Table of Contents

Editorial

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- Christian Boitard,
- Erol Cerasi,
- Suad Efendic,
- Jean-Claude Henquin,
- Donald F. Steiner,
- and Ele Ferrannini
Editorial: Novel Factors in the Regulation of β-Cell Function
Diabetes February 2004 53:S1-S3; doi:10.2337/diabetes.53.2007.S1

Section I: Genetic Factors in Type 2 Diabetes -- In Search of New Links

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- Edward H. Leiter and
- Peter C. Reifsnyder
Differential Levels of Diabetogenic Stress in Two New Mouse Models of Obesity and Type 2 Diabetes
Diabetes February 2004 53:S4-S11; doi:10.2337/diabetes.53.2007.S4
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- Koichi Suzuki,
- Shoji Hata,
- Yukiko Kawabata,
- and Hiroyuki Sorimachi
Structure, Activation, and Biology of Calpain
Diabetes February 2004 53:S12-S18; doi:10.2337/diabetes.53.2007.S12
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- Nancy J. Cox,
- M. Geoffrey Hayes,
- Cheryl A. Roe,
- Takafumi Tsuchiya,
- and Graeme I. Bell
Linkage of Calpain 10 to Type 2 Diabetes: The Biological Rationale
Diabetes February 2004 53:S19-S25; doi:10.2337/diabetes.53.2007.S19
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- Leen M. ’t Hart,
- Andreas Fritsche,
- Ingrid Rietveld,
- Jacqueline M. Dekker,
- Giel Nijpels,
- Fausto Machicao,
- Michael Stumvoll,
- Cornelia M. van Duijn,
- Hans U. Häring,
- Robert J. Heine,
- J. Antonie Maassen,
- and Timon W. van Haeften
Genetic Factors and Insulin Secretion: Gene Variants in the IGF Genes
Diabetes February 2004 53:S26-S30; doi:10.2337/diabetes.53.2007.S26
Select this article
- Harvest F. Gu,
- Adili Abulaiti,
- Claes-Göran Östenson,
- Keith Humphreys,
- Claes Wahlestedt,
- Anthony J. Brookes,
- and Suad Efendic
Single Nucleotide Polymorphisms in the Proximal Promoter Region of the Adiponectin (APM1) Gene Are Associated With Type 2 Diabetes in Swedish Caucasians
Diabetes February 2004 53:S31-S35; doi:10.2337/diabetes.53.2007.S31

Section II: Nuclear Receptors and Islet Function

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- Knut R. Steffensen and
- Jan-Åke Gustafsson
Putative Metabolic Effects of the Liver X Receptor (LXR)
Diabetes February 2004 53:S36-S42; doi:10.2337/diabetes.53.2007.S36
Select this article
- Pascal Ferré
The Biology of Peroxisome Proliferator-Activated Receptors: Relationship With Lipid Metabolism and Insulin Sensitivity
Diabetes February 2004 53:S43-S50; doi:10.2337/diabetes.53.2007.S43
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- Behrous Davani,
- Neil Portwood,
- Galina Bryzgalova,
- Martina Kvist Reimer,
- Thomas Heiden,
- Claes-Göran Östenson,
- Sam Okret,
- Bo Ahren,
- Suad Efendic,
- and Akhtar Khan
Aged Transgenic Mice With Increased Glucocorticoid Sensitivity in Pancreatic β-Cells Develop Diabetes
Diabetes February 2004 53:S51-S59; doi:10.2337/diabetes.53.2007.S51
Select this article
- Ha-il Kim and
- Yong-ho Ahn
Role of Peroxisome Proliferator-Activated Receptor-γ in the Glucose-Sensing Apparatus of Liver and β-Cells
Diabetes February 2004 53:S60-S65; doi:10.2337/diabetes.53.2007.S60
Select this article
- So-youn Kim,
- Ha-il Kim,
- Sang-Kyu Park,
- Seung-Soon Im,
- Tianzhu Li,
- Hyae Gyeong Cheon,
- and Yong-ho Ahn
Liver Glucokinase Can Be Activated by Peroxisome Proliferator-Activated Receptor-γ
Diabetes February 2004 53:S66-S70; doi:10.2337/diabetes.53.2007.S66
Select this article
- Mary C. Sugden and
- Mark J. Holness
Potential Role of Peroxisome Proliferator-Activated Receptor-α in the Modulation of Glucose-Stimulated Insulin Secretion
Diabetes February 2004 53:S71-S81; doi:10.2337/diabetes.53.2007.S71
Select this article
- Günter Päth,
- Anne Opel,
- Anita Knoll,
- and Jochen Seufert
Nuclear Protein p8 Is Associated With Glucose-Induced Pancreatic β-Cell Growth
Diabetes February 2004 53:S82-S85; doi:10.2337/diabetes.53.2007.S82
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- Bernat Soria,
- Ivan Quesada,
- Ana B. Ropero,
- José A. Pertusa,
- Franz Martín,
- and Angel Nadal
Novel Players in Pancreatic Islet Signaling: From Membrane Receptors to Nuclear Channels
Diabetes February 2004 53:S86-S91; doi:10.2337/diabetes.53.2007.S86
Select this article
- Ivan Quesada,
- Franz Martin,
- Enrique Roche,
- and Bernat Soria
Nutrients Induce Different Ca²⁺ Signals in Cytosol and Nucleus in Pancreatic β-Cells
Diabetes February 2004 53:S92-S95; doi:10.2337/diabetes.53.2007.S92

Section III: Mitochondria, Beta-Cell Function, and Type 2 Diabetes

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- Michael R. Duchen
Roles of Mitochondria in Health and Disease
Diabetes February 2004 53:S96-S102; doi:10.2337/diabetes.53.2007.S96
Select this article
- J. Antonie Maassen,
- Leen. M. ‘t Hart,
- Einar van Essen,
- Rob J. Heine,
- Giel Nijpels,
- Roshan S. Jahangir Tafrechi,
- Anton K. Raap,
- George M.C. Janssen,
- and Herman H.P.J. Lemkes
Mitochondrial Diabetes: Molecular Mechanisms and Clinical Presentation
Diabetes February 2004 53:S103-S109; doi:10.2337/diabetes.53.2007.S103
Select this article
- Katherine Green,
- Martin D. Brand,
- and Michael P. Murphy
Prevention of Mitochondrial Oxidative Damage as a Therapeutic Strategy in Diabetes
Diabetes February 2004 53:S110-S118; doi:10.2337/diabetes.53.2007.S110
Select this article
- R. Paul Robertson,
- Jamie Harmon,
- Phuong Oanh T. Tran,
- and Vincent Poitout
β-Cell Glucose Toxicity, Lipotoxicity, and Chronic Oxidative Stress in Type 2 Diabetes
Diabetes February 2004 53:S119-S124; doi:10.2337/diabetes.53.2007.S119
Select this article
- Clayton E. Mathews,
- Rebecca Bagley,
- and Edward H. Leiter
ALS/Lt: A New Type 2 Diabetes Mouse Model Associated With Low Free Radical Scavenging Potential
Diabetes February 2004 53:S125-S129; doi:10.2337/diabetes.53.2007.S125
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- Sophie Rousset,
- Marie-Clotilde Alves-Guerra,
- Julien Mozo,
- Bruno Miroux,
- Anne-Marie Cassard-Doulcier,
- Frédéric Bouillaud,
- and Daniel Ricquier
The Biology of Mitochondrial Uncoupling Proteins
Diabetes February 2004 53:S130-S135; doi:10.2337/diabetes.53.2007.S130
Select this article
- Catherine B. Chan,
- Monique C. Saleh,
- Vasilij Koshkin,
- and Michael B. Wheeler
Uncoupling Protein 2 and Islet Function
Diabetes February 2004 53:S136-S142; doi:10.2337/diabetes.53.2007.S136

Section IV: Lipid Modulators of Islet Function

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- Peter J. Havel
Update on Adipocyte Hormones: Regulation of Energy Balance and Carbohydrate/Lipid Metabolism
Diabetes February 2004 53:S143-S151; doi:10.2337/diabetes.53.2007.S143
Select this article
- Jochen Seufert
Leptin Effects on Pancreatic β-Cell Gene Expression and Function
Diabetes February 2004 53:S152-S158; doi:10.2337/diabetes.53.2007.S152
Select this article
- Trevor J. Biden,
- Darren Robinson,
- Damien Cordery,
- William E. Hughes,
- and Anna K. Busch
Chronic Effects of Fatty Acids on Pancreatic β-Cell Function: New Insights From Functional Genomics
Diabetes February 2004 53:S159-S165; doi:10.2337/diabetes.53.2007.S159
Select this article
- Mark J. Holness,
- Nicholas D. Smith,
- Gemma K. Greenwood,
- and Mary C. Sugden
Acute ω-3 Fatty Acid Enrichment Selectively Reverses High-Saturated Fat Feeding-Induced Insulin Hypersecretion But Does Not Improve Peripheral Insulin Resistance
Diabetes February 2004 53:S166-S171; doi:10.2337/diabetes.53.2007.S166
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- Peter M. Jones,
- Christopher J. Burns,
- Véronique D. Belin,
- Helen M. Roderigo-Milne,
- and Shanta J. Persaud
The Role of Cytosolic Phospholipase A₂ in Insulin Secretion
Diabetes February 2004 53:S172-S178; doi:10.2337/diabetes.53.2007.S172
Select this article
- Sasanka Ramanadham,
- Haowei Song,
- Shunzhong Bao,
- Fong-Fu Hsu,
- Sheng Zhang,
- Zhongmin Ma,
- Chun Jin,
- and John Turk
Islet Complex Lipids: Involvement in the Actions of Group VIA Calcium-Independent Phospholipase A₂ in β-Cells
Diabetes February 2004 53:S179-S185; doi:10.2337/diabetes.53.2007.S179
Select this article
- Shunzhong Bao,
- Chun Jin,
- Sheng Zhang,
- John Turk,
- Zhongmin Ma,
- and Sasanka Ramanadham
β-Cell Calcium-Independent Group VIA Phospholipase A₂ (iPLA₂β): Tracking iPLA₂β Movements in Response to Stimulation With Insulin Secretagogues in INS-1 Cells
Diabetes February 2004 53:S186-S189; doi:10.2337/diabetes.53.2007.S186
Select this article
- Shanta J. Persaud,
- Chris J. Burns,
- Véronique D. Belin,
- and Peter M. Jones
Glucose-Induced Regulation of COX-2 Expression in Human Islets of Langerhans
Diabetes February 2004 53:S190-S192; doi:10.2337/diabetes.53.2007.S190

Diabetes

Editorial

Editorial: Novel Factors in the Regulation of β-Cell Function

Section I: Genetic Factors in Type 2 Diabetes -- In Search of New Links

Differential Levels of Diabetogenic Stress in Two New Mouse Models of Obesity and Type 2 Diabetes

Structure, Activation, and Biology of Calpain

Linkage of Calpain 10 to Type 2 Diabetes: The Biological Rationale

Genetic Factors and Insulin Secretion: Gene Variants in the IGF Genes

Single Nucleotide Polymorphisms in the Proximal Promoter Region of the Adiponectin (APM1) Gene Are Associated With Type 2 Diabetes in Swedish Caucasians

Section II: Nuclear Receptors and Islet Function

Putative Metabolic Effects of the Liver X Receptor (LXR)

The Biology of Peroxisome Proliferator-Activated Receptors: Relationship With Lipid Metabolism and Insulin Sensitivity

Aged Transgenic Mice With Increased Glucocorticoid Sensitivity in Pancreatic β-Cells Develop Diabetes

Role of Peroxisome Proliferator-Activated Receptor-γ in the Glucose-Sensing Apparatus of Liver and β-Cells

Liver Glucokinase Can Be Activated by Peroxisome Proliferator-Activated Receptor-γ

Potential Role of Peroxisome Proliferator-Activated Receptor-α in the Modulation of Glucose-Stimulated Insulin Secretion

Nuclear Protein p8 Is Associated With Glucose-Induced Pancreatic β-Cell Growth

Novel Players in Pancreatic Islet Signaling: From Membrane Receptors to Nuclear Channels

Nutrients Induce Different Ca²⁺ Signals in Cytosol and Nucleus in Pancreatic β-Cells

Section III: Mitochondria, Beta-Cell Function, and Type 2 Diabetes

Roles of Mitochondria in Health and Disease

Mitochondrial Diabetes: Molecular Mechanisms and Clinical Presentation

Prevention of Mitochondrial Oxidative Damage as a Therapeutic Strategy in Diabetes

β-Cell Glucose Toxicity, Lipotoxicity, and Chronic Oxidative Stress in Type 2 Diabetes

ALS/Lt: A New Type 2 Diabetes Mouse Model Associated With Low Free Radical Scavenging Potential

The Biology of Mitochondrial Uncoupling Proteins

Uncoupling Protein 2 and Islet Function

Section IV: Lipid Modulators of Islet Function

Update on Adipocyte Hormones: Regulation of Energy Balance and Carbohydrate/Lipid Metabolism

Leptin Effects on Pancreatic β-Cell Gene Expression and Function

Chronic Effects of Fatty Acids on Pancreatic β-Cell Function: New Insights From Functional Genomics

Acute ω-3 Fatty Acid Enrichment Selectively Reverses High-Saturated Fat Feeding-Induced Insulin Hypersecretion But Does Not Improve Peripheral Insulin Resistance

The Role of Cytosolic Phospholipase A₂ in Insulin Secretion

Islet Complex Lipids: Involvement in the Actions of Group VIA Calcium-Independent Phospholipase A₂ in β-Cells

β-Cell Calcium-Independent Group VIA Phospholipase A₂ (iPLA₂β): Tracking iPLA₂β Movements in Response to Stimulation With Insulin Secretagogues in INS-1 Cells

Glucose-Induced Regulation of COX-2 Expression in Human Islets of Langerhans

This Issue

Current Issue

Diabetes

Table of Contents

Editorial

Editorial: Novel Factors in the Regulation of β-Cell Function

Section I: Genetic Factors in Type 2 Diabetes -- In Search of New Links

Differential Levels of Diabetogenic Stress in Two New Mouse Models of Obesity and Type 2 Diabetes

Structure, Activation, and Biology of Calpain

Linkage of Calpain 10 to Type 2 Diabetes: The Biological Rationale

Genetic Factors and Insulin Secretion: Gene Variants in the IGF Genes

Single Nucleotide Polymorphisms in the Proximal Promoter Region of the Adiponectin (APM1) Gene Are Associated With Type 2 Diabetes in Swedish Caucasians

Section II: Nuclear Receptors and Islet Function

Putative Metabolic Effects of the Liver X Receptor (LXR)

The Biology of Peroxisome Proliferator-Activated Receptors: Relationship With Lipid Metabolism and Insulin Sensitivity

Aged Transgenic Mice With Increased Glucocorticoid Sensitivity in Pancreatic β-Cells Develop Diabetes

Role of Peroxisome Proliferator-Activated Receptor-γ in the Glucose-Sensing Apparatus of Liver and β-Cells

Liver Glucokinase Can Be Activated by Peroxisome Proliferator-Activated Receptor-γ

Potential Role of Peroxisome Proliferator-Activated Receptor-α in the Modulation of Glucose-Stimulated Insulin Secretion

Nuclear Protein p8 Is Associated With Glucose-Induced Pancreatic β-Cell Growth

Novel Players in Pancreatic Islet Signaling: From Membrane Receptors to Nuclear Channels

Nutrients Induce Different Ca2+ Signals in Cytosol and Nucleus in Pancreatic β-Cells

Section III: Mitochondria, Beta-Cell Function, and Type 2 Diabetes

Roles of Mitochondria in Health and Disease

Mitochondrial Diabetes: Molecular Mechanisms and Clinical Presentation

Prevention of Mitochondrial Oxidative Damage as a Therapeutic Strategy in Diabetes

β-Cell Glucose Toxicity, Lipotoxicity, and Chronic Oxidative Stress in Type 2 Diabetes

ALS/Lt: A New Type 2 Diabetes Mouse Model Associated With Low Free Radical Scavenging Potential

The Biology of Mitochondrial Uncoupling Proteins

Uncoupling Protein 2 and Islet Function

Section IV: Lipid Modulators of Islet Function

Update on Adipocyte Hormones: Regulation of Energy Balance and Carbohydrate/Lipid Metabolism

Leptin Effects on Pancreatic β-Cell Gene Expression and Function

Chronic Effects of Fatty Acids on Pancreatic β-Cell Function: New Insights From Functional Genomics

Acute ω-3 Fatty Acid Enrichment Selectively Reverses High-Saturated Fat Feeding-Induced Insulin Hypersecretion But Does Not Improve Peripheral Insulin Resistance

The Role of Cytosolic Phospholipase A2 in Insulin Secretion

Islet Complex Lipids: Involvement in the Actions of Group VIA Calcium-Independent Phospholipase A2 in β-Cells

β-Cell Calcium-Independent Group VIA Phospholipase A2 (iPLA2β): Tracking iPLA2β Movements in Response to Stimulation With Insulin Secretagogues in INS-1 Cells

Glucose-Induced Regulation of COX-2 Expression in Human Islets of Langerhans

This Issue

Current Issue

Nutrients Induce Different Ca²⁺ Signals in Cytosol and Nucleus in Pancreatic β-Cells

The Role of Cytosolic Phospholipase A₂ in Insulin Secretion

Islet Complex Lipids: Involvement in the Actions of Group VIA Calcium-Independent Phospholipase A₂ in β-Cells

β-Cell Calcium-Independent Group VIA Phospholipase A₂ (iPLA₂β): Tracking iPLA₂β Movements in Response to Stimulation With Insulin Secretagogues in INS-1 Cells