Glucose Toxicity in β-Cells: Type 2 Diabetes, Good Radicals Gone Bad, and the Glutathione Connection

TABLE 1

Literature supporting chronic oxidative stress as a mechanism for glucose toxicity of the β-cell

References
ROS can be formed from glucose 17, 18, 23, 24
Islets contain unusually low concentrations of antioxidant enzymes and activity 20, 23, 2529
Antioxidant drugs protect the β-cell from the effects of chronic exposure to supraphysiological glucose levels 12, 22, 3037
Antioxidant gene transfer techniques enhance protection of β-cells from oxidative stress 23, 3845
Type 2 diabetes in humans is associated with increased markers of oxidative stress 4653

This Article

  1. Diabetes vol. 52 no. 3 581-587