Table of Contents

Perspectives in Diabetes

Select this article
- Cecilia C. Low Wang,
- Marc L. Goalstone,
- and Boris Draznin
Molecular Mechanisms of Insulin Resistance That Impact Cardiovascular Biology
Diabetes November 2004 53:2735-2740; doi:10.2337/diabetes.53.11.2735

Metabolism

Select this article
- Martin Ellmerer,
- Stella P. Kim,
- Marianthe Hamilton-Wessler,
- Katrin Hücking,
- Erlinda Kirkman,
- and Richard N. Bergman
Physiological Hyperinsulinemia in Dogs Augments Access of Macromolecules to Insulin-Sensitive Tissues
Diabetes November 2004 53:2741-2747; doi:10.2337/diabetes.53.11.2741

Signal Transduction

Select this article
- Jae Eun Kim and
- Jie Chen
Regulation of Peroxisome Proliferator–Activated Receptor-γ Activity by Mammalian Target of Rapamycin and Amino Acids in Adipogenesis
Diabetes November 2004 53:2748-2756; doi:10.2337/diabetes.53.11.2748
Select this article
- Sang-kyu Park,
- So-Young Oh,
- Min-Young Lee,
- Sarah Yoon,
- Kyung-Sup Kim,
- and Jae-woo Kim
CCAAT/Enhancer Binding Protein and Nuclear Factor-Y Regulate Adiponectin Gene Expression in Adipose Tissue
Diabetes November 2004 53:2757-2766; doi:10.2337/diabetes.53.11.2757
Select this article
- Xavier Fioramonti,
- Anne Lorsignol,
- Anne Taupignon,
- and Luc Pénicaud
A New ATP-Sensitive K⁺ Channel–Independent Mechanism Is Involved in Glucose-Excited Neurons of Mouse Arcuate Nucleus
Diabetes November 2004 53:2767-2775; doi:10.2337/diabetes.53.11.2767
Select this article
- Tomoyuki Yuasa,
- Rei Kakuhata,
- Kazuhiro Kishi,
- Toshiyuki Obata,
- Yasuo Shinohara,
- Yoshimi Bando,
- Keisuke Izumi,
- Fumiko Kajiura,
- Mitsuru Matsumoto,
- and Yousuke Ebina
Platelet-Derived Growth Factor Stimulates Glucose Transport in Skeletal Muscles of Transgenic Mice Specifically Expressing Platelet-Derived Growth Factor Receptor in the Muscle, but It Does Not Affect Blood Glucose Levels
Diabetes November 2004 53:2776-2786; doi:10.2337/diabetes.53.11.2776

Obesity Study

Select this article
- Susann Blüher,
- Stergios Moschos,
- John Bullen, Jr.,
- Efi Kokkotou,
- Eleftheria Maratos-Flier,
- Stanley J. Wiegand,
- Mark W. Sleeman,
- and Christos S. Mantzoros
Ciliary Neurotrophic Factor_Ax15 Alters Energy Homeostasis, Decreases Body Weight, and Improves Metabolic Control in Diet-Induced Obese and UCP1-DTA Mice
Diabetes November 2004 53:2787-2796; doi:10.2337/diabetes.53.11.2787

Immunology and Transplantation

Select this article
- Luis Vence,
- Christophe Benoist,
- and Diane Mathis
Fas Deficiency Prevents Type 1 Diabetes by Inducing Hyporesponsiveness in Islet β-Cell−Reactive T-Cells
Diabetes November 2004 53:2797-2803; doi:10.2337/diabetes.53.11.2797

Islet Study

Select this article
- Juan L. Contreras,
- Christopher Eckstein,
- Cheryl A. Smyth,
- Guadalupe Bilbao,
- Mario Vilatoba,
- Sharman E. Ringland,
- Carlton Young,
- J. Anthony Thompson,
- José A. Fernández,
- John H. Griffin,
- and Devin E. Eckhoff
Activated Protein C Preserves Functional Islet Mass After Intraportal Transplantation: A Novel Link Between Endothelial Cell Activation, Thrombosis, Inflammation, and Islet Cell Death
Diabetes November 2004 53:2804-2814; doi:10.2337/diabetes.53.11.2804
Select this article
- Saida Abdelli,
- Jeff Ansite,
- Raphael Roduit,
- Tiziana Borsello,
- Ippei Matsumoto,
- Toshiya Sawada,
- Nathalie Allaman-Pillet,
- Hugues Henry,
- Jacques S. Beckmann,
- Bernhard J. Hering,
- and Christophe Bonny
Intracellular Stress Signaling Pathways Activated During Human Islet Preparation and Following Acute Cytokine Exposure
Diabetes November 2004 53:2815-2823; doi:10.2337/diabetes.53.11.2815
Select this article
- Kok-Hooi Yew,
- Krishna L. Prasadan,
- Barry L. Preuett,
- Mark J. Hembree,
- Christopher R. McFall,
- Christina L. Benjes,
- Amanda R. Crowley,
- Susan L. Sharp,
- Zhixing Li,
- Sidhartha S. Tulachan,
- Sheilendra S. Mehta,
- and George K. Gittes
Interplay of Glucagon-Like Peptide-1 and Transforming Growth Factor-β Signaling in Insulin-Positive Differentiation of AR42J Cells
Diabetes November 2004 53:2824-2835; doi:10.2337/diabetes.53.11.2824
Select this article
- Charlotta S. Olofsson,
- Albert Salehi,
- Sven O. Göpel,
- Cecilia Holm,
- and Patrik Rorsman
Palmitate Stimulation of Glucagon Secretion in Mouse Pancreatic α-Cells Results From Activation of l-Type Calcium Channels and Elevation of Cytoplasmic Calcium
Diabetes November 2004 53:2836-2843; doi:10.2337/diabetes.53.11.2836
Select this article
- Junji Matsui,
- Yasuo Terauchi,
- Naoto Kubota,
- Iseki Takamoto,
- Kazuhiro Eto,
- Tokuyuki Yamashita,
- Kajuro Komeda,
- Toshimasa Yamauchi,
- Junji Kamon,
- Shunbun Kita,
- Mitsuhiko Noda,
- and Takashi Kadowaki
Pioglitazone Reduces Islet Triglyceride Content and Restores Impaired Glucose-Stimulated Insulin Secretion in Heterozygous Peroxisome Proliferator–Activated Receptor-γ–Deficient Mice on a High-Fat Diet
Diabetes November 2004 53:2844-2854; doi:10.2337/diabetes.53.11.2844

Pathophysiology

Select this article
- Naveed Sattar,
- Olga Scherbakova,
- Ian Ford,
- Denis St. J. O’Reilly,
- Adrian Stanley,
- Ewan Forrest,
- Peter W. MacFarlane,
- Chris J. Packard,
- Stuart M. Cobbe,
- and James Shepherd
Elevated Alanine Aminotransferase Predicts New-Onset Type 2 Diabetes Independently of Classical Risk Factors, Metabolic Syndrome, and C-Reactive Protein in the West of Scotland Coronary Prevention Study
Diabetes November 2004 53:2855-2860; doi:10.2337/diabetes.53.11.2855
Select this article
- Susanna Iossa,
- Maria Pina Mollica,
- Lillà Lionetti,
- Raffaella Crescenzo,
- Rosaria Tasso,
- and Giovanna Liverini
A Possible Link Between Skeletal Muscle Mitochondrial Efficiency and Age-Induced Insulin Resistance
Diabetes November 2004 53:2861-2866; doi:10.2337/diabetes.53.11.2861
Select this article
- Kristina M. Utzschneider,
- Darcy B. Carr,
- Rebecca L. Hull,
- Keiichi Kodama,
- Jane B. Shofer,
- Barbara M. Retzlaff,
- Robert H. Knopp,
- and Steven E. Kahn
Impact of Intra-Abdominal Fat and Age on Insulin Sensitivity and β-Cell Function
Diabetes November 2004 53:2867-2872; doi:10.2337/diabetes.53.11.2867
Select this article
- Renate T. de Jongh,
- Erik H. Serné,
- Richard G. IJzerman,
- Greetje de Vries,
- and Coen D.A. Stehouwer
Free Fatty Acid Levels Modulate Microvascular Function: Relevance for Obesity-Associated Insulin Resistance, Hypertension, and Microangiopathy
Diabetes November 2004 53:2873-2882; doi:10.2337/diabetes.53.11.2873
Select this article
- Biljana Miljanovic,
- Robert J. Glynn,
- David M. Nathan,
- JoAnn E. Manson,
- and Debra A. Schaumberg
A Prospective Study of Serum Lipids and Risk of Diabetic Macular Edema in Type 1 Diabetes
Diabetes November 2004 53:2883-2892; doi:10.2337/diabetes.53.11.2883
Select this article
- Gary F. Lewis,
- Susan Murdoch,
- Kristine Uffelman,
- Mark Naples,
- Linda Szeto,
- Alegria Albers,
- Khosrow Adeli,
- and John D. Brunzell
Hepatic Lipase mRNA, Protein, and Plasma Enzyme Activity Is Increased in the Insulin-Resistant, Fructose-Fed Syrian Golden Hamster and Is Partially Normalized by the Insulin Sensitizer Rosiglitazone
Diabetes November 2004 53:2893-2900; doi:10.2337/diabetes.53.11.2893
Select this article
- Hong Zhao,
- Shoshana Yakar,
- Oksana Gavrilova,
- Hui Sun,
- Yang Zhang,
- Hyunsook Kim,
- Jennifer Setser,
- William Jou,
- and Derek LeRoith
Phloridzin Improves Hyperglycemia But Not Hepatic Insulin Resistance in a Transgenic Mouse Model of Type 2 Diabetes
Diabetes November 2004 53:2901-2909; doi:10.2337/diabetes.53.11.2901

Complication

Select this article
- Kota V. Ramana,
- Brian Friedrich,
- Sanjay Srivastava,
- Aruni Bhatnagar,
- and Satish K. Srivastava
Activation of Nulcear Factor-κB by Hyperglycemia in Vascular Smooth Muscle Cells Is Regulated by Aldose Reductase
Diabetes November 2004 53:2910-2920; doi:10.2337/diabetes.53.11.2910
Select this article
- Vicki Thallas-Bonke,
- Carsten Lindschau,
- Bishoy Rizkalla,
- Leon A. Bach,
- Geoffrey Boner,
- Matthias Meier,
- Hermann Haller,
- Mark E. Cooper,
- and Josephine M. Forbes
Attenuation of Extracellular Matrix Accumulation in Diabetic Nephropathy by the Advanced Glycation End Product Cross-Link Breaker ALT-711 via a Protein Kinase C-α−Dependent Pathway
Diabetes November 2004 53:2921-2930; doi:10.2337/diabetes.53.11.2921
Select this article
- Jens R. Nyengaard,
- Yassuo Ido,
- Charles Kilo,
- and Joseph R. Williamson
Interactions Between Hyperglycemia and Hypoxia: Implications for Diabetic Retinopathy
Diabetes November 2004 53:2931-2938; doi:10.2337/diabetes.53.11.2931
Select this article
- Sheldon Chen,
- Yuki Kasama,
- Joseph S. Lee,
- Belinda Jim,
- Maria Marin,
- and Fuad N. Ziyadeh
Podocyte-Derived Vascular Endothelial Growth Factor Mediates the Stimulation of α3(IV) Collagen Production by Transforming Growth Factor-β1 in Mouse Podocytes
Diabetes November 2004 53:2939-2949; doi:10.2337/diabetes.53.11.2939
Select this article
- Chunxiang Zhang,
- Jian Yang,
- and Lisa K. Jennings
Leukocyte-Derived Myeloperoxidase Amplifies High-Glucose—Induced Endothelial Dysfunction Through Interaction With High-Glucose—Stimulated, Vascular Non—Leukocyte-Derived Reactive Oxygen Species
Diabetes November 2004 53:2950-2959; doi:10.2337/diabetes.53.11.2950
Select this article
- Ling Zheng,
- Csaba Szabó,
- and Timothy S. Kern
Poly(ADP-Ribose) Polymerase Is Involved in the Development of Diabetic Retinopathy via Regulation of Nuclear Factor-κB
Diabetes November 2004 53:2960-2967; doi:10.2337/diabetes.53.11.2960
Select this article
- Bahaedin M. Ben-Mahmud,
- Giovanni E. Mann,
- Alessandro Datti,
- Aldo Orlacchio,
- Eva M. Kohner,
- and Rakesh Chibber
Tumor Necrosis Factor-α in Diabetic Plasma Increases the Activity of Core 2 GlcNAc-T and Adherence of Human Leukocytes to Retinal Endothelial Cells: Significance of Core 2 GlcNAc-T in Diabetic Retinopathy
Diabetes November 2004 53:2968-2976; doi:10.2337/diabetes.53.11.2968

Genetic

Select this article
- Fernando Gibson and
- Philippe Froguel
Genetics of the APM1 Locus and Its Contribution to Type 2 Diabetes Susceptibility in French Caucasians
Diabetes November 2004 53:2977-2983; doi:10.2337/diabetes.53.11.2977
Select this article
- Hai-Lu Zhao,
- Peter C.Y. Tong,
- Fernand M.M. Lai,
- Brian Tomlinson,
- and Juliana C.N. Chan
Association of Glomerulopathy With the 5′-End Polymorphism of the Aldose Reductase Gene and Renal Insufficiency in Type 2 Diabetic Patients
Diabetes November 2004 53:2984-2991; doi:10.2337/diabetes.53.11.2984

Brief Genetics Report

Select this article
- Gitte Andersen,
- Lise Wegner,
- Christian Schack Rose,
- Jianxin Xie,
- Hao Zhu,
- Kevin Larade,
- Anders Johansen,
- Jakob Ek,
- Jeannet Lauenborg,
- Thomas Drivsholm,
- Knut Borch-Johnsen,
- Peter Damm,
- Torben Hansen,
- H. Franklin Bunn,
- and Oluf Pedersen
Variation in NCB5OR: Studies of Relationships to Type 2 Diabetes, Maturity-Onset Diabetes of the Young, and Gestational Diabetes Mellitus
Diabetes November 2004 53:2992-2997; doi:10.2337/diabetes.53.11.2992
Select this article
- Emma L. Edghill,
- Anna L. Gloyn,
- Kathleen M. Gillespie,
- A. Paul Lambert,
- Neil T. Raymond,
- Peter G. Swift,
- Sian Ellard,
- Edwin A.M. Gale,
- and Andrew T. Hattersley
Activating Mutations in the KCNJ11 Gene Encoding the ATP-Sensitive K⁺ Channel Subunit Kir6.2 Are Rare in Clinically Defined Type 1 Diabetes Diagnosed Before 2 Years
Diabetes November 2004 53:2998-3001; doi:10.2337/diabetes.53.11.2998
Select this article
- Michael N. Weedon,
- Katharine R. Owen,
- Beverley Shields,
- Graham Hitman,
- Mark Walker,
- Mark I. McCarthy,
- Latisha D. Love-Gregory,
- M. Alan Permutt,
- Andrew T. Hattersley,
- and Timothy M. Frayling
Common Variants of the Hepatocyte Nuclear Factor-4α P2 Promoter Are Associated With Type 2 Diabetes in the U.K. Population
Diabetes November 2004 53:3002-3006; doi:10.2337/diabetes.53.11.3002
Select this article
- Jennifer L. Bento,
- Nicholette D. Palmer,
- Josyf C. Mychaleckyj,
- Leslie A. Lange,
- Carl D. Langefeld,
- Stephen S. Rich,
- Barry I. Freedman,
- and Donald W. Bowden
Association of Protein Tyrosine Phosphatase 1B Gene Polymorphisms With Type 2 Diabetes
Diabetes November 2004 53:3007-3012; doi:10.2337/diabetes.53.11.3007
Select this article
- Nicholette D. Palmer,
- Jennifer L. Bento,
- Josyf C. Mychaleckyj,
- Carl D. Langefeld,
- Joel K. Campbell,
- Jill M. Norris,
- Stephen M. Haffner,
- Richard N. Bergman,
- and Donald W. Bowden
Association of Protein Tyrosine Phosphatase 1B Gene Polymorphisms With Measures of Glucose Homeostasis in Hispanic Americans: The Insulin Resistance Atherosclerosis Study (IRAS) Family Study
Diabetes November 2004 53:3013-3019; doi:10.2337/diabetes.53.11.3013
Select this article
- Deborah Smyth,
- Jason D. Cooper,
- Joanne E. Collins,
- Joanne M. Heward,
- Jayne A. Franklyn,
- Joanna M.M. Howson,
- Adrian Vella,
- Sarah Nutland,
- Helen E. Rance,
- Lisa Maier,
- Bryan J. Barratt,
- Cristian Guja,
- Constantin Ionescu-Tı̂rgovişte,
- David A. Savage,
- David B. Dunger,
- Barry Widmer,
- David P. Strachan,
- Susan M. Ring,
- Neil Walker,
- David G. Clayton,
- Rebecca C.J. Twells,
- Stephen C.L. Gough,
- and John A. Todd
Replication of an Association Between the Lymphoid Tyrosine Phosphatase Locus (LYP/PTPN22) With Type 1 Diabetes, and Evidence for Its Role as a General Autoimmunity Locus
Diabetes November 2004 53:3020-3023; doi:10.2337/diabetes.53.11.3020

Pharmacology & Therapeutics

Select this article
- Manfred Hallschmid,
- Christian Benedict,
- Bernd Schultes,
- Horst-Lorenz Fehm,
- Jan Born,
- and Werner Kern
Intranasal Insulin Reduces Body Fat in Men but not in Women
Diabetes November 2004 53:3024-3029; doi:10.2337/diabetes.53.11.3024

Diabetes

Perspectives in Diabetes

Molecular Mechanisms of Insulin Resistance That Impact Cardiovascular Biology

Metabolism

Physiological Hyperinsulinemia in Dogs Augments Access of Macromolecules to Insulin-Sensitive Tissues

Signal Transduction

Regulation of Peroxisome Proliferator–Activated Receptor-γ Activity by Mammalian Target of Rapamycin and Amino Acids in Adipogenesis

CCAAT/Enhancer Binding Protein and Nuclear Factor-Y Regulate Adiponectin Gene Expression in Adipose Tissue

A New ATP-Sensitive K+ Channel–Independent Mechanism Is Involved in Glucose-Excited Neurons of Mouse Arcuate Nucleus

Platelet-Derived Growth Factor Stimulates Glucose Transport in Skeletal Muscles of Transgenic Mice Specifically Expressing Platelet-Derived Growth Factor Receptor in the Muscle, but It Does Not Affect Blood Glucose Levels

Obesity Study

Ciliary Neurotrophic FactorAx15 Alters Energy Homeostasis, Decreases Body Weight, and Improves Metabolic Control in Diet-Induced Obese and UCP1-DTA Mice

Immunology and Transplantation

Fas Deficiency Prevents Type 1 Diabetes by Inducing Hyporesponsiveness in Islet β-Cell−Reactive T-Cells

Islet Study

Activated Protein C Preserves Functional Islet Mass After Intraportal Transplantation: A Novel Link Between Endothelial Cell Activation, Thrombosis, Inflammation, and Islet Cell Death

Intracellular Stress Signaling Pathways Activated During Human Islet Preparation and Following Acute Cytokine Exposure

Interplay of Glucagon-Like Peptide-1 and Transforming Growth Factor-β Signaling in Insulin-Positive Differentiation of AR42J Cells

Palmitate Stimulation of Glucagon Secretion in Mouse Pancreatic α-Cells Results From Activation of l-Type Calcium Channels and Elevation of Cytoplasmic Calcium

Pioglitazone Reduces Islet Triglyceride Content and Restores Impaired Glucose-Stimulated Insulin Secretion in Heterozygous Peroxisome Proliferator–Activated Receptor-γ–Deficient Mice on a High-Fat Diet

Pathophysiology

Elevated Alanine Aminotransferase Predicts New-Onset Type 2 Diabetes Independently of Classical Risk Factors, Metabolic Syndrome, and C-Reactive Protein in the West of Scotland Coronary Prevention Study

A Possible Link Between Skeletal Muscle Mitochondrial Efficiency and Age-Induced Insulin Resistance

Impact of Intra-Abdominal Fat and Age on Insulin Sensitivity and β-Cell Function

Free Fatty Acid Levels Modulate Microvascular Function: Relevance for Obesity-Associated Insulin Resistance, Hypertension, and Microangiopathy

A Prospective Study of Serum Lipids and Risk of Diabetic Macular Edema in Type 1 Diabetes

Hepatic Lipase mRNA, Protein, and Plasma Enzyme Activity Is Increased in the Insulin-Resistant, Fructose-Fed Syrian Golden Hamster and Is Partially Normalized by the Insulin Sensitizer Rosiglitazone

Phloridzin Improves Hyperglycemia But Not Hepatic Insulin Resistance in a Transgenic Mouse Model of Type 2 Diabetes

Complication

Activation of Nulcear Factor-κB by Hyperglycemia in Vascular Smooth Muscle Cells Is Regulated by Aldose Reductase

Attenuation of Extracellular Matrix Accumulation in Diabetic Nephropathy by the Advanced Glycation End Product Cross-Link Breaker ALT-711 via a Protein Kinase C-α−Dependent Pathway

Interactions Between Hyperglycemia and Hypoxia: Implications for Diabetic Retinopathy

Podocyte-Derived Vascular Endothelial Growth Factor Mediates the Stimulation of α3(IV) Collagen Production by Transforming Growth Factor-β1 in Mouse Podocytes

Leukocyte-Derived Myeloperoxidase Amplifies High-Glucose—Induced Endothelial Dysfunction Through Interaction With High-Glucose—Stimulated, Vascular Non—Leukocyte-Derived Reactive Oxygen Species

Poly(ADP-Ribose) Polymerase Is Involved in the Development of Diabetic Retinopathy via Regulation of Nuclear Factor-κB

Tumor Necrosis Factor-α in Diabetic Plasma Increases the Activity of Core 2 GlcNAc-T and Adherence of Human Leukocytes to Retinal Endothelial Cells: Significance of Core 2 GlcNAc-T in Diabetic Retinopathy

Genetic

Genetics of the APM1 Locus and Its Contribution to Type 2 Diabetes Susceptibility in French Caucasians

Association of Glomerulopathy With the 5′-End Polymorphism of the Aldose Reductase Gene and Renal Insufficiency in Type 2 Diabetic Patients

Brief Genetics Report

Variation in NCB5OR: Studies of Relationships to Type 2 Diabetes, Maturity-Onset Diabetes of the Young, and Gestational Diabetes Mellitus

Activating Mutations in the KCNJ11 Gene Encoding the ATP-Sensitive K+ Channel Subunit Kir6.2 Are Rare in Clinically Defined Type 1 Diabetes Diagnosed Before 2 Years

Common Variants of the Hepatocyte Nuclear Factor-4α P2 Promoter Are Associated With Type 2 Diabetes in the U.K. Population

Association of Protein Tyrosine Phosphatase 1B Gene Polymorphisms With Type 2 Diabetes

Association of Protein Tyrosine Phosphatase 1B Gene Polymorphisms With Measures of Glucose Homeostasis in Hispanic Americans: The Insulin Resistance Atherosclerosis Study (IRAS) Family Study

Replication of an Association Between the Lymphoid Tyrosine Phosphatase Locus (LYP/PTPN22) With Type 1 Diabetes, and Evidence for Its Role as a General Autoimmunity Locus

Pharmacology & Therapeutics

Intranasal Insulin Reduces Body Fat in Men but not in Women

This Issue

Current Issue

A New ATP-Sensitive K⁺ Channel–Independent Mechanism Is Involved in Glucose-Excited Neurons of Mouse Arcuate Nucleus

Ciliary Neurotrophic Factor_Ax15 Alters Energy Homeostasis, Decreases Body Weight, and Improves Metabolic Control in Diet-Induced Obese and UCP1-DTA Mice

Activating Mutations in the KCNJ11 Gene Encoding the ATP-Sensitive K⁺ Channel Subunit Kir6.2 Are Rare in Clinically Defined Type 1 Diabetes Diagnosed Before 2 Years