Glucose Toxicity in β-Cells: Type 2 Diabetes, Good Radicals Gone Bad, and the Glutathione Connection

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

FIG. 2.FIG. 2.
FIG. 2.

A: Marked attenuation of the development of hyperglycemia in ZDF rats treated daily with N-acetylcysteine (NAC). Controls were ZDF animals treated with N-acetylcysteine vehicle and Zucker Lean Control (ZLC) rats, which do not spontaneously develop diabetes. B: Effect of GPx (AdGPx) adenoviral overexpression in isolated Wister rat islets. a: Adenoviral GPx overexpression in islets caused a sixfold increase in islet GPx activity. b: Adenoviral GPx prevented the decrease in islet insulin mRNA levels caused by exposure to ribose, a sugar that generates ROS in islets. c: Adenoviral GPx prevented the decrease in islet insulin content caused by exposure to ribose. d: Adenoviral GPx prevented the decrease in glucose-induced insulin secretion caused by exposure to ribose. Taken from Tanaka et al. (12,23): *P < 0.05–0.001.

This Article

  1. Diabetes vol. 52 no. 3 581-587