Table of Contents

Rapid Publication

Select this article
- Kerstin Koczwara,
- Ezio Bonifacio,
- and Anette-Gabriele Ziegler
Transmission of Maternal Islet Antibodies and Risk of Autoimmune Diabetes in Offspring of Mothers With Type 1 Diabetes
Diabetes January 2004 53:1-4; published ahead of print November 3, 2003, doi:10.2337/diabetes.53.1.1

Perspectives in Diabetes

Select this article
- George G. Holz
Epac: A New cAMP-Binding Protein in Support of Glucagon-Like Peptide-1 Receptor-Mediated Signal Transduction in the Pancreatic β-Cell
Diabetes January 2004 53:5-13; doi:10.2337/diabetes.53.1.5

Metabolism

Select this article
- Mary Courtney Moore,
- W. Blair Geho,
- Margaret Lautz,
- Ben Farmer,
- Doss W. Neal,
- and Alan D. Cherrington
Portal Serotonin Infusion and Glucose Disposal in Conscious Dogs
Diabetes January 2004 53:14-20; doi:10.2337/diabetes.53.1.14
Select this article
- Sebastio Perrini,
- Jan Henriksson,
- Juleen R. Zierath,
- and Ulrika Widegren
Exercise-Induced Protein Kinase C Isoform-Specific Activation in Human Skeletal Muscle
Diabetes January 2004 53:21-24; doi:10.2337/diabetes.53.1.21
Select this article
- John M. Adams II,
- Thongchai Pratipanawatr,
- Rachele Berria,
- Elaine Wang,
- Ralph A. DeFronzo,
- M. Cameron Sullards,
- and Lawrence J. Mandarino
Ceramide Content Is Increased in Skeletal Muscle From Obese Insulin-Resistant Humans
Diabetes January 2004 53:25-31; doi:10.2337/diabetes.53.1.25
Select this article
- Mary Courtney Moore,
- Shosuke Satake,
- Margaret Lautz,
- Scott A. Soleimanpour,
- Doss W. Neal,
- Marta Smith,
- and Alan D. Cherrington
Nonesterified Fatty Acids and Hepatic Glucose Metabolism in the Conscious Dog
Diabetes January 2004 53:32-40; doi:10.2337/diabetes.53.1.32

Signal Transduction

Select this article
- Sebastio Perrini,
- Annalisa Natalicchio,
- Luigi Laviola,
- Gaetana Belsanti,
- Carmela Montrone,
- Angelo Cignarelli,
- Vincenza Minielli,
- Maria Grano,
- Giovanni De Pergola,
- Riccardo Giorgino,
- and Francesco Giorgino
Dehydroepiandrosterone Stimulates Glucose Uptake in Human and Murine Adipocytes by Inducing GLUT1 and GLUT4 Translocation to the Plasma Membrane
Diabetes January 2004 53:41-52; doi:10.2337/diabetes.53.1.41
Select this article
- Lee Carpenter,
- Christopher J. Mitchell,
- Zheng Z. Xu,
- Philip Poronnik,
- Gerald W. Both,
- and Trevor J. Biden
PKCα Is Activated But Not Required During Glucose-Induced Insulin Secretion From Rat Pancreatic Islets
Diabetes January 2004 53:53-60; doi:10.2337/diabetes.53.1.53
Select this article
- Jake A. Kushner,
- Fawaz G. Haj,
- Lori D. Klaman,
- Matthew A. Dow,
- Barbara B. Kahn,
- Benjamin G. Neel,
- and Morris F. White
Islet-Sparing Effects of Protein Tyrosine Phosphatase-1b Deficiency Delays Onset of Diabetes in IRS2 Knockout Mice
Diabetes January 2004 53:61-66; doi:10.2337/diabetes.53.1.61
Select this article
- Xue-Jun Yang,
- Lee-Ming Kow,
- Donald W. Pfaff,
- and Charles V. Mobbs
Metabolic Pathways That Mediate Inhibition of Hypothalamic Neurons by Glucose
Diabetes January 2004 53:67-73; doi:10.2337/diabetes.53.1.67
Select this article
- Allan Green,
- John M. Rumberger,
- Charles A. Stuart,
- and Mary S. Ruhoff
Stimulation of Lipolysis by Tumor Necrosis Factor-α in 3T3-L1 Adipocytes Is Glucose Dependent: Implications for Long-Term Regulation of Lipolysis
Diabetes January 2004 53:74-81; doi:10.2337/diabetes.53.1.74

Obesity Studies

Select this article
- Susann Blüher,
- Mary Ziotopoulou,
- John W. Bullen, Jr,
- Stergios J. Moschos,
- Linda Ungsunan,
- Efi Kokkotou,
- Eleftheria Maratos-Flier,
- and Christos S. Mantzoros
Responsiveness to Peripherally Administered Melanocortins in Lean and Obese Mice
Diabetes January 2004 53:82-90; doi:10.2337/diabetes.53.1.82

Immunology and Transplantation

Select this article
- Vikram Mathews,
- Piia T. Hanson,
- Eric Ford,
- Jun Fujita,
- Kenneth S. Polonsky,
- and Timothy A. Graubert
Recruitment of Bone Marrow-Derived Endothelial Cells to Sites of Pancreatic β-Cell Injury
Diabetes January 2004 53:91-98; doi:10.2337/diabetes.53.1.91
Select this article
- William H. Schott,
- Bradford D. Haskell,
- Hubert M. Tse,
- Martha J. Milton,
- Jon D. Piganelli,
- Caroline Morgane Choisy-Rossi,
- Peter C. Reifsnyder,
- Alexander V. Chervonsky,
- and Edward H. Leiter
Caspase-1 Is Not Required for Type 1 Diabetes in the NOD Mouse
Diabetes January 2004 53:99-104; doi:10.2337/diabetes.53.1.99
Select this article
- Teru Okitsu,
- Naoya Kobayashi,
- Hee-Sook Jun,
- Seungjin Shin,
- Su-Jin Kim,
- Jaeseok Han,
- Hyokjoon Kwon,
- Masakiyo Sakaguchi,
- Toshinori Totsugawa,
- Michinori Kohara,
- Karen A. Westerman,
- Noriaki Tanaka,
- Philippe Leboulch,
- and Ji-Won Yoon
Transplantation of Reversibly Immortalized Insulin-Secreting Human Hepatocytes Controls Diabetes in Pancreatectomized Pigs
Diabetes January 2004 53:105-112; doi:10.2337/diabetes.53.1.105
Select this article
- Helen E. Thomas,
- Windy Irawaty,
- Rima Darwiche,
- Thomas C. Brodnicki,
- Pere Santamaria,
- Janette Allison,
- and Thomas W.H. Kay
IL-1 Receptor Deficiency Slows Progression to Diabetes in the NOD Mouse
Diabetes January 2004 53:113-121; doi:10.2337/diabetes.53.1.113

Islet Studies

Select this article
- Hindrik Mulder,
- Shumin Yang,
- Maria Sörhede Winzell,
- Cecilia Holm,
- and Bo Ahrén
Inhibition of Lipase Activity and Lipolysis in Rat Islets Reduces Insulin Secretion
Diabetes January 2004 53:122-128; doi:10.2337/diabetes.53.1.122
Select this article
- Xiaolin Wang,
- Hui Li,
- Domenica De Leo,
- Wanbei Guo,
- Vasilij Koshkin,
- I. George Fantus,
- Adria Giacca,
- Catherine B. Chan,
- Sandy Der,
- and Michael B. Wheeler
Gene and Protein Kinase Expression Profiling of Reactive Oxygen Species-Associated Lipotoxicity in the Pancreatic β-Cell Line MIN6
Diabetes January 2004 53:129-140; doi:10.2337/diabetes.53.1.129
Select this article
- Lucy Marzban,
- Genny Trigo-Gonzalez,
- Xiaorong Zhu,
- Christopher J. Rhodes,
- Philippe A. Halban,
- Donald F. Steiner,
- and C. Bruce Verchere
Role of β-Cell Prohormone Convertase (PC)1/3 in Processing of Pro-Islet Amyloid Polypeptide
Diabetes January 2004 53:141-148; doi:10.2337/diabetes.53.1.141
Select this article
- Irene Cozar-Castellano,
- Karen K. Takane,
- Rita Bottino,
- A.N. Balamurugan,
- and Andrew F. Stewart
Induction of β-Cell Proliferation and Retinoblastoma Protein Phosphorylation in Rat and Human Islets Using Adenovirus-Mediated Transfer of Cyclin-Dependent Kinase-4 and Cyclin D₁
Diabetes January 2004 53:149-159; doi:10.2337/diabetes.53.1.149

Pathophysiology

Select this article
- Ele Ferrannini,
- Monica Nannipieri,
- Ken Williams,
- Clicerio Gonzales,
- Steve M. Haffner,
- and Michael P. Stern
Mode of Onset of Type 2 Diabetes from Normal or Impaired Glucose Tolerance
Diabetes January 2004 53:160-165; doi:10.2337/diabetes.53.1.160

Complications

Select this article
- Allan Flyvbjerg,
- Larry Denner,
- Bieke F. Schrijvers,
- Ronald G. Tilton,
- Trine H. Mogensen,
- Søren R. Paludan,
- and Ruth Rasch
Long-Term Renal Effects of a Neutralizing RAGE Antibody in Obese Type 2 Diabetic Mice
Diabetes January 2004 53:166-172; doi:10.2337/diabetes.53.1.166
Select this article
- Bruce A. Berkowitz,
- Hongmei Luan,
- Rita R. Gupta,
- Daniel Pacheco,
- Andres Seidner,
- Robin Roberts,
- Jessica Liggett,
- Deborah L. Knoerzer,
- Jane R. Connor,
- Yunpeng Du,
- Timothy S. Kern,
- and Yasuki Ito
Regulation of the Early Subnormal Retinal Oxygenation Response in Experimental Diabetes by Inducible Nitric Oxide Synthase
Diabetes January 2004 53:173-178; doi:10.2337/diabetes.53.1.173
Select this article
- Tien Yin Wong,
- Anoop Shankar,
- Ronald Klein,
- and Barbara E.K. Klein
Retinal Vessel Diameters and the Incidence of Gross Proteinuria and Renal Insufficiency in People With Type 1 Diabetes
Diabetes January 2004 53:179-184; doi:10.2337/diabetes.53.1.179
Select this article
- Haider Raza,
- Subbuswamy K. Prabu,
- Mari-Anne Robin,
- and Narayan G. Avadhani
Elevated Mitochondrial Cytochrome P450 2E1 and Glutathione S-Transferase A4-4 in Streptozotocin-Induced Diabetic Rats: Tissue-Specific Variations and Roles in Oxidative Stress
Diabetes January 2004 53:185-194; doi:10.2337/diabetes.53.1.185
Select this article
- Cindy J.M. Loomans,
- Eelco J.P. de Koning,
- Frank J.T. Staal,
- Maarten B. Rookmaaker,
- Caroline Verseyden,
- Hetty C. de Boer,
- Marianne C. Verhaar,
- Branko Braam,
- Ton J. Rabelink,
- and Anton-Jan van Zonneveld
Endothelial Progenitor Cell Dysfunction: A Novel Concept in the Pathogenesis of Vascular Complications of Type 1 Diabetes
Diabetes January 2004 53:195-199; doi:10.2337/diabetes.53.1.195
Select this article
- Baoliang Guo,
- Daisuke Koya,
- Motohide Isono,
- Toshiro Sugimoto,
- Atsunori Kashiwagi,
- and Masakazu Haneda
Peroxisome Proliferator-Activated Receptor-γ Ligands Inhibit TGF-β1-Induced Fibronectin Expression in Glomerular Mesangial Cells
Diabetes January 2004 53:200-208; doi:10.2337/diabetes.53.1.200

Genetics

Select this article
- Frank B. Hu,
- Alessandro Doria,
- Tricia Li,
- James B. Meigs,
- Simin Liu,
- Asli Memisoglu,
- David Hunter,
- and JoAnn E. Manson
Genetic Variation at the Adiponectin Locus and Risk of Type 2 Diabetes in Women
Diabetes January 2004 53:209-213; doi:10.2337/diabetes.53.1.209
Select this article
- Mark O. Goodarzi,
- Xiuqing Guo,
- Kent D. Taylor,
- Manuel J. Quiñones,
- Mohammad F. Saad,
- Huiying Yang,
- Willa A. Hsueh,
- and Jerome I. Rotter
Lipoprotein Lipase Is a Gene for Insulin Resistance in Mexican Americans
Diabetes January 2004 53:214-220; doi:10.2337/diabetes.53.1.214
Select this article
- Anders Molven,
- Guri E. Matre,
- Marinus Duran,
- Ronald J. Wanders,
- Unni Rishaug,
- Pål R. Njølstad,
- Egil Jellum,
- and Oddmund Søvik
Familial Hyperinsulinemic Hypoglycemia Caused by a Defect in the SCHAD Enzyme of Mitochondrial Fatty Acid Oxidation
Diabetes January 2004 53:221-227; doi:10.2337/diabetes.53.1.221
Select this article
- Kunsan Xiang,
- Yanqing Wang,
- Taishan Zheng,
- Weiping Jia,
- Jie Li,
- Lei Chen,
- Kunxue Shen,
- Songhua Wu,
- Xin Lin,
- Guodong Zhang,
- Congrong Wang,
- Suijun Wang,
- Huijuan Lu,
- Qichen Fang,
- Yi Shi,
- Rong Zhang,
- Jing Xu,
- and Qin Weng
Genome-Wide Search for Type 2 Diabetes/Impaired Glucose Homeostasis Susceptibility Genes in the Chinese: Significant Linkage to Chromosome 6q21-q23 and Chromosome 1q21-q24
Diabetes January 2004 53:228-234; doi:10.2337/diabetes.53.1.228

Brief Genetics Report

Select this article
- Sophie Le Fur,
- Catherine Le Stunff,
- Christine Dos Santos,
- and Pierre Bougnères
The Common −866 G/A Polymorphism in the Promoter of Uncoupling Protein 2 Is Associated With Increased Carbohydrate and Decreased Lipid Oxidation in Juvenile Obesity
Diabetes January 2004 53:235-239; doi:10.2337/diabetes.53.1.235
Select this article
- Hong Lan,
- Mary E. Rabaglia,
- Kathryn L. Schueler,
- Christine Mata,
- Brian S. Yandell,
- and Alan D. Attie
Distinguishing Covariation From Causation in Diabetes: A Lesson From the Protein Disulfide Isomerase mRNA Abundance Trait
Diabetes January 2004 53:240-244; doi:10.2337/diabetes.53.1.240
Select this article
- Jonathan P. Stoehr,
- Jessica E. Byers,
- Susanne M. Clee,
- Hong Lan,
- Igor V. Boronenkov,
- Kathryn L. Schueler,
- Brian S. Yandell,
- and Alan D. Attie
Identification of Major Quantitative Trait Loci Controlling Body Weight Variation in ob/ob Mice
Diabetes January 2004 53:245-249; doi:10.2337/diabetes.53.1.245

ADA Workshop Report

Select this article
- Jerry P. Palmer,
- G. Alexander Fleming,
- Carla J. Greenbaum,
- Kevan C. Herold,
- Lisa D. Jansa,
- Hubert Kolb,
- John M. Lachin,
- Kenneth S. Polonsky,
- Paolo Pozzilli,
- Jay S. Skyler,
- and Michael W. Steffes
C-Peptide Is the Appropriate Outcome Measure for Type 1 Diabetes Clinical Trials to Preserve β-Cell Function: Report of an ADA Workshop, 21–22 October 2001
Diabetes January 2004 53:250-264; doi:10.2337/diabetes.53.1.250

Diabetes

Rapid Publication

Transmission of Maternal Islet Antibodies and Risk of Autoimmune Diabetes in Offspring of Mothers With Type 1 Diabetes

Perspectives in Diabetes

Epac: A New cAMP-Binding Protein in Support of Glucagon-Like Peptide-1 Receptor-Mediated Signal Transduction in the Pancreatic β-Cell

Metabolism

Portal Serotonin Infusion and Glucose Disposal in Conscious Dogs

Exercise-Induced Protein Kinase C Isoform-Specific Activation in Human Skeletal Muscle

Ceramide Content Is Increased in Skeletal Muscle From Obese Insulin-Resistant Humans

Nonesterified Fatty Acids and Hepatic Glucose Metabolism in the Conscious Dog

Signal Transduction

Dehydroepiandrosterone Stimulates Glucose Uptake in Human and Murine Adipocytes by Inducing GLUT1 and GLUT4 Translocation to the Plasma Membrane

PKCα Is Activated But Not Required During Glucose-Induced Insulin Secretion From Rat Pancreatic Islets

Islet-Sparing Effects of Protein Tyrosine Phosphatase-1b Deficiency Delays Onset of Diabetes in IRS2 Knockout Mice

Metabolic Pathways That Mediate Inhibition of Hypothalamic Neurons by Glucose

Stimulation of Lipolysis by Tumor Necrosis Factor-α in 3T3-L1 Adipocytes Is Glucose Dependent: Implications for Long-Term Regulation of Lipolysis

Obesity Studies

Responsiveness to Peripherally Administered Melanocortins in Lean and Obese Mice

Immunology and Transplantation

Recruitment of Bone Marrow-Derived Endothelial Cells to Sites of Pancreatic β-Cell Injury

Caspase-1 Is Not Required for Type 1 Diabetes in the NOD Mouse

Transplantation of Reversibly Immortalized Insulin-Secreting Human Hepatocytes Controls Diabetes in Pancreatectomized Pigs

IL-1 Receptor Deficiency Slows Progression to Diabetes in the NOD Mouse

Islet Studies

Inhibition of Lipase Activity and Lipolysis in Rat Islets Reduces Insulin Secretion

Gene and Protein Kinase Expression Profiling of Reactive Oxygen Species-Associated Lipotoxicity in the Pancreatic β-Cell Line MIN6

Role of β-Cell Prohormone Convertase (PC)1/3 in Processing of Pro-Islet Amyloid Polypeptide

Induction of β-Cell Proliferation and Retinoblastoma Protein Phosphorylation in Rat and Human Islets Using Adenovirus-Mediated Transfer of Cyclin-Dependent Kinase-4 and Cyclin D1

Pathophysiology

Mode of Onset of Type 2 Diabetes from Normal or Impaired Glucose Tolerance

Complications

Long-Term Renal Effects of a Neutralizing RAGE Antibody in Obese Type 2 Diabetic Mice

Regulation of the Early Subnormal Retinal Oxygenation Response in Experimental Diabetes by Inducible Nitric Oxide Synthase

Retinal Vessel Diameters and the Incidence of Gross Proteinuria and Renal Insufficiency in People With Type 1 Diabetes

Elevated Mitochondrial Cytochrome P450 2E1 and Glutathione S-Transferase A4-4 in Streptozotocin-Induced Diabetic Rats: Tissue-Specific Variations and Roles in Oxidative Stress

Endothelial Progenitor Cell Dysfunction: A Novel Concept in the Pathogenesis of Vascular Complications of Type 1 Diabetes

Peroxisome Proliferator-Activated Receptor-γ Ligands Inhibit TGF-β1-Induced Fibronectin Expression in Glomerular Mesangial Cells

Genetics

Genetic Variation at the Adiponectin Locus and Risk of Type 2 Diabetes in Women

Lipoprotein Lipase Is a Gene for Insulin Resistance in Mexican Americans

Familial Hyperinsulinemic Hypoglycemia Caused by a Defect in the SCHAD Enzyme of Mitochondrial Fatty Acid Oxidation

Genome-Wide Search for Type 2 Diabetes/Impaired Glucose Homeostasis Susceptibility Genes in the Chinese: Significant Linkage to Chromosome 6q21-q23 and Chromosome 1q21-q24

Brief Genetics Report

The Common −866 G/A Polymorphism in the Promoter of Uncoupling Protein 2 Is Associated With Increased Carbohydrate and Decreased Lipid Oxidation in Juvenile Obesity

Distinguishing Covariation From Causation in Diabetes: A Lesson From the Protein Disulfide Isomerase mRNA Abundance Trait

Identification of Major Quantitative Trait Loci Controlling Body Weight Variation in ob/ob Mice

ADA Workshop Report

C-Peptide Is the Appropriate Outcome Measure for Type 1 Diabetes Clinical Trials to Preserve β-Cell Function: Report of an ADA Workshop, 21–22 October 2001

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Current Issue

Induction of β-Cell Proliferation and Retinoblastoma Protein Phosphorylation in Rat and Human Islets Using Adenovirus-Mediated Transfer of Cyclin-Dependent Kinase-4 and Cyclin D₁