Table of Contents

Perspective in Diabetes

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- Carolyn F. Deacon
Therapeutic Strategies Based on Glucagon-Like Peptide 1
Diabetes September 2004 53:2181-2189; doi:10.2337/diabetes.53.9.2181

New Methodology and Database

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- James R. Bain,
- Jonathan C. Schisler,
- Koji Takeuchi,
- Christopher B. Newgard,
- and Thomas C. Becker
An Adenovirus Vector for Efficient RNA Interference–Mediated Suppression of Target Genes in Insulinoma Cells and Pancreatic Islets of Langerhans
Diabetes September 2004 53:2190-2194; doi:10.2337/diabetes.53.9.2190

Metabolism

Select this article
- Harald Staiger,
- Simone Kaltenbach,
- Katrin Staiger,
- Norbert Stefan,
- Andreas Fritsche,
- Alke Guirguis,
- Claudia Péterfi,
- Melanie Weisser,
- Fausto Machicao,
- Michael Stumvoll,
- and Hans-Ulrich Häring
Expression of Adiponectin Receptor mRNA in Human Skeletal Muscle Cells Is Related to In Vivo Parameters of Glucose and Lipid Metabolism
Diabetes September 2004 53:2195-2201; doi:10.2337/diabetes.53.9.2195
Select this article
- Manfred Hallschmid,
- Bernd Schultes,
- Lisa Marshall,
- Matthias Mölle,
- Werner Kern,
- Julia Bredthauer,
- Horst L. Fehm,
- and Jan Born
Transcortical Direct Current Potential Shift Reflects Immediate Signaling of Systemic Insulin to the Human Brain
Diabetes September 2004 53:2202-2208; doi:10.2337/diabetes.53.9.2202
Select this article
- Claire C. Bastie,
- Tahar Hajri,
- Victor A. Drover,
- Paul A. Grimaldi,
- and Nada A. Abumrad
CD36 in Myocytes Channels Fatty Acids to a Lipase-Accessible Triglyceride Pool That Is Related to Cell Lipid and Insulin Responsiveness
Diabetes September 2004 53:2209-2216; doi:10.2337/diabetes.53.9.2209
Select this article
- Helena Gylling,
- Juha A. Tuominen,
- Veikko A. Koivisto,
- and Tatu A. Miettinen
Cholesterol Metabolism in Type 1 Diabetes
Diabetes September 2004 53:2217-2222; doi:10.2337/diabetes.53.9.2217

Signal Transduction

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- Beth A. Spurlin,
- So-Young Park,
- Angela K. Nevins,
- Jason K. Kim,
- and Debbie C. Thurmond
Syntaxin 4 Transgenic Mice Exhibit Enhanced Insulin-Mediated Glucose Uptake in Skeletal Muscle
Diabetes September 2004 53:2223-2231; doi:10.2337/diabetes.53.9.2223
Select this article
- Jennifer Rieusset,
- Karim Bouzakri,
- Emmanuel Chevillotte,
- Nadège Ricard,
- Delphine Jacquet,
- Jean-Philippe Bastard,
- Martine Laville,
- and Hubert Vidal
Suppressor of Cytokine Signaling 3 Expression and Insulin Resistance in Skeletal Muscle of Obese and Type 2 Diabetic Patients
Diabetes September 2004 53:2232-2241; doi:10.2337/diabetes.53.9.2232
Select this article
- Josep A. Villena,
- Benoit Viollet,
- Fabrizzio Andreelli,
- Axel Kahn,
- Sophie Vaulont,
- and Hei Sook Sul
Induced Adiposity and Adipocyte Hypertrophy in Mice Lacking the AMP-Activated Protein Kinase-α2 Subunit
Diabetes September 2004 53:2242-2249; doi:10.2337/diabetes.53.9.2242

Obesity Study

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- Takayuki Masaki,
- Seiichi Chiba,
- Tohru Yasuda,
- Hitoshi Noguchi,
- Tetsuya Kakuma,
- Takeshi Watanabe,
- Toshiie Sakata,
- and Hironobu Yoshimatsu
Involvement of Hypothalamic Histamine H₁ Receptor in the Regulation of Feeding Rhythm and Obesity
Diabetes September 2004 53:2250-2260; doi:10.2337/diabetes.53.9.2250
Select this article
- Yasuo Terauchi,
- Junji Matsui,
- Junji Kamon,
- Toshimasa Yamauchi,
- Naoto Kubota,
- Kajuro Komeda,
- Shinichi Aizawa,
- Yasuo Akanuma,
- Motowo Tomita,
- and Takashi Kadowaki
Increased Serum Leptin Protects From Adiposity Despite the Increased Glucose Uptake in White Adipose Tissue in Mice Lacking p85α Phosphoinositide 3-Kinase
Diabetes September 2004 53:2261-2270; doi:10.2337/diabetes.53.9.2261

Immunology and Transplantation

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- Ewa Gurgul,
- Stephan Lortz,
- Markus Tiedge,
- Anne Jörns,
- and Sigurd Lenzen
Mitochondrial Catalase Overexpression Protects Insulin-Producing Cells Against Toxicity of Reactive Oxygen Species and Proinflammatory Cytokines
Diabetes September 2004 53:2271-2280; doi:10.2337/diabetes.53.9.2271
Select this article
- Dongmei Han,
- Xiumin Xu,
- David Baidal,
- Jenifer Leith,
- Camillo Ricordi,
- Rodolfo Alejandro,
- and Norma S. Kenyon
Assessment of Cytotoxic Lymphocyte Gene Expression in the Peripheral Blood of Human Islet Allograft Recipients: Elevation Precedes Clinical Evidence of Rejection
Diabetes September 2004 53:2281-2290; doi:10.2337/diabetes.53.9.2281
Select this article
- Paolo Fiorina,
- Franco Folli,
- Armando D’Angelo,
- Giovanna Finzi,
- Fabio Pellegatta,
- Valeria Guzzi,
- Carlo Fedeli,
- Patrizia Della Valle,
- Luciana Usellini,
- Claudia Placidi,
- Francesco Bifari,
- Daniela Belloni,
- Elisabetta Ferrero,
- Carlo Capella,
- and Antonio Secchi
Normalization of Multiple Hemostatic Abnormalities in Uremic Type 1 Diabetic Patients After Kidney-Pancreas Transplantation
Diabetes September 2004 53:2291-2300; doi:10.2337/diabetes.53.9.2291
Select this article
- Valeria A. Judkowski,
- Gina M. Allicotti,
- Nora Sarvetnick,
- and Clemencia Pinilla
Peptides From Common Viral and Bacterial Pathogens Can Efficiently Activate Diabetogenic T-Cells
Diabetes September 2004 53:2301-2309; doi:10.2337/diabetes.53.9.2301

Islet Study

Select this article
- Michael Matos,
- Richard Park,
- Diane Mathis,
- and Christophe Benoist
Progression to Islet Destruction in a Cyclophosphamide-Induced Transgenic Model: A Microarray Overview
Diabetes September 2004 53:2310-2321; doi:10.2337/diabetes.53.9.2310
Select this article
- Emilie Gesina,
- François Tronche,
- Pedro Herrera,
- Belinda Duchene,
- Willemène Tales,
- Paul Czernichow,
- and Bernadette Breant
Dissecting the Role of Glucocorticoids on Pancreas Development
Diabetes September 2004 53:2322-2329; doi:10.2337/diabetes.53.9.2322
Select this article
- Fabrice Chimienti,
- Séverine Devergnas,
- Alain Favier,
- and Michel Seve
Identification and Cloning of a β-Cell–Specific Zinc Transporter, ZnT-8, Localized Into Insulin Secretory Granules
Diabetes September 2004 53:2330-2337; doi:10.2337/diabetes.53.9.2330
Select this article
- Qixin Shi,
- Donghua Wang,
- Gregg A. Hadley,
- Adam W. Bingaman,
- Stephen T. Bartlett,
- and Donna L. Farber
Long-Term Islet Graft Survival in NOD Mice by Abrogation of Recurrent Autoimmunity
Diabetes September 2004 53:2338-2345; doi:10.2337/diabetes.53.9.2338
Select this article
- Catherine Arden,
- Andrew Harbottle,
- Simone Baltrusch,
- Markus Tiedge,
- and Loranne Agius
Glucokinase Is an Integral Component of the Insulin Granules in Glucose-Responsive Insulin Secretory Cells and Does Not Translocate During Glucose Stimulation
Diabetes September 2004 53:2346-2352; doi:10.2337/diabetes.53.9.2346

Pathophysiology

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- Alessandra Gambineri,
- Carla Pelusi,
- Elisa Manicardi,
- Valentina Vicennati,
- Mauro Cacciari,
- Antonio Maria Morselli-Labate,
- Uberto Pagotto,
- and Renato Pasquali
Glucose Intolerance in a Large Cohort of Mediterranean Women With Polycystic Ovary Syndrome: Phenotype and Associated Factors
Diabetes September 2004 53:2353-2358; doi:10.2337/diabetes.53.9.2353
Select this article
- Natalia N. Rudovich,
- Helmut J. Rochlitz,
- and Andreas F.H. Pfeiffer
Reduced Hepatic Insulin Extraction in Response to Gastric Inhibitory Polypeptide Compensates for Reduced Insulin Secretion in Normal-Weight and Normal Glucose Tolerant First-Degree Relatives of Type 2 Diabetic Patients
Diabetes September 2004 53:2359-2365; doi:10.2337/diabetes.53.9.2359
Select this article
- Pradip K. Mazumder,
- Brian T. O’Neill,
- Matthew W. Roberts,
- Jonathan Buchanan,
- Ui Jeong Yun,
- Robert C. Cooksey,
- Sihem Boudina,
- and E. Dale Abel
Impaired Cardiac Efficiency and Increased Fatty Acid Oxidation in Insulin-Resistant ob/ob Mouse Hearts
Diabetes September 2004 53:2366-2374; doi:10.2337/diabetes.53.9.2366
Select this article
- Mary C. Gannon and
- Frank Q. Nuttall
Effect of a High-Protein, Low-Carbohydrate Diet on Blood Glucose Control in People With Type 2 Diabetes
Diabetes September 2004 53:2375-2382; doi:10.2337/diabetes.53.9.2375
Select this article
- Raffaele Marfella,
- Katherine Esposito,
- Francesco Nappo,
- Mario Siniscalchi,
- Ferdinando Carlo Sasso,
- Michele Portoghese,
- Maria Pia Di Marino,
- Alfonso Baldi,
- Salvatore Cuzzocrea,
- Clara Di Filippo,
- Guglielmo Barboso,
- Feliciano Baldi,
- Francesco Rossi,
- Michele D’Amico,
- and Dario Giugliano
Expression of Angiogenic Factors During Acute Coronary Syndromes in Human Type 2 Diabetes
Diabetes September 2004 53:2383-2391; doi:10.2337/diabetes.53.9.2383
Select this article
- Mark D. Richardson,
- Jason D. Kilts,
- and Madan M. Kwatra
Increased Expression of G_i-Coupled Muscarinic Acetylcholine Receptor and G_i in Atrium of Elderly Diabetic Subjects
Diabetes September 2004 53:2392-2396; doi:10.2337/diabetes.53.9.2392
Select this article
- Kristine B. Degn,
- Birgitte Brock,
- Claus B. Juhl,
- Christian B. Djurhuus,
- Jaime Grubert,
- Dennis Kim,
- Jenny Han,
- Kristin Taylor,
- Mark Fineman,
- and Ole Schmitz
Effect of Intravenous Infusion of Exenatide (Synthetic Exendin-4) on Glucose-Dependent Insulin Secretion and Counterregulation During Hypoglycemia
Diabetes September 2004 53:2397-2403; doi:10.2337/diabetes.53.9.2397

Complications

Brief Genetics Report

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- John S. Hulme,
- Bryan J. Barratt,
- Rebecca C.J. Twells,
- Jason D. Cooper,
- Chris E. Lowe,
- Joanna M.M. Howson,
- Alex C. Lam,
- Luc J. Smink,
- David A. Savage,
- Dag E. Undlien,
- Cristian Guja,
- Constantin Ionescu-Tîırgovişte,
- Eva Tuomilehto-Wolf,
- Jaakko Tuomilehto,
- and John A. Todd
Association Analysis of the Lymphocyte-Specific Protein Tyrosine Kinase (LCK) Gene in Type 1 Diabetes
Diabetes September 2004 53:2479-2482; doi:10.2337/diabetes.53.9.2479
Select this article
- Emmanuelle Durand,
- Philippe Boutin,
- David Meyre,
- M. Aline Charles,
- Karine Clement,
- Christian Dina,
- and Philippe Froguel
Polymorphisms in the Amino Acid Transporter Solute Carrier Family 6 (Neurotransmitter Transporter) Member 14 Gene Contribute to Polygenic Obesity in French Caucasians
Diabetes September 2004 53:2483-2486; doi:10.2337/diabetes.53.9.2483
Select this article
- Wei-Dong Li,
- Chuanhui Dong,
- Ding Li,
- Cathleen Garrigan,
- and R. Arlen Price
A Quantitative Trait Locus Influencing Fasting Plasma Glucose in Chromosome Region 18q22-23
Diabetes September 2004 53:2487-2491; doi:10.2337/diabetes.53.9.2487

Pharmacology and Therapeutic

Select this article
- Laurie L. Baggio,
- Qingling Huang,
- Theodore J. Brown,
- and Daniel J. Drucker
A Recombinant Human Glucagon-Like Peptide (GLP)-1–Albumin Protein (Albugon) Mimics Peptidergic Activation of GLP-1 Receptor–Dependent Pathways Coupled With Satiety, Gastrointestinal Motility, and Glucose Homeostasis
Diabetes September 2004 53:2492-2500; doi:10.2337/diabetes.53.9.2492
Select this article
- Garth J.S. Cooper,
- Anthony R.J. Phillips,
- Soon Y. Choong,
- Bridget L. Leonard,
- David J. Crossman,
- Dianne H. Brunton,
- ’Etuate L. Saafi,
- Ajith M. Dissanayake,
- Brett R. Cowan,
- Alistair A. Young,
- Christopher J. Occleshaw,
- Yih-Kai Chan,
- Fiona E. Leahy,
- Geraldine F. Keogh,
- Gregory D. Gamble,
- Grant R. Allen,
- Adèle J. Pope,
- Peter D.W. Boyd,
- Sally D. Poppitt,
- Thomas K. Borg,
- Robert N. Doughty,
- and John R. Baker
Regeneration of the Heart in Diabetes by Selective Copper Chelation
Diabetes September 2004 53:2501-2508; doi:10.2337/diabetes.53.9.2501
Select this article
- Mariarosaria Galeano,
- Domenica Altavilla,
- Domenico Cucinotta,
- Giuseppina T. Russo,
- Margherita Calò,
- Alessandra Bitto,
- Herbert Marini,
- Rolando Marini,
- Elena B. Adamo,
- Paolo Seminara,
- Letteria Minutoli,
- Valerio Torre,
- and Francesco Squadrito
Recombinant Human Erythropoietin Stimulates Angiogenesis and Wound Healing in the Genetically Diabetic Mouse
Diabetes September 2004 53:2509-2517; doi:10.2337/diabetes.53.9.2509

Erratum

Select this article

Erratum
Diabetes September 2004 53:2518; doi:10.2337/diabetes.53.9.2518

Diabetes

Perspective in Diabetes

Therapeutic Strategies Based on Glucagon-Like Peptide 1

New Methodology and Database

An Adenovirus Vector for Efficient RNA Interference–Mediated Suppression of Target Genes in Insulinoma Cells and Pancreatic Islets of Langerhans

Metabolism

Expression of Adiponectin Receptor mRNA in Human Skeletal Muscle Cells Is Related to In Vivo Parameters of Glucose and Lipid Metabolism

Transcortical Direct Current Potential Shift Reflects Immediate Signaling of Systemic Insulin to the Human Brain

CD36 in Myocytes Channels Fatty Acids to a Lipase-Accessible Triglyceride Pool That Is Related to Cell Lipid and Insulin Responsiveness

Cholesterol Metabolism in Type 1 Diabetes

Signal Transduction

Syntaxin 4 Transgenic Mice Exhibit Enhanced Insulin-Mediated Glucose Uptake in Skeletal Muscle

Suppressor of Cytokine Signaling 3 Expression and Insulin Resistance in Skeletal Muscle of Obese and Type 2 Diabetic Patients

Induced Adiposity and Adipocyte Hypertrophy in Mice Lacking the AMP-Activated Protein Kinase-α2 Subunit

Obesity Study

Involvement of Hypothalamic Histamine H1 Receptor in the Regulation of Feeding Rhythm and Obesity

Increased Serum Leptin Protects From Adiposity Despite the Increased Glucose Uptake in White Adipose Tissue in Mice Lacking p85α Phosphoinositide 3-Kinase

Immunology and Transplantation

Mitochondrial Catalase Overexpression Protects Insulin-Producing Cells Against Toxicity of Reactive Oxygen Species and Proinflammatory Cytokines

Assessment of Cytotoxic Lymphocyte Gene Expression in the Peripheral Blood of Human Islet Allograft Recipients: Elevation Precedes Clinical Evidence of Rejection

Normalization of Multiple Hemostatic Abnormalities in Uremic Type 1 Diabetic Patients After Kidney-Pancreas Transplantation

Peptides From Common Viral and Bacterial Pathogens Can Efficiently Activate Diabetogenic T-Cells

Islet Study

Progression to Islet Destruction in a Cyclophosphamide-Induced Transgenic Model: A Microarray Overview

Dissecting the Role of Glucocorticoids on Pancreas Development

Identification and Cloning of a β-Cell–Specific Zinc Transporter, ZnT-8, Localized Into Insulin Secretory Granules

Long-Term Islet Graft Survival in NOD Mice by Abrogation of Recurrent Autoimmunity

Glucokinase Is an Integral Component of the Insulin Granules in Glucose-Responsive Insulin Secretory Cells and Does Not Translocate During Glucose Stimulation

Pathophysiology

Glucose Intolerance in a Large Cohort of Mediterranean Women With Polycystic Ovary Syndrome: Phenotype and Associated Factors

Reduced Hepatic Insulin Extraction in Response to Gastric Inhibitory Polypeptide Compensates for Reduced Insulin Secretion in Normal-Weight and Normal Glucose Tolerant First-Degree Relatives of Type 2 Diabetic Patients

Impaired Cardiac Efficiency and Increased Fatty Acid Oxidation in Insulin-Resistant ob/ob Mouse Hearts

Effect of a High-Protein, Low-Carbohydrate Diet on Blood Glucose Control in People With Type 2 Diabetes

Expression of Angiogenic Factors During Acute Coronary Syndromes in Human Type 2 Diabetes

Increased Expression of Gi-Coupled Muscarinic Acetylcholine Receptor and Gi in Atrium of Elderly Diabetic Subjects

Effect of Intravenous Infusion of Exenatide (Synthetic Exendin-4) on Glucose-Dependent Insulin Secretion and Counterregulation During Hypoglycemia

Complications

Studies of Rat and Human Retinas Predict a Role for the Polyol Pathway in Human Diabetic Retinopathy

Involvement of Brain-Derived Neurotrophic Factor in Early Retinal Neuropathy of Streptozotocin-Induced Diabetes in Rats: Therapeutic Potential of Brain-Derived Neurotrophic Factor for Dopaminergic Amacrine Cells

Development of Albuminuria and Glomerular Lesions in Normoglycemic B6 Recipients of db/db Mice Bone Marrow: The Role of Mesangial Cell Progenitors

Changes in IGF Activities in Human Diabetic Vitreous

Nitration and Functional Loss of Voltage-Gated K+ Channels in Rat Coronary Microvessels Exposed to High Glucose

Leptin Stimulates Ischemia-Induced Retinal Neovascularization: Possible Role of Vascular Endothelial Growth Factor Expressed in Retinal Endothelial Cells

Population-Based Assessment of Familial Clustering of Diabetic Nephropathy in Type 1 Diabetes

Functional Variants in the Glutathione Peroxidase-1 (GPx-1) Gene Are Associated With Increased Intima-Media Thickness of Carotid Arteries and Risk of Macrovascular Diseases in Japanese Type 2 Diabetic Patients

Studies of the Peptide YY and Neuropeptide Y2 Receptor Genes in Relation to Human Obesity and Obesity-Related Traits

Genetic Variation in BEACON Influences Quantitative Variation in Metabolic Syndrome–Related Phenotypes

Adiponectin and the Development of Type 2 Diabetes: The Atherosclerosis Risk in Communities Study

Brief Genetics Report

Association Analysis of the Lymphocyte-Specific Protein Tyrosine Kinase (LCK) Gene in Type 1 Diabetes

Polymorphisms in the Amino Acid Transporter Solute Carrier Family 6 (Neurotransmitter Transporter) Member 14 Gene Contribute to Polygenic Obesity in French Caucasians

A Quantitative Trait Locus Influencing Fasting Plasma Glucose in Chromosome Region 18q22-23

Pharmacology and Therapeutic

A Recombinant Human Glucagon-Like Peptide (GLP)-1–Albumin Protein (Albugon) Mimics Peptidergic Activation of GLP-1 Receptor–Dependent Pathways Coupled With Satiety, Gastrointestinal Motility, and Glucose Homeostasis

Regeneration of the Heart in Diabetes by Selective Copper Chelation

Recombinant Human Erythropoietin Stimulates Angiogenesis and Wound Healing in the Genetically Diabetic Mouse

Erratum

Erratum

This Issue

Current Issue

Involvement of Hypothalamic Histamine H₁ Receptor in the Regulation of Feeding Rhythm and Obesity

Increased Expression of G_i-Coupled Muscarinic Acetylcholine Receptor and G_i in Atrium of Elderly Diabetic Subjects

Nitration and Functional Loss of Voltage-Gated K⁺ Channels in Rat Coronary Microvessels Exposed to High Glucose