Regulation of ATP/ADP in Pancreatic Islets

TABLE 1

Parameter values used to calculate ATP/ADP/Pi

Parameter Value
Q 380
Ema3 (V) 0.125
EmCu (V) 0.34
k1′ (μmol · l−1 · min−1)−1 5100
k2 (μmol · l−1 · min−1)−1 6000
K3 0.1
k4A′ (μmol · l−1 · min−1)−1 5100
k4b′ (μmol · l−1 · min−1)−1 660
K5 (μmmol/l)−1 0.003
a3T (μmmol/l) 1.75
cT (μmmol/l) 3.5
  • Total concentrations of cytochrome c and a3 were estimated by fitting data as described in the appendix. All other parameters were obtained by Wilson et al. (11) in studies of pigeon heart mitochondria.

This Article

  1. Diabetes vol. 53 no. 2 401-409