Prolonged Incubation in PUGNAc Results in Increased Protein O-Linked Glycosylation and Insulin Resistance in Rat Skeletal
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Phosphorylation status of Akt(S473) following 19 h of incubation of muscle with or without 100 μmol/l PUGNAc. Paired muscles
incubated with or without PUGNAc for 19 h and with 0.6 nmol/l insulin (A) during the final 75 min of incubation (n = 7 per group) or 12 nmol/l insulin (B) during the final 75 min of incubation (n= 8 per group). Bands corresponding to P-Akt(S473) were quantitated by densitometry and expressed as the mean ± SE.