Table of Contents

Metabolism

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- Bret H. Goodpaster,
- Andreas Katsiaras,
- and David E. Kelley
Enhanced Fat Oxidation Through Physical Activity Is Associated With Improvements in Insulin Sensitivity in Obesity
Diabetes September 2003 52:2191-2197; doi:10.2337/diabetes.52.9.2191
Select this article
- Darleen A. Sandoval,
- Ling Ping,
- Anthony Ray Neill,
- Sachiko Morrey,
- and Stephen N. Davis
Cortisol Acts Through Central Mechanisms to Blunt Counterregulatory Responses to Hypoglycemia in Conscious Rats
Diabetes September 2003 52:2198-2204; doi:10.2337/diabetes.52.9.2198
Select this article
- Zhi-Ping Chen,
- Terry J. Stephens,
- Sid Murthy,
- Benedict J. Canny,
- Mark Hargreaves,
- Lee A. Witters,
- Bruce E. Kemp,
- and Glenn K. McConell
Effect of Exercise Intensity on Skeletal Muscle AMPK Signaling in Humans
Diabetes September 2003 52:2205-2212; doi:10.2337/diabetes.52.9.2205
Select this article
- Aron Adkins,
- Rita Basu,
- Mai Persson,
- Betty Dicke,
- Pankaj Shah,
- Adrian Vella,
- W. Frederick Schwenk,
- and Robert Rizza
Higher Insulin Concentrations Are Required to Suppress Gluconeogenesis Than Glycogenolysis in Nondiabetic Humans
Diabetes September 2003 52:2213-2220; doi:10.2337/diabetes.52.9.2213
Select this article
- Carlos Lerín,
- Eulàlia Montell,
- Teresa Nolasco,
- Cathy Clark,
- Matthew J. Brady,
- Christopher B. Newgard,
- and Anna M. Gómez-Foix
Regulation and Function of the Muscle Glycogen-Targeting Subunit of Protein Phosphatase 1 (G_M) in Human Muscle Cells Depends on the COOH-Terminal Region and Glycogen Content
Diabetes September 2003 52:2221-2226; doi:10.2337/diabetes.52.9.2221

Signal Transduction

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- Irini Rakatzi,
- Stefanie Ramrath,
- Daniela Ledwig,
- Olaf Dransfeld,
- Thomas Bartels,
- Gerhard Seipke,
- and Jürgen Eckel
A Novel Insulin Analog With Unique Properties: Lys^B3,Glu^B29 Insulin Induces Prominent Activation of Insulin Receptor Substrate 2, but Marginal Phosphorylation of Insulin Receptor Substrate 1
Diabetes September 2003 52:2227-2238; doi:10.2337/diabetes.52.9.2227
Select this article
- Angela M. Valverde,
- Deborah J. Burks,
- Isabel Fabregat,
- Tracey L. Fisher,
- José Carretero,
- Morris F. White,
- and Manuel Benito
Molecular Mechanisms of Insulin Resistance in IRS-2-Deficient Hepatocytes
Diabetes September 2003 52:2239-2248; doi:10.2337/diabetes.52.9.2239

Obesity Studies

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- Philip J. Larsen,
- Per Bo Jensen,
- Rikke V. Sørensen,
- Leif Kongskov Larsen,
- Niels Vrang,
- Erik M. Wulff,
- and Karsten Wassermann
Differential Influences of Peroxisome Proliferator–Activated Receptorsγ and -α on Food Intake and Energy Homeostasis
Diabetes September 2003 52:2249-2259; doi:10.2337/diabetes.52.9.2249
Select this article
- Lucy F. Faulconbridge,
- David E. Cummings,
- Joel M. Kaplan,
- and Harvey J. Grill
Hyperphagic Effects of Brainstem Ghrelin Administration
Diabetes September 2003 52:2260-2265; doi:10.2337/diabetes.52.9.2260
Select this article
- Takayuki Masaki,
- Seiichi Chiba,
- Tohru Yasuda,
- Tetsuo Tsubone,
- Tetsuya Kakuma,
- Iichiro Shimomura,
- Tohru Funahashi,
- Yuji Matsuzawa,
- and Hironobu Yoshimatsu
Peripheral, But Not Central, Administration of Adiponectin Reduces Visceral Adiposity and Upregulates the Expression of Uncoupling Protein in Agouti Yellow (A^y/a) Obese Mice
Diabetes September 2003 52:2266-2273; doi:10.2337/diabetes.52.9.2266

Immunology and Transplantation

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- Salah-Eddine Lamhamedi-Cherradi,
- Shijun Zheng,
- Roland M. Tisch,
- and Youhai H. Chen
Critical Roles of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand in Type 1 Diabetes
Diabetes September 2003 52:2274-2278; doi:10.2337/diabetes.52.9.2274
Select this article
- Yulian Wu,
- Bing Han,
- Hongyu Luo,
- Raphael Roduit,
- Theodora W. Salcedo,
- Paul A. Moore,
- Jun Zhang,
- and Jiangping Wu
DcR3/TR6 Effectively Prevents Islet Primary Nonfunction After Transplantation
Diabetes September 2003 52:2279-2286; doi:10.2337/diabetes.52.9.2279
Select this article
- Mia Westerholm-Ormio,
- Outi Vaarala,
- Päivi Pihkala,
- Jorma Ilonen,
- and Erkki Savilahti
Immunologic Activity in the Small Intestinal Mucosa of Pediatric Patients With Type 1 Diabetes
Diabetes September 2003 52:2287-2295; doi:10.2337/diabetes.52.9.2287
Select this article
- Xiaopei Cao,
- Zhiyong Gao,
- Claudia E. Robert,
- Scott Greene,
- Gang Xu,
- Weizhen Xu,
- Ewan Bell,
- Don Campbell,
- Yuan Zhu,
- Robert Young,
- Matteo Trucco,
- James F. Markmann,
- Ali Naji,
- and Bryan A. Wolf
Pancreatic-Derived Factor (FAM3B), a Novel Islet Cytokine, Induces Apoptosis of Insulin-Secreting β-Cells
Diabetes September 2003 52:2296-2303; doi:10.2337/diabetes.52.9.2296

Islet Studies

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- Alexandra E. Butler,
- Juliette Janson,
- Walter C. Soeller,
- and Peter C. Butler
Increased β-Cell Apoptosis Prevents Adaptive Increase in β-Cell Mass in Mouse Model of Type 2 Diabetes: Evidence for Role of Islet Amyloid Formation Rather Than Direct Action of Amyloid
Diabetes September 2003 52:2304-2314; doi:10.2337/diabetes.52.9.2304
Select this article
- Robert G. Bennett,
- Frederick G. Hamel,
- and William C. Duckworth
An Insulin-Degrading Enzyme Inhibitor Decreases Amylin Degradation, Increases Amylin-Induced Cytotoxicity, and Increases Amyloid Formation in Insulinoma Cell Cultures
Diabetes September 2003 52:2315-2320; doi:10.2337/diabetes.52.9.2315

Pathophysiology

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- Susanne E. la Fleur,
- Hong Ji,
- Sotara L. Manalo,
- Mark I. Friedman,
- and Mary F. Dallman
The Hepatic Vagus Mediates Fat-Induced Inhibition of Diabetic Hyperphagia
Diabetes September 2003 52:2321-2330; doi:10.2337/diabetes.52.9.2321
Select this article
- Eun Hee Koh,
- Min-Seon Kim,
- Joong-Yeol Park,
- Hyun Sik Kim,
- Ji-Young Youn,
- Hye-Sun Park,
- Jang Hyun Youn,
- and Ki-Up Lee
Peroxisome Proliferator-Activated Receptor (PPAR)-α Activation Prevents Diabetes in OLETF Rats: Comparison With PPAR-γ Activation
Diabetes September 2003 52:2331-2337; doi:10.2337/diabetes.52.9.2331
Select this article
- Clinton R. Bruce,
- Andrew L. Carey,
- John A. Hawley,
- and Mark A. Febbraio
Intramuscular Heat Shock Protein 72 and Heme Oxygenase-1 mRNA Are Reduced in Patients With Type 2 Diabetes: Evidence That Insulin Resistance Is Associated With a Disturbed Antioxidant Defense Mechanism
Diabetes September 2003 52:2338-2345; doi:10.2337/diabetes.52.9.2338
Select this article
- Earl S. Ford,
- Ali H. Mokdad,
- Wayne H. Giles,
- and David W. Brown
The Metabolic Syndrome and Antioxidant Concentrations: Findings From the Third National Health and Nutrition Examination Survey
Diabetes September 2003 52:2346-2352; doi:10.2337/diabetes.52.9.2346

Complications

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- Selim Cellek,
- Neale A. Foxwell,
- and Salvador Moncada
Two Phases of Nitrergic Neuropathy in Streptozotocin-Induced Diabetic Rats
Diabetes September 2003 52:2353-2362; doi:10.2337/diabetes.52.9.2353
Select this article
- Chu Cheng and
- Douglas W. Zochodne
Sensory Neurons With Activated Caspase-3 Survive Long-Term Experimental Diabetes
Diabetes September 2003 52:2363-2371; doi:10.2337/diabetes.52.9.2363
Select this article
- Nicola M. Sayers,
- Lisa J. Beswick,
- Alicia Middlemas,
- Nigel A. Calcutt,
- Andrew P. Mizisin,
- David R. Tomlinson,
- and Paul Fernyhough
Neurotrophin-3 Prevents the Proximal Accumulation of Neurofilament Proteins in Sensory Neurons of Streptozocin-Induced Diabetic Rats
Diabetes September 2003 52:2372-2380; doi:10.2337/diabetes.52.9.2372
Select this article
- Sean S. Shaw,
- Ann Marie Schmidt,
- Amy K. Banes,
- Xiaodan Wang,
- David M. Stern,
- and Mario B. Marrero
S100B-RAGE-Mediated Augmentation of Angiotensin II-Induced Activation of JAK2 in Vascular Smooth Muscle Cells Is Dependent on PLD2
Diabetes September 2003 52:2381-2388; doi:10.2337/diabetes.52.9.2381
Select this article
- Anke C. Rosenkranz,
- Sally G. Hood,
- Robyn L. Woods,
- Gregory J. Dusting,
- and Rebecca H. Ritchie
B-Type Natriuretic Peptide Prevents Acute Hypertrophic Responses in the Diabetic Rat Heart: Importance of Cyclic GMP
Diabetes September 2003 52:2389-2395; doi:10.2337/diabetes.52.9.2389
Select this article
- Matthew R. Nangle,
- Mary A. Cotter,
- and Norman E. Cameron
Effects of Rosuvastatin on Nitric Oxide–Dependent Function in Aorta and Corpus Cavernosum of Diabetic Mice: Relationship to Cholesterol Biosynthesis Pathway Inhibition and Lipid Lowering
Diabetes September 2003 52:2396-2402; doi:10.2337/diabetes.52.9.2396

Genetics

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- Paul S. Thornton,
- Courtney MacMullen,
- Arupa Ganguly,
- Eduardo Ruchelli,
- Linda Steinkrauss,
- Ana Crane,
- Lydia Aguilar-Bryan,
- and Charles A. Stanley
Clinical and Molecular Characterization of a Dominant Form of Congenital Hyperinsulinism Caused by a Mutation in the High-Affinity Sulfonylurea Receptor
Diabetes September 2003 52:2403-2410; doi:10.2337/diabetes.52.9.2403
Select this article
- Xudong Huang,
- Allan Vaag,
- Emma Carlsson,
- Mona Hansson,
- Bo Ahrén,
- and Leif Groop
Impaired Cathepsin L Gene Expression in Skeletal Muscle Is Associated With Type 2 Diabetes
Diabetes September 2003 52:2411-2418; doi:10.2337/diabetes.52.9.2411
Select this article
- Robert S. Lindsay,
- Tohru Funahashi,
- Jonathan Krakoff,
- Yuji Matsuzawa,
- Sachiyo Tanaka,
- Sayuko Kobes,
- Peter H. Bennett,
- P. Antonio Tataranni,
- William C. Knowler,
- and Robert L. Hanson
Genome-Wide Linkage Analysis of Serum Adiponectin in the Pima Indian Population
Diabetes September 2003 52:2419-2425; doi:10.2337/diabetes.52.9.2419
Select this article
- Aruna Asipu,
- Bruce E. Hayward,
- John O’Reilly,
- and David T. Bonthron
Properties of Normal and Mutant Recombinant Human Ketohexokinases and Implications for the Pathogenesis of Essential Fructosuria
Diabetes September 2003 52:2426-2432; doi:10.2337/diabetes.52.9.2426
Select this article
- Anna L. Gloyn,
- Kees Noordam,
- Michèl A.A.P. Willemsen,
- Sian Ellard,
- Wayne W.K. Lam,
- Ian W. Campbell,
- Paula Midgley,
- Chyio Shiota,
- Carol Buettger,
- Mark A. Magnuson,
- Franz M. Matschinsky,
- and Andrew T. Hattersley
Insights Into the Biochemical and Genetic Basis of Glucokinase Activation From Naturally Occurring Hypoglycemia Mutations
Diabetes September 2003 52:2433-2440; doi:10.2337/diabetes.52.9.2433

Brief Genetics Reports

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- R. David G. Leslie,
- Huriya Beyan,
- Pam Sawtell,
- Bernard O. Boehm,
- Tim D. Spector,
- and Harold Snieder
Level of an Advanced Glycated End Product Is Genetically Determined: A Study of Normal Twins
Diabetes September 2003 52:2441-2444; doi:10.2337/diabetes.52.9.2441
Select this article
- Gitte Andersen,
- Christian Schack Rose,
- Yasmin Hassan Hamid,
- Thomas Drivsholm,
- Knut Borch-Johnsen,
- Torben Hansen,
- and Oluf Pedersen
Genetic Variation of the GLUT10 Glucose Transporter (SLC2A10) and Relationships to Type 2 Diabetes and Intermediary Traits
Diabetes September 2003 52:2445-2448; doi:10.2337/diabetes.52.9.2445

Erratum

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Errata
Diabetes September 2003 52:2449; doi:10.2337/diabetes.52.9.2449

Diabetes

Metabolism

Enhanced Fat Oxidation Through Physical Activity Is Associated With Improvements in Insulin Sensitivity in Obesity

Cortisol Acts Through Central Mechanisms to Blunt Counterregulatory Responses to Hypoglycemia in Conscious Rats

Effect of Exercise Intensity on Skeletal Muscle AMPK Signaling in Humans

Higher Insulin Concentrations Are Required to Suppress Gluconeogenesis Than Glycogenolysis in Nondiabetic Humans

Regulation and Function of the Muscle Glycogen-Targeting Subunit of Protein Phosphatase 1 (GM) in Human Muscle Cells Depends on the COOH-Terminal Region and Glycogen Content

Signal Transduction

A Novel Insulin Analog With Unique Properties: LysB3,GluB29 Insulin Induces Prominent Activation of Insulin Receptor Substrate 2, but Marginal Phosphorylation of Insulin Receptor Substrate 1

Molecular Mechanisms of Insulin Resistance in IRS-2-Deficient Hepatocytes

Obesity Studies

Differential Influences of Peroxisome Proliferator–Activated Receptorsγ and -α on Food Intake and Energy Homeostasis

Hyperphagic Effects of Brainstem Ghrelin Administration

Peripheral, But Not Central, Administration of Adiponectin Reduces Visceral Adiposity and Upregulates the Expression of Uncoupling Protein in Agouti Yellow (Ay/a) Obese Mice

Immunology and Transplantation

Critical Roles of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand in Type 1 Diabetes

DcR3/TR6 Effectively Prevents Islet Primary Nonfunction After Transplantation

Immunologic Activity in the Small Intestinal Mucosa of Pediatric Patients With Type 1 Diabetes

Pancreatic-Derived Factor (FAM3B), a Novel Islet Cytokine, Induces Apoptosis of Insulin-Secreting β-Cells

Islet Studies

Increased β-Cell Apoptosis Prevents Adaptive Increase in β-Cell Mass in Mouse Model of Type 2 Diabetes: Evidence for Role of Islet Amyloid Formation Rather Than Direct Action of Amyloid

An Insulin-Degrading Enzyme Inhibitor Decreases Amylin Degradation, Increases Amylin-Induced Cytotoxicity, and Increases Amyloid Formation in Insulinoma Cell Cultures

Pathophysiology

The Hepatic Vagus Mediates Fat-Induced Inhibition of Diabetic Hyperphagia

Peroxisome Proliferator-Activated Receptor (PPAR)-α Activation Prevents Diabetes in OLETF Rats: Comparison With PPAR-γ Activation

Intramuscular Heat Shock Protein 72 and Heme Oxygenase-1 mRNA Are Reduced in Patients With Type 2 Diabetes: Evidence That Insulin Resistance Is Associated With a Disturbed Antioxidant Defense Mechanism

The Metabolic Syndrome and Antioxidant Concentrations: Findings From the Third National Health and Nutrition Examination Survey

Complications

Two Phases of Nitrergic Neuropathy in Streptozotocin-Induced Diabetic Rats

Sensory Neurons With Activated Caspase-3 Survive Long-Term Experimental Diabetes

Neurotrophin-3 Prevents the Proximal Accumulation of Neurofilament Proteins in Sensory Neurons of Streptozocin-Induced Diabetic Rats

S100B-RAGE-Mediated Augmentation of Angiotensin II-Induced Activation of JAK2 in Vascular Smooth Muscle Cells Is Dependent on PLD2

B-Type Natriuretic Peptide Prevents Acute Hypertrophic Responses in the Diabetic Rat Heart: Importance of Cyclic GMP

Effects of Rosuvastatin on Nitric Oxide–Dependent Function in Aorta and Corpus Cavernosum of Diabetic Mice: Relationship to Cholesterol Biosynthesis Pathway Inhibition and Lipid Lowering

Genetics

Clinical and Molecular Characterization of a Dominant Form of Congenital Hyperinsulinism Caused by a Mutation in the High-Affinity Sulfonylurea Receptor

Impaired Cathepsin L Gene Expression in Skeletal Muscle Is Associated With Type 2 Diabetes

Genome-Wide Linkage Analysis of Serum Adiponectin in the Pima Indian Population

Properties of Normal and Mutant Recombinant Human Ketohexokinases and Implications for the Pathogenesis of Essential Fructosuria

Insights Into the Biochemical and Genetic Basis of Glucokinase Activation From Naturally Occurring Hypoglycemia Mutations

Brief Genetics Reports

Level of an Advanced Glycated End Product Is Genetically Determined: A Study of Normal Twins

Genetic Variation of the GLUT10 Glucose Transporter (SLC2A10) and Relationships to Type 2 Diabetes and Intermediary Traits

Erratum

Errata

This Issue

Current Issue

Regulation and Function of the Muscle Glycogen-Targeting Subunit of Protein Phosphatase 1 (G_M) in Human Muscle Cells Depends on the COOH-Terminal Region and Glycogen Content

A Novel Insulin Analog With Unique Properties: Lys^B3,Glu^B29 Insulin Induces Prominent Activation of Insulin Receptor Substrate 2, but Marginal Phosphorylation of Insulin Receptor Substrate 1

Peripheral, But Not Central, Administration of Adiponectin Reduces Visceral Adiposity and Upregulates the Expression of Uncoupling Protein in Agouti Yellow (A^y/a) Obese Mice