Table of Contents

March 2003; 52 (3)

Perspectives in Diabetes

Select this article
- R. Paul Robertson,
- Jamie Harmon,
- Phuong Oanh Tran,
- Yoshito Tanaka,
- and Hiroki Takahashi
Glucose Toxicity in β-Cells: Type 2 Diabetes, Good Radicals Gone Bad, and the Glutathione Connection
Diabetes March 2003 52:581-587; doi:10.2337/diabetes.52.3.581

Obesity Studies

Select this article
- Deborah J. Clegg,
- Christine A. Riedy,
- Kathleen A. Blake Smith,
- Stephen C. Benoit,
- and Stephen C. Woods
Differential Sensitivity to Central Leptin and Insulin in Male and Female Rats
Diabetes March 2003 52:682-687; doi:10.2337/diabetes.52.3.682
Select this article
- Hong Lan,
- Mary E. Rabaglia,
- Jonathan P. Stoehr,
- Samuel T. Nadler,
- Kathryn L. Schueler,
- Fei Zou,
- Brian S. Yandell,
- and Alan D. Attie
Gene Expression Profiles of Nondiabetic and Diabetic Obese Mice Suggest a Role of Hepatic Lipogenic Capacity in Diabetes Susceptibility
Diabetes March 2003 52:688-700; doi:10.2337/diabetes.52.3.688
Select this article
- Mirja Tiikkainen,
- Robert Bergholm,
- Satu Vehkavaara,
- Aila Rissanen,
- Anna-Maija Häkkinen,
- Marjo Tamminen,
- Kari Teramo,
- and Hannele Yki-Järvinen
Effects of Identical Weight Loss on Body Composition and Features of Insulin Resistance in Obese Women With High and Low Liver Fat Content
Diabetes March 2003 52:701-707; doi:10.2337/diabetes.52.3.701

Immunology and Transplantation

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- Y. Clare Zhang,
- Antonello Pileggi,
- Anupam Agarwal,
- R. Damaris Molano,
- Matthew Powers,
- Todd Brusko,
- Clive Wasserfall,
- Kevin Goudy,
- Elsie Zahr,
- Raffaella Poggioli,
- Marda Scott-Jorgensen,
- Martha Campbell-Thompson,
- James M. Crawford,
- Harry Nick,
- Terence Flotte,
- Tamir M. Ellis,
- Camillo Ricordi,
- Luca Inverardi,
- and Mark A. Atkinson
Adeno-Associated Virus-Mediated IL-10 Gene Therapy Inhibits Diabetes Recurrence in Syngeneic Islet Cell Transplantation of NOD Mice
Diabetes March 2003 52:708-716; doi:10.2337/diabetes.52.3.708
Select this article
- James E. Greening,
- Timothy I.M. Tree,
- Karolena T. Kotowicz,
- Astrid G. van Halteren,
- Bart O. Roep,
- Nigel J. Klein,
- and Mark Peakman
Processing and Presentation of the Islet Autoantigen GAD by Vascular Endothelial Cells Promotes Transmigration of Autoreactive T-Cells
Diabetes March 2003 52:717-725; doi:10.2337/diabetes.52.3.717

Islet Studies

Select this article
- Kathrin Maedler,
- José Oberholzer,
- Pascal Bucher,
- Giatgen A. Spinas,
- and Marc Y. Donath
Monounsaturated Fatty Acids Prevent the Deleterious Effects of Palmitate and High Glucose on Human Pancreatic β-Cell Turnover and Function
Diabetes March 2003 52:726-733; doi:10.2337/diabetes.52.3.726
Select this article
- Doris A. Stoffers,
- Biva M. Desai,
- Diva D. DeLeon,
- and Rebecca A. Simmons
Neonatal Exendin-4 Prevents the Development of Diabetes in the Intrauterine Growth Retarded Rat
Diabetes March 2003 52:734-740; doi:10.2337/diabetes.52.3.734
Select this article
- J. Andrew Pospisilik,
- Jennifer Martin,
- Timothy Doty,
- Jan A. Ehses,
- Nathalie Pamir,
- Francis C. Lynn,
- Shalea Piteau,
- Hans-Ulrich Demuth,
- Christopher H.S. McIntosh,
- and Raymond A. Pederson
Dipeptidyl Peptidase IV Inhibitor Treatment Stimulates β-Cell Survival and Islet Neogenesis in Streptozotocin-Induced Diabetic Rats
Diabetes March 2003 52:741-750; doi:10.2337/diabetes.52.3.741
Select this article
- Jung-Guk Kim,
- Laurie L. Baggio,
- Dominique P. Bridon,
- Jean-Paul Castaigne,
- Martin F. Robitaille,
- Lucie Jetté,
- Corinne Benquet,
- and Daniel J. Drucker
Development and Characterization of a Glucagon-Like Peptide 1-Albumin Conjugate: The Ability to Activate the Glucagon-Like Peptide 1 Receptor In Vivo
Diabetes March 2003 52:751-759; doi:10.2337/diabetes.52.3.751
Select this article
- Tomoaki Morioka,
- Hidenori Koyama,
- Hisako Yamamura,
- Shinji Tanaka,
- Shinya Fukumoto,
- Masanori Emoto,
- Hiroyuki Mizuguchi,
- Takao Hayakawa,
- Itaru Kojima,
- Katsuhito Takahashi,
- and Yoshiki Nishizawa
Role of H1-Calponin in Pancreatic AR42J Cell Differentiation Into Insulin-Producing Cells
Diabetes March 2003 52:760-766; doi:10.2337/diabetes.52.3.760
Select this article
- Xuehui Geng,
- Lehong Li,
- Simon Watkins,
- Paul D. Robbins,
- and Peter Drain
The Insulin Secretory Granule Is the Major Site of K_ATP Channels of the Endocrine Pancreas
Diabetes March 2003 52:767-776; doi:10.2337/diabetes.52.3.767

Pathophysiology

Select this article
- Gang Ye,
- Naira S. Metreveli,
- Jun Ren,
- and Paul N. Epstein
Metallothionein Prevents Diabetes-Induced Deficits in Cardiomyocytes by Inhibiting Reactive Oxygen Species Production
Diabetes March 2003 52:777-783; doi:10.2337/diabetes.52.3.777
Select this article
- Christine Sempoux,
- Yves Guiot,
- Karin Dahan,
- Pierre Moulin,
- Martine Stevens,
- Virginie Lambot,
- Pascale de Lonlay,
- Jean-Christophe Fournet,
- Claudine Junien,
- Francis Jaubert,
- Claire Nihoul-Fekete,
- Jean-Marie Saudubray,
- and Jacques Rahier
The Focal Form of Persistent Hyperinsulinemic Hypoglycemia of Infancy: Morphological and Molecular Studies Show Structural and Functional Differences With Insulinoma
Diabetes March 2003 52:784-794; doi:10.2337/diabetes.52.3.784
Select this article
- Angelo Avogaro,
- Gianna Toffolo,
- Edward Kiwanuka,
- Saula Vigili de Kreutzenberg,
- Paolo Tessari,
- and Claudio Cobelli
l-Arginine-Nitric Oxide Kinetics in Normal and Type 2 Diabetic Subjects: A Stable-Labelled ¹⁵N Arginine Approach
Diabetes March 2003 52:795-802; doi:10.2337/diabetes.52.3.795
Select this article
- Gerald F. Watts,
- P. Hugh R. Barrett,
- Juying Ji,
- Adrian P. Serone,
- Dick C. Chan,
- Kevin D. Croft,
- Franziska Loehrer,
- and Anthony G. Johnson
Differential Regulation of Lipoprotein Kinetics by Atorvastatin and Fenofibrate in Subjects With the Metabolic Syndrome
Diabetes March 2003 52:803-811; doi:10.2337/diabetes.52.3.803
Select this article
- Joachim Spranger,
- Anja Kroke,
- Matthias Möhlig,
- Kurt Hoffmann,
- Manuela M. Bergmann,
- Michael Ristow,
- Heiner Boeing,
- and Andreas F.H. Pfeiffer
Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes: Results of the Prospective Population-Based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
Diabetes March 2003 52:812-817; doi:10.2337/diabetes.52.3.812

Complications

Select this article
- Renu A. Kowluru
Effect of Reinstitution of Good Glycemic Control on Retinal Oxidative Stress and Nitrative Stress in Diabetic Rats
Diabetes March 2003 52:818-823; doi:10.2337/diabetes.52.3.818
Select this article
- Tetsuto Kanzaki and
- Masako Otabe
Latent Transforming Growth Factor-β Binding Protein-1, a Component of Latent Transforming Growth Factor-β Complex, Accelerates the Migration of Aortic Smooth Muscle Cells in Diabetic Rats Through Integrin-β₃
Diabetes March 2003 52:824-828; doi:10.2337/diabetes.52.3.824
Select this article
- Toru Abiko,
- Atsuko Abiko,
- Allen C. Clermont,
- Brett Shoelson,
- Naoichi Horio,
- Junichi Takahashi,
- Anthony P. Adamis,
- George L. King,
- and Sven-Erik Bursell
Characterization of Retinal Leukostasis and Hemodynamics in Insulin Resistance and Diabetes: Role of Oxidants and Protein Kinase-C Activation
Diabetes March 2003 52:829-837; doi:10.2337/diabetes.52.3.829
Select this article
- Tamotsu Yokota,
- Ronald C. Ma,
- Joong-Yeol Park,
- Keiji Isshiki,
- Konstantinos B. Sotiropoulos,
- Ravi K. Rauniyar,
- Karin E. Bornfeldt,
- and George L. King
Role of Protein Kinase C on the Expression of Platelet-Derived Growth Factor and Endothelin-1 in the Retina of Diabetic Rats and Cultured Retinal Capillary Pericytes
Diabetes March 2003 52:838-845; doi:10.2337/diabetes.52.3.838
Select this article
- Andrea D. Hodgkinson,
- Tracey Bartlett,
- Peter J. Oates,
- Beverley A. Millward,
- and Andrew G. Demaine
The Response of Antioxidant Genes to Hyperglycemia Is Abnormal in Patients With Type 1 Diabetes and Diabetic Nephropathy
Diabetes March 2003 52:846-851; doi:10.2337/diabetes.52.3.846
Select this article
- Finn F. Lauszus,
- Joachim G. Klebe,
- Toke Bek,
- and Allan Flyvbjerg
Increased Serum IGF-I During Pregnancy Is Associated With Progression of Diabetic Retinopathy
Diabetes March 2003 52:852-856; doi:10.2337/diabetes.52.3.852
Select this article
- P. Elizabeth Rakoczy,
- Meliha Brankov,
- Angela Fonceca,
- Tammy Zaknich,
- Ben C. Rae,
- and Chooi-May Lai
Enhanced Recombinant Adeno-Associated Virus-Mediated Vascular Endothelial Growth Factor Expression in the Adult Mouse Retina: A Potential Model for Diabetic Retinopathy
Diabetes March 2003 52:857-863; doi:10.2337/diabetes.52.3.857
Select this article
- Irina G. Obrosova,
- Alexander G. Minchenko,
- Rukmini Vasupuram,
- Lauren White,
- Omorodola I. Abatan,
- Arno K. Kumagai,
- Robert N. Frank,
- and Martin J. Stevens
Aldose Reductase Inhibitor Fidarestat Prevents Retinal Oxidative Stress and Vascular Endothelial Growth Factor Overexpression in Streptozotocin-Diabetic Rats
Diabetes March 2003 52:864-871; doi:10.2337/diabetes.52.3.864

Genetics

Select this article
- Timothy M. Frayling,
- Cecilia M. Lindgren,
- Jean Claude Chevre,
- Stephan Menzel,
- Marie Wishart,
- Yamina Benmezroua,
- Alison Brown,
- Julie C. Evans,
- Pamidghantam Subba Rao,
- Christian Dina,
- Cécile Lecoeur,
- Timo Kanninen,
- Peter Almgren,
- Michael P. Bulman,
- Youxiang Wang,
- James Mills,
- Rosemarie Wright-Pascoe,
- Melanie M. Mahtani,
- Francesco Prisco,
- Angels Costa,
- Ignacio Cognet,
- Torben Hansen,
- Oluf Pedersen,
- Sian Ellard,
- Tiinamaija Tuomi,
- Leif C. Groop,
- Philippe Froguel,
- Andrew T. Hattersley,
- and Martine Vaxillaire
A Genome-Wide Scan in Families With Maturity-Onset Diabetes of the Young: Evidence for Further Genetic Heterogeneity
Diabetes March 2003 52:872-881; doi:10.2337/diabetes.52.3.872

Brief Genetics Reports

Select this article
- David T. Robles,
- George S. Eisenbarth,
- Natalie J.M. Dailey,
- Laurence B. Peterson,
- and Linda S. Wicker
Insulin Autoantibodies Are Associated With Islet Inflammation But Not Always Related to Diabetes Progression in NOD Congenic Mice
Diabetes March 2003 52:882-886; doi:10.2337/diabetes.52.3.882
Select this article
- Massimo Federici,
- Antonio Petrone,
- Ottavia Porzio,
- Carla Bizzarri,
- Davide Lauro,
- Rossella D’Alfonso,
- Ippolita Patera,
- Marco Cappa,
- Lorenza Nisticò,
- Marco Baroni,
- Giorgio Sesti,
- Umberto di Mario,
- Renato Lauro,
- and Raffaella Buzzetti
The Gly⁹⁷²→Arg IRS-1 Variant Is Associated With Type 1 Diabetes in Continental Italy
Diabetes March 2003 52:887-890; doi:10.2337/diabetes.52.3.887
Select this article
- Kim Pettersson-Fernholm,
- Carol Forsblom,
- Barry I. Hudson,
- Markus Perola,
- Peter J. Grant,
- and Per-Henrik Groop
The Functional −374 T/A RAGE Gene Polymorphism Is Associated With Proteinuria and Cardiovascular Disease in Type 1 Diabetic Patients
Diabetes March 2003 52:891-894; doi:10.2337/diabetes.52.3.891
Select this article
- Yunhua Li Muller,
- Clifton Bogardus,
- Oluf Pedersen,
- and Leslie Baier
A Gly482Ser Missense Mutation in the Peroxisome Proliferator-Activated Receptor γ Coactivator-1 Is Associated With Altered Lipid Oxidation and Early Insulin Secretion in Pima Indians
Diabetes March 2003 52:895-898; doi:10.2337/diabetes.52.3.895

Current Issue

February 2012, 61 (2)

Print ISSN: 0012-1797
Online ISSN: 1939-327X

Diabetes

Perspectives in Diabetes

Glucose Toxicity in β-Cells: Type 2 Diabetes, Good Radicals Gone Bad, and the Glutathione Connection

Metabolism and Signal Transduction

Selective Glycogen Synthase Kinase 3 Inhibitors Potentiate Insulin Activation of Glucose Transport and Utilization In Vitro and In Vivo

Disruption of the Striated Muscle Glycogen Targeting Subunit PPP1R3A of Protein Phosphatase 1 Leads to Increased Weight Gain, Fat Deposition, and Development of Insulin Resistance

Role of Corticotrophin-Releasing Hormone in the Impairment of Counterregulatory Responses to Hypoglycemia

Contribution of Fatty Acids Released From Lipolysis of Plasma Triglycerides to Total Plasma Fatty Acid Flux and Tissue-Specific Fatty Acid Uptake

Acute Hyperglycemia Causes Intracellular Formation of CML and Activation of ras, p42/44 MAPK, and Nuclear Factor κB in PBMCs

Enhanced Basal Activation of Mitogen-Activated Protein Kinases in Adipocytes From Type 2 Diabetes: Potential Role of p38 in the Downregulation of GLUT4 Expression

Regulation of PGC-1 Promoter Activity by Protein Kinase B and the Forkhead Transcription Factor FKHR

Palmitate-Induced Activation of the Hexosamine Pathway in Human Myotubes: Increased Expression of Glutamine:Fructose-6-Phosphate Aminotransferase

Effect of Short-Term Fasting and Refeeding on Transcriptional Regulation of Metabolic Genes in Human Skeletal Muscle

Local Lactate Perfusion of the Ventromedial Hypothalamus Suppresses Hypoglycemic Counterregulation

Modulation of Circulating and Adipose Tissue Adiponectin Levels by Antidiabetic Therapy

Nocturnal and Postprandial Free Fatty Acid Kinetics in Normal and Type 2 Diabetic Subjects: Effects of Insulin Sensitization Therapy

Obesity Studies

Differential Sensitivity to Central Leptin and Insulin in Male and Female Rats

Gene Expression Profiles of Nondiabetic and Diabetic Obese Mice Suggest a Role of Hepatic Lipogenic Capacity in Diabetes Susceptibility

Effects of Identical Weight Loss on Body Composition and Features of Insulin Resistance in Obese Women With High and Low Liver Fat Content

Immunology and Transplantation

Adeno-Associated Virus-Mediated IL-10 Gene Therapy Inhibits Diabetes Recurrence in Syngeneic Islet Cell Transplantation of NOD Mice

Processing and Presentation of the Islet Autoantigen GAD by Vascular Endothelial Cells Promotes Transmigration of Autoreactive T-Cells

Islet Studies

Monounsaturated Fatty Acids Prevent the Deleterious Effects of Palmitate and High Glucose on Human Pancreatic β-Cell Turnover and Function

Neonatal Exendin-4 Prevents the Development of Diabetes in the Intrauterine Growth Retarded Rat

Dipeptidyl Peptidase IV Inhibitor Treatment Stimulates β-Cell Survival and Islet Neogenesis in Streptozotocin-Induced Diabetic Rats

Development and Characterization of a Glucagon-Like Peptide 1-Albumin Conjugate: The Ability to Activate the Glucagon-Like Peptide 1 Receptor In Vivo

Role of H1-Calponin in Pancreatic AR42J Cell Differentiation Into Insulin-Producing Cells

The Insulin Secretory Granule Is the Major Site of KATP Channels of the Endocrine Pancreas

Pathophysiology

Metallothionein Prevents Diabetes-Induced Deficits in Cardiomyocytes by Inhibiting Reactive Oxygen Species Production

The Focal Form of Persistent Hyperinsulinemic Hypoglycemia of Infancy: Morphological and Molecular Studies Show Structural and Functional Differences With Insulinoma

l-Arginine-Nitric Oxide Kinetics in Normal and Type 2 Diabetic Subjects: A Stable-Labelled 15N Arginine Approach

Differential Regulation of Lipoprotein Kinetics by Atorvastatin and Fenofibrate in Subjects With the Metabolic Syndrome

Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes: Results of the Prospective Population-Based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study

Complications

Effect of Reinstitution of Good Glycemic Control on Retinal Oxidative Stress and Nitrative Stress in Diabetic Rats

Latent Transforming Growth Factor-β Binding Protein-1, a Component of Latent Transforming Growth Factor-β Complex, Accelerates the Migration of Aortic Smooth Muscle Cells in Diabetic Rats Through Integrin-β3

Characterization of Retinal Leukostasis and Hemodynamics in Insulin Resistance and Diabetes: Role of Oxidants and Protein Kinase-C Activation

Role of Protein Kinase C on the Expression of Platelet-Derived Growth Factor and Endothelin-1 in the Retina of Diabetic Rats and Cultured Retinal Capillary Pericytes

The Response of Antioxidant Genes to Hyperglycemia Is Abnormal in Patients With Type 1 Diabetes and Diabetic Nephropathy

Increased Serum IGF-I During Pregnancy Is Associated With Progression of Diabetic Retinopathy

Enhanced Recombinant Adeno-Associated Virus-Mediated Vascular Endothelial Growth Factor Expression in the Adult Mouse Retina: A Potential Model for Diabetic Retinopathy

Aldose Reductase Inhibitor Fidarestat Prevents Retinal Oxidative Stress and Vascular Endothelial Growth Factor Overexpression in Streptozotocin-Diabetic Rats

Genetics

A Genome-Wide Scan in Families With Maturity-Onset Diabetes of the Young: Evidence for Further Genetic Heterogeneity

Brief Genetics Reports

Insulin Autoantibodies Are Associated With Islet Inflammation But Not Always Related to Diabetes Progression in NOD Congenic Mice

The Gly972→Arg IRS-1 Variant Is Associated With Type 1 Diabetes in Continental Italy

The Functional −374 T/A RAGE Gene Polymorphism Is Associated With Proteinuria and Cardiovascular Disease in Type 1 Diabetic Patients

A Gly482Ser Missense Mutation in the Peroxisome Proliferator-Activated Receptor γ Coactivator-1 Is Associated With Altered Lipid Oxidation and Early Insulin Secretion in Pima Indians

This Issue

Current Issue

The Insulin Secretory Granule Is the Major Site of K_ATP Channels of the Endocrine Pancreas

l-Arginine-Nitric Oxide Kinetics in Normal and Type 2 Diabetic Subjects: A Stable-Labelled ¹⁵N Arginine Approach

Latent Transforming Growth Factor-β Binding Protein-1, a Component of Latent Transforming Growth Factor-β Complex, Accelerates the Migration of Aortic Smooth Muscle Cells in Diabetic Rats Through Integrin-β₃

The Gly⁹⁷²→Arg IRS-1 Variant Is Associated With Type 1 Diabetes in Continental Italy