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Table of Contents

December 2004; 53 (12)

Perspectives in Diabetes

    • R. David G. Leslie and
    • Michela Delli Castelli

    Age-Dependent Influences on the Origins of Autoimmune Diabetes: Evidence and Implications

    Diabetes December 2004 53:3033-3040; doi:10.2337/diabetes.53.12.3033

Metabolism

    • R. Richard Pencek,
    • Freyja D. James,
    • D. Brooks Lacy,
    • Kareem Jabbour,
    • Phillip E. Williams,
    • Patrick T. Fueger,
    • and David H. Wasserman

    Exercise-Induced Changes in Insulin and Glucagon Are Not Required for Enhanced Hepatic Glucose Uptake After Exercise but Influence the Fate of Glucose Within the Liver

    Diabetes December 2004 53:3041-3047; doi:10.2337/diabetes.53.12.3041
    • Martin Krssak,
    • Attila Brehm,
    • Elisabeth Bernroider,
    • Christian Anderwald,
    • Peter Nowotny,
    • Chiara Dalla Man,
    • Claudio Cobelli,
    • Gary W. Cline,
    • Gerald I. Shulman,
    • Werner Waldhäusl,
    • and Michael Roden

    Alterations in Postprandial Hepatic Glycogen Metabolism in Type 2 Diabetes

    Diabetes December 2004 53:3048-3056; doi:10.2337/diabetes.53.12.3048

Signal Transduction

    • Wei Qiu,
    • Rita Kohen Avramoglu,
    • Nadia Dubé,
    • Taryne M. Chong,
    • Mark Naples,
    • Crystal Au,
    • Konstantinos G. Sidiropoulos,
    • Gary F. Lewis,
    • Jeffrey S. Cohn,
    • Michel L. Tremblay,
    • and Khosrow Adeli

    Hepatic PTP-1B Expression Regulates the Assembly and Secretion of Apolipoprotein B–Containing Lipoproteins: Evidence From Protein Tyrosine Phosphatase-1B Overexpression, Knockout, and RNAi Studies

    Diabetes December 2004 53:3057-3066; doi:10.2337/diabetes.53.12.3057
    • Sarah H. Bates,
    • Trevor A. Dundon,
    • Matthew Seifert,
    • Michael Carlson,
    • Eleftheria Maratos-Flier,
    • and Martin G. Myers, Jr

    LRb-STAT3 Signaling Is Required for the Neuroendocrine Regulation of Energy Expenditure by Leptin

    Diabetes December 2004 53:3067-3073; doi:10.2337/diabetes.53.12.3067
    • Sebastian B. Jørgensen,
    • Jakob N. Nielsen,
    • Jesper B. Birk,
    • Grith Skytte Olsen,
    • Benoit Viollet,
    • Fabrizio Andreelli,
    • Peter Schjerling,
    • Sophie Vaulont,
    • D. Grahame Hardie,
    • Bo F. Hansen,
    • Erik A. Richter,
    • and Jørgen F.P. Wojtaszewski

    The α2–5′AMP-Activated Protein Kinase Is a Site 2 Glycogen Synthase Kinase in Skeletal Muscle and Is Responsive to Glucose Loading

    Diabetes December 2004 53:3074-3081; doi:10.2337/diabetes.53.12.3074
    • Ian S. Harris,
    • Ilya Treskov,
    • Michael W. Rowley,
    • Scott Heximer,
    • Kevin Kaltenbronn,
    • Brian N. Finck,
    • Richard W. Gross,
    • Daniel P. Kelly,
    • Kendall J. Blumer,
    • and Anthony J. Muslin

    G-Protein Signaling Participates in the Development of Diabetic Cardiomyopathy

    Diabetes December 2004 53:3082-3090; doi:10.2337/diabetes.53.12.3082

Obesity Study

    • Juraj Koska,
    • Angelo DelParigi,
    • Barbora de Courten,
    • Christian Weyer,
    • and P. Antonio Tataranni

    Pancreatic Polypeptide Is Involved in the Regulation of Body Weight in Pima Indian Male Subjects

    Diabetes December 2004 53:3091-3096; doi:10.2337/diabetes.53.12.3091
    • Louise Hutley,
    • Wenda Shurety,
    • Felicity Newell,
    • Ross McGeary,
    • Nicole Pelton,
    • Jennifer Grant,
    • Adrian Herington,
    • Donald Cameron,
    • Jon Whitehead,
    • and Johannes Prins

    Fibroblast Growth Factor 1: A Key Regulator of Human Adipogenesis

    Diabetes December 2004 53:3097-3106; doi:10.2337/diabetes.53.12.3097

Immunology and Transplantation

    • Cale N. Street,
    • Jonathan R.T. Lakey,
    • A.M. James Shapiro,
    • Sharleen Imes,
    • Ray V. Rajotte,
    • Edmond A. Ryan,
    • James G. Lyon,
    • Tatsuya Kin,
    • Jose Avila,
    • Toshiaki Tsujimura,
    • and Gregory S. Korbutt

    Islet Graft Assessment in the Edmonton Protocol: Implications for Predicting Long-Term Clinical Outcome

    Diabetes December 2004 53:3107-3114; doi:10.2337/diabetes.53.12.3107
    • Matteo G. Levisetti,
    • Anish Suri,
    • Katherine Frederick,
    • and Emil R. Unanue

    Absence of Lymph Nodes in NOD Mice Treated With Lymphotoxin-β Receptor Immunoglobulin Protects From Diabetes

    Diabetes December 2004 53:3115-3119; doi:10.2337/diabetes.53.12.3115

Islet Study

    • Yuichi Fujinaka,
    • Darinka Sipula,
    • Adolfo Garcia-Ocaña,
    • and Rupangi C. Vasavada

    Characterization of Mice Doubly Transgenic for Parathyroid Hormone-Related Protein and Murine Placental Lactogen: A Novel Role for Placental Lactogen in Pancreatic β-Cell Survival

    Diabetes December 2004 53:3120-3130; doi:10.2337/diabetes.53.12.3120
    • Yarong Lu,
    • Pedro L. Herrera,
    • Yubin Guo,
    • David Sun,
    • Zhengyi Tang,
    • Derek LeRoith,
    • and Jun-Li Liu

    Pancreatic-Specific Inactivation of IGF-I Gene Causes Enlarged Pancreatic Islets and Significant Resistance to Diabetes

    Diabetes December 2004 53:3131-3141; doi:10.2337/diabetes.53.12.3131
    • Katsuya Dezaki,
    • Hiroshi Hosoda,
    • Masafumi Kakei,
    • Suzuko Hashiguchi,
    • Masatomo Watanabe,
    • Kenji Kangawa,
    • and Toshihiko Yada

    Endogenous Ghrelin in Pancreatic Islets Restricts Insulin Release by Attenuating Ca2+ Signaling in β-Cells: Implication in the Glycemic Control in Rodents

    Diabetes December 2004 53:3142-3151; doi:10.2337/diabetes.53.12.3142
    • Susanne G. Straub and
    • Geoffrey W. G. Sharp

    Massive Augmentation of Stimulated Insulin Secretion Induced by Fatty Acid–Free BSA in Rat Pancreatic Islets

    Diabetes December 2004 53:3152-3158; doi:10.2337/diabetes.53.12.3152
    • Maria S. Remedi,
    • Joseph. C. Koster,
    • Kamelia Markova,
    • Susumu Seino,
    • Takashi Miki,
    • Brian L. Patton,
    • Michael L. McDaniel,
    • and Colin G. Nichols

    Diet-Induced Glucose Intolerance in Mice With Decreased β-Cell ATP-Sensitive K+ Channels

    Diabetes December 2004 53:3159-3167; doi:10.2337/diabetes.53.12.3159
    • Li-Zhen Cao,
    • Dong-Qi Tang,
    • Marko E. Horb,
    • Shi-Wu Li,
    • and Li-Jun Yang

    High Glucose Is Necessary for Complete Maturation of Pdx1-VP16–Expressing Hepatic Cells into Functional Insulin-Producing Cells

    Diabetes December 2004 53:3168-3178; doi:10.2337/diabetes.53.12.3168
    • Susanne G. Straub,
    • Geetha Shanmugam,
    • and Geoffrey W.G. Sharp

    Stimulation of Insulin Release by Glucose Is Associated With an Increase in the Number of Docked Granules in the β-Cells of Rat Pancreatic Islets

    Diabetes December 2004 53:3179-3183; doi:10.2337/diabetes.53.12.3179

Pathophysiology

    • Gipsy Majumdar,
    • Jeremiah Wright,
    • Paul Markowitz,
    • Antonio Martinez-Hernandez,
    • Rajendra Raghow,
    • and Solomon S. Solomon

    Insulin Stimulates and Diabetes Inhibits O-Linked N-Acetylglucosamine Transferase and O-Glycosylation of Sp1

    Diabetes December 2004 53:3184-3192; doi:10.2337/diabetes.53.12.3184
    • Bernard Zinman,
    • Steven E. Kahn,
    • Steven M. Haffner,
    • M. Colleen O’Neill,
    • Mark A. Heise,
    • and Martin I. Freed

    Phenotypic Characteristics of GAD Antibody-Positive Recently Diagnosed Patients With Type 2 Diabetes in North America and Europe

    Diabetes December 2004 53:3193-3200; doi:10.2337/diabetes.53.12.3193
    • Darrell D. Belke,
    • Eric A. Swanson,
    • and Wolfgang H. Dillmann

    Decreased Sarcoplasmic Reticulum Activity and Contractility in Diabetic db/db Mouse Heart

    Diabetes December 2004 53:3201-3208; doi:10.2337/diabetes.53.12.3201
    • Harald Staiger,
    • Katrin Staiger,
    • Norbert Stefan,
    • Hans Günther Wahl,
    • Fausto Machicao,
    • Monika Kellerer,
    • and Hans-Ulrich Häring

    Palmitate-Induced Interleukin-6 Expression in Human Coronary Artery Endothelial Cells

    Diabetes December 2004 53:3209-3216; doi:10.2337/diabetes.53.12.3209

Complication

    • Najib Lamharzi,
    • Catherine B. Renard,
    • Farah Kramer,
    • Subramaniam Pennathur,
    • Jay W. Heinecke,
    • Alan Chait,
    • and Karin E. Bornfeldt

    Hyperlipidemia in Concert With Hyperglycemia Stimulates the Proliferation of Macrophages in Atherosclerotic Lesions: Potential Role of Glucose-Oxidized LDL

    Diabetes December 2004 53:3217-3225; doi:10.2337/diabetes.53.12.3217
    • Sergiu-Bogdan Catrina,
    • Kensaku Okamoto,
    • Teresa Pereira,
    • Kerstin Brismar,
    • and Lorenz Poellinger

    Hyperglycemia Regulates Hypoxia-Inducible Factor-1α Protein Stability and Function

    Diabetes December 2004 53:3226-3232; doi:10.2337/diabetes.53.12.3226
    • Renu A. Kowluru and
    • Sarah Odenbach

    Effect of Long-Term Administration of α-Lipoic Acid on Retinal Capillary Cell Death and the Development of Retinopathy in Diabetic Rats

    Diabetes December 2004 53:3233-3238; doi:10.2337/diabetes.53.12.3233
    • Kenji Uehara,
    • Shin-Ichiro Yamagishi,
    • Saori Otsuki,
    • Shyunsuke Chin,
    • and Soroku Yagihashi

    Effects of Polyol Pathway Hyperactivity on Protein Kinase C Activity, Nociceptive Peptide Expression, and Neuronal Structure in Dorsal Root Ganglia in Diabetic Mice

    Diabetes December 2004 53:3239-3247; doi:10.2337/diabetes.53.12.3239
    • Shirong Zheng,
    • William T. Noonan,
    • Naira S. Metreveli,
    • Susan Coventry,
    • Patricia M. Kralik,
    • Edward C. Carlson,
    • and Paul N. Epstein

    Development of Late-Stage Diabetic Nephropathy in OVE26 Diabetic Mice

    Diabetes December 2004 53:3248-3257; doi:10.2337/diabetes.53.12.3248

Pharmacology & Therapeutic

    • Mark E. Cleasby,
    • Nicolas Dzamko,
    • Bronwyn D. Hegarty,
    • Gregory J. Cooney,
    • Edward W. Kraegen,
    • and Ji-Ming Ye

    Metformin Prevents the Development of Acute Lipid-Induced Insulin Resistance in the Rat Through Altered Hepatic Signaling Mechanisms

    Diabetes December 2004 53:3258-3266; doi:10.2337/diabetes.53.12.3258
    • Sajjad A. Qureshi,
    • Mari Rios Candelore,
    • Dan Xie,
    • Xiaodong Yang,
    • Laurie M. Tota,
    • Victor D.-H. Ding,
    • Zhihua Li,
    • Alka Bansal,
    • Corin Miller,
    • Sheila M. Cohen,
    • Guoqiang Jiang,
    • Ed Brady,
    • Richard Saperstein,
    • Joseph L. Duffy,
    • James R. Tata,
    • Kevin T. Chapman,
    • David E. Moller,
    • and Bei B. Zhang

    A Novel Glucagon Receptor Antagonist Inhibits Glucagon-Mediated Biological Effects

    Diabetes December 2004 53:3267-3273; doi:10.2337/diabetes.53.12.3267

Genetic

    • Katrine Almind and
    • C. Ronald Kahn

    Genetic Determinants of Energy Expenditure and Insulin Resistance in Diet-Induced Obesity in Mice

    Diabetes December 2004 53:3274-3285; doi:10.2337/diabetes.53.12.3274
    • Costantino Motzo,
    • Daniela Contu,
    • Heather J. Cordell,
    • Rosanna Lampis,
    • Mauro Congia,
    • Maria Giovanna Marrosu,
    • John A. Todd,
    • Marcella Devoto,
    • and Francesco Cucca

    Heterogeneity in the Magnitude of the Insulin Gene Effect on HLA Risk in Type 1 Diabetes

    Diabetes December 2004 53:3286-3291; doi:10.2337/diabetes.53.12.3286
    • Mao Fu,
    • Coleen M. Damcott,
    • Mona Sabra,
    • Toni I. Pollin,
    • Sandra H. Ott,
    • Jian Wang,
    • Michael J. Garant,
    • Jeffrey R. O’Connell,
    • Braxton D. Mitchell,
    • and Alan R. Shuldiner

    Polymorphism in the Calsequestrin 1 (CASQ1) Gene on Chromosome 1q21 Is Associated With Type 2 Diabetes in the Old Order Amish

    Diabetes December 2004 53:3292-3299; doi:10.2337/diabetes.53.12.3292

Brief Genetic Report

    • Swapan Kumar Das,
    • Winston Chu,
    • Zhengxian Zhang,
    • Sandra J. Hasstedt,
    • and Steven C. Elbein

    Calsquestrin 1 (CASQ1) Gene Polymorphisms Under Chromosome 1q21 Linkage Peak Are Associated With Type 2 Diabetes in Northern European Caucasians

    Diabetes December 2004 53:3300-3306; doi:10.2337/diabetes.53.12.3300
    • Christy L. Avery,
    • Barry I. Freedman,
    • Gerardo Heiss,
    • Aldi Kraja,
    • Treva Rice,
    • Donna Arnett,
    • Michael B. Miller,
    • James S. Pankow,
    • Cora E. Lewis,
    • Richard H. Myers,
    • Steven C. Hunt,
    • Laura Almasy,
    • and Kari E. North

    Linkage Analysis of Diabetes Status Among Hypertensive Families: The Hypertension Genetic Epidemiology Network Study

    Diabetes December 2004 53:3307-3312; doi:10.2337/diabetes.53.12.3307
    • Jose C. Florez,
    • Marketa Sjögren,
    • Noël Burtt,
    • Marju Orho-Melander,
    • Steve Schayer,
    • Maria Sun,
    • Peter Almgren,
    • Ulf Lindblad,
    • Tiinamaija Tuomi,
    • Daniel Gaudet,
    • Thomas J. Hudson,
    • Mark J. Daly,
    • Kristin G. Ardlie,
    • Joel N. Hirschhorn,
    • David Altshuler,
    • and Leif Groop

    Association Testing in 9,000 People Fails to Confirm the Association of the Insulin Receptor Substrate-1 G972R Polymorphism With Type 2 Diabetes

    Diabetes December 2004 53:3313-3318; doi:10.2337/diabetes.53.12.3313
    • Eleftheria Zeggini,
    • James Parkinson,
    • Stephanie Halford,
    • Katharine R. Owen,
    • Timothy M. Frayling,
    • Mark Walker,
    • Graham A. Hitman,
    • Jonathan C. Levy,
    • Mike J. Sampson,
    • Edith J.M. Feskens,
    • Andrew T. Hattersley,
    • and Mark I. McCarthy

    Association Studies of Insulin Receptor Substrate 1 Gene (IRS1) Variants in Type 2 Diabetes Samples Enriched for Family History and Early Age of Onset

    Diabetes December 2004 53:3319-3322; doi:10.2337/diabetes.53.12.3319
    • Nathalie Deruytter,
    • Olivier Boulard,
    • and Henri-Jean Garchon

    Mapping Non–Class II H2-Linked Loci for Type 1 Diabetes in Nonobese Diabetic Mice

    Diabetes December 2004 53:3323-3327; doi:10.2337/diabetes.53.12.3323
    • James M. Cheverud,
    • Thomas H. Ehrich,
    • Tomas Hrbek,
    • Jane P. Kenney,
    • L. Susan Pletscher,
    • and Clay F. Semenkovich

    Quantitative Trait Loci for Obesity- and Diabetes-Related Traits and Their Dietary Responses to High-Fat Feeding in LGXSM Recombinant Inbred Mouse Strains

    Diabetes December 2004 53:3328-3336; doi:10.2337/diabetes.53.12.3328
    • Coleen M. Damcott,
    • Nicole Hoppman,
    • Sandra H. Ott,
    • Laurie J. Reinhart,
    • Jian Wang,
    • Toni I. Pollin,
    • Jeffrey R. O’Connell,
    • Braxton D. Mitchell,
    • and Alan R. Shuldiner

    Polymorphisms in Both Promoters of Hepatocyte Nuclear Factor 4-α Are Associated With Type 2 Diabetes in the Amish

    Diabetes December 2004 53:3337-3341; doi:10.2337/diabetes.53.12.3337
    • Yasmin H. Hamid,
    • Søren A. Urhammer,
    • Dorit P. Jensen,
    • Charlotte Glümer,
    • Knut Borch-Johnsen,
    • Torben Jørgensen,
    • Torben Hansen,
    • and Oluf Pedersen

    Variation in the Interleukin-6 Receptor Gene Associates With Type 2 Diabetes in Danish Whites

    Diabetes December 2004 53:3342-3345; doi:10.2337/diabetes.53.12.3342
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This Issue

December 2004; 53 (12)
  1. Perspectives in Diabetes
  2. Metabolism
  3. Signal Transduction
  4. Obesity Study
  5. Immunology and Transplantation
  6. Islet Study
  7. Pathophysiology
  8. Complication
  9. Pharmacology & Therapeutic
  10. Genetic
  11. Brief Genetic Report

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