Glycation Inactivation of the Complement Regulatory Protein CD59

TABLE 2

Immunostaining for glycated hCD59 and MAC in kidney and nerve biopsies

Nephropathy
Neuropathy
Diabetic individuals Nondiabetic individuals Diabetic individuals Nondiabetic individuals
n 13 17 12 14
GlycCD59 (%) 58 0 60 0
Colocalized MAC + GlycCD59 (%) 57 0 58 0
  • Serial sections of paraffin-embedded renal and sural nerve tissue obtained by biopsies from diabetic and nondiabetic individuals were immunostained with either anti–glycated hCD59 or anti-MAC antibody. Results are percent of positive and negative staining for each marker.

This Article

  1. Diabetes vol. 53 no. 10 2653-2661