Magnetic Resonance-Defined Periportal Steatosis Following Intraportal Islet Transplantation
A Functional Footprint of Islet Graft Survival?
- James F. Markmann1,
- Mark Rosen2,
- Evan S. Siegelman2,
- Michael C. Soulen2,
- Shaoping Deng1,
- Clyde F. Barker1 and
- Ali Naji1
- 1Department of Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania
- 2Department of Radiology, University of Pennsylvania Health System, Philadelphia, Pennsylvania
- Address correspondence and reprint requests to James F. Markmann, MD, Department of Surgery, Hospital of the University of Pennsylvania, 4th Floor Silverstein, 3400 Spruce St., Philadelphia, PA 19104. E-mail: james.markmann{at}uphs.upenn.edu
Abstract
There is growing interest in more widespread application of isolated islet transplantation for the treatment of type 1 diabetes; however, the sequelae of long-term islet residence within the liver are unknown. We report herein a consequence of intraportal islet transplantation, specifically the development of periportal hepatic steatosis apparently induced by the local secretion of insulin within the liver.
Footnotes
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- Accepted April 28, 2003.
- Received December 27, 2002.
- DIABETES
