Table of Contents

Perspectives in Diabetes

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- Barry E. Levin,
- Vanessa H. Routh,
- Ling Kang,
- Nicole M. Sanders,
- and Ambrose A. Dunn-Meynell
Neuronal Glucosensing: What Do We Know After 50 Years?
Diabetes October 2004 53:2521-2528; doi:10.2337/diabetes.53.10.2521

Signal Transduction

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- Anita M. van den Hoek,
- Peter J. Voshol,
- Barbara N. Karnekamp,
- Ruud M. Buijs,
- Johannes A. Romijn,
- Louis M. Havekes,
- and Hanno Pijl
Intracerebroventricular Neuropeptide Y Infusion Precludes Inhibition of Glucose and VLDL Production by Insulin
Diabetes October 2004 53:2529-2534; doi:10.2337/diabetes.53.10.2529
Select this article
- John M. Rumberger,
- Theodore Peters, Jr,
- Christine Burrington,
- and Allan Green
Transferrin and Iron Contribute to the Lipolytic Effect of Serum in Isolated Adipocytes
Diabetes October 2004 53:2535-2541; doi:10.2337/diabetes.53.10.2535
Select this article
- Mark L. Evans,
- Rory J. McCrimmon,
- Daniel E. Flanagan,
- Tara Keshavarz,
- Xiaoning Fan,
- Ewan C. McNay,
- Ralph J. Jacob,
- and Robert S. Sherwin
Hypothalamic ATP-sensitive K ⁺ Channels Play a Key Role in Sensing Hypoglycemia and Triggering Counterregulatory Epinephrine and Glucagon Responses
Diabetes October 2004 53:2542-2551; doi:10.2337/diabetes.53.10.2542

Obesity Study

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- Ruben Nogueiras,
- Sulay Tovar,
- Sharon E. Mitchell,
- D. Vernon Rayner,
- Zoe A. Archer,
- Carlos Dieguez,
- and Lynda M. Williams
Regulation of Growth Hormone Secretagogue Receptor Gene Expression in the Arcuate Nuclei of the Rat by Leptin and Ghrelin
Diabetes October 2004 53:2552-2558; doi:10.2337/diabetes.53.10.2552

Immunology and Transplantation

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- Rita Bottino,
- A.N. Balamurugan,
- Hubert Tse,
- C. Thirunavukkarasu,
- Xinhui Ge,
- Jennifer Profozich,
- Martha Milton,
- Audra Ziegenfuss,
- Massimo Trucco,
- and Jon D. Piganelli
Response of Human Islets to Isolation Stress and the Effect of Antioxidant Treatment
Diabetes October 2004 53:2559-2568; doi:10.2337/diabetes.53.10.2559
Select this article
- H. Peter Chase,
- Sonia Cooper,
- Iris Osberg,
- Lars C. Stene,
- Katherine Barriga,
- Jill Norris,
- George S. Eisenbarth,
- and Marian Rewers
Elevated C-Reactive Protein Levels in the Development of Type 1 Diabetes
Diabetes October 2004 53:2569-2573; doi:10.2337/diabetes.53.10.2569
Select this article
- Angelica P. Olcott,
- Georges Tocco,
- Jide Tian,
- Dan Zekzer,
- Jon Fukuto,
- Louis Ignarro,
- and Daniel L. Kaufman
A Salen-Manganese Catalytic Free Radical Scavenger Inhibits Type 1 Diabetes and Islet Allograft Rejection
Diabetes October 2004 53:2574-2580; doi:10.2337/diabetes.53.10.2574
Select this article
- F. Susan Wong,
- Li Wen,
- Michelle Tang,
- Murugappan Ramanathan,
- Irene Visintin,
- Joanne Daugherty,
- Lynn G. Hannum,
- Charles A. Janeway, Jr,
- and Mark J. Shlomchik
Investigation of the Role of B-Cells in Type 1 Diabetes in the NOD Mouse
Diabetes October 2004 53:2581-2587; doi:10.2337/diabetes.53.10.2581
Select this article
- Claus Haase,
- Kresten Skak,
- Birgitte K. Michelsen,
- and Helle Markholst
Local Activation of Dendritic Cells Leads to Insulitis and Development of Insulin-Dependent Diabetes in Transgenic Mice Expressing CD154 on the Pancreatic β-Cells
Diabetes October 2004 53:2588-2595; doi:10.2337/diabetes.53.10.2588

Islet Study

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- Takeki Ogata,
- Lei Li,
- Satoko Yamada,
- Yoritsuna Yamamoto,
- Yuji Tanaka,
- Izumi Takei,
- Kazuo Umezawa,
- and Itaru Kojima
Promotion of β-Cell Differentiation by Conophylline in Fetal and Neonatal Rat Pancreas
Diabetes October 2004 53:2596-2602; doi:10.2337/diabetes.53.10.2596
Select this article
- Mattias Hansson,
- Anna Tonning,
- Ulrik Frandsen,
- Andreas Petri,
- Jayaraj Rajagopal,
- Mikael C.O. Englund,
- R. Scott Heller,
- Joakim Håkansson,
- Jan Fleckner,
- Helen Nilsson Sköld,
- Douglas Melton,
- Henrik Semb,
- and Palle Serup
Artifactual Insulin Release From Differentiated Embryonic Stem Cells
Diabetes October 2004 53:2603-2609; doi:10.2337/diabetes.53.10.2603
Select this article
- Patrick C. Moore,
- Marco A. Ugas,
- Derek K. Hagman,
- Susan D. Parazzoli,
- and Vincent Poitout
Evidence Against the Involvement of Oxidative Stress in Fatty Acid Inhibition of Insulin Secretion
Diabetes October 2004 53:2610-2616; doi:10.2337/diabetes.53.10.2610

Pathophysiology

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- Patricia Vuguin,
- Elisabeth Raab,
- Bing Liu,
- Nir Barzilai,
- and Rebecca Simmons
Hepatic Insulin Resistance Precedes the Development of Diabetes in a Model of Intrauterine Growth Retardation
Diabetes October 2004 53:2617-2622; doi:10.2337/diabetes.53.10.2617
Select this article
- Anthony J.G. Hanley,
- Ken Williams,
- Andreas Festa,
- Lynne E. Wagenknecht,
- Ralph B. D’Agostino, Jr.,
- Judy Kempf,
- Bernard Zinman,
- and Steven M. Haffner
Elevations in Markers of Liver Injury and Risk of Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study
Diabetes October 2004 53:2623-2632; doi:10.2337/diabetes.53.10.2623
Select this article
- Martina Schneider,
- Bruno Vergès,
- Alexis Klein,
- Elizabeth R. Miller,
- Valérie Deckert,
- Catherine Desrumaux,
- David Masson,
- Philippe Gambert,
- Jean-Marcel Brun,
- Jamila Fruchart-Najib,
- Denis Blache,
- Joseph L. Witztum,
- and Laurent Lagrost
Alterations in Plasma Vitamin E Distribution in Type 2 Diabetic Patients With Elevated Plasma Phospholipid Transfer Protein Activity
Diabetes October 2004 53:2633-2639; doi:10.2337/diabetes.53.10.2633

Complications

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- Klaus Witte,
- Jochen Hachenberger,
- Maria F. Castell,
- Christian F. Vahl,
- and Christlieb Haller
Nitric Oxide–Sensitive Soluble Guanylyl Cyclase Activity Is Preserved in Internal Mammary Artery of Type 2 Diabetic Patients
Diabetes October 2004 53:2640-2644; doi:10.2337/diabetes.53.10.2640
Select this article
- Stephen B. Wheatcroft,
- Ajay M. Shah,
- Jian-Mei Li,
- Edward Duncan,
- Brian T. Noronha,
- Paul A. Crossey,
- and Mark T. Kearney
Preserved Glucoregulation but Attenuation of the Vascular Actions of Insulin in Mice Heterozygous for Knockout of the Insulin Receptor
Diabetes October 2004 53:2645-2652; doi:10.2337/diabetes.53.10.2645
Select this article
- Xuebin Qin,
- Allison Goldfine,
- Nicole Krumrei,
- Luciano Grubissich,
- Juan Acosta,
- Michael Chorev,
- Arthur P. Hays,
- and Jose A. Halperin
Glycation Inactivation of the Complement Regulatory Protein CD59: A Possible Role in the Pathogenesis of the Vascular Complications of Human Diabetes
Diabetes October 2004 53:2653-2661; doi:10.2337/diabetes.53.10.2653
Select this article
- Nikolaus Marx,
- Daniel Walcher,
- Nina Ivanova,
- Kirstin Rautzenberg,
- Annelie Jung,
- Reinhard Friedl,
- Vinzenz Hombach,
- Raffaele de Caterina,
- Giuseppina Basta,
- Marie-Paule Wautier,
- and Jean-Luc Wautiers
Thiazolidinediones Reduce Endothelial Expression of Receptors for Advanced Glycation End Products
Diabetes October 2004 53:2662-2668; doi:10.2337/diabetes.53.10.2662
Select this article
- Yun Jiang,
- Jens Randel Nyengaard,
- Jin Song Zhang,
- and Johannes Jakobsen
Selective Loss of Calcitonin Gene-Related Peptide-Expressing Primary Sensory Neurons of the A-Cell Phenotype in Early Experimental Diabetes
Diabetes October 2004 53:2669-2675; doi:10.2337/diabetes.53.10.2669

Genetics

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- Maggie C.Y. Ng,
- Wing-Yee So,
- Vincent K.L. Lam,
- Clive S. Cockram,
- Graeme I. Bell,
- Nancy J. Cox,
- and Juliana C.N. Chan
Genome-wide Scan for Metabolic Syndrome and Related Quantitative Traits in Hong Kong Chinese and Confirmation of a Susceptibility Locus on Chromosome 1q21-q25
Diabetes October 2004 53:2676-2683; doi:10.2337/diabetes.53.10.2676
Select this article
- Satoshi Murao,
- Hideichi Makino,
- Yukikazu Kaino,
- Etsushi Konoue,
- Jun Ohashi,
- Kaichi Kida,
- Yasuhisa Fujii,
- Ikki Shimizu,
- Eiji Kawasaki,
- Masao Fujiyama,
- Shiori Kondo,
- Kiyonobu Tanaka,
- Yoshinao Tarumi,
- Isamu Seto,
- Kenichi Kato,
- Keizo Ohno,
- Yukiko Kusunoki,
- Osamu Ebisui,
- Yasuharu Takada,
- Katsuya Tanabe,
- Koji Takemoto,
- Hiroshi Onuma,
- Tatsuya Nishimiya,
- and Haruhiko Osawa
Differences in the Contribution of HLA-DR and -DQ Haplotypes to Susceptibility to Adult- and Childhood-Onset Type 1 Diabetes in Japanese Patients
Diabetes October 2004 53:2684-2690; doi:10.2337/diabetes.53.10.2684

Brief Genetics Report

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- Jack W. Kent, Jr,
- Anthony G. Comuzzie,
- Michael C. Mahaney,
- Laura Almasy,
- David L. Rainwater,
- John L. VandeBerg,
- Jean W. MacCluer,
- and John Blangero
Intercellular Adhesion Molecule-1 Concentration Is Genetically Correlated With Insulin Resistance, Obesity, and HDL Concentration in Mexican Americans
Diabetes October 2004 53:2691-2695; doi:10.2337/diabetes.53.10.2691
Select this article
- Lijun Ma,
- P. Antonio Tataranni,
- Clifton Bogardus,
- and Leslie J. Baier
Melanocortin 4 Receptor Gene Variation Is Associated With Severe Obesity in Pima Indians
Diabetes October 2004 53:2696-2699; doi:10.2337/diabetes.53.10.2696
Select this article
- James M. Cheverud,
- Thomas H. Ehrich,
- Jane P. Kenney,
- L. Susan Pletscher,
- and Clay F. Semenkovich
Genetic Evidence for Discordance Between Obesity- and Diabetes-Related Traits in the LGXSM Recombinant Inbred Mouse Strains
Diabetes October 2004 53:2700-2708; doi:10.2337/diabetes.53.10.2700
Select this article
- Sergey Nejentsev,
- Jason D. Cooper,
- Lisa Godfrey,
- Joanna M.M. Howson,
- Helen Rance,
- Sarah Nutland,
- Neil M. Walker,
- Cristian Guja,
- Constantin Ionescu-Tirgovişte,
- David A. Savage,
- Dag E. Undlien,
- Kjersti S. Rønningen,
- Eva Tuomilehto-Wolf,
- Jaakko Tuomilehto,
- Kathleen M. Gillespie,
- Susan M. Ring,
- David P. Strachan,
- Barry Widmer,
- David Dunger,
- and John A. Todd
Analysis of the Vitamin D Receptor Gene Sequence Variants in Type 1 Diabetes
Diabetes October 2004 53:2709-2712; doi:10.2337/diabetes.53.10.2709
Select this article
- Jørn V. Sagen,
- Helge Ræder,
- Eba Hathout,
- Naim Shehadeh,
- Kolbeinn Gudmundsson,
- Halvor Bævre,
- Dianne Abuelo,
- Chanika Phornphutkul,
- Janne Molnes,
- Graeme I. Bell,
- Anna L. Gloyn,
- Andrew T. Hattersley,
- Anders Molven,
- Oddmund Søvik,
- and Pål R. Njølstad
Permanent Neonatal Diabetes due to Mutations in KCNJ11 Encoding Kir6.2: Patient Characteristics and Initial Response to Sulfonylurea Therapy
Diabetes October 2004 53:2713-2718; doi:10.2337/diabetes.53.10.2713
Select this article
- Martine Vaxillaire,
- Céline Populaire,
- Kanetee Busiah,
- Hélène Cavé,
- Anna L. Gloyn,
- Andrew T. Hattersley,
- Paul Czernichow,
- Philippe Froguel,
- and Michel Polak
Kir6.2 Mutations Are a Common Cause of Permanent Neonatal Diabetes in a Large Cohort of French Patients
Diabetes October 2004 53:2719-2722; doi:10.2337/diabetes.53.10.2719

Pharmacology and Therapeutics

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- Katsumi Sasaki,
- Michael B. Chancellor,
- William F. Goins,
- Michael W. Phelan,
- Joseph C. Glorioso,
- William C. de Groat,
- and Naoki Yoshimura
Gene Therapy Using Replication-Defective Herpes Simplex Virus Vectors Expressing Nerve Growth Factor in a Rat Model of Diabetic Cystopathy
Diabetes October 2004 53:2723-2730; doi:10.2337/diabetes.53.10.2723

Erratum

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Erratum
Diabetes October 2004 53:2731; doi:10.2337/diabetes.53.10.2731

Diabetes

Perspectives in Diabetes

Neuronal Glucosensing: What Do We Know After 50 Years?

Signal Transduction

Intracerebroventricular Neuropeptide Y Infusion Precludes Inhibition of Glucose and VLDL Production by Insulin

Transferrin and Iron Contribute to the Lipolytic Effect of Serum in Isolated Adipocytes

Hypothalamic ATP-sensitive K + Channels Play a Key Role in Sensing Hypoglycemia and Triggering Counterregulatory Epinephrine and Glucagon Responses

Obesity Study

Regulation of Growth Hormone Secretagogue Receptor Gene Expression in the Arcuate Nuclei of the Rat by Leptin and Ghrelin

Immunology and Transplantation

Response of Human Islets to Isolation Stress and the Effect of Antioxidant Treatment

Elevated C-Reactive Protein Levels in the Development of Type 1 Diabetes

A Salen-Manganese Catalytic Free Radical Scavenger Inhibits Type 1 Diabetes and Islet Allograft Rejection

Investigation of the Role of B-Cells in Type 1 Diabetes in the NOD Mouse

Local Activation of Dendritic Cells Leads to Insulitis and Development of Insulin-Dependent Diabetes in Transgenic Mice Expressing CD154 on the Pancreatic β-Cells

Islet Study

Promotion of β-Cell Differentiation by Conophylline in Fetal and Neonatal Rat Pancreas

Artifactual Insulin Release From Differentiated Embryonic Stem Cells

Evidence Against the Involvement of Oxidative Stress in Fatty Acid Inhibition of Insulin Secretion

Pathophysiology

Hepatic Insulin Resistance Precedes the Development of Diabetes in a Model of Intrauterine Growth Retardation

Elevations in Markers of Liver Injury and Risk of Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study

Alterations in Plasma Vitamin E Distribution in Type 2 Diabetic Patients With Elevated Plasma Phospholipid Transfer Protein Activity

Complications

Nitric Oxide–Sensitive Soluble Guanylyl Cyclase Activity Is Preserved in Internal Mammary Artery of Type 2 Diabetic Patients

Preserved Glucoregulation but Attenuation of the Vascular Actions of Insulin in Mice Heterozygous for Knockout of the Insulin Receptor

Glycation Inactivation of the Complement Regulatory Protein CD59: A Possible Role in the Pathogenesis of the Vascular Complications of Human Diabetes

Thiazolidinediones Reduce Endothelial Expression of Receptors for Advanced Glycation End Products

Selective Loss of Calcitonin Gene-Related Peptide-Expressing Primary Sensory Neurons of the A-Cell Phenotype in Early Experimental Diabetes

Genetics

Genome-wide Scan for Metabolic Syndrome and Related Quantitative Traits in Hong Kong Chinese and Confirmation of a Susceptibility Locus on Chromosome 1q21-q25

Differences in the Contribution of HLA-DR and -DQ Haplotypes to Susceptibility to Adult- and Childhood-Onset Type 1 Diabetes in Japanese Patients

Brief Genetics Report

Intercellular Adhesion Molecule-1 Concentration Is Genetically Correlated With Insulin Resistance, Obesity, and HDL Concentration in Mexican Americans

Melanocortin 4 Receptor Gene Variation Is Associated With Severe Obesity in Pima Indians

Genetic Evidence for Discordance Between Obesity- and Diabetes-Related Traits in the LGXSM Recombinant Inbred Mouse Strains

Analysis of the Vitamin D Receptor Gene Sequence Variants in Type 1 Diabetes

Permanent Neonatal Diabetes due to Mutations in KCNJ11 Encoding Kir6.2: Patient Characteristics and Initial Response to Sulfonylurea Therapy

Kir6.2 Mutations Are a Common Cause of Permanent Neonatal Diabetes in a Large Cohort of French Patients

Pharmacology and Therapeutics

Gene Therapy Using Replication-Defective Herpes Simplex Virus Vectors Expressing Nerve Growth Factor in a Rat Model of Diabetic Cystopathy

Erratum

Erratum

This Issue

Current Issue

Hypothalamic ATP-sensitive K ⁺ Channels Play a Key Role in Sensing Hypoglycemia and Triggering Counterregulatory Epinephrine and Glucagon Responses