Table of Contents

Rapid Publication

Select this article
- Shamina M. Rangwala,
- A. Sophie Rich,
- Ben Rhoades,
- Jennifer S. Shapiro,
- Silvana Obici,
- Luciano Rossetti,
- and Mitchell A. Lazar
Abnormal Glucose Homeostasis due to Chronic Hyperresistinemia
Diabetes August 2004 53:1937-1941; published ahead of print June 9, 2004, doi:10.2337/diabetes.53.8.1937

Perspectives in Diabetes

Select this article
- Leonid E. Fridlyand and
- Louis H. Philipson
Does the Glucose-Dependent Insulin Secretion Mechanism Itself Cause Oxidative Stress in Pancreatic β-Cells?
Diabetes August 2004 53:1942-1948; doi:10.2337/diabetes.53.8.1942

Signal Transduction

Select this article
- Anita M. van den Hoek,
- Annemieke C. Heijboer,
- Eleonora P.M. Corssmit,
- Peter J. Voshol,
- Johannes A. Romijn,
- Louis M. Havekes,
- and Hanno Pijl
PYY_3–36 Reinforces Insulin Action on Glucose Disposal in Mice Fed a High-Fat Diet
Diabetes August 2004 53:1949-1952; doi:10.2337/diabetes.53.8.1949
Select this article
- Rory J. McCrimmon,
- Xiaoning Fan,
- Yuyan Ding,
- Wanling Zhu,
- Ralph J. Jacob,
- and Robert S. Sherwin
Potential Role for AMP-Activated Protein Kinase in Hypoglycemia Sensing in the Ventromedial Hypothalamus
Diabetes August 2004 53:1953-1958; doi:10.2337/diabetes.53.8.1953

Obesity Studies

Select this article
- R. Wang,
- X. Liu,
- S.T. Hentges,
- A.A. Dunn-Meynell,
- B.E. Levin,
- W. Wang,
- and V.H. Routh
The Regulation of Glucose-Excited Neurons in the Hypothalamic Arcuate Nucleus by Glucose and Feeding-Relevant Peptides
Diabetes August 2004 53:1959-1965; doi:10.2337/diabetes.53.8.1959
Select this article
- Elisabet Arvidsson,
- Nathalie Viguerie,
- Ingalena Andersson,
- Camilla Verdich,
- Dominique Langin,
- and Peter Arner
Effects of Different Hypocaloric Diets on Protein Secretion From Adipose Tissue of Obese Women
Diabetes August 2004 53:1966-1971; doi:10.2337/diabetes.53.8.1966

Immunology and Transplantation

Select this article
- Todd Pearson,
- Peter Weiser,
- Thomas G. Markees,
- David V. Serreze,
- Linda S. Wicker,
- Laurence B. Peterson,
- Anne-Marie Cumisky,
- Leonard D. Shultz,
- John P. Mordes,
- Aldo A. Rossini,
- and Dale L. Greiner
Islet Allograft Survival Induced by Costimulation Blockade in NOD Mice Is Controlled by Allelic Variants of Idd3
Diabetes August 2004 53:1972-1978; doi:10.2337/diabetes.53.8.1972
Select this article
- Gerben Bouma,
- Wai Kwan Lam-Tse,
- Annet F. Wierenga-Wolf,
- Hemmo A. Drexhage,
- and Marjan A. Versnel
Increased Serum Levels of MRP-8/14 in Type 1 Diabetes Induce an Increased Expression of CD11b and an Enhanced Adhesion of Circulating Monocytes to Fibronectin
Diabetes August 2004 53:1979-1986; doi:10.2337/diabetes.53.8.1979
Select this article
- Helena Reijonen,
- Roberto Mallone,
- Anne-Kristin Heninger,
- Elsa M. Laughlin,
- Sharon A. Kochik,
- Ben Falk,
- William W. Kwok,
- Carla Greenbaum,
- and Gerald T. Nepom
GAD65-Specific CD4⁺ T-Cells with High Antigen Avidity Are Prevalent in Peripheral Blood of Patients With Type 1 Diabetes
Diabetes August 2004 53:1987-1994; doi:10.2337/diabetes.53.8.1987
Select this article
- Paula M. Chilton,
- Francine Rezzoug,
- Isabelle Fugier-Vivier,
- Leslie A. Weeter,
- Hong Xu,
- Yiming Huang,
- Mukunda B. Ray,
- and Suzanne T. Ildstad
Flt3-Ligand Treatment Prevents Diabetes in NOD Mice
Diabetes August 2004 53:1995-2002; doi:10.2337/diabetes.53.8.1995
Select this article
- Shabbir Hussain,
- Konstantin V. Salojin,
- and Terry L. Delovitch
Hyperresponsiveness, Resistance to B-Cell Receptor—Dependent Activation-Induced Cell Death, and Accumulation of Hyperactivated B-Cells in Islets Is Associated With the Onset of Insulitis but not Type 1 Diabetes
Diabetes August 2004 53:2003-2011; doi:10.2337/diabetes.53.8.2003
Select this article
- James I. Elliott and
- Christopher F. Higgins
Major Histocompatibility Complex Class I Shedding and Programmed Cell Death Stimulated Through the Proinflammatory P2X₇ Receptor: A Candidate Susceptibility Gene for NOD Diabetes
Diabetes August 2004 53:2012-2017; doi:10.2337/diabetes.53.8.2012

Islet Studies

Select this article
- Víctor Navarro-Tableros,
- M. Carmen Sánchez-Soto,
- Santiago García,
- and Marcia Hiriart
Autocrine Regulation of Single Pancreatic β-Cell Survival
Diabetes August 2004 53:2018-2023; doi:10.2337/diabetes.53.8.2018
Select this article
- You-Qing Zhang,
- Mary Malo Cleary,
- Yingjie Si,
- Guoxun Liu,
- Yuzuru Eto,
- Marcie Kritzik,
- Sandrine Dabernat,
- Ayse G. Kayali,
- and Nora Sarvetnick
Inhibition of Activin Signaling Induces Pancreatic Epithelial Cell Expansion and Diminishes Terminal Differentiation of Pancreatic β-Cells
Diabetes August 2004 53:2024-2033; doi:10.2337/diabetes.53.8.2024
Select this article
- Eva Hammar,
- Géraldine Parnaud,
- Domenico Bosco,
- Nadja Perriraz,
- Kathrin Maedler,
- Marc Donath,
- Dominique G. Rouiller,
- and Philippe A. Halban
Extracellular Matrix Protects Pancreatic β-Cells Against Apoptosis: Role of Short- and Long-Term Signaling Pathways
Diabetes August 2004 53:2034-2041; doi:10.2337/diabetes.53.8.2034
Select this article
- Atsushi Suzuki,
- Hiromitsu Nakauchi,
- and Hideki Taniguchi
Prospective Isolation of Multipotent Pancreatic Progenitors Using Flow-Cytometric Cell Sorting
Diabetes August 2004 53:2143-2152; doi:10.2337/diabetes.53.8.2143

Pathophysiology

Select this article
- Rita Basu,
- Ananda Basu,
- C. Michael Johnson,
- W. Frederick Schwenk,
- and Robert A. Rizza
Insulin Dose-Response Curves for Stimulation of Splanchnic Glucose Uptake and Suppression of Endogenous Glucose Production Differ in Nondiabetic Humans and Are Abnormal in People With Type 2 Diabetes
Diabetes August 2004 53:2042-2050; doi:10.2337/diabetes.53.8.2042
Select this article
- Rita Basu,
- Ravinder J. Singh,
- Ananda Basu,
- Elizabeth G. Chittilapilly,
- C. Michael Johnson,
- Gianna Toffolo,
- Claudio Cobelli,
- and Robert A. Rizza
Splanchnic Cortisol Production Occurs in Humans: Evidence for Conversion of Cortisone to Cortisol Via the 11-β Hydroxysteroid Dehydrogenase (11β-HSD) Type 1 Pathway
Diabetes August 2004 53:2051-2059; doi:10.2337/diabetes.53.8.2051
Select this article
- Kieren J. Mather,
- Amale Lteif,
- Helmut O. Steinberg,
- and Alain D. Baron
Interactions Between Endothelin and Nitric Oxide in the Regulation of Vascular Tone in Obesity and Diabetes
Diabetes August 2004 53:2060-2066; doi:10.2337/diabetes.53.8.2060
Select this article
- Stéphane Cook,
- Olivier Hugli,
- Marc Egli,
- Barbara Ménard,
- Sébastien Thalmann,
- Claudio Sartori,
- Christophe Perrin,
- Pascal Nicod,
- Bernard Thorens,
- Peter Vollenweider,
- Urs Scherrer,
- and Rémy Burcelin
Partial Gene Deletion of Endothelial Nitric Oxide Synthase Predisposes to Exaggerated High-Fat Diet—Induced Insulin Resistance and Arterial Hypertension
Diabetes August 2004 53:2067-2072; doi:10.2337/diabetes.53.8.2067
Select this article
- Cara J. Weisbrod,
- Peter R. Eastwood,
- Gerard O’Driscoll,
- Jennifer H. Walsh,
- Matthew Best,
- John R. Halliwill,
- and Daniel J. Green
Vasomotor Responses to Hypoxia in Type 2 Diabetes
Diabetes August 2004 53:2073-2078; doi:10.2337/diabetes.53.8.2073
Select this article
- Frankie B. Stentz,
- Guillermo E. Umpierrez,
- Ruben Cuervo,
- and Abbas E. Kitabchi
Proinflammatory Cytokines, Markers of Cardiovascular Risks, Oxidative Stress, and Lipid Peroxidation in Patients With Hyperglycemic Crises
Diabetes August 2004 53:2079-2086; doi:10.2337/diabetes.53.8.2079
Select this article
- Darcy B. Carr,
- Kristina M. Utzschneider,
- Rebecca L. Hull,
- Keiichi Kodama,
- Barbara M. Retzlaff,
- John D. Brunzell,
- Jane B. Shofer,
- Brian E. Fish,
- Robert H. Knopp,
- and Steven E. Kahn
Intra-Abdominal Fat Is a Major Determinant of the National Cholesterol Education Program Adult Treatment Panel III Criteria for the Metabolic Syndrome
Diabetes August 2004 53:2087-2094; doi:10.2337/diabetes.53.8.2087
Select this article
- Deirdre R. Blake,
- James B. Meigs,
- Denis C. Muller,
- Samer S. Najjar,
- Reubin Andres,
- and David M. Nathan
Impaired Glucose Tolerance, but not Impaired Fasting Glucose, Is Associated With Increased Levels of Coronary Heart Disease Risk Factors: Results From the Baltimore Longitudinal Study on Aging
Diabetes August 2004 53:2095-2100; doi:10.2337/diabetes.53.8.2095

Complication

Select this article
- Jan Menne,
- Joon-Keun Park,
- Martin Boehne,
- Marlies Elger,
- Carsten Lindschau,
- Torsten Kirsch,
- Matthias Meier,
- Faikah Gueler,
- Annette Fiebeler,
- Ferdinand H. Bahlmann,
- Michael Leitges,
- and Hermann Haller
Diminished Loss of Proteoglycans and Lack of Albuminuria in Protein Kinase C-α—Deficient Diabetic Mice
Diabetes August 2004 53:2101-2109; doi:10.2337/diabetes.53.8.2101
Select this article
- Ana I. Duarte,
- Maria S. Santos,
- Raquel Seiça,
- and Catarina R. Oliveira
Oxidative Stress Affects Synaptosomal γ-Aminobutyric Acid and Glutamate Transport in Diabetic Rats: The Role of Insulin
Diabetes August 2004 53:2110-2116; doi:10.2337/diabetes.53.8.2110
Select this article
- Natalia Cabeza,
- Zhongyan Li,
- Christian Schulz,
- Elisabeth Kremmer,
- Steffen Massberg,
- Andreas Bültmann,
- and Meinrad Gawaz
Surface Expression of Collagen Receptor Fc Receptor-γ/Glycoprotein VI Is Enhanced on Platelets in Type 2 Diabetes and Mediates Release of CD40 Ligand and Activation of Endothelial Cells
Diabetes August 2004 53:2117-2121; doi:10.2337/diabetes.53.8.2117

Brief Genetics Report

Select this article
- Alan E. Jackson,
- Paul G. Cassell,
- Bernard V. North,
- Shanti Vijayaraghavan,
- Susan V. Gelding,
- Ambady Ramachandran,
- Chamukuttan Snehalatha,
- and Graham A. Hitman
Polymorphic Variations in the Neurogenic Differentiation-1, Neurogenin-3, and Hepatocyte Nuclear Factor-1α Genes Contribute to Glucose Intolerance in a South Indian Population
Diabetes August 2004 53:2122-2125; doi:10.2337/diabetes.53.8.2122
Select this article
- Amanda J. Bennett,
- Ulla Sovio,
- Aimo Ruokonen,
- Hannu Martikainen,
- Anneli Pouta,
- Saara Taponen,
- Anna-Liisa Hartikainen,
- Vanessa J. King,
- Paul Elliott,
- Marjo-Riitta Järvelin,
- and Mark I. McCarthy
Variation at the Insulin Gene VNTR (Variable Number Tandem Repeat) Polymorphism and Early Growth: Studies in a Large Finnish Birth Cohort
Diabetes August 2004 53:2126-2131; doi:10.2337/diabetes.53.8.2126
Select this article
- Hua Wang,
- Hailing Zhang,
- Yiwen Jia,
- Zhengxian Zhang,
- Rebekah Craig,
- Xiaoqin Wang,
- and Steven C. Elbein
Adiponectin Receptor 1 Gene (ADIPOR1) as a Candidate for Type 2 Diabetes and Insulin Resistance
Diabetes August 2004 53:2132-2136; doi:10.2337/diabetes.53.8.2132
Select this article
- Harvest F. Gu,
- Suad Efendic,
- Sofia Nordman,
- Claes-Göran Östenson,
- Kerstin Brismar,
- Anthony J. Brookes,
- and Jonathan A. Prince
Quantitative Trait Loci Near the Insulin-Degrading Enzyme (IDE) Gene Contribute to Variation in Plasma Insulin Levels
Diabetes August 2004 53:2137-2142; doi:10.2337/diabetes.53.8.2137
Select this article
- Delphine Eberlé,
- Karine Clément,
- David Meyre,
- Mourad Sahbatou,
- Martine Vaxillaire,
- Annie Le Gall,
- Pascal Ferré,
- Arnaud Basdevant,
- Philippe Froguel,
- and Fabienne Foufelle
SREBF-1 Gene Polymorphisms Are Associated With Obesity and Type 2 Diabetes in French Obese and Diabetic Cohorts
Diabetes August 2004 53:2153-2157; doi:10.2337/diabetes.53.8.2153
Select this article
- Thomas D. Cruz,
- Ana M. Valdes,
- Alma Santiago,
- Teresa Frazer de Llado,
- Leslie J. Raffel,
- Adina Zeidler,
- Jerome I. Rotter,
- Henry A. Erlich,
- Marian Rewers,
- Teodorica Bugawan,
- and Janelle A. Noble
DPB1 Alleles Are Associated With Type 1 Diabetes Susceptibility in Multiple Ethnic Groups
Diabetes August 2004 53:2158-2163; doi:10.2337/diabetes.53.8.2158
Select this article
- Antonio L. Cuesta-Muñoz,
- Hanna Huopio,
- Timo Otonkoski,
- Juan M. Gomez-Zumaquero,
- Kirsti Näntö-Salonen,
- Jacques Rahier,
- Soledad López-Enriquez,
- Maria A. García-Gimeno,
- Pascual Sanz,
- Federico C. Soriguer,
- and Markku Laakso
Severe Persistent Hyperinsulinemic Hypoglycemia due to a De Novo Glucokinase Mutation
Diabetes August 2004 53:2164-2168; doi:10.2337/diabetes.53.8.2164

Pharmacology & Therapeutics

Select this article
- Mirja Tiikkainen,
- Anna-Maija Häkkinen,
- Elena Korsheninnikova,
- Tuulikki Nyman,
- Sari Mäkimattila,
- and Hannele Yki-Järvinen
Effects of Rosiglitazone and Metformin on Liver Fat Content, Hepatic Insulin Resistance, Insulin Clearance, and Gene Expression in Adipose Tissue in Patients With Type 2 Diabetes
Diabetes August 2004 53:2169-2176; doi:10.2337/diabetes.53.8.2169

Errata

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Errata
Diabetes August 2004 53:2177; doi:10.2337/diabetes.53.8.2177
Select this article

Errata
Diabetes August 2004 53:2177; doi:10.2337/diabetes.53.8.2177-a

Diabetes

Rapid Publication

Abnormal Glucose Homeostasis due to Chronic Hyperresistinemia

Perspectives in Diabetes

Does the Glucose-Dependent Insulin Secretion Mechanism Itself Cause Oxidative Stress in Pancreatic β-Cells?

Signal Transduction

PYY3–36 Reinforces Insulin Action on Glucose Disposal in Mice Fed a High-Fat Diet

Potential Role for AMP-Activated Protein Kinase in Hypoglycemia Sensing in the Ventromedial Hypothalamus

Obesity Studies

The Regulation of Glucose-Excited Neurons in the Hypothalamic Arcuate Nucleus by Glucose and Feeding-Relevant Peptides

Effects of Different Hypocaloric Diets on Protein Secretion From Adipose Tissue of Obese Women

Immunology and Transplantation

Islet Allograft Survival Induced by Costimulation Blockade in NOD Mice Is Controlled by Allelic Variants of Idd3

Increased Serum Levels of MRP-8/14 in Type 1 Diabetes Induce an Increased Expression of CD11b and an Enhanced Adhesion of Circulating Monocytes to Fibronectin

GAD65-Specific CD4+ T-Cells with High Antigen Avidity Are Prevalent in Peripheral Blood of Patients With Type 1 Diabetes

Flt3-Ligand Treatment Prevents Diabetes in NOD Mice

Hyperresponsiveness, Resistance to B-Cell Receptor—Dependent Activation-Induced Cell Death, and Accumulation of Hyperactivated B-Cells in Islets Is Associated With the Onset of Insulitis but not Type 1 Diabetes

Major Histocompatibility Complex Class I Shedding and Programmed Cell Death Stimulated Through the Proinflammatory P2X7 Receptor: A Candidate Susceptibility Gene for NOD Diabetes

Islet Studies

Autocrine Regulation of Single Pancreatic β-Cell Survival

Inhibition of Activin Signaling Induces Pancreatic Epithelial Cell Expansion and Diminishes Terminal Differentiation of Pancreatic β-Cells

Extracellular Matrix Protects Pancreatic β-Cells Against Apoptosis: Role of Short- and Long-Term Signaling Pathways

Prospective Isolation of Multipotent Pancreatic Progenitors Using Flow-Cytometric Cell Sorting

Pathophysiology

Insulin Dose-Response Curves for Stimulation of Splanchnic Glucose Uptake and Suppression of Endogenous Glucose Production Differ in Nondiabetic Humans and Are Abnormal in People With Type 2 Diabetes

Splanchnic Cortisol Production Occurs in Humans: Evidence for Conversion of Cortisone to Cortisol Via the 11-β Hydroxysteroid Dehydrogenase (11β-HSD) Type 1 Pathway

Interactions Between Endothelin and Nitric Oxide in the Regulation of Vascular Tone in Obesity and Diabetes

Partial Gene Deletion of Endothelial Nitric Oxide Synthase Predisposes to Exaggerated High-Fat Diet—Induced Insulin Resistance and Arterial Hypertension

Vasomotor Responses to Hypoxia in Type 2 Diabetes

Proinflammatory Cytokines, Markers of Cardiovascular Risks, Oxidative Stress, and Lipid Peroxidation in Patients With Hyperglycemic Crises

Intra-Abdominal Fat Is a Major Determinant of the National Cholesterol Education Program Adult Treatment Panel III Criteria for the Metabolic Syndrome

Impaired Glucose Tolerance, but not Impaired Fasting Glucose, Is Associated With Increased Levels of Coronary Heart Disease Risk Factors: Results From the Baltimore Longitudinal Study on Aging

Complication

Diminished Loss of Proteoglycans and Lack of Albuminuria in Protein Kinase C-α—Deficient Diabetic Mice

Oxidative Stress Affects Synaptosomal γ-Aminobutyric Acid and Glutamate Transport in Diabetic Rats: The Role of Insulin

Surface Expression of Collagen Receptor Fc Receptor-γ/Glycoprotein VI Is Enhanced on Platelets in Type 2 Diabetes and Mediates Release of CD40 Ligand and Activation of Endothelial Cells

Brief Genetics Report

Polymorphic Variations in the Neurogenic Differentiation-1, Neurogenin-3, and Hepatocyte Nuclear Factor-1α Genes Contribute to Glucose Intolerance in a South Indian Population

Variation at the Insulin Gene VNTR (Variable Number Tandem Repeat) Polymorphism and Early Growth: Studies in a Large Finnish Birth Cohort

Adiponectin Receptor 1 Gene (ADIPOR1) as a Candidate for Type 2 Diabetes and Insulin Resistance

Quantitative Trait Loci Near the Insulin-Degrading Enzyme (IDE) Gene Contribute to Variation in Plasma Insulin Levels

SREBF-1 Gene Polymorphisms Are Associated With Obesity and Type 2 Diabetes in French Obese and Diabetic Cohorts

DPB1 Alleles Are Associated With Type 1 Diabetes Susceptibility in Multiple Ethnic Groups

Severe Persistent Hyperinsulinemic Hypoglycemia due to a De Novo Glucokinase Mutation

Pharmacology & Therapeutics

Effects of Rosiglitazone and Metformin on Liver Fat Content, Hepatic Insulin Resistance, Insulin Clearance, and Gene Expression in Adipose Tissue in Patients With Type 2 Diabetes

Errata

Errata

Errata

This Issue

Current Issue

PYY_3–36 Reinforces Insulin Action on Glucose Disposal in Mice Fed a High-Fat Diet

GAD65-Specific CD4⁺ T-Cells with High Antigen Avidity Are Prevalent in Peripheral Blood of Patients With Type 1 Diabetes

Major Histocompatibility Complex Class I Shedding and Programmed Cell Death Stimulated Through the Proinflammatory P2X₇ Receptor: A Candidate Susceptibility Gene for NOD Diabetes