Table of Contents

Metabolism

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- Alan D. Cherrington,
- Doss W. Neal,
- Dale S. Edgerton,
- Dana Glass,
- Larry Bowen,
- Charles H. Hobbs,
- Chet Leach,
- Ralf Rosskamp,
- and Thomas R. Strack
Inhalation of Insulin in Dogs: Assessment of Insulin Levels and Comparison to Subcutaneous Injection
Diabetes April 2004 53:877-881; doi:10.2337/diabetes.53.4.877

Signal Transduction

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- Francisco Felipe,
- M. Luisa Bonet,
- Joan Ribot,
- and Andreu Palou
Modulation of Resistin Expression by Retinoic Acid and Vitamin A Status
Diabetes April 2004 53:882-889; doi:10.2337/diabetes.53.4.882
Select this article
- Daniel Duran-Sandoval,
- Gisèle Mautino,
- Geneviève Martin,
- Fréderic Percevault,
- Olivier Barbier,
- Jean-Charles Fruchart,
- Folkert Kuipers,
- and Bart Staels
Glucose Regulates the Expression of the Farnesoid X Receptor in Liver
Diabetes April 2004 53:890-898; doi:10.2337/diabetes.53.4.890
Select this article
- Hye-Sook Kwon,
- Boli Huang,
- Terry G. Unterman,
- and Robert A. Harris
Protein Kinase B-α Inhibits Human Pyruvate Dehydrogenase Kinase-4 Gene Induction by Dexamethasone Through Inactivation of FOXO Transcription Factors
Diabetes April 2004 53:899-910; doi:10.2337/diabetes.53.4.899
Select this article
- Joseph F. Kelly,
- Carol F. Elias,
- Charlotte E. Lee,
- Rexford S. Ahima,
- Randy J. Seeley,
- Christian Bjørbæk,
- Takakazu Oka,
- Clifford B. Saper,
- Jeffrey S. Flier,
- and Joel K. Elmquist
Ciliary Neurotrophic Factor and Leptin Induce Distinct Patterns of Immediate Early Gene Expression in the Brain
Diabetes April 2004 53:911-920; doi:10.2337/diabetes.53.4.911
Select this article
- Edward B. Arias,
- Junghoon Kim,
- and Gregory D. Cartee
Prolonged Incubation in PUGNAc Results in Increased Protein O-Linked Glycosylation and Insulin Resistance in Rat Skeletal Muscle
Diabetes April 2004 53:921-930; doi:10.2337/diabetes.53.4.921

Obesity Study

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- Nicholas M. Morton,
- Janice M. Paterson,
- Hiroaki Masuzaki,
- Megan C. Holmes,
- Bart Staels,
- Catherine Fievet,
- Brian R. Walker,
- Jeffrey S. Flier,
- John J. Mullins,
- and Jonathan R. Seckl
Novel Adipose Tissue–Mediated Resistance to Diet-Induced Visceral Obesity in 11β-Hydroxysteroid Dehydrogenase Type 1–Deficient Mice
Diabetes April 2004 53:931-938; doi:10.2337/diabetes.53.4.931
Select this article
- Menotti Calvani,
- Antonio Scarfone,
- Luigi Granato,
- Elena Valera Mora,
- Giuseppe Nanni,
- Marco Castagneto,
- Aldo V. Greco,
- Melania Manco,
- and Geltrude Mingrone
Restoration of Adiponectin Pulsatility in Severely Obese Subjects After Weight Loss
Diabetes April 2004 53:939-947; doi:10.2337/diabetes.53.4.939

Immunology and Transplantation

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- Göran Mattsson,
- Leif Jansson,
- Astrid Nordin,
- Arne Andersson,
- and Per-Ola Carlsson
Evidence of Functional Impairment of Syngeneically Transplanted Mouse Pancreatic Islets Retrieved from the Liver
Diabetes April 2004 53:948-954; doi:10.2337/diabetes.53.4.948
Select this article
- Edmond A. Ryan,
- Tami Shandro,
- Kristy Green,
- Breay W. Paty,
- Peter A. Senior,
- David Bigam,
- A.M. James Shapiro,
- and Marie-Christine Vantyghem
Assessment of the Severity of Hypoglycemia and Glycemic Lability in Type 1 Diabetic Subjects Undergoing Islet Transplantation
Diabetes April 2004 53:955-962; doi:10.2337/diabetes.53.4.955
Select this article
- Nan Zhang,
- Anja Richter,
- Jenny Suriawinata,
- Sonal Harbaran,
- Jennifer Altomonte,
- Lin Cong,
- Haojiang Zhang,
- Keying Song,
- Marcia Meseck,
- Jonathan Bromberg,
- and Hengjiang Dong
Elevated Vascular Endothelial Growth Factor Production in Islets Improves Islet Graft Vascularization
Diabetes April 2004 53:963-970; doi:10.2337/diabetes.53.4.963
Select this article
- Roberto Mallone,
- Sharon A. Kochik,
- Elsa M. Laughlin,
- Vivian H. Gersuk,
- Helena Reijonen,
- William W. Kwok,
- and Gerald T. Nepom
Differential Recognition and Activation Thresholds in Human Autoreactive GAD-Specific T-Cells
Diabetes April 2004 53:971-977; doi:10.2337/diabetes.53.4.971
Select this article
- Mary E. Pauza,
- Cathleen M. Dobbs,
- Jing He,
- Tricia Patterson,
- Steven Wagner,
- Brian S. Anobile,
- Brenda J. Bradley,
- David Lo,
- and Kathryn Haskins
T-Cell Receptor Transgenic Response to an Endogenous Polymorphic Autoantigen Determines Susceptibility to Diabetes
Diabetes April 2004 53:978-988; doi:10.2337/diabetes.53.4.978

Islet Study

Select this article
- Christos Tikellis,
- Peter J. Wookey,
- Riccardo Candido,
- Sof Andrikopoulos,
- Merlin C. Thomas,
- and Mark E. Cooper
Improved Islet Morphology after Blockade of the Renin- Angiotensin System in the ZDF Rat
Diabetes April 2004 53:989-997; doi:10.2337/diabetes.53.4.989
Select this article
- Shunsuke Uehara,
- Akiko Muroyama,
- Noriko Echigo,
- Riyo Morimoto,
- Masato Otsuka,
- Shouki Yatsushiro,
- and Yoshinori Moriyama
Metabotropic Glutamate Receptor Type 4 Is Involved in Autoinhibitory Cascade for Glucagon Secretion by α-Cells of Islet of Langerhans
Diabetes April 2004 53:998-1006; doi:10.2337/diabetes.53.4.998
Select this article
- Raphaël Roduit,
- Christopher Nolan,
- Cristina Alarcon,
- Patrick Moore,
- Annie Barbeau,
- Viviane Delghingaro-Augusto,
- Ewa Przybykowski,
- Johane Morin,
- Frédéric Massé,
- Bernard Massie,
- Neil Ruderman,
- Christopher Rhodes,
- Vincent Poitout,
- and Marc Prentki
A Role for the Malonyl-CoA/Long-Chain Acyl-CoA Pathway of Lipid Signaling in the Regulation of Insulin Secretion in Response to Both Fuel and Nonfuel Stimuli
Diabetes April 2004 53:1007-1019; doi:10.2337/diabetes.53.4.1007
Select this article
- Laura Massa,
- Simone Baltrusch,
- David A. Okar,
- Alex J. Lange,
- Sigurd Lenzen,
- and Markus Tiedge
Interaction of 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase (PFK-2/FBPase-2) With Glucokinase Activates Glucose Phosphorylation and Glucose Metabolism in Insulin-Producing Cells
Diabetes April 2004 53:1020-1029; doi:10.2337/diabetes.53.4.1020
Select this article
- Satsuki Miyazaki,
- Eiji Yamato,
- and Jun-ichi Miyazaki
Regulated Expression of pdx-1 Promotes In Vitro Differentiation of Insulin-Producing Cells From Embryonic Stem Cells
Diabetes April 2004 53:1030-1037; doi:10.2337/diabetes.53.4.1030
Select this article
- Anna Wendt,
- Bryndis Birnir,
- Karsten Buschard,
- Jesper Gromada,
- Albert Salehi,
- Sabine Sewing,
- Patrik Rorsman,
- and Matthias Braun
Glucose Inhibition of Glucagon Secretion From Rat α-Cells Is Mediated by GABA Released From Neighboring β-Cells
Diabetes April 2004 53:1038-1045; doi:10.2337/diabetes.53.4.1038

Pathophysiology

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- Evelyne Véricel,
- Caroline Januel,
- Martine Carreras,
- Philippe Moulin,
- and Michel Lagarde
Diabetic Patients Without Vascular Complications Display Enhanced Basal Platelet Activation and Decreased Antioxidant Status
Diabetes April 2004 53:1046-1051; doi:10.2337/diabetes.53.4.1046
Select this article
- Barbara Brunmair,
- Katrin Staniek,
- Florian Gras,
- Nicole Scharf,
- Aleksandra Althaym,
- Renate Clara,
- Michael Roden,
- Erich Gnaiger,
- Hans Nohl,
- Werner Waldhäusl,
- and Clemens Fürnsinn
Thiazolidinediones, Like Metformin, Inhibit Respiratory Complex I: A Common Mechanism Contributing to Their Antidiabetic Actions?
Diabetes April 2004 53:1052-1059; doi:10.2337/diabetes.53.4.1052
Select this article
- Hyo-Jeong Kim,
- Takamasa Higashimori,
- So-Young Park,
- Hyejeong Choi,
- Jianying Dong,
- Yoon-Jung Kim,
- Hye-Lim Noh,
- You-Ree Cho,
- Gary Cline,
- Young-Bum Kim,
- and Jason K. Kim
Differential Effects of Interleukin-6 and -10 on Skeletal Muscle and Liver Insulin Action In Vivo
Diabetes April 2004 53:1060-1067; doi:10.2337/diabetes.53.4.1060
Select this article
- Paul Holvoet,
- Stephen B. Kritchevsky,
- Russell P. Tracy,
- Ann Mertens,
- Susan M. Rubin,
- Javed Butler,
- Bret Goodpaster,
- and Tamara B. Harris
The Metabolic Syndrome, Circulating Oxidized LDL, and Risk of Myocardial Infarction in Well-Functioning Elderly People in the Health, Aging, and Body Composition Cohort
Diabetes April 2004 53:1068-1073; doi:10.2337/diabetes.53.4.1068
Select this article
- Yi Pang,
- Pam Bounelis,
- John C. Chatham,
- and Richard B. Marchase
Hexosamine Pathway Is Responsible for Inhibition by Diabetes of Phenylephrine-Induced Inotropy
Diabetes April 2004 53:1074-1081; doi:10.2337/diabetes.53.4.1074
Select this article
- Manuela Aragno,
- Raffaella Mastrocola,
- Maria Graziella Catalano,
- Enrico Brignardello,
- Oliviero Danni,
- and Giuseppe Boccuzzi
Oxidative Stress Impairs Skeletal Muscle Repair in Diabetic Rats
Diabetes April 2004 53:1082-1088; doi:10.2337/diabetes.53.4.1082
Select this article
- Kresten Skak,
- Carsten F. Gotfredsen,
- Dorthe Lundsgaard,
- John Bondo Hansen,
- Jeppe Sturis,
- and Helle Markholst
Improved β-Cell Survival and Reduced Insulitis in a Type 1 Diabetic Rat Model After Treatment With a β-Cell–Selective K_ATP Channel Opener
Diabetes April 2004 53:1089-1095; doi:10.2337/diabetes.53.4.1089

Complication

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- Costanza Emanueli,
- Galliam Graiani,
- Maria B. Salis,
- Sergio Gadau,
- Elisa Desortes,
- and Paolo Madeddu
Prophylactic Gene Therapy With Human Tissue Kallikrein Ameliorates Limb Ischemia Recovery in Type 1 Diabetic Mice
Diabetes April 2004 53:1096-1103; doi:10.2337/diabetes.53.4.1096
Select this article
- Hans-Peter Hammes,
- Jihong Lin,
- Patrick Wagner,
- Yuxi Feng,
- Franziska vom Hagen,
- Thomas Krzizok,
- Oliver Renner,
- Georg Breier,
- Michael Brownlee,
- and Urban Deutsch
Angiopoietin-2 Causes Pericyte Dropout in the Normal Retina: Evidence for Involvement in Diabetic Retinopathy
Diabetes April 2004 53:1104-1110; doi:10.2337/diabetes.53.4.1104
Select this article
- Maria E. Pueyo,
- Mireille Challah,
- Dominique Gauguier,
- Liliane Louedec,
- Monique Philippe,
- Roger Gaertner,
- Michel Marre,
- Jean-Baptiste Michel,
- and Marie-Paule Jacob
Transforming Growth Factor-β1 Production Is Correlated With Genetically Determined ACE Expression in Congenic Rats: A Possible Link Between ACE Genotype and Diabetic Nephropathy
Diabetes April 2004 53:1111-1118; doi:10.2337/diabetes.53.4.1111
Select this article
- Josep M. Cruzado,
- Núria Lloberas,
- Joan Torras,
- Marta Riera,
- Cristina Fillat,
- Immaculada Herrero-Fresneda,
- Josep M. Aran,
- Gabriela Alperovich,
- August Vidal,
- and Josep M. Grinyó
Regression of Advanced Diabetic Nephropathy by Hepatocyte Growth Factor Gene Therapy in Rats
Diabetes April 2004 53:1119-1127; doi:10.2337/diabetes.53.4.1119

Genetics

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- Ken K. Ong,
- Clive J. Petry,
- Bryan J. Barratt,
- Susan Ring,
- Heather J. Cordell,
- Diane L. Wingate,
- Marcus E. Pembrey,
- John A. Todd,
- and David B. Dunger
Maternal-Fetal Interactions and Birth Order Influence Insulin Variable Number of Tandem Repeats Allele Class Associations with Head Size at Birth and Childhood Weight Gain
Diabetes April 2004 53:1128-1133; doi:10.2337/diabetes.53.4.1128
Select this article
- Latisha D. Love-Gregory,
- Jonathon Wasson,
- Jiyan Ma,
- Carol H. Jin,
- Benjamin Glaser,
- Brian K. Suarez,
- and M. Alan Permutt
A Common Polymorphism in the Upstream Promoter Region of the Hepatocyte Nuclear Factor-4α Gene on Chromosome 20q Is Associated With Type 2 Diabetes and Appears to Contribute to the Evidence for Linkage in an Ashkenazi Jewish Population
Diabetes April 2004 53:1134-1140; published ahead of print March 9, 2004, doi:10.2337/diabetes.53.4.1134
Select this article
- Kaisa Silander,
- Karen L. Mohlke,
- Laura J. Scott,
- Erin C. Peck,
- Pablo Hollstein,
- Andrew D. Skol,
- Anne U. Jackson,
- Panagiotis Deloukas,
- Sarah Hunt,
- George Stavrides,
- Peter S. Chines,
- Michael R. Erdos,
- Narisu Narisu,
- Karen N. Conneely,
- Chun Li,
- Tasha E. Fingerlin,
- Sharanjeet K. Dhanjal,
- Timo T. Valle,
- Richard N. Bergman,
- Jaakko Tuomilehto,
- Richard M. Watanabe,
- Michael Boehnke,
- and Francis S. Collins
Genetic Variation Near the Hepatocyte Nuclear Factor-4α Gene Predicts Susceptibility to Type 2 Diabetes
Diabetes April 2004 53:1141-1149; published ahead of print March 9, 2004, doi:10.2337/diabetes.53.4.1141

Brief Genetics Report

Select this article
- Frédéric Fumeron,
- Roberte Aubert,
- Afshan Siddiq,
- Dina Betoulle,
- Frank Péan,
- Samy Hadjadj,
- Jean Tichet,
- Elsie Wilpart,
- Marie-Claude Chesnier,
- Beverley Balkau,
- Philippe Froguel,
- and Michel Marre
Adiponectin Gene Polymorphisms and Adiponectin Levels Are Independently Associated With the Development of Hyperglycemia During a 3-Year Period: The Epidemiologic Data on the Insulin Resistance Syndrome Prospective Study
Diabetes April 2004 53:1150-1157; doi:10.2337/diabetes.53.4.1150
Select this article
- Adrian Vella,
- Joanna M.M. Howson,
- Bryan J. Barratt,
- Rebecca C.J. Twells,
- Helen E. Rance,
- Sarah Nutland,
- Eva Tuomilehto-Wolf,
- Jaakko Tuomilehto,
- Dag E. Undlien,
- Kjersti S. Rønningen,
- Cristian Guja,
- Constantin Ionescu-Tîrgovişte,
- David A. Savage,
- and John A. Todd
Lack of Association of the Ala⁴⁵Thr Polymorphism and Other Common Variants of the NeuroD Gene With Type 1 Diabetes
Diabetes April 2004 53:1158-1161; doi:10.2337/diabetes.53.4.1158
Select this article
- Bryan R. Conway,
- A. Peter Maxwell,
- David A. Savage,
- Chris C. Patterson,
- Peter P. Doran,
- Madeline Murphy,
- Hugh R. Brady,
- and Damian G. Fogarty
Association Between Variation in the Actin-Binding Gene Caldesmon and Diabetic Nephropathy in Type 1 Diabetes
Diabetes April 2004 53:1162-1165; doi:10.2337/diabetes.53.4.1162
Select this article
- Melissa A. Austin,
- Karen L. Edwards,
- Marguerite J. McNeely,
- Wayne L. Chandler,
- Donna L. Leonetti,
- Philippa J. Talmud,
- Steve E. Humphries,
- and Wilfred Y. Fujimoto
Heritability of Multivariate Factors of the Metabolic Syndrome in Nondiabetic Japanese Americans
Diabetes April 2004 53:1166-1169; doi:10.2337/diabetes.53.4.1166
Select this article
- Carl D. Langefeld,
- Lynne E. Wagenknecht,
- Jerome I. Rotter,
- Adrienne H. Williams,
- John E. Hokanson,
- Mohammad F. Saad,
- Donald W. Bowden,
- Stephen Haffner,
- Jill M. Norris,
- Stephen S. Rich,
- and Braxton D. Mitchell
Linkage of the Metabolic Syndrome to 1q23-q31 in Hispanic Families: The Insulin Resistance Atherosclerosis Study Family Study
Diabetes April 2004 53:1170-1174; doi:10.2337/diabetes.53.4.1170

Erratum

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Erratum
Diabetes April 2004 53:1175-1176; doi:10.2337/diabetes.53.4.1175
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Erratum
Diabetes April 2004 53:1177-1178; doi:10.2337/diabetes.53.4.1177

Diabetes

Metabolism

Inhalation of Insulin in Dogs: Assessment of Insulin Levels and Comparison to Subcutaneous Injection

Signal Transduction

Modulation of Resistin Expression by Retinoic Acid and Vitamin A Status

Glucose Regulates the Expression of the Farnesoid X Receptor in Liver

Protein Kinase B-α Inhibits Human Pyruvate Dehydrogenase Kinase-4 Gene Induction by Dexamethasone Through Inactivation of FOXO Transcription Factors

Ciliary Neurotrophic Factor and Leptin Induce Distinct Patterns of Immediate Early Gene Expression in the Brain

Prolonged Incubation in PUGNAc Results in Increased Protein O-Linked Glycosylation and Insulin Resistance in Rat Skeletal Muscle

Obesity Study

Novel Adipose Tissue–Mediated Resistance to Diet-Induced Visceral Obesity in 11β-Hydroxysteroid Dehydrogenase Type 1–Deficient Mice

Restoration of Adiponectin Pulsatility in Severely Obese Subjects After Weight Loss

Immunology and Transplantation

Evidence of Functional Impairment of Syngeneically Transplanted Mouse Pancreatic Islets Retrieved from the Liver

Assessment of the Severity of Hypoglycemia and Glycemic Lability in Type 1 Diabetic Subjects Undergoing Islet Transplantation

Elevated Vascular Endothelial Growth Factor Production in Islets Improves Islet Graft Vascularization

Differential Recognition and Activation Thresholds in Human Autoreactive GAD-Specific T-Cells

T-Cell Receptor Transgenic Response to an Endogenous Polymorphic Autoantigen Determines Susceptibility to Diabetes

Islet Study

Improved Islet Morphology after Blockade of the Renin- Angiotensin System in the ZDF Rat

Metabotropic Glutamate Receptor Type 4 Is Involved in Autoinhibitory Cascade for Glucagon Secretion by α-Cells of Islet of Langerhans

A Role for the Malonyl-CoA/Long-Chain Acyl-CoA Pathway of Lipid Signaling in the Regulation of Insulin Secretion in Response to Both Fuel and Nonfuel Stimuli

Interaction of 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase (PFK-2/FBPase-2) With Glucokinase Activates Glucose Phosphorylation and Glucose Metabolism in Insulin-Producing Cells

Regulated Expression of pdx-1 Promotes In Vitro Differentiation of Insulin-Producing Cells From Embryonic Stem Cells

Glucose Inhibition of Glucagon Secretion From Rat α-Cells Is Mediated by GABA Released From Neighboring β-Cells

Pathophysiology

Diabetic Patients Without Vascular Complications Display Enhanced Basal Platelet Activation and Decreased Antioxidant Status

Thiazolidinediones, Like Metformin, Inhibit Respiratory Complex I: A Common Mechanism Contributing to Their Antidiabetic Actions?

Differential Effects of Interleukin-6 and -10 on Skeletal Muscle and Liver Insulin Action In Vivo

The Metabolic Syndrome, Circulating Oxidized LDL, and Risk of Myocardial Infarction in Well-Functioning Elderly People in the Health, Aging, and Body Composition Cohort

Hexosamine Pathway Is Responsible for Inhibition by Diabetes of Phenylephrine-Induced Inotropy

Oxidative Stress Impairs Skeletal Muscle Repair in Diabetic Rats

Improved β-Cell Survival and Reduced Insulitis in a Type 1 Diabetic Rat Model After Treatment With a β-Cell–Selective KATP Channel Opener

Complication

Prophylactic Gene Therapy With Human Tissue Kallikrein Ameliorates Limb Ischemia Recovery in Type 1 Diabetic Mice

Angiopoietin-2 Causes Pericyte Dropout in the Normal Retina: Evidence for Involvement in Diabetic Retinopathy

Transforming Growth Factor-β1 Production Is Correlated With Genetically Determined ACE Expression in Congenic Rats: A Possible Link Between ACE Genotype and Diabetic Nephropathy

Regression of Advanced Diabetic Nephropathy by Hepatocyte Growth Factor Gene Therapy in Rats

Genetics

Maternal-Fetal Interactions and Birth Order Influence Insulin Variable Number of Tandem Repeats Allele Class Associations with Head Size at Birth and Childhood Weight Gain

A Common Polymorphism in the Upstream Promoter Region of the Hepatocyte Nuclear Factor-4α Gene on Chromosome 20q Is Associated With Type 2 Diabetes and Appears to Contribute to the Evidence for Linkage in an Ashkenazi Jewish Population

Genetic Variation Near the Hepatocyte Nuclear Factor-4α Gene Predicts Susceptibility to Type 2 Diabetes

Brief Genetics Report

Adiponectin Gene Polymorphisms and Adiponectin Levels Are Independently Associated With the Development of Hyperglycemia During a 3-Year Period: The Epidemiologic Data on the Insulin Resistance Syndrome Prospective Study

Lack of Association of the Ala45Thr Polymorphism and Other Common Variants of the NeuroD Gene With Type 1 Diabetes

Association Between Variation in the Actin-Binding Gene Caldesmon and Diabetic Nephropathy in Type 1 Diabetes

Heritability of Multivariate Factors of the Metabolic Syndrome in Nondiabetic Japanese Americans

Linkage of the Metabolic Syndrome to 1q23-q31 in Hispanic Families: The Insulin Resistance Atherosclerosis Study Family Study

Erratum

Erratum

Erratum

This Issue

Current Issue

Improved β-Cell Survival and Reduced Insulitis in a Type 1 Diabetic Rat Model After Treatment With a β-Cell–Selective K_ATP Channel Opener

Lack of Association of the Ala⁴⁵Thr Polymorphism and Other Common Variants of the NeuroD Gene With Type 1 Diabetes