Mapping Non–Class II H2-Linked Loci for Type 1 Diabetes in Nonobese Diabetic Mice
- Address correspondence and reprint requests to Henri-Jean Garchon, INSERM U580, 161 rue de Sèvres, 75743 Paris cedex 15, France. E-mail: garchon{at}necker.fr
Abstract
Major histocompatibility complex (MHC) plays a largely predominant role in the genetic predisposition to type 1 diabetes, in both humans and rodents. While class II loci have long been recognized as essential, they do not fully explain the MHC-linked genetic component of type 1 diabetes. In the present study, using new NOD congenic strains harboring defined chromosomal segments from C57BL/6 mice, we circumscribed three distinct loci influencing murine type 1 diabetes and tightly linked to but separated from the class II region. Our findings might guide the search for additional HLA-linked loci in human type 1 diabetes.
Footnotes
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- Accepted August 25, 2004.
- Received June 10, 2004.
- DIABETES
