Table of Contents

Obesity Studies

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- Manjinder S. Sandhu,
- J. Martin Gibson,
- Adrian H. Heald,
- David B. Dunger,
- and Nicholas J. Wareham
Low Circulating IGF-II Concentrations Predict Weight Gain and Obesity in Humans
Diabetes June 2003 52:1403-1408; doi:10.2337/diabetes.52.6.1403
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- Yanjun Liu,
- Yuichi Nakagawa,
- Ying Wang,
- Renshan Li,
- Xiaojun Li,
- Takehiko Ohzeki,
- and Theodore C. Friedman
Leptin Activation of Corticosterone Production in Hepatocytes May Contribute to the Reversal of Obesity and Hyperglycemia in Leptin-Deficient ob/ob Mice
Diabetes June 2003 52:1409-1416; doi:10.2337/diabetes.52.6.1409
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- Hind Ray,
- Michel Beylot,
- Peter Arner,
- Dominique Larrouy,
- Dominique Langin,
- Cecilia Holm,
- and Valérie Large
The Presence of a Catalytically Inactive Form of Hormone-Sensitive Lipase Is Associated With Decreased Lipolysis in Abdominal Subcutaneous Adipose Tissue of Obese Subjects
Diabetes June 2003 52:1417-1422; doi:10.2337/diabetes.52.6.1417

Immunology and Transplantation

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- Veronique Vien Tran,
- Guoxun Chen,
- Christopher B. Newgard,
- and Hans E. Hohmeier
Discrete and Complementary Mechanisms of Protection of β-Cells Against Cytokine-Induced and Oxidative Damage Achieved by bcl-2 Overexpression and a Cytokine Selection Strategy
Diabetes June 2003 52:1423-1432; doi:10.2337/diabetes.52.6.1423
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- Gina R. Rayat,
- Zachary A. Johnson,
- Joshua N. Beilke,
- Gregory S. Korbutt,
- Ray V. Rajotte,
- and Ronald G. Gill
The Degree of Phylogenetic Disparity of Islet Grafts Dictates the Reliance on Indirect CD4 T-Cell Antigen Recognition for Rejection
Diabetes June 2003 52:1433-1440; doi:10.2337/diabetes.52.6.1433
Select this article
- Melpomeni Peppa,
- Cijiang He,
- Masakazu Hattori,
- Robert McEvoy,
- Feng Zheng,
- and Helen Vlassara
Fetal or Neonatal Low-Glycotoxin Environment Prevents Autoimmune Diabetes in NOD Mice
Diabetes June 2003 52:1441-1448; doi:10.2337/diabetes.52.6.1441

Islet Studies

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- Paula I. Moreira,
- Maria S. Santos,
- António M. Moreno,
- Raquel Seiça,
- and Catarina R. Oliveira
Increased Vulnerability of Brain Mitochondria in Diabetic (Goto-Kakizaki) Rats With Aging and Amyloid-β Exposure
Diabetes June 2003 52:1449-1456; doi:10.2337/diabetes.52.6.1449
Select this article
- Henriette R. Oliveira,
- Rozangela Verlengia,
- Carla R.O. Carvalho,
- Luiz R.G. Britto,
- Rui Curi,
- and Angelo R. Carpinelli
Pancreatic β-Cells Express Phagocyte-Like NAD(P)H Oxidase
Diabetes June 2003 52:1457-1463; doi:10.2337/diabetes.52.6.1457

Pathophysiology

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- Jamal S. Rana,
- Kenneth J. Mukamal,
- James P. Morgan,
- James E. Muller,
- and Murray A. Mittleman
Circadian Variation in the Onset of Myocardial Infarction: Effect of Duration of Diabetes
Diabetes June 2003 52:1464-1468; doi:10.2337/diabetes.52.6.1464
Select this article
- Robert T.C.E. Robinson,
- Nigel D. Harris,
- Robert H. Ireland,
- Stuart Lee,
- Christopher Newman,
- and Simon R. Heller
Mechanisms of Abnormal Cardiac Repolarization During Insulin-Induced Hypoglycemia
Diabetes June 2003 52:1469-1474; doi:10.2337/diabetes.52.6.1469
Select this article
- James B. Meigs,
- Denis C. Muller,
- David M. Nathan,
- Deirdre R. Blake,
- and Reubin Andres
The Natural History of Progression From Normal Glucose Tolerance to Type 2 Diabetes in the Baltimore Longitudinal Study of Aging
Diabetes June 2003 52:1475-1484; doi:10.2337/diabetes.52.6.1475
Select this article
- André Carpentier,
- Bernard Zinman,
- Nathalie Leung,
- Adria Giacca,
- Anthony J.G. Hanley,
- Stewart B. Harris,
- Robert A. Hegele,
- and Gary F. Lewis
Free Fatty Acid-Mediated Impairment of Glucose-Stimulated Insulin Secretion in Nondiabetic Oji-Cree Individuals From the Sandy Lake Community of Ontario, Canada: A Population at Very High Risk for Developing Type 2 Diabetes
Diabetes June 2003 52:1485-1495; doi:10.2337/diabetes.52.6.1485

Complications

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- Richard D. Egleton,
- Christopher C. Campos,
- Jason D. Huber,
- Rachel C. Brown,
- and Thomas P. Davis
Differential Effects of Diabetes on Rat Choroid Plexus Ion Transporter Expression
Diabetes June 2003 52:1496-1501; doi:10.2337/diabetes.52.6.1496
Select this article
- Ronaldo B. Santana,
- Lei Xu,
- Hermik Babakhanlou Chase,
- Salomon Amar,
- Dana T. Graves,
- and Philip C. Trackman
A Role for Advanced Glycation End Products in Diminished Bone Healing in Type 1 Diabetes
Diabetes June 2003 52:1502-1510; doi:10.2337/diabetes.52.6.1502
Select this article
- Gianpaolo Zerbini,
- Anna Maestroni,
- Diego Breviario,
- Ruggero Mangili,
- and Giorgio Casari
Alternative Splicing of NHE-1 Mediates Na-Li Countertransport and Associates With Activity Rate
Diabetes June 2003 52:1511-1518; doi:10.2337/diabetes.52.6.1511
Select this article
- Rakesh Chibber,
- Bahaedin M. Ben-Mahmud,
- Giovanni E. Mann,
- Jin J. Zhang,
- and Eva M. Kohner
Protein Kinase C β2-Dependent Phosphorylation of Core 2 GlcNAc-T Promotes Leukocyte-Endothelial Cell Adhesion: A Mechanism Underlying Capillary Occlusion in Diabetic Retinopathy
Diabetes June 2003 52:1519-1527; doi:10.2337/diabetes.52.6.1519

Genetics

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- Rohit N. Kulkarni,
- Katrine Almind,
- H. Joseph Goren,
- Jonathon N. Winnay,
- Kohjiro Ueki,
- Terumasa Okada,
- and C. Ronald Kahn
Impact of Genetic Background on Development of Hyperinsulinemia and Diabetes in Insulin Receptor/Insulin Receptor Substrate-1 Double Heterozygous Mice
Diabetes June 2003 52:1528-1534; doi:10.2337/diabetes.52.6.1528
Select this article
- Katrine Almind,
- Rohit N. Kulkarni,
- Scott M. Lannon,
- and C. Ronald Kahn
Identification of Interactive Loci Linked to Insulin and Leptin in Mice With Genetic Insulin Resistance
Diabetes June 2003 52:1535-1543; doi:10.2337/diabetes.52.6.1535
Select this article
- Norbert Stefan,
- Peter Kovacs,
- Michael Stumvoll,
- Robert L. Hanson,
- Angela Lehn-Stefan,
- Paska A. Permana,
- Leslie J. Baier,
- P. Antonio Tataranni,
- Kristi Silver,
- and Clifton Bogardus
Metabolic Effects of the Gly1057Asp Polymorphism in IRS-2 and Interactions With Obesity
Diabetes June 2003 52:1544-1550; doi:10.2337/diabetes.52.6.1544

Brief Genetics Reports

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- Carlos Penha-Gonçalves,
- Carolyn Moule,
- Luc J. Smink,
- Joanna Howson,
- Simon Gregory,
- Jane Rogers,
- Paul A. Lyons,
- Joseph J. Suttie,
- Christopher J. Lord,
- Laurence B. Peterson,
- John A. Todd,
- and Linda S. Wicker
Identification of a Structurally Distinct CD101 Molecule Encoded in the 950-kb Idd10 Region of NOD Mice
Diabetes June 2003 52:1551-1556; doi:10.2337/diabetes.52.6.1551
Select this article
- Wei-Dong Li,
- Ding Li,
- Shuang Wang,
- Shuanglin Zhang,
- Hongyu Zhao,
- and R. Arlen Price
Linkage and Linkage Disequilibrium Mapping of Genes Influencing Human Obesity in Chromosome Region 7q22.1–7q35
Diabetes June 2003 52:1557-1561; doi:10.2337/diabetes.52.6.1557
Select this article
- Samer Karamohamed,
- Serkalem Demissie,
- Jeannine Volcjak,
- Chunyu Liu,
- Nancy Heard-Costa,
- Jun Liu,
- Christina M. Shoemaker,
- Carolien I. Panhuysen,
- James B. Meigs,
- Peter Wilson,
- Larry D. Atwood,
- L. Adrienne Cupples,
- and Alan Herbert
Polymorphisms in the Insulin-Degrading Enzyme Gene Are Associated With Type 2 Diabetes in Men From the NHLBI Framingham Heart Study
Diabetes June 2003 52:1562-1567; doi:10.2337/diabetes.52.6.1562
Select this article
- W.H. Linda Kao,
- Josef Coresh,
- Alan R. Shuldiner,
- Eric Boerwinkle,
- Molly S. Bray,
- and Frederick L. Brancati
Pro12Ala of the Peroxisome Proliferator–Activated Receptor-γ2 Gene Is Associated With Lower Serum Insulin Levels in Nonobese African Americans: The Atherosclerosis Risk in Communities Study
Diabetes June 2003 52:1568-1572; doi:10.2337/diabetes.52.6.1568
Select this article
- Jocelyne Magré,
- Marc Delépine,
- Lionel Van Maldergem,
- Jean-Jacques Robert,
- J. Antonie Maassen,
- Muriel Meier,
- Vanessa R. Panz,
- Chong Ae Kim,
- Nadia Tubiana-Rufi,
- Paul Czernichow,
- Eva Seemanova,
- Charles R. Buchanan,
- Didier Lacombe,
- Corinne Vigouroux,
- Olivier Lascols,
- C. Ronald Kahn,
- Jacqueline Capeau,
- and Mark Lathrop
Prevalence of Mutations in AGPAT2 Among Human Lipodystrophies
Diabetes June 2003 52:1573-1578; doi:10.2337/diabetes.52.6.1573
Select this article
- Janelle A. Noble,
- Amy M. White,
- Laura C. Lazzeroni,
- Ana M. Valdes,
- Daniel B. Mirel,
- Rebecca Reynolds,
- Andrew Grupe,
- Dee Aud,
- Gary Peltz,
- and Henry A. Erlich
A Polymorphism in the TCF7 Gene, C883A, Is Associated With Type 1 Diabetes
Diabetes June 2003 52:1579-1582; doi:10.2337/diabetes.52.6.1579
Select this article
- Timo A. Lakka,
- Tuomo Rankinen,
- S. John Weisnagel,
- Yvon C. Chagnon,
- Treva Rice,
- Arthur S. Leon,
- James S. Skinner,
- Jack H. Wilmore,
- D.C. Rao,
- and Claude Bouchard
A Quantitative Trait Locus on 7q31 for the Changes in Plasma Insulin in Response to Exercise Training: The HERITAGE Family Study
Diabetes June 2003 52:1583-1587; doi:10.2337/diabetes.52.6.1583

Letter to the Editor

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- Mayer B. Davidson
Status of Research Funded by the American Diabetes Association—Year 4
Diabetes June 2003 52:1588; doi:10.2337/diabetes.52.6.1588

Diabetes

Metabolism and Signal Transduction

Differential Effects of Rosiglitazone on Skeletal Muscle and Liver Insulin Resistance in A-ZIP/F-1 Fatless Mice

Reduced Activation of Phosphatidylinositol-3 Kinase and Increased Serine 636 Phosphorylation of Insulin Receptor Substrate-1 in Primary Culture of Skeletal Muscle Cells From Patients With Type 2 Diabetes

Fetal Programming of Perivenous Glucose Uptake Reveals a Regulatory Mechanism Governing Hepatic Glucose Output During Refeeding

Glucose 6-Phosphate Regulates Hepatic Glycogenolysis Through Inactivation of Phosphorylase

Insulin Resistance and Lipodystrophy in Mice Lacking Ribosomal S6 Kinase 2

Combined Infusion of Epinephrine and Norepinephrine During Moderate Exercise Reproduces the Glucoregulatory Response of Intense Exercise

Involvement of AMP-Activated Protein Kinase in Glucose Uptake Stimulated by the Globular Domain of Adiponectin in Primary Rat Adipocytes

Pioglitazone Reduces Hepatic Fat Content and Augments Splanchnic Glucose Uptake in Patients With Type 2 Diabetes

Starvation and Diabetes Reduce the Amount of Pyruvate Dehydrogenase Phosphatase in Rat Heart and Kidney

Differential Regulation of Protein Dynamics in Splanchnic and Skeletal Muscle Beds by Insulin and Amino Acids in Healthy Human Subjects

Renal Compensation for Impaired Hepatic Glucose Release During Hypoglycemia in Type 2 Diabetes: Further Evidence for Hepatorenal Reciprocity

Increased Phosphorylation of Skeletal Muscle Glycogen Synthase at NH2-Terminal Sites During Physiological Hyperinsulinemia in Type 2 Diabetes

Obesity Studies

Low Circulating IGF-II Concentrations Predict Weight Gain and Obesity in Humans

Leptin Activation of Corticosterone Production in Hepatocytes May Contribute to the Reversal of Obesity and Hyperglycemia in Leptin-Deficient ob/ob Mice

The Presence of a Catalytically Inactive Form of Hormone-Sensitive Lipase Is Associated With Decreased Lipolysis in Abdominal Subcutaneous Adipose Tissue of Obese Subjects

Immunology and Transplantation

Discrete and Complementary Mechanisms of Protection of β-Cells Against Cytokine-Induced and Oxidative Damage Achieved by bcl-2 Overexpression and a Cytokine Selection Strategy

The Degree of Phylogenetic Disparity of Islet Grafts Dictates the Reliance on Indirect CD4 T-Cell Antigen Recognition for Rejection

Fetal or Neonatal Low-Glycotoxin Environment Prevents Autoimmune Diabetes in NOD Mice

Islet Studies

Increased Vulnerability of Brain Mitochondria in Diabetic (Goto-Kakizaki) Rats With Aging and Amyloid-β Exposure

Pancreatic β-Cells Express Phagocyte-Like NAD(P)H Oxidase

Pathophysiology

Circadian Variation in the Onset of Myocardial Infarction: Effect of Duration of Diabetes

Mechanisms of Abnormal Cardiac Repolarization During Insulin-Induced Hypoglycemia

The Natural History of Progression From Normal Glucose Tolerance to Type 2 Diabetes in the Baltimore Longitudinal Study of Aging

Free Fatty Acid-Mediated Impairment of Glucose-Stimulated Insulin Secretion in Nondiabetic Oji-Cree Individuals From the Sandy Lake Community of Ontario, Canada: A Population at Very High Risk for Developing Type 2 Diabetes

Complications

Differential Effects of Diabetes on Rat Choroid Plexus Ion Transporter Expression

A Role for Advanced Glycation End Products in Diminished Bone Healing in Type 1 Diabetes

Alternative Splicing of NHE-1 Mediates Na-Li Countertransport and Associates With Activity Rate

Protein Kinase C β2-Dependent Phosphorylation of Core 2 GlcNAc-T Promotes Leukocyte-Endothelial Cell Adhesion: A Mechanism Underlying Capillary Occlusion in Diabetic Retinopathy

Genetics

Impact of Genetic Background on Development of Hyperinsulinemia and Diabetes in Insulin Receptor/Insulin Receptor Substrate-1 Double Heterozygous Mice

Identification of Interactive Loci Linked to Insulin and Leptin in Mice With Genetic Insulin Resistance

Metabolic Effects of the Gly1057Asp Polymorphism in IRS-2 and Interactions With Obesity

Brief Genetics Reports

Identification of a Structurally Distinct CD101 Molecule Encoded in the 950-kb Idd10 Region of NOD Mice

Linkage and Linkage Disequilibrium Mapping of Genes Influencing Human Obesity in Chromosome Region 7q22.1–7q35

Polymorphisms in the Insulin-Degrading Enzyme Gene Are Associated With Type 2 Diabetes in Men From the NHLBI Framingham Heart Study

Pro12Ala of the Peroxisome Proliferator–Activated Receptor-γ2 Gene Is Associated With Lower Serum Insulin Levels in Nonobese African Americans: The Atherosclerosis Risk in Communities Study

Prevalence of Mutations in AGPAT2 Among Human Lipodystrophies

A Polymorphism in the TCF7 Gene, C883A, Is Associated With Type 1 Diabetes

A Quantitative Trait Locus on 7q31 for the Changes in Plasma Insulin in Response to Exercise Training: The HERITAGE Family Study

Letter to the Editor

Status of Research Funded by the American Diabetes Association—Year 4

This Issue

Current Issue

Increased Phosphorylation of Skeletal Muscle Glycogen Synthase at NH₂-Terminal Sites During Physiological Hyperinsulinemia in Type 2 Diabetes