
- Ingo B. Leibiger,
- Mikael Turunen,
- Iouri L. Kapelioukh,
- Linda Bakkman,
- Ioulia B. Appelskog,
- Jacques Boutet de Monvel,
- Gabriela Imreh,
- and Per-Olof Berggren
On-Line Monitoring of Apoptosis in Insulin-Secreting Cells
Diabetes December 2003 52:2943-2950; doi:10.2337/diabetes.52.12.2943

Pathophysiology

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- Tatjana Radaelli,
- Ali Varastehpour,
- Patrick Catalano,
- and Sylvie Hauguel-de Mouzon
Gestational Diabetes Induces Placental Genes for Chronic Stress and Inflammatory Pathways
Diabetes December 2003 52:2951-2958; doi:10.2337/diabetes.52.12.2951

Complications

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- Jun Cai,
- Shakil Ahmad,
- Wen G. Jiang,
- Jianhua Huang,
- Christopher D. Kontos,
- Mike Boulton,
- and Asif Ahmed
Activation of Vascular Endothelial Growth Factor Receptor-1 Sustains Angiogenesis and Bcl-2 Expression Via the Phosphatidylinositol 3-Kinase Pathway in Endothelial Cells
Diabetes December 2003 52:2959-2968; doi:10.2337/diabetes.52.12.2959
Select this article
- Anu Pätäri,
- Carol Forsblom,
- Marika Havana,
- Heidi Taipale,
- Per-Henrik Groop,
- and Harry Holthöfer
Nephrinuria in Diabetic Nephropathy of Type 1 Diabetes
Diabetes December 2003 52:2969-2974; doi:10.2337/diabetes.52.12.2969
Select this article
- Suzanne Lam,
- Reinier N. van der Geest,
- Nicole A.M. Verhagen,
- Frans A. van Nieuwenhoven,
- Ingrid E. Blom,
- Jan Aten,
- Roel Goldschmeding,
- Mohamed R. Daha,
- and Cees van Kooten
Connective Tissue Growth Factor and IGF-I Are Produced by Human Renal Fibroblasts and Cooperate in the Induction of Collagen Production by High Glucose
Diabetes December 2003 52:2975-2983; doi:10.2337/diabetes.52.12.2975

Genetics

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- Heike Biebermann,
- Heiko Krude,
- Andrea Elsner,
- Vladimir Chubanov,
- Thomas Gudermann,
- and Annette Grüters
Autosomal-Dominant Mode of Inheritance of a Melanocortin-4 Receptor Mutation in a Patient with Severe Early-Onset Obesity Is Due to a Dominant-Negative Effect Caused by Receptor Dimerization
Diabetes December 2003 52:2984-2988; doi:10.2337/diabetes.52.12.2984
Select this article
- Symi Richter,
- David Q. Shih,
- Ewan R. Pearson,
- Christian Wolfrum,
- Stefan S. Fajans,
- Andrew T. Hattersley,
- and Markus Stoffel
Regulation of Apolipoprotein M Gene Expression by MODY3 Gene Hepatocyte Nuclear Factor-1α: Haploinsufficiency Is Associated With Reduced Serum Apolipoprotein M Levels
Diabetes December 2003 52:2989-2995; doi:10.2337/diabetes.52.12.2989

Brief Genetics Report

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- Cecile Lubrano-Berthelier,
- Martha Cavazos,
- Catherine Le Stunff,
- Kurt Haas,
- Astrid Shapiro,
- Sumei Zhang,
- Pierre Bougneres,
- and Christian Vaisse
The Human MC4R Promoter: Characterization and Role in Obesity
Diabetes December 2003 52:2996-3000; doi:10.2337/diabetes.52.12.2996
Select this article
- Yurii S. Aulchenko,
- Norbert Vaessen,
- Peter Heutink,
- Jan Pullen,
- Pieter J.L.M. Snijders,
- Albert Hofman,
- Lodewijk A. Sandkuijl,
- Jeanine J. Houwing-Duistermaat,
- Mark Edwards,
- Simon Bennett,
- Ben A. Oostra,
- and Cornelia M. van Duijn
A Genome-Wide Search for Genes Involved in Type 2 Diabetes in a Recently Genetically Isolated Population From the Netherlands
Diabetes December 2003 52:3001-3004; doi:10.2337/diabetes.52.12.3001
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- Peter Kovacs,
- Robert L. Hanson,
- Yong-Ho Lee,
- Xiaolin Yang,
- Sayuko Kobes,
- Paska A. Permana,
- Clifton Bogardus,
- and Leslie J. Baier
The Role of Insulin Receptor Substrate-1 Gene (IRS1) in Type 2 Diabetes in Pima Indians
Diabetes December 2003 52:3005-3009; doi:10.2337/diabetes.52.12.3005
Select this article
- Maria Luiza Caramori,
- Luis Henrique Canani,
- Luciana A. Costa,
- and Jorge Luiz Gross
The Human Peroxisome Proliferator-Activated Receptor γ2 (PPARγ2) Pro12Ala Polymorphism Is Associated With Decreased Risk of Diabetic Nephropathy in Patients With Type 2 Diabetes
Diabetes December 2003 52:3010-3013; doi:10.2337/diabetes.52.12.3010

Errata

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Errata
Diabetes December 2003 52:3014; doi:10.2337/diabetes.52.12.3014

Diabetes

Perspectives in Diabetes

Microvascular Complications of Impaired Glucose Tolerance

Metabolism

Endurance Training in Humans Leads to Fiber Type-Specific Increases in Levels of Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 and Peroxisome Proliferator-Activated Receptor-α in Skeletal Muscle

Elevation of Free Fatty Acids Induces Inflammation and Impairs Vascular Reactivity in Healthy Subjects

A Mammalian Protein Homologous to Fructosamine-3-Kinase Is a Ketosamine-3-Kinase Acting on Psicosamines and Ribulosamines but not on Fructosamines

Signal Transduction

Oxidative Stress Induces Nucleo-Cytoplasmic Translocation of Pancreatic Transcription Factor PDX-1 Through Activation of c-Jun NH₂-terminal Kinase

Hepatic Akt Activation Induces Marked Hypoglycemia, Hepatomegaly, and Hypertriglyceridemia With Sterol Regulatory Element Binding Protein Involvement

Obesity Study

Agouti Expression in Human Adipose Tissue: Functional Consequences and Increased Expression in Type 2 Diabetes

Insulin is Required for Prandial Ghrelin Suppression in Humans

Adrenalectomy Alters the Sensitivity of the Central Nervous System Melanocortin System

Immunology and Transplantation

Brain Death Significantly Reduces Isolated Pancreatic Islet Yields and Functionality In Vitro and In Vivo After Transplantation in Rats

Islet Study

On-Line Monitoring of Apoptosis in Insulin-Secreting Cells

Pathophysiology

Gestational Diabetes Induces Placental Genes for Chronic Stress and Inflammatory Pathways

Complications

Activation of Vascular Endothelial Growth Factor Receptor-1 Sustains Angiogenesis and Bcl-2 Expression Via the Phosphatidylinositol 3-Kinase Pathway in Endothelial Cells

Nephrinuria in Diabetic Nephropathy of Type 1 Diabetes

Connective Tissue Growth Factor and IGF-I Are Produced by Human Renal Fibroblasts and Cooperate in the Induction of Collagen Production by High Glucose

Genetics

Autosomal-Dominant Mode of Inheritance of a Melanocortin-4 Receptor Mutation in a Patient with Severe Early-Onset Obesity Is Due to a Dominant-Negative Effect Caused by Receptor Dimerization

Regulation of Apolipoprotein M Gene Expression by MODY3 Gene Hepatocyte Nuclear Factor-1α: Haploinsufficiency Is Associated With Reduced Serum Apolipoprotein M Levels

Brief Genetics Report

The Human MC4R Promoter: Characterization and Role in Obesity

A Genome-Wide Search for Genes Involved in Type 2 Diabetes in a Recently Genetically Isolated Population From the Netherlands

The Role of Insulin Receptor Substrate-1 Gene (IRS1) in Type 2 Diabetes in Pima Indians

The Human Peroxisome Proliferator-Activated Receptor γ2 (PPARγ2) Pro12Ala Polymorphism Is Associated With Decreased Risk of Diabetic Nephropathy in Patients With Type 2 Diabetes

Errata

Errata

This Issue

Current Issue

Diabetes

Table of Contents

Perspectives in Diabetes

Microvascular Complications of Impaired Glucose Tolerance

Metabolism

Endurance Training in Humans Leads to Fiber Type-Specific Increases in Levels of Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 and Peroxisome Proliferator-Activated Receptor-α in Skeletal Muscle

Elevation of Free Fatty Acids Induces Inflammation and Impairs Vascular Reactivity in Healthy Subjects

A Mammalian Protein Homologous to Fructosamine-3-Kinase Is a Ketosamine-3-Kinase Acting on Psicosamines and Ribulosamines but not on Fructosamines

Signal Transduction

Oxidative Stress Induces Nucleo-Cytoplasmic Translocation of Pancreatic Transcription Factor PDX-1 Through Activation of c-Jun NH2-terminal Kinase

Hepatic Akt Activation Induces Marked Hypoglycemia, Hepatomegaly, and Hypertriglyceridemia With Sterol Regulatory Element Binding Protein Involvement

Obesity Study

Agouti Expression in Human Adipose Tissue: Functional Consequences and Increased Expression in Type 2 Diabetes

Insulin is Required for Prandial Ghrelin Suppression in Humans

Adrenalectomy Alters the Sensitivity of the Central Nervous System Melanocortin System

Immunology and Transplantation

Brain Death Significantly Reduces Isolated Pancreatic Islet Yields and Functionality In Vitro and In Vivo After Transplantation in Rats

Islet Study

On-Line Monitoring of Apoptosis in Insulin-Secreting Cells

Pathophysiology

Gestational Diabetes Induces Placental Genes for Chronic Stress and Inflammatory Pathways

Complications

Activation of Vascular Endothelial Growth Factor Receptor-1 Sustains Angiogenesis and Bcl-2 Expression Via the Phosphatidylinositol 3-Kinase Pathway in Endothelial Cells

Nephrinuria in Diabetic Nephropathy of Type 1 Diabetes

Connective Tissue Growth Factor and IGF-I Are Produced by Human Renal Fibroblasts and Cooperate in the Induction of Collagen Production by High Glucose

Genetics

Autosomal-Dominant Mode of Inheritance of a Melanocortin-4 Receptor Mutation in a Patient with Severe Early-Onset Obesity Is Due to a Dominant-Negative Effect Caused by Receptor Dimerization

Regulation of Apolipoprotein M Gene Expression by MODY3 Gene Hepatocyte Nuclear Factor-1α: Haploinsufficiency Is Associated With Reduced Serum Apolipoprotein M Levels

Brief Genetics Report

The Human MC4R Promoter: Characterization and Role in Obesity

A Genome-Wide Search for Genes Involved in Type 2 Diabetes in a Recently Genetically Isolated Population From the Netherlands

The Role of Insulin Receptor Substrate-1 Gene (IRS1) in Type 2 Diabetes in Pima Indians

The Human Peroxisome Proliferator-Activated Receptor γ2 (PPARγ2) Pro12Ala Polymorphism Is Associated With Decreased Risk of Diabetic Nephropathy in Patients With Type 2 Diabetes

Errata

Errata

This Issue

Current Issue

Oxidative Stress Induces Nucleo-Cytoplasmic Translocation of Pancreatic Transcription Factor PDX-1 Through Activation of c-Jun NH₂-terminal Kinase