Genome-Wide Search for Type 2 Diabetes/Impaired Glucose Homeostasis Susceptibility Genes in the Chinese

Significant Linkage to Chromosome 6q21-q23 and Chromosome 1q21-q24

  1. Kunsan Xiang12,
  2. Yanqing Wang1,
  3. Taishan Zheng1,
  4. Weiping Jia12,
  5. Jie Li1,
  6. Lei Chen12,
  7. Kunxue Shen1,
  8. Songhua Wu12,
  9. Xin Lin1,
  10. Guodong Zhang1,
  11. Congrong Wang2,
  12. Suijun Wang12,
  13. Huijuan Lu1,
  14. Qichen Fang1,
  15. Yi Shi1,
  16. Rong Zhang1,
  17. Jing Xu1 and
  18. Qin Weng1
  1. 1Shanghai Diabetes Institute, Shanghai Jiaotong University No. 6 People’s Hospital, Shanghai, China
  2. 2Department of Endocrinology and Metabolism, Shanghai Jiaotong University No. 6 People’s Hospital, Shanghai, China
  1. Address correspondence and reprint requests to Dr. Kunsan Xiang, Shanghai Diabetes Institute, Shanghai Jiaotong University No. 6 People’s Hospital, 600 Yishan Rd., Shanghai 200233, China. E-mail: sphxiang{at}public.sta.net.cn

Abstract

This genome-wide search for susceptibility genes to type 2 diabetes/impaired glucose homeostasis (IGH) was performed on a relatively homogenous Chinese sample with a total number of 257 pedigrees and 385 affected sibpairs. Two regions showed significant linkage to type 2 diabetes/IGH in the Chinese. The region showing linkage to type 2 diabetes/IGH from the entire sample group analysis was located on chromosome 6q21-q23 (128.93 cM, 1-LOD [logarithm of odds] support interval between 124 and 142 cM, according to the Marshfield genetic map), with a maximum likelihood score of 6.23, a nonparametric linkage (all) score of 4.48, and empirical P value <0.001. With a subanalysis based on 101 affected sibpairs with age at diagnosis of type 2 diabetes/IGH <40 years, we detected significant evidence for linkage to chromosome 1q21-q24 (192.1 cM, 1-LOD support interval between 182 and 197 cM), with a maximum likelihood score of 8.91, a nonparametric linkage (all) score of 5.70, and empirical P value <0.001. No interaction was observed between these two regions. Our independent replication of the region on chromosome 1q that has been shown to be linked significantly to type 2 diabetes/IGH in Chinese supports the notion that gene(s) in this region may be universally important in the development of human type 2 diabetes.

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This Article

  1. doi: 10.2337/diabetes.53.1.228 Diabetes January 2004 vol. 53 no. 1 228-234
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