Preferential Stiffening of Central Over Peripheral Arteries in Type 2 Diabetes
- Eiji Kimoto1,
- Tetsuo Shoji1,
- Kayo Shinohara1,
- Masaaki Inaba1,
- Yasuhisa Okuno2,
- Takami Miki3,
- Hidenori Koyama1,
- Masanori Emoto1 and
- Yoshiki Nishizawa1
- 1Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
- 2Department of Cardiovascular Medicine, Osaka City University Medical School, Osaka, Japan
- 3Department of Geriatrics and Neurology, Osaka City University Medical School, Osaka, Japan
Abstract
Arterial stiffness affects cardiac functions, peripheral circulation, and cardiovascular mortality. We examined whether arterial stiffness in different regions is equally affected by diabetes and other factors. The subjects were 161 patients with type 2 diabetes and 129 healthy subjects comparable in age and sex. Arterial stiffness was evaluated by measuring pulse wave velocity (PWV) in the heart-carotid, heart-brachial, heart-femoral, and femoral-ankle segments using an automatic device. The diabetic patients had greater PWV than the healthy subjects in the four arterial regions, and the effect of diabetes on PWV was greater in the heart-carotid and heart-femoral segments (central) than in the heart-brachial and femoral-ankle regions (peripheral). PWV increased with age in the four arterial regions, and the effect of age on PWV was greater in the central than in peripheral arteries. In multiple regression analysis, age and systolic blood pressure had significant impacts on PWV of the four regions, whereas diabetes was significantly associated only with PWV of the central arteries. In contrast, sex was associated with PWV of the peripheral arteries. Thus, type 2 diabetes had greater impact on PWV of the central arteries, and different factors were involved in PWV among different arterial regions.
Footnotes
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Address correspondence and reprint requests to Tetsuo Shoji, MD, Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan. E-mail: t-shoji{at}med.osaka-cu.ac.jp.
Received for publication 20 May 2002 and accepted in revised form 16 October 2002.
AGE, advanced glycation end products; HRT, hormone replacement therapy; PWV, pulse wave velocity.
- DIABETES
