Mitochondrial Diabetes

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

FIG. 4.
FIG. 4.

The rate of oxygen consumption in relation to heteroplasmy levels for the A3243G mutation. Human osteosarcoma cells were repopulated with donor mitochondria originating from fibroblasts from patients carrying the A3243G mutation in the heteroplasmic state. Individual clones were isolated, and heteroplasmy levels and the rate of oxygen consumption were determined. Oxygen consumption for each clone is represented in relation to the degree of heteroplasmy. A 50% decline in the rate of oxygen consumption occurs at ∼85% heteroplasmy.

This Article

  1. Diabetes vol. 53 no. suppl 1 S103-S109