Table of Contents

Metabolism

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- Jørn W. Helge and
- Flemming Dela
Effect of Training on Muscle Triacylglycerol and Structural Lipids: A Relation to Insulin Sensitivity?
Diabetes August 2003 52:1881-1887; doi:10.2337/diabetes.52.8.1881
Select this article
- Kevin R. Short,
- Janet L. Vittone,
- Maureen L. Bigelow,
- David N. Proctor,
- Robert A. Rizza,
- Jill M. Coenen-Schimke,
- and K. Sreekumaran Nair
Impact of Aerobic Exercise Training on Age-Related Changes in Insulin Sensitivity and Muscle Oxidative Capacity
Diabetes August 2003 52:1888-1896; doi:10.2337/diabetes.52.8.1888
Select this article
- R. Richard Pencek,
- Freyja James,
- D. Brooks Lacy,
- Kareem Jabbour,
- Phillip E. Williams,
- Patrick T. Fueger,
- and David H. Wasserman
Interaction of Insulin and Prior Exercise in Control of Hepatic Metabolism of a Glucose Load
Diabetes August 2003 52:1897-1903; doi:10.2337/diabetes.52.8.1897

Signal Transduction

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- Jason J. Wilkes,
- Andrea Hevener,
- and Jerrold Olefsky
Chronic Endothelin-1 Treatment Leads to Insulin Resistance In Vivo
Diabetes August 2003 52:1904-1909; doi:10.2337/diabetes.52.8.1904
Select this article
- Beth A. Spurlin,
- Rhonda M. Thomas,
- Angela K. Nevins,
- Hyo-Jeong Kim,
- Yoon-Jung Kim,
- Hye-Lim Noh,
- Gerald I. Shulman,
- Jason K. Kim,
- and Debbie C. Thurmond
Insulin Resistance in Tetracycline-Repressible Munc18c Transgenic Mice
Diabetes August 2003 52:1910-1917; doi:10.2337/diabetes.52.8.1910
Select this article
- Lorraine A. Nolte,
- Dong-Ho Han,
- Polly A. Hansen,
- Kathleen A. Hucker,
- and John O. Holloszy
A Peroxovanadium Compound Stimulates Muscle Glucose Transport as Powerfully as Insulin and Contractions Combined
Diabetes August 2003 52:1918-1925; doi:10.2337/diabetes.52.8.1918
Select this article
- Mary Beeson,
- Mini P. Sajan,
- Michelle Dizon,
- Dmitry Grebenev,
- Joaquin Gomez-Daspet,
- Atsushi Miura,
- Yoshinori Kanoh,
- Jennifer Powe,
- Gautam Bandyopadhyay,
- Mary L. Standaert,
- and Robert V. Farese
Activation of Protein Kinase C-ζ by Insulin and Phosphatidylinositol-3,4,5-(PO₄)₃ Is Defective in Muscle in Type 2 Diabetes and Impaired Glucose Tolerance: Amelioration by Rosiglitazone and Exercise
Diabetes August 2003 52:1926-1934; doi:10.2337/diabetes.52.8.1926
Select this article
- Young-Bum Kim,
- Ko Kotani,
- Theodore P. Ciaraldi,
- Robert R. Henry,
- and Barbara B. Kahn
Insulin-Stimulated Protein Kinase C λ/ζ Activity Is Reduced in Skeletal Muscle of Humans With Obesity and Type 2 Diabetes: Reversal With Weight Reduction
Diabetes August 2003 52:1935-1942; doi:10.2337/diabetes.52.8.1935
Select this article
- Yoshinori Miyazaki,
- Helen He,
- Lawrence J. Mandarino,
- and Ralph A. DeFronzo
Rosiglitazone Improves Downstream Insulin Receptor Signaling in Type 2 Diabetic Patients
Diabetes August 2003 52:1943-1950; doi:10.2337/diabetes.52.8.1943

Obesity

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- Gang Li,
- Charles V. Mobbs,
- and Philip J. Scarpace
Central Pro-opiomelanocortin Gene Delivery Results in Hypophagia, Reduced Visceral Adiposity, and Improved Insulin Sensitivity in Genetically Obese Zucker Rats
Diabetes August 2003 52:1951-1957; doi:10.2337/diabetes.52.8.1951
Select this article
- Martin Rossmeisl,
- Jong S. Rim,
- Robert A. Koza,
- and Leslie P. Kozak
Variation in Type 2 Diabetes-Related Traits in Mouse Strains Susceptible to Diet-Induced Obesity
Diabetes August 2003 52:1958-1966; doi:10.2337/diabetes.52.8.1958

Immunology

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- Qing-Sheng Mi,
- Dalam Ly,
- S.-E. Lamhamedi-Cherradi,
- Konstantin V. Salojin,
- Li Zhou,
- Marsha Grattan,
- Craig Meagher,
- Peter Zucker,
- Youhai H. Chen,
- James Nagle,
- Dennis Taub,
- and Terry L. Delovitch
Blockade of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Exacerbates Type 1 Diabetes in NOD Mice
Diabetes August 2003 52:1967-1975; doi:10.2337/diabetes.52.8.1967
Select this article
- Linlin Ma,
- Shiguang Qian,
- Xiaoyan Liang,
- Lianfu Wang,
- Jennifer E. Woodward,
- Nick Giannoukakis,
- Paul D. Robbins,
- Suzanne Bertera,
- Massimo Trucco,
- John J. Fung,
- and Lina Lu
Prevention of Diabetes in NOD Mice by Administration of Dendritic Cells Deficient in Nuclear Transcription Factor-κB Activity
Diabetes August 2003 52:1976-1985; doi:10.2337/diabetes.52.8.1976

Pathophysiology

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- Stephen B. Wheatcroft,
- Mark T. Kearney,
- Ajay M. Shah,
- David J. Grieve,
- Ian L. Williams,
- John P. Miell,
- and Paul A. Crossey
Vascular Endothelial Function and Blood Pressure Homeostasis in Mice Overexpressing IGF Binding Protein-1
Diabetes August 2003 52:2075-2082; doi:10.2337/diabetes.52.8.2075
Select this article
- Bharathi Raju,
- Veronica P. McGregor,
- and Philip E. Cryer
Cortisol Elevations Comparable to Those That Occur During Hypoglycemia Do Not Cause Hypoglycemia-Associated Autonomic Failure
Diabetes August 2003 52:2083-2089; doi:10.2337/diabetes.52.8.2083
Select this article
- Chittaranjan S. Yajnik,
- Charu V. Joglekar,
- Anand N. Pandit,
- Ashish R. Bavdekar,
- Swati A. Bapat,
- Sheila A. Bhave,
- Samantha D. Leary,
- and Caroline H.D. Fall
Higher Offspring Birth Weight Predicts the Metabolic Syndrome in Mothers but Not Fathers 8 Years After Delivery: The Pune Children’s Study
Diabetes August 2003 52:2090-2096; doi:10.2337/diabetes.52.8.2090
Select this article
- Gunnar Engström,
- Bo Hedblad,
- Lars Stavenow,
- Peter Lind,
- Lars Janzon,
- and Folke Lindgärde
Inflammation-Sensitive Plasma Proteins Are Associated With Future Weight Gain
Diabetes August 2003 52:2097-2101; doi:10.2337/diabetes.52.8.2097

Complications

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- Hyoh Kim,
- Teiji Sasaki,
- Kengo Maeda,
- Daisuke Koya,
- Atsunori Kashiwagi,
- and Hitoshi Yasuda
Protein Kinase Cβ Selective Inhibitor LY333531 Attenuates Diabetic Hyperalgesia Through Ameliorating cGMP Level of Dorsal Root Ganglion Neurons
Diabetes August 2003 52:2102-2109; doi:10.2337/diabetes.52.8.2102
Select this article
- Roya Babaei-Jadidi,
- Nikolaos Karachalias,
- Naila Ahmed,
- Sinan Battah,
- and Paul J. Thornalley
Prevention of Incipient Diabetic Nephropathy by High-Dose Thiamine and Benfotiamine
Diabetes August 2003 52:2110-2120; doi:10.2337/diabetes.52.8.2110
Select this article
- Fritz Maingrette and
- Geneviève Renier
Leptin Increases Lipoprotein Lipase Secretion by Macrophages: Involvement of Oxidative Stress and Protein Kinase C
Diabetes August 2003 52:2121-2128; doi:10.2337/diabetes.52.8.2121
Select this article
- Tze-Jen Huang,
- Sally A. Price,
- Lucy Chilton,
- Nigel A. Calcutt,
- David R. Tomlinson,
- Alex Verkhratsky,
- and Paul Fernyhough
Insulin Prevents Depolarization of the Mitochondrial Inner Membrane in Sensory Neurons of Type 1 Diabetic Rats in the Presence of Sustained Hyperglycemia
Diabetes August 2003 52:2129-2136; doi:10.2337/diabetes.52.8.2129
Select this article
- Melissa M. Anderson and
- Jay W. Heinecke
Production of N^ε-(Carboxymethyl)Lysine Is Impaired in Mice Deficient in NADPH Oxidase: A Role for Phagocyte-Derived Oxidants in the Formation of Advanced Glycation End Products During Inflammation
Diabetes August 2003 52:2137-2143; doi:10.2337/diabetes.52.8.2137
Select this article
- Shuxia Wang,
- Xing Wu,
- Thomas M. Lincoln,
- and Joanne E. Murphy-Ullrich
Expression of Constitutively Active cGMP-Dependent Protein Kinase Prevents Glucose Stimulation of Thrombospondin 1 Expression and TGF-β Activity
Diabetes August 2003 52:2144-2150; doi:10.2337/diabetes.52.8.2144

Genetics

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- Karen H.S. Wilson,
- Sarah E. Eckenrode,
- Quan-Zhen Li,
- Qing-Guo Ruan,
- Ping Yang,
- Jing-Da Shi,
- Abdoreza Davoodi-Semiromi,
- Richard A. McIndoe,
- Byron P. Croker,
- and Jin-Xiong She
Microarray Analysis of Gene Expression in the Kidneys of New- and Post-Onset Diabetic NOD Mice
Diabetes August 2003 52:2151-2159; doi:10.2337/diabetes.52.8.2151
Select this article
- James B. Meigs,
- Peter W.F. Wilson,
- David M. Nathan,
- Ralph B. D’Agostino, Sr.,
- Ken Williams,
- and Steven M. Haffner
Prevalence and Characteristics of the Metabolic Syndrome in the San Antonio Heart and Framingham Offspring Studies
Diabetes August 2003 52:2160-2167; doi:10.2337/diabetes.52.8.2160
Select this article
- Richard N. Bergman,
- Daniel J. Zaccaro,
- Richard M. Watanabe,
- Steven M. Haffner,
- Mohammed F. Saad,
- Jill M. Norris,
- Lynne E. Wagenknecht,
- James E. Hokanson,
- Jerome I. Rotter,
- and Steven S. Rich
Minimal Model-Based Insulin Sensitivity Has Greater Heritability and a Different Genetic Basis Than Homeostasis Model Assessment or Fasting Insulin
Diabetes August 2003 52:2168-2174; doi:10.2337/diabetes.52.8.2168
Select this article
- Tomohito Gohda,
- Yuichiro Makita,
- Toshihide Shike,
- Mitsuo Tanimoto,
- Kazuhiko Funabiki,
- Satoshi Horikoshi,
- and Yasuhiko Tomino
Identification of Epistatic Interaction Involved in Obesity Using the KK/Ta Mouse as a Type 2 Diabetes Model: Is Zn-α₂ Glycoprotein-1 a Candidate Gene for Obesity?
Diabetes August 2003 52:2175-2181; doi:10.2337/diabetes.52.8.2175

Brief Genetics Report

Select this article
- Sung-Hoon Kim,
- Xiaowei Ma,
- Tomasz Klupa,
- Christine Powers,
- Marcus Pezzolesi,
- James H. Warram,
- Stephen S. Rich,
- Andrzej S. Krolewski,
- and Alessandro Doria
Genetic Modifiers of the Age at Diagnosis of Diabetes (MODY3) in Carriers of Hepatocyte Nuclear Factor-1α Mutations Map to Chromosomes 5p15, 9q22, and 14q24
Diabetes August 2003 52:2182-2186; doi:10.2337/diabetes.52.8.2182

Diabetes

Metabolism

Effect of Training on Muscle Triacylglycerol and Structural Lipids: A Relation to Insulin Sensitivity?

Impact of Aerobic Exercise Training on Age-Related Changes in Insulin Sensitivity and Muscle Oxidative Capacity

Interaction of Insulin and Prior Exercise in Control of Hepatic Metabolism of a Glucose Load

Signal Transduction

Chronic Endothelin-1 Treatment Leads to Insulin Resistance In Vivo

Insulin Resistance in Tetracycline-Repressible Munc18c Transgenic Mice

A Peroxovanadium Compound Stimulates Muscle Glucose Transport as Powerfully as Insulin and Contractions Combined

Activation of Protein Kinase C-ζ by Insulin and Phosphatidylinositol-3,4,5-(PO4)3 Is Defective in Muscle in Type 2 Diabetes and Impaired Glucose Tolerance: Amelioration by Rosiglitazone and Exercise

Insulin-Stimulated Protein Kinase C λ/ζ Activity Is Reduced in Skeletal Muscle of Humans With Obesity and Type 2 Diabetes: Reversal With Weight Reduction

Rosiglitazone Improves Downstream Insulin Receptor Signaling in Type 2 Diabetic Patients

Obesity

Central Pro-opiomelanocortin Gene Delivery Results in Hypophagia, Reduced Visceral Adiposity, and Improved Insulin Sensitivity in Genetically Obese Zucker Rats

Variation in Type 2 Diabetes-Related Traits in Mouse Strains Susceptible to Diet-Induced Obesity

Immunology

Blockade of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Exacerbates Type 1 Diabetes in NOD Mice

Prevention of Diabetes in NOD Mice by Administration of Dendritic Cells Deficient in Nuclear Transcription Factor-κB Activity

Islet

Endothelial Differentiation Gene Receptors in Pancreatic Islets and INS-1 Cells

Free Radicals and the Pathogenesis of Type 1 Diabetes: β-Cell Cytokine-Mediated Free Radical Generation Via Cyclooxygenase-2

Small-Conductance Calcium-Activated K+ Channels Are Expressed in Pancreatic Islets and Regulate Glucose Responses

Characterization of Endocrine Progenitor Cells and Critical Factors for Their Differentiation in Human Adult Pancreatic Cell Culture

Pancreatic Precursors and Differentiated Islet Cell Types From Murine Embryonic Stem Cells: An In Vitro Model to Study Islet Differentiation

Diabetogenic Potential of Human Pathogens Uncovered in Experimentally Permissive β-Cells

Label-Retaining Cells in the Rat Pancreas: Location and Differentiation Potential in Vitro

KATP Channels and Pancreatic Islet Blood Flow in Anesthetized Rats: Increased Blood Flow Induced by Potassium Channel Openers

Insulin Constitutively Secreted by β-Cells Is Necessary for Glucose-Stimulated Insulin Secretion

Pancreatic β-Cell Lipotoxicity Induced by Overexpression of Hormone-Sensitive Lipase

Vesicular Inhibitory Amino Acid Transporter Is Present in Glucagon-Containing Secretory Granules in αTC6 Cells, Mouse Clonal α-Cells, and α-Cells of Islets of Langerhans

Pathophysiology

Vascular Endothelial Function and Blood Pressure Homeostasis in Mice Overexpressing IGF Binding Protein-1

Cortisol Elevations Comparable to Those That Occur During Hypoglycemia Do Not Cause Hypoglycemia-Associated Autonomic Failure

Higher Offspring Birth Weight Predicts the Metabolic Syndrome in Mothers but Not Fathers 8 Years After Delivery: The Pune Children’s Study

Inflammation-Sensitive Plasma Proteins Are Associated With Future Weight Gain

Complications

Protein Kinase Cβ Selective Inhibitor LY333531 Attenuates Diabetic Hyperalgesia Through Ameliorating cGMP Level of Dorsal Root Ganglion Neurons

Prevention of Incipient Diabetic Nephropathy by High-Dose Thiamine and Benfotiamine

Leptin Increases Lipoprotein Lipase Secretion by Macrophages: Involvement of Oxidative Stress and Protein Kinase C

Insulin Prevents Depolarization of the Mitochondrial Inner Membrane in Sensory Neurons of Type 1 Diabetic Rats in the Presence of Sustained Hyperglycemia

Production of Nε-(Carboxymethyl)Lysine Is Impaired in Mice Deficient in NADPH Oxidase: A Role for Phagocyte-Derived Oxidants in the Formation of Advanced Glycation End Products During Inflammation

Expression of Constitutively Active cGMP-Dependent Protein Kinase Prevents Glucose Stimulation of Thrombospondin 1 Expression and TGF-β Activity

Genetics

Microarray Analysis of Gene Expression in the Kidneys of New- and Post-Onset Diabetic NOD Mice

Prevalence and Characteristics of the Metabolic Syndrome in the San Antonio Heart and Framingham Offspring Studies

Minimal Model-Based Insulin Sensitivity Has Greater Heritability and a Different Genetic Basis Than Homeostasis Model Assessment or Fasting Insulin

Identification of Epistatic Interaction Involved in Obesity Using the KK/Ta Mouse as a Type 2 Diabetes Model: Is Zn-α2 Glycoprotein-1 a Candidate Gene for Obesity?

Brief Genetics Report

Genetic Modifiers of the Age at Diagnosis of Diabetes (MODY3) in Carriers of Hepatocyte Nuclear Factor-1α Mutations Map to Chromosomes 5p15, 9q22, and 14q24

This Issue

Current Issue

Activation of Protein Kinase C-ζ by Insulin and Phosphatidylinositol-3,4,5-(PO₄)₃ Is Defective in Muscle in Type 2 Diabetes and Impaired Glucose Tolerance: Amelioration by Rosiglitazone and Exercise

Small-Conductance Calcium-Activated K⁺ Channels Are Expressed in Pancreatic Islets and Regulate Glucose Responses

K_ATP Channels and Pancreatic Islet Blood Flow in Anesthetized Rats: Increased Blood Flow Induced by Potassium Channel Openers

Production of N^ε-(Carboxymethyl)Lysine Is Impaired in Mice Deficient in NADPH Oxidase: A Role for Phagocyte-Derived Oxidants in the Formation of Advanced Glycation End Products During Inflammation

Identification of Epistatic Interaction Involved in Obesity Using the KK/Ta Mouse as a Type 2 Diabetes Model: Is Zn-α₂ Glycoprotein-1 a Candidate Gene for Obesity?