Glucose Toxicity in β-Cells: Type 2 Diabetes, Good Radicals Gone Bad, and the Glutathione Connection

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

FIG. 3.
FIG. 3.

Four biochemical pathways that are sensitive to glucose and produce ROS (see text). The islet is particularly at risk for chronic oxidative stress when exposed to long-term hyperglycemia because it expresses very low levels of antioxidant mRNA, protein, and activity (see text and Table 1.).

This Article

  1. Diabetes vol. 52 no. 3 581-587