Table of Contents

Rapid Publication

Select this article
- Claire Beuneu,
- Olivier Vosters,
- Babak Movahedi,
- Myriam Remmelink,
- Isabelle Salmon,
- Daniel Pipeleers,
- Olivier Pradier,
- Michel Goldman,
- and Valérie Verhasselt
Human Pancreatic Duct Cells Exert Tissue Factor-Dependent Procoagulant Activity: Relevance to Islet Transplantation
Diabetes June 2004 53:1407-1411; published ahead of print April 7, 2004, doi:10.2337/diabetes.53.6.1407

Perspective in Diabetes

Select this article
- Patrick Schrauwen and
- Matthijs K.C. Hesselink
Oxidative Capacity, Lipotoxicity, and Mitochondrial Damage in Type 2 Diabetes
Diabetes June 2004 53:1412-1417; doi:10.2337/diabetes.53.6.1412

Metabolism

Select this article
- Michelle A. Vincent,
- Lucy H. Clerk,
- Jonathan R. Lindner,
- Alexander L. Klibanov,
- Michael G. Clark,
- Stephen Rattigan,
- and Eugene J. Barrett
Microvascular Recruitment Is an Early Insulin Effect That Regulates Skeletal Muscle Glucose Uptake In Vivo
Diabetes June 2004 53:1418-1423; doi:10.2337/diabetes.53.6.1418
Select this article
- Håkan K.R. Karlsson,
- Hiroki Tsuchida,
- Staffan Lake,
- Heikki A. Koistinen,
- and Anna Krook
Relationship Between Serum Amyloid A Level and Tanis/SelS mRNA Expression in Skeletal Muscle and Adipose Tissue From Healthy and Type 2 Diabetic Subjects
Diabetes June 2004 53:1424-1428; doi:10.2337/diabetes.53.6.1424

Signal Transduction

Select this article
- Jane Shearer,
- Patrick T. Fueger,
- Brittney Vorndick,
- Deanna P. Bracy,
- Jeffery N. Rottman,
- Jeffery A. Clanton,
- and David H. Wasserman
AMP Kinase-Induced Skeletal Muscle Glucose But Not Long-Chain Fatty Acid Uptake Is Dependent on Nitric Oxide
Diabetes June 2004 53:1429-1435; doi:10.2337/diabetes.53.6.1429
Select this article
- Ying Leng,
- Tatiana L. Steiler,
- and Juleen R. Zierath
Effects of Insulin, Contraction, and Phorbol Esters on Mitogen-Activated Protein Kinase Signaling in Skeletal Muscle From Lean and ob/ob Mice
Diabetes June 2004 53:1436-1444; doi:10.2337/diabetes.53.6.1436
Select this article
- Hubert C. Chen,
- Meghana Rao,
- Mini P. Sajan,
- Mary Standaert,
- Yoshinori Kanoh,
- Atsushi Miura,
- Robert V. Farese, Jr.,
- and Robert V. Farese
Role of Adipocyte-Derived Factors in Enhancing Insulin Signaling in Skeletal Muscle and White Adipose Tissue of Mice Lacking Acyl CoA:Diacylglycerol Acyltransferase 1
Diabetes June 2004 53:1445-1451; doi:10.2337/diabetes.53.6.1445

Immunology and Transplantation

Select this article
- Claire L. Price,
- Patrick S. Sharp,
- Margaret E. North,
- Sandra J. Rainbow,
- and Stella C. Knight
Advanced Glycation End Products Modulate the Maturation and Function of Peripheral Blood Dendritic Cells
Diabetes June 2004 53:1452-1458; doi:10.2337/diabetes.53.6.1452
Select this article
- Anna Moore,
- Jan Grimm,
- Bingye Han,
- and Pere Santamaria
Tracking the Recruitment of Diabetogenic CD8⁺ T-Cells to the Pancreas in Real Time
Diabetes June 2004 53:1459-1466; doi:10.2337/diabetes.53.6.1459

Islet Study

Select this article
- Anne-Dominique Lajoix,
- Martine Pugnière,
- Françoise Roquet,
- Jean-Claude Mani,
- Samuel Dietz,
- Nathalie Linck,
- Fleur Faurie,
- Gérard Ribes,
- Pierre Petit,
- and René Gross
Changes in the Dimeric State of Neuronal Nitric Oxide Synthase Affect the Kinetics of Secretagogue-Induced Insulin Response
Diabetes June 2004 53:1467-1474; doi:10.2337/diabetes.53.6.1467
Select this article
- Xiao Yu,
- Koji Murao,
- Yoshitaka Sayo,
- Hitomi Imachi,
- Wen M. Cao,
- Shouji Ohtsuka,
- Michio Niimi,
- Hiroshi Tokumitsu,
- Hiroyuki Inuzuka,
- Norman C.W. Wong,
- Ryoji Kobayashi,
- and Toshihiko Ishida
The Role of Calcium/Calmodulin-Dependent Protein Kinase Cascade in Glucose Upregulation of Insulin Gene Expression
Diabetes June 2004 53:1475-1481; doi:10.2337/diabetes.53.6.1475
Select this article
- Huarong Zhou,
- Phuong Oanh T. Tran,
- Shilin Yang,
- Tao Zhang,
- Eric LeRoy,
- Elizabeth Oseid,
- and R. Paul Robertson
Regulation of α-Cell Function by the β-Cell During Hypoglycemia in Wistar Rats: the “Switch-off” Hypothesis
Diabetes June 2004 53:1482-1487; doi:10.2337/diabetes.53.6.1482
Select this article
- Kristine M. Hope,
- Phuong Oanh T. Tran,
- Huarong Zhou,
- Elizabeth Oseid,
- Eric Leroy,
- and R. Paul Robertson
Regulation of α-Cell Function by the β-Cell in Isolated Human and Rat Islets Deprived of Glucose: the “Switch-off” Hypothesis
Diabetes June 2004 53:1488-1495; doi:10.2337/diabetes.53.6.1488
Select this article
- Mitsuru Ohsugi,
- Corentin Cras-Méneur,
- Yiyong Zhou,
- Wesley Warren,
- Ernesto Bernal-Mizrachi,
- and M. Alan Permutt
Glucose and Insulin Treatment of Insulinoma Cells Results in Transcriptional Regulation of a Common Set of Genes
Diabetes June 2004 53:1496-1508; doi:10.2337/diabetes.53.6.1496
Select this article
- Alexandra E. Butler,
- Jennifer Jang,
- Tatyana Gurlo,
- Maynard D. Carty,
- Walter C. Soeller,
- and Peter C. Butler
Diabetes Due to a Progressive Defect in β-Cell Mass in Rats Transgenic for Human Islet Amyloid Polypeptide (HIP Rat): A New Model for Type 2 Diabetes
Diabetes June 2004 53:1509-1516; doi:10.2337/diabetes.53.6.1509
Select this article
- Rohit N. Kulkarni,
- Michael G. Roper,
- Gabriella Dahlgren,
- David Q. Shih,
- Lisa M. Kauri,
- Jennifer L. Peters,
- Markus Stoffel,
- and Robert T. Kennedy
Islet Secretory Defect in Insulin Receptor Substrate 1 Null Mice Is Linked With Reduced Calcium Signaling and Expression of Sarco(endo)plasmic Reticulum Ca²⁺-ATPase (SERCA)-2b and -3
Diabetes June 2004 53:1517-1525; doi:10.2337/diabetes.53.6.1517
Select this article
- Sophie Julien,
- Jean Laine,
- and Jean Morisset
Regulation of Rat Pancreatic CCK_B Receptor and Somatostatin Expression by Insulin
Diabetes June 2004 53:1526-1534; doi:10.2337/diabetes.53.6.1526

Pathophysiology

Select this article
- Stuart P. Lee,
- Lishan Yeoh,
- Nigel D. Harris,
- Catherine M. Davies,
- Robert T. Robinson,
- Andrew Leathard,
- Christopher Newman,
- Ian A. Macdonald,
- and Simon R. Heller
Influence of Autonomic Neuropathy on QTc Interval Lengthening During Hypoglycemia in Type 1 Diabetes
Diabetes June 2004 53:1535-1542; doi:10.2337/diabetes.53.6.1535
Select this article
- Henning Andersen,
- Søren Nielsen,
- Carl E. Mogensen,
- and Johannes Jakobsen
Muscle Strength in Type 2 Diabetes
Diabetes June 2004 53:1543-1548; doi:10.2337/diabetes.53.6.1543
Select this article
- Andreas Festa,
- Ralph D’Agostino, Jr.,
- Anthony J.G. Hanley,
- Andrew J. Karter,
- Mohammed F. Saad,
- and Steven M. Haffner
Differences in Insulin Resistance in Nondiabetic Subjects With Isolated Impaired Glucose Tolerance or Isolated Impaired Fasting Glucose
Diabetes June 2004 53:1549-1555; doi:10.2337/diabetes.53.6.1549

Complication

Select this article
- Anders A.F. Sima,
- Weixian Zhang,
- Zhen-Guo Li,
- Yuichi Murakawa,
- and Christopher R. Pierson
Molecular Alterations Underlie Nodal and Paranodal Degeneration in Type 1 Diabetic Neuropathy and Are Prevented by C-Peptide
Diabetes June 2004 53:1556-1563; doi:10.2337/diabetes.53.6.1556
Select this article
- Dominique Sigaudo-Roussel,
- Claire Demiot,
- Bérengère Fromy,
- Audrey Koïtka,
- Georges Lefthériotis,
- Pierre Abraham,
- and Jean Louis Saumet
Early Endothelial Dysfunction Severely Impairs Skin Blood Flow Response to Local Pressure Application in Streptozotocin-Induced Diabetic Mice
Diabetes June 2004 53:1564-1569; doi:10.2337/diabetes.53.6.1564
Select this article
- Troels K. Hansen,
- Lise Tarnow,
- Steffen Thiel,
- Rudi Steffensen,
- Coen D. Stehouwer,
- Casper G. Schalkwijk,
- Hans-Henrik Parving,
- and Allan Flyvbjerg
Association Between Mannose-Binding Lectin and Vascular Complications in Type 1 Diabetes
Diabetes June 2004 53:1570-1576; doi:10.2337/diabetes.53.6.1570

Genetics

Select this article
- Ayo A. Toye,
- Lee Moir,
- Alison Hugill,
- Liz Bentley,
- Julie Quarterman,
- Vesna Mijat,
- Tertius Hough,
- Michelle Goldsworthy,
- Alison Haynes,
- A. Jacqueline Hunter,
- Mick Browne,
- Nigel Spurr,
- and Roger D. Cox
A New Mouse Model of Type 2 Diabetes, Produced by N-Ethyl-Nitrosourea Mutagenesis, Is the Result of a Missense Mutation in the Glucokinase Gene
Diabetes June 2004 53:1577-1583; doi:10.2337/diabetes.53.6.1577
Select this article
- Pernilla Holm,
- Berit Rydlander,
- Holger Luthman,
- and Ingrid Kockum
Interaction and Association Analysis of a Type 1 Diabetes Susceptibility Locus on Chromosome 5q11-q13 and the 7q32 Chromosomal Region in Scandinavian Families
Diabetes June 2004 53:1584-1591; doi:10.2337/diabetes.53.6.1584
Select this article
- Kurt Højlund,
- Torben Hansen,
- Maria Lajer,
- Jan Erik Henriksen,
- Klaus Levin,
- Jörgen Lindholm,
- Oluf Pedersen,
- and Henning Beck-Nielsen
A Novel Syndrome of Autosomal-Dominant Hyperinsulinemic Hypoglycemia Linked to a Mutation in the Human Insulin Receptor Gene
Diabetes June 2004 53:1592-1598; doi:10.2337/diabetes.53.6.1592

Brief Genetics Report

Select this article
- Bin Xu,
- Shi-Quan Hu,
- Ying-Chi Chu,
- Shuhua Wang,
- Run-ying Wang,
- Satoe H. Nakagawa,
- Panayotis G. Katsoyannis,
- and Michael A. Weiss
Diabetes-Associated Mutations in Insulin Identify Invariant Receptor Contacts
Diabetes June 2004 53:1599-1602; doi:10.2337/diabetes.53.6.1599
Select this article
- Timo A. Lakka,
- Tuomo Rankinen,
- S. John Weisnagel,
- Yvon C. Chagnon,
- Hanna-Maaria Lakka,
- Olavi Ukkola,
- Normand Boulé,
- Treva Rice,
- Arthur S. Leon,
- James S. Skinner,
- Jack H. Wilmore,
- D.C. Rao,
- Richard Bergman,
- and Claude Bouchard
Leptin and Leptin Receptor Gene Polymorphisms and Changes in Glucose Homeostasis in Response to Regular Exercise in Nondiabetic Individuals: The HERITAGE Family Study
Diabetes June 2004 53:1603-1608; doi:10.2337/diabetes.53.6.1603
Select this article
- Maggie C.Y. Ng,
- Wing-Yee So,
- Nancy J. Cox,
- Vincent K.L. Lam,
- Clive S. Cockram,
- Julian A.J.H. Critchley,
- Graeme I. Bell,
- and Juliana C.N. Chan
Genome-wide Scan for Type 2 Diabetes Loci in Hong Kong Chinese and Confirmation of a Susceptibility Locus on Chromosome 1q21-q25
Diabetes June 2004 53:1609-1613; doi:10.2337/diabetes.53.6.1609

Pharmacology and Therapeutics

Select this article
- Tim Heise,
- Leszek Nosek,
- Birgitte Biilmann Rønn,
- Lars Endahl,
- Lutz Heinemann,
- Christoph Kapitza,
- and Eberhard Draeger
Lower Within-Subject Variability of Insulin Detemir in Comparison to NPH Insulin and Insulin Glargine in People With Type 1 Diabetes
Diabetes June 2004 53:1614-1620; doi:10.2337/diabetes.53.6.1614
Select this article
- Julia Tonelli,
- Weijie Li,
- Preeti Kishore,
- Utpal B. Pajvani,
- Elize Kwon,
- Charles Weaver,
- Philipp E. Scherer,
- and Meredith Hawkins
Mechanisms of Early Insulin-Sensitizing Effects of Thiazolidinediones in Type 2 Diabetes
Diabetes June 2004 53:1621-1629; doi:10.2337/diabetes.53.6.1621

Diabetes

Rapid Publication

Human Pancreatic Duct Cells Exert Tissue Factor-Dependent Procoagulant Activity: Relevance to Islet Transplantation

Perspective in Diabetes

Oxidative Capacity, Lipotoxicity, and Mitochondrial Damage in Type 2 Diabetes

Metabolism

Microvascular Recruitment Is an Early Insulin Effect That Regulates Skeletal Muscle Glucose Uptake In Vivo

Relationship Between Serum Amyloid A Level and Tanis/SelS mRNA Expression in Skeletal Muscle and Adipose Tissue From Healthy and Type 2 Diabetic Subjects

Signal Transduction

AMP Kinase-Induced Skeletal Muscle Glucose But Not Long-Chain Fatty Acid Uptake Is Dependent on Nitric Oxide

Effects of Insulin, Contraction, and Phorbol Esters on Mitogen-Activated Protein Kinase Signaling in Skeletal Muscle From Lean and ob/ob Mice

Role of Adipocyte-Derived Factors in Enhancing Insulin Signaling in Skeletal Muscle and White Adipose Tissue of Mice Lacking Acyl CoA:Diacylglycerol Acyltransferase 1

Immunology and Transplantation

Advanced Glycation End Products Modulate the Maturation and Function of Peripheral Blood Dendritic Cells

Tracking the Recruitment of Diabetogenic CD8+ T-Cells to the Pancreas in Real Time

Islet Study

Changes in the Dimeric State of Neuronal Nitric Oxide Synthase Affect the Kinetics of Secretagogue-Induced Insulin Response

The Role of Calcium/Calmodulin-Dependent Protein Kinase Cascade in Glucose Upregulation of Insulin Gene Expression

Regulation of α-Cell Function by the β-Cell During Hypoglycemia in Wistar Rats: the “Switch-off” Hypothesis

Regulation of α-Cell Function by the β-Cell in Isolated Human and Rat Islets Deprived of Glucose: the “Switch-off” Hypothesis

Glucose and Insulin Treatment of Insulinoma Cells Results in Transcriptional Regulation of a Common Set of Genes

Diabetes Due to a Progressive Defect in β-Cell Mass in Rats Transgenic for Human Islet Amyloid Polypeptide (HIP Rat): A New Model for Type 2 Diabetes

Islet Secretory Defect in Insulin Receptor Substrate 1 Null Mice Is Linked With Reduced Calcium Signaling and Expression of Sarco(endo)plasmic Reticulum Ca2+-ATPase (SERCA)-2b and -3

Regulation of Rat Pancreatic CCKB Receptor and Somatostatin Expression by Insulin

Pathophysiology

Influence of Autonomic Neuropathy on QTc Interval Lengthening During Hypoglycemia in Type 1 Diabetes

Muscle Strength in Type 2 Diabetes

Differences in Insulin Resistance in Nondiabetic Subjects With Isolated Impaired Glucose Tolerance or Isolated Impaired Fasting Glucose

Complication

Molecular Alterations Underlie Nodal and Paranodal Degeneration in Type 1 Diabetic Neuropathy and Are Prevented by C-Peptide

Early Endothelial Dysfunction Severely Impairs Skin Blood Flow Response to Local Pressure Application in Streptozotocin-Induced Diabetic Mice

Association Between Mannose-Binding Lectin and Vascular Complications in Type 1 Diabetes

Genetics

A New Mouse Model of Type 2 Diabetes, Produced by N-Ethyl-Nitrosourea Mutagenesis, Is the Result of a Missense Mutation in the Glucokinase Gene

Interaction and Association Analysis of a Type 1 Diabetes Susceptibility Locus on Chromosome 5q11-q13 and the 7q32 Chromosomal Region in Scandinavian Families

A Novel Syndrome of Autosomal-Dominant Hyperinsulinemic Hypoglycemia Linked to a Mutation in the Human Insulin Receptor Gene

Brief Genetics Report

Diabetes-Associated Mutations in Insulin Identify Invariant Receptor Contacts

Leptin and Leptin Receptor Gene Polymorphisms and Changes in Glucose Homeostasis in Response to Regular Exercise in Nondiabetic Individuals: The HERITAGE Family Study

Genome-wide Scan for Type 2 Diabetes Loci in Hong Kong Chinese and Confirmation of a Susceptibility Locus on Chromosome 1q21-q25

Pharmacology and Therapeutics

Lower Within-Subject Variability of Insulin Detemir in Comparison to NPH Insulin and Insulin Glargine in People With Type 1 Diabetes

Mechanisms of Early Insulin-Sensitizing Effects of Thiazolidinediones in Type 2 Diabetes

This Issue

Current Issue

Tracking the Recruitment of Diabetogenic CD8⁺ T-Cells to the Pancreas in Real Time

Islet Secretory Defect in Insulin Receptor Substrate 1 Null Mice Is Linked With Reduced Calcium Signaling and Expression of Sarco(endo)plasmic Reticulum Ca²⁺-ATPase (SERCA)-2b and -3

Regulation of Rat Pancreatic CCK_B Receptor and Somatostatin Expression by Insulin