Table of Contents

• Carla J. Greenbaum and
• Leonard C. Harrison

Guidelines for Intervention Trials in Subjects With Newly Diagnosed Type 1 Diabetes

• Heikki A. Koistinen,
• Dana Galuska,
• Alexander V. Chibalin,
• Jing Yang,
• Juleen R. Zierath,
• Geoffrey D. Holman,
• and Harriet Wallberg-Henriksson

5-Amino-Imidazole Carboxamide Riboside Increases Glucose Transport and Cell-Surface GLUT4 Content in Skeletal Muscle From Subjects With Type 2 Diabetes

• Wo-Shing Au,
• Hsiang-fu Kung,
• and Marie C. Lin

Regulation of Microsomal Triglyceride Transfer Protein Gene by Insulin in HepG2 Cells: Roles of MAPK^erk and MAPK^p38

• Coen H. Wiegman,
• Robert H.J. Bandsma,
• Margriet Ouwens,
• Fjodor H. van der Sluijs,
• Rick Havinga,
• Theo Boer,
• Dirk-Jan Reijngoud,
• Johannes A. Romijn,
• and Folkert Kuipers

Hepatic VLDL Production in ob/ob Mice Is Not Stimulated by Massive De Novo Lipogenesis but Is Less Sensitive to the Suppressive Effects of Insulin

• Raffaella Crescenzo,
• Sonia Samec,
• Vladan Antic,
• Francoise Rohner-Jeanrenaud,
• Josiane Seydoux,
• Jean-Pierre Montani,
• and Abdul G. Dulloo

A Role for Suppressed Thermogenesis Favoring Catch-Up Fat in the Pathophysiology of Catch-Up Growth

• Eftihia V. Polyzogopoulou,
• Fotios Kalfarentzos,
• Apostolos G. Vagenakis,
• and Theodore K. Alexandrides

Restoration of Euglycemia and Normal Acute Insulin Response to Glucose in Obese Subjects With Type 2 Diabetes Following Bariatric Surgery

• Cristiana E. Juge-Aubry,
• Emmanuel Somm,
• Vittorio Giusti,
• Agnès Pernin,
• Rachel Chicheportiche,
• Chantal Verdumo,
• Françoise Rohner-Jeanrenaud,
• Danielle Burger,
• Jean-Michel Dayer,
• and Christoph A. Meier

Adipose Tissue Is a Major Source of Interleukin-1 Receptor Antagonist: Upregulation in Obesity and Inflammation

• Peter Schmidt,
• Henrik Krook,
• Akira Maeda,
• Olle Korsgren,
• and Birgitta Benda

A New Murine Model of Islet Xenograft Rejection: Graft Destruction Is Dependent on a Major Histocompatibility–Specific Interaction Between T-Cells and Macrophages

• Melissa A. Pierce,
• Harold D. Chapman,
• Cristina M. Post,
• Anton Svetlanov,
• Shimon Efrat,
• Marshall Horwitz,
• and David V. Serreze

Adenovirus Early Region 3 Antiapoptotic 10.4K, 14.5K, and 14.7K Genes Decrease the Incidence of Autoimmune Diabetes in NOD Mice

• Polly J. Bingley,
• Ezio Bonifacio,
• and Patricia W. Mueller

Diabetes Antibody Standardization Program: First Assay Proficiency Evaluation

• Pejman Hanifi-Moghaddam,
• Nanette C. Schloot,
• Simone Kappler,
• Jochen Seiβler,
• and Hubert Kolb

An Association of Autoantibody Status and Serum Cytokine Levels in Type 1 Diabetes

• Heide Brandhorst,
• Daniel Brandhorst,
• Friederike Hesse,
• Dorothee Ambrosius,
• Mathias Brendel,
• Yoshiyuki Kawakami,
• and Reinhard G. Bretzel

Successful Human Islet Isolation Utilizing Recombinant Collagenase

• Fiona M. Gribble,
• Leanne Williams,
• Anna K. Simpson,
• and Frank Reimann

A Novel Glucose-Sensing Mechanism Contributing to Glucagon-Like Peptide-1 Secretion From the GLUTag Cell Line

• Kyohei Yamamoto,
• Hitoshi Hashimoto,
• Shuhei Tomimoto,
• Norihito Shintani,
• Jun-ichi Miyazaki,
• Fumi Tashiro,
• Hiroyuki Aihara,
• Takao Nammo,
• Ming Li,
• Kazuya Yamagata,
• Jun-ichiro Miyagawa,
• Yuji Matsuzawa,
• Yuki Kawabata,
• Yuji Fukuyama,
• Kazumi Koga,
• Wakaba Mori,
• Kazuhiro Tanaka,
• Toshio Matsuda,
• and Akemichi Baba

Overexpression of PACAP in Transgenic Mouse Pancreatic β-Cells Enhances Insulin Secretion and Ameliorates Streptozotocin-induced Diabetes

• Yusuke Moritoh,
• Eiji Yamato,
• Yumiko Yasui,
• Satsuki Miyazaki,
• and Jun-ichi Miyazaki

Analysis of Insulin-Producing Cells During In Vitro Differentiation From Feeder-Free Embryonic Stem Cells

• Inik Chang,
• Sunshin Kim,
• Ja Young Kim,
• Namjoo Cho,
• Yun-Hee Kim,
• Hun Sik Kim,
• Moon-Kyu Lee,
• Kwang-Won Kim,
• and Myung-Shik Lee

Nuclear Factor κB Protects Pancreatic β-Cells From Tumor Necrosis Factor-α-Mediated Apoptosis

• Kenan Cejvan,
• David H. Coy,
• and Suad Efendic

Intra-Islet Somatostatin Regulates Glucagon Release via Type 2 Somatostatin Receptors in Rats

• F. Pellmé,
• U. Smith,
• T. Funahashi,
• Y. Matsuzawa,
• H. Brekke,
• O. Wiklund,
• M.-R. Taskinen,
• and P.-A. Jansson

Circulating Adiponectin Levels Are Reduced in Nonobese but Insulin-Resistant First-Degree Relatives of Type 2 Diabetic Patients

• Ya Xu,
• Li Lu,
• Clifford Greyson,
• Jenny Lee,
• Michael Gen,
• Koichiro Kinugawa,
• Carlin S. Long,
• and Gregory G. Schwartz

Deleterious Effects of Acute Treatment With a Peroxisome Proliferator–Activated Receptor-γ Activator in Myocardial Ischemia and Reperfusion in Pigs

• Salomon Banarer and
• Philip E. Cryer

Sleep-Related Hypoglycemia-Associated Autonomic Failure in Type 1 Diabetes: Reduced Awakening From Sleep During Hypoglycemia

• Francesco S. Facchini and
• Kami L. Saylor

A Low-Iron-Available, Polyphenol-Enriched, Carbohydrate-Restricted Diet to Slow Progression of Diabetic Nephropathy

• Charles M. Alexander,
• Pamela B. Landsman,
• Steven M. Teutsch,
• and Steven M. Haffner

NCEP-Defined Metabolic Syndrome, Diabetes, and Prevalence of Coronary Heart Disease Among NHANES III Participants Age 50 Years and Older

• Ayad A. Jaffa,
• Ramon Durazo-Arvizu,
• Deyi Zheng,
• Daniel T. Lackland,
• Sujata Srikanth,
• W. Timothy Garvey,
• and Alvin H. Schmaier

Plasma Prekallikrein: A Risk Marker for Hypertension and Nephropathy in Type 1 Diabetes

• Parri Wentzel,
• Andreas Ejdesjö,
• and Ulf J. Eriksson

Maternal Diabetes In Vivo and High Glucose In Vitro Diminish GAPDH Activity in Rat Embryos

• Sayon Roy,
• Tsuyoshi Sato,
• Gulabray Paryani,
• and Richard Kao

Downregulation of Fibronectin Overexpression Reduces Basement Membrane Thickening and Vascular Lesions in Retinas of Galactose-Fed Rats

• Aihua Deng,
• Karen A. Munger,
• Jose M. Valdivielso,
• Joseph Satriano,
• Mark Lortie,
• Roland C. Blantz,
• and Scott C. Thomson

Increased Expression of Ornithine Decarboxylase in Distal Tubules of Early Diabetic Rat Kidneys: Are Polyamines Paracrine Hypertrophic Factors?

• Michaela Artwohl,
• Wolfgang F. Graier,
• Michael Roden,
• Martin Bischof,
• Angelika Freudenthaler,
• Werner Waldhäusl,
• and Sabina M. Baumgartner-Parzer

Diabetic LDL Triggers Apoptosis in Vascular Endothelial Cells

• Nicola A. Englyst,
• Janis M. Taube,
• Timothy J. Aitman,
• Trevor P. Baglin,
• and Christopher D. Byrne

A Novel Role for CD36 in VLDL-Enhanced Platelet Activation

• Narkunaraja Shanmugam,
• Marpadga A. Reddy,
• Mausumee Guha,
• and Rama Natarajan

High Glucose-Induced Expression of Proinflammatory Cytokine and Chemokine Genes in Monocytic Cells

• Shengxu Li,
• Wei Chen,
• Sathanur R. Srinivasan,
• Eric Boerwinkle,
• and Gerald S. Berenson

The Peroxisome Proliferator-Activated Receptor-γ2 Gene Polymorphism (Pro12Ala) Beneficially Influences Insulin Resistance and Its Tracking From Childhood to Adulthood: The Bogalusa Heart Study

• Lucilla D. Monti,
• Cristina Barlassina,
• Lorena Citterio,
• Elena Galluccio,
• Carlo Berzuini,
• Emanuela Setola,
• Gianpietro Valsecchi,
• Pietro Lucotti,
• Guido Pozza,
• Luisa Bernardinelli,
• Giorgio Casari,
• and PierMarco Piatti

Endothelial Nitric Oxide Synthase Polymorphisms Are Associated With Type 2 Diabetes and the Insulin Resistance Syndrome

• Simon M.S. Mitchell,
• Michael N. Weedon,
• Katharine R. Owen,
• Beverley Shields,
• Beverley Wilkins-Wall,
• Mark Walker,
• Mark I. McCarthy,
• Timothy M. Frayling,
• and Andrew T. Hattersley

Genetic Variation in the Small Heterodimer Partner Gene and Young-Onset Type 2 Diabetes, Obesity, and Birth Weight in U.K. Subjects

• Giorgio Sesti,
• Marina Cardellini,
• Maria Adelaide Marini,
• Simona Frontoni,
• Monica D’Adamo,
• Silvia Del Guerra,
• Davide Lauro,
• Pierluigi De Nicolais,
• Paolo Sbraccia,
• Stefano Del Prato,
• Sergio Gambardella,
• Massimo Federici,
• Piero Marchetti,
• and Renato Lauro

A Common Polymorphism in the Promoter of UCP2 Contributes to the Variation in Insulin Secretion in Glucose-Tolerant Subjects

• Amy Luke,
• Xiaodong Wu,
• Xiaofeng Zhu,
• Donghui Kan,
• Yan Su,
• and Richard Cooper

Linkage for BMI at 3q27 Region Confirmed in an African-American Population

• Chiao-Chien Connie Hung,
• I. Sadaf Farooqi,
• Ken Ong,
• Jian’an Luan,
• Julia M. Keogh,
• Marcus Pembrey,
• Giles S.H. Yeo,
• David Dunger,
• Nicholas J. Wareham,
• and Stephen O’ Rahilly

Contribution of Variants in the Small Heterodimer Partner Gene to Birthweight, Adiposity, and Insulin Levels: Mutational Analysis and Association Studies in Multiple Populations

• Peter Kovacs,
• Angela Lehn-Stefan,
• Michael Stumvoll,
• Clifton Bogardus,
• and Leslie J. Baier

Genetic Variation in the Human Winged Helix/Forkhead Transcription Factor Gene FOXC2 in Pima Indians

• Sumit Bhattacharyya,
• Jian’an Luan,
• Benjamin Challis,
• Catherine Schmitz,
• Paul Clarkson,
• Paul W. Franks,
• Rita Middelberg,
• Julia Keogh,
• I. Sadaf Farooqi,
• Carl Montague,
• John Brennand,
• Nicholas J. Wareham,
• and Stephen O’Rahilly

Association of Polymorphisms in GPR10, the Gene Encoding the Prolactin-Releasing Peptide Receptor With Blood Pressure, but not Obesity, in a U.K. Caucasian Population

• Christopher J. Groves,
• Steven Wiltshire,
• Damian Smedley,
• Katherine R. Owen,
• Timothy M. Frayling,
• Mark Walker,
• Graham A. Hitman,
• Jonathan C. Levy,
• Stephen O’Rahilly,
• Stephan Menzel,
• Andrew T. Hattersley,
• and Mark I. McCarthy

Association and Haplotype Analysis of the Insulin-Degrading Enzyme (IDE) Gene, a Strong Positional and Biological Candidate for Type 2 Diabetes Susceptibility

Errata