A: Marked attenuation of the development of hyperglycemia in ZDF rats treated daily with N-acetylcysteine (NAC). Controls were ZDF animals treated with N-acetylcysteine vehicle and Zucker Lean Control (ZLC) rats, which do not spontaneously develop diabetes. B: Effect of GPx (AdGPx) adenoviral overexpression in isolated Wister rat islets. a: Adenoviral GPx overexpression in islets caused a sixfold increase in islet GPx activity. b: Adenoviral GPx prevented the decrease in islet insulin mRNA levels caused by exposure to ribose, a sugar that generates
ROS in islets. c: Adenoviral GPx prevented the decrease in islet insulin content caused by exposure to ribose. d: Adenoviral GPx prevented the decrease in glucose-induced insulin secretion caused by exposure to ribose. Taken from Tanaka
et al. (12,23): *P < 0.05–0.001.