Table of Contents

Editorial

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- Jean-Claude Henquin,
- Christian Boitard,
- Erol Cerasi,
- Ele Ferrannini,
- Donald F. Steiner,
- and Suad Efendic
Impact of Treatment on Islet Function in Type 2 Diabetes
Diabetes December 2004 53:S1-S5; doi:10.2337/diabetes.53.suppl_3.S1

Section I: Insulin Resistance-Beta-Cell Connection in Type 2 Diabetes

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- Hiroaki Kitano,
- Kanae Oda,
- Tomomi Kimura,
- Yukiko Matsuoka,
- Marie Csete,
- John Doyle,
- and Masaaki Muramatsu
Metabolic Syndrome and Robustness Tradeoffs
Diabetes December 2004 53:S6-S15; doi:10.2337/diabetes.53.suppl_3.S6
Select this article
- Gordon C. Weir and
- Susan Bonner-Weir
Five Stages of Evolving Beta-Cell Dysfunction During Progression to Diabetes
Diabetes December 2004 53:S16-S21; doi:10.2337/diabetes.53.suppl_3.S16
Select this article
- Michael E. Røder and
- Steven E. Kahn
Suppression of Beta-Cell Secretion by Somatostatin Does Not Fully Reverse the Disproportionate Proinsulinemia of Type 2 Diabetes
Diabetes December 2004 53:S22-S25; doi:10.2337/diabetes.53.suppl_3.S22
Select this article
- Ele Ferrannini,
- Stefania Camastra,
- Amalia Gastaldelli,
- Anna Maira Sironi,
- Andrea Natali,
- Elza Muscelli,
- Geltrude Mingrone,
- and Andrea Mari
Beta-Cell Function in Obesity: Effects of Weight Loss
Diabetes December 2004 53:S26-S33; doi:10.2337/diabetes.53.suppl_3.S26
Select this article
- J.-L. Chiasson and
- Rémi Rabasa-Lhoret
Prevention of Type 2 Diabetes: Insulin Resistance and Beta-Cell Function
Diabetes December 2004 53:S34-S38; doi:10.2337/diabetes.53.suppl_3.S34
Select this article
- Peter Gæde and
- Oluf Pedersen
Intensive Integrated Therapy of Type 2 Diabetes: Implications for Long-Term Prognosis
Diabetes December 2004 53:S39-S47; doi:10.2337/diabetes.53.suppl_3.S39

Section II: Beta-Cell Therapeutic Targets Other Than ATP-Sensitive K+ Channels

Select this article
- Jean-Claude Henquin
Pathways in Beta-Cell Stimulus-Secretion Coupling as Targets for Therapeutic Insulin Secretagogues
Diabetes December 2004 53:S48-S58; doi:10.2337/diabetes.53.suppl_3.S48
Select this article
- Tadao Shibasaki,
- Yasuhiro Sunaga,
- and Susumu Seino
Integration of ATP, cAMP, and Ca²⁺ Signals in Insulin Granule Exocytosis
Diabetes December 2004 53:S59-S62; doi:10.2337/diabetes.53.suppl_3.S59
Select this article
- A. Farret,
- M. Vignaud,
- S. Dietz,
- J. Vignon,
- P. Petit,
- and R. Gross
P2Y Purinergic Potentiation of Glucose-Induced Insulin Secretion and Pancreatic Beta-Cell Metabolism
Diabetes December 2004 53:S63-S66; doi:10.2337/diabetes.53.suppl_3.S63
Select this article
- Isabelle Leclerc and
- Guy A. Rutter
AMP-Activated Protein Kinase: A New Beta-Cell Glucose Sensor?: Regulation by Amino Acids and Calcium Ions
Diabetes December 2004 53:S67-S74; doi:10.2337/diabetes.53.suppl_3.S67
Select this article
- Alexander M. Efanov,
- Sabine Sewing,
- Krister Bokvist,
- and Jesper Gromada
Liver X Receptor Activation Stimulates Insulin Secretion via Modulation of Glucose and Lipid Metabolism in Pancreatic Beta-Cells
Diabetes December 2004 53:S75-S78; doi:10.2337/diabetes.53.suppl_3.S75
Select this article
- Eleonora Santini,
- Poupak Fallahi,
- Silvia Martina Ferrari,
- Antonio Masoni,
- Alessandro Antonelli,
- and Ele Ferrannini
Effect of PPAR-γ Activation and Inhibition on Glucose-Stimulated Insulin Release in INS-1e Cells
Diabetes December 2004 53:S79-S83; doi:10.2337/diabetes.53.suppl_3.S79
Select this article
- Frederique Diraison,
- Efthimios Motakis,
- Laura E. Parton,
- Guy P. Nason,
- Isabelle Leclerc,
- and Guy A. Rutter
Impact of Adenoviral Transduction With SREBP1c or AMPK on Pancreatic Islet Gene Expression Profile: Analysis With Oligonucleotide Microarrays
Diabetes December 2004 53:S84-S91; doi:10.2337/diabetes.53.suppl_3.S84
Select this article
- Maria Sörhede Winzell,
- Giovanni Pacini,
- Claes B. Wollheim,
- and Bo Ahrén
Beta-Cell-Targeted Expression of a Dominant-Negative Mutant of Hepatocyte Nuclear Factor-1α in Mice: Diabetes Model with β-Cell Dysfunction Partially Rescued by Nonglucose Secretagogues
Diabetes December 2004 53:S92-S96; doi:10.2337/diabetes.53.suppl_3.S92
Select this article
- Brice Emanuelli,
- Murielle Glondu,
- Chantal Filloux,
- Pascal Peraldi,
- and Emmanuel Van Obberghen
The Potential Role of SOCS-3 in the Interleukin-1β-Induced Desensitization of Insulin Signaling in Pancreatic Beta-Cells
Diabetes December 2004 53:S97-S103; doi:10.2337/diabetes.53.suppl_3.S97

Section III: The Beta-Cell ATP-Sensitive K+ Channels

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- Joseph Bryan,
- Wanda H. Vila-Carriles,
- Guiling Zhao,
- Audrey P. Babenko,
- and Lydia Aguilar-Bryan
Toward Linking Structure With Function in ATP-Sensitive K+ Channels
Diabetes December 2004 53:S104-S112; doi:10.2337/diabetes.53.suppl_3.S104
Select this article
- Andrei Tarasov,
- Julien Dusonchet,
- and Frances Ashcroft
Metabolic Regulation of the Pancreatic Beta-Cell ATP-Sensitive K⁺ Channel: A Pas de Deux
Diabetes December 2004 53:S113-S122; doi:10.2337/diabetes.53.suppl_3.S113
Select this article
- Jeff D. Campbell,
- Peter Proks,
- Jonathan D. Lippiat,
- Mark S.P. Sansom,
- and Frances M. Ashcroft
Identification of a Functionally Important Negatively Charged Residue Within the Second Catalytic Site of the SUR1 Nucleotide-Binding Domains
Diabetes December 2004 53:S123-S127; doi:10.2337/diabetes.53.suppl_3.S123
Select this article
- Annette Hambrock,
- Tülay Kayar,
- Demet Stumpp,
- and Hartmut Osswald
Effect of Two Amino Acids in TM17 of Sulfonylurea Receptor SUR1 on the Binding of ATP-Sensitive K⁺ Channel Modulators
Diabetes December 2004 53:S128-S134; doi:10.2337/diabetes.53.suppl_3.S128
Select this article
- Claudia Bleck,
- Antje Wienbergen,
- and Ingo Rustenbeck
Glucose Dependence of Imidazoline-Induced Insulin Secretion: Different Characteristics of Two ATP-Sensitive K⁺ Channel–Blocking Compounds
Diabetes December 2004 53:S135-S139; doi:10.2337/diabetes.53.suppl_3.S135
Select this article
- Ingo Rustenbeck,
- Antje Wienbergen,
- Claudia Bleck,
- and Anne Jörns
Desensitization of Insulin Secretion by Depolarizing Insulin Secretagogues
Diabetes December 2004 53:S140-S150; doi:10.2337/diabetes.53.suppl_3.S140
Select this article
- Arne Melander
Kinetics-Effect Relations of Insulin-Releasing Drugs in Patients With Type 2 Diabetes: Brief Overview
Diabetes December 2004 53:S151-S155; doi:10.2337/diabetes.53.suppl_3.S151

Section IV: Non-Beta-Cell ATP-Sensitive K+ Channels

Select this article
- Ulrich Quast,
- Damian Stephan,
- Susanne Bieger,
- and Ulrich Russ
The Impact of ATP-Sensitive K⁺ Channel Subtype Selectivity of Insulin Secretagogues for the Coronary Vasculature and the Myocardium
Diabetes December 2004 53:S156-S164; doi:10.2337/diabetes.53.suppl_3.S156
Select this article
- Xiao-Ke Liu,
- Satsuki Yamada,
- Garvan C. Kane,
- Alexey E. Alekseev,
- Denice M. Hodgson,
- Fearghas O’Cochlain,
- Arshad Jahangir,
- Takashi Miki,
- Susumu Seino,
- and Andre Terzic
Genetic Disruption of Kir6.2, the Pore-Forming Subunit of ATP-Sensitive K⁺ Channel, Predisposes to Catecholamine-Induced Ventricular Dysrhythmia
Diabetes December 2004 53:S165-S168; doi:10.2337/diabetes.53.suppl_3.S165
Select this article
- Garvan C. Kane,
- Atta Behfar,
- Satsuki Yamada,
- Carmen Perez-Terzic,
- Fearghas O’Cochlain,
- Santiago Reyes,
- Petras P. Dzeja,
- Takashi Miki,
- Susumu Seino,
- and Andre Terzic
ATP-Sensitive K⁺ Channel Knockout Compromises the Metabolic Benefit of Exercise Training, Resulting in Cardiac Deficits
Diabetes December 2004 53:S169-S175; doi:10.2337/diabetes.53.suppl_3.S169
Select this article
- Kohtaro Minami,
- Takashi Miki,
- Takashi Kadowaki,
- and Susumu Seino
Roles of ATP-Sensitive K+ Channels as Metabolic Sensors: Studies of Kir6.x Null Mice
Diabetes December 2004 53:S176-S180; doi:10.2337/diabetes.53.suppl_3.S176
Select this article
- Jesper Gromada,
- Xiaosong Ma,
- Marianne Høy,
- Krister Bokvist,
- Albert Salehi,
- Per-Olof Berggren,
- and Patrik Rorsman
ATP-Sensitive K⁺ Channel–Dependent Regulation of Glucagon Release and Electrical Activity by Glucose in Wild-Type and SUR1^−/− Mouse α-Cells
Diabetes December 2004 53:S181-S189; doi:10.2337/diabetes.53.suppl_3.S181

Section V: The Incretin Pathway

Select this article
- Michael A. Nauck,
- Birgit Baller,
- and Juris J. Meier
Gastric Inhibitory Polypeptide and Glucagon-Like Peptide-1 in the Pathogenesis of Type 2 Diabetes
Diabetes December 2004 53:S190-S196; doi:10.2337/diabetes.53.suppl_3.S190
Select this article
- Jens Juul Holst and
- Cathrine Ørskov
The Incretin Approach for Diabetes Treatment: Modulation of Islet Hormone Release by GLP-1 Agonism
Diabetes December 2004 53:S197-S204; doi:10.2337/diabetes.53.suppl_3.S197
Select this article
- Laurie L. Baggio,
- Jung-Guk Kim,
- and Daniel J. Drucker
Chronic Exposure to GLP-1R Agonists Promotes Homologous GLP-1 Receptor Desensitization In Vitro but Does Not Attenuate GLP-1R–Dependent Glucose Homeostasis In Vivo
Diabetes December 2004 53:S205-S214; doi:10.2337/diabetes.53.suppl_3.S205
Select this article
- Maria Sörhede Winzell and
- Bo Ahrén
The High-Fat Diet–Fed Mouse: A Model for Studying Mechanisms and Treatment of Impaired Glucose Tolerance and Type 2 Diabetes
Diabetes December 2004 53:S215-S219; doi:10.2337/diabetes.53.suppl_3.S215
Select this article
- Juris J. Meier,
- Baptist Gallwitz,
- Bartholomaeus Kask,
- Carolyn F. Deacon,
- Jens J. Holst,
- Wolfgang E. Schmidt,
- and Michael A. Nauck
Stimulation of Insulin Secretion by Intravenous Bolus Injection and Continuous Infusion of Gastric Inhibitory Polypeptide in Patients With Type 2 Diabetes and Healthy Control Subjects
Diabetes December 2004 53:S220-S224; doi:10.2337/diabetes.53.suppl_3.S220
Select this article
- Guim Kwon,
- Connie A. Marshall,
- Kirk L. Pappan,
- Maria S. Remedi,
- and Michael L. McDaniel
Signaling Elements Involved in the Metabolic Regulation of mTOR by Nutrients, Incretins, and Growth Factors in Islets
Diabetes December 2004 53:S225-S232; doi:10.2337/diabetes.53.suppl_3.S225
Select this article
- Ole Schmitz,
- Birgitte Brock,
- and Jorgen Rungby
Amylin Agonists: A Novel Approach in the Treatment of Diabetes
Diabetes December 2004 53:S233-S238; doi:10.2337/diabetes.53.suppl_3.S233

Diabetes

Editorial

Impact of Treatment on Islet Function in Type 2 Diabetes

Section I: Insulin Resistance-Beta-Cell Connection in Type 2 Diabetes

Metabolic Syndrome and Robustness Tradeoffs

Five Stages of Evolving Beta-Cell Dysfunction During Progression to Diabetes

Suppression of Beta-Cell Secretion by Somatostatin Does Not Fully Reverse the Disproportionate Proinsulinemia of Type 2 Diabetes

Beta-Cell Function in Obesity: Effects of Weight Loss

Prevention of Type 2 Diabetes: Insulin Resistance and Beta-Cell Function

Intensive Integrated Therapy of Type 2 Diabetes: Implications for Long-Term Prognosis

Section II: Beta-Cell Therapeutic Targets Other Than ATP-Sensitive K+ Channels

Pathways in Beta-Cell Stimulus-Secretion Coupling as Targets for Therapeutic Insulin Secretagogues

Integration of ATP, cAMP, and Ca2+ Signals in Insulin Granule Exocytosis

P2Y Purinergic Potentiation of Glucose-Induced Insulin Secretion and Pancreatic Beta-Cell Metabolism

AMP-Activated Protein Kinase: A New Beta-Cell Glucose Sensor?: Regulation by Amino Acids and Calcium Ions

Liver X Receptor Activation Stimulates Insulin Secretion via Modulation of Glucose and Lipid Metabolism in Pancreatic Beta-Cells

Effect of PPAR-γ Activation and Inhibition on Glucose-Stimulated Insulin Release in INS-1e Cells

Impact of Adenoviral Transduction With SREBP1c or AMPK on Pancreatic Islet Gene Expression Profile: Analysis With Oligonucleotide Microarrays

Beta-Cell-Targeted Expression of a Dominant-Negative Mutant of Hepatocyte Nuclear Factor-1α in Mice: Diabetes Model with β-Cell Dysfunction Partially Rescued by Nonglucose Secretagogues

The Potential Role of SOCS-3 in the Interleukin-1β-Induced Desensitization of Insulin Signaling in Pancreatic Beta-Cells

Section III: The Beta-Cell ATP-Sensitive K+ Channels

Toward Linking Structure With Function in ATP-Sensitive K+ Channels

Metabolic Regulation of the Pancreatic Beta-Cell ATP-Sensitive K+ Channel: A Pas de Deux

Identification of a Functionally Important Negatively Charged Residue Within the Second Catalytic Site of the SUR1 Nucleotide-Binding Domains

Effect of Two Amino Acids in TM17 of Sulfonylurea Receptor SUR1 on the Binding of ATP-Sensitive K+ Channel Modulators

Glucose Dependence of Imidazoline-Induced Insulin Secretion: Different Characteristics of Two ATP-Sensitive K+ Channel–Blocking Compounds

Desensitization of Insulin Secretion by Depolarizing Insulin Secretagogues

Kinetics-Effect Relations of Insulin-Releasing Drugs in Patients With Type 2 Diabetes: Brief Overview

Section IV: Non-Beta-Cell ATP-Sensitive K+ Channels

The Impact of ATP-Sensitive K+ Channel Subtype Selectivity of Insulin Secretagogues for the Coronary Vasculature and the Myocardium

Genetic Disruption of Kir6.2, the Pore-Forming Subunit of ATP-Sensitive K+ Channel, Predisposes to Catecholamine-Induced Ventricular Dysrhythmia

ATP-Sensitive K+ Channel Knockout Compromises the Metabolic Benefit of Exercise Training, Resulting in Cardiac Deficits

Roles of ATP-Sensitive K+ Channels as Metabolic Sensors: Studies of Kir6.x Null Mice

ATP-Sensitive K+ Channel–Dependent Regulation of Glucagon Release and Electrical Activity by Glucose in Wild-Type and SUR1−/− Mouse α-Cells

Section V: The Incretin Pathway

Gastric Inhibitory Polypeptide and Glucagon-Like Peptide-1 in the Pathogenesis of Type 2 Diabetes

The Incretin Approach for Diabetes Treatment: Modulation of Islet Hormone Release by GLP-1 Agonism

Chronic Exposure to GLP-1R Agonists Promotes Homologous GLP-1 Receptor Desensitization In Vitro but Does Not Attenuate GLP-1R–Dependent Glucose Homeostasis In Vivo

The High-Fat Diet–Fed Mouse: A Model for Studying Mechanisms and Treatment of Impaired Glucose Tolerance and Type 2 Diabetes

Stimulation of Insulin Secretion by Intravenous Bolus Injection and Continuous Infusion of Gastric Inhibitory Polypeptide in Patients With Type 2 Diabetes and Healthy Control Subjects

Signaling Elements Involved in the Metabolic Regulation of mTOR by Nutrients, Incretins, and Growth Factors in Islets

Amylin Agonists: A Novel Approach in the Treatment of Diabetes

This Issue

Current Issue

Integration of ATP, cAMP, and Ca²⁺ Signals in Insulin Granule Exocytosis

Metabolic Regulation of the Pancreatic Beta-Cell ATP-Sensitive K⁺ Channel: A Pas de Deux

Effect of Two Amino Acids in TM17 of Sulfonylurea Receptor SUR1 on the Binding of ATP-Sensitive K⁺ Channel Modulators

Glucose Dependence of Imidazoline-Induced Insulin Secretion: Different Characteristics of Two ATP-Sensitive K⁺ Channel–Blocking Compounds

The Impact of ATP-Sensitive K⁺ Channel Subtype Selectivity of Insulin Secretagogues for the Coronary Vasculature and the Myocardium

Genetic Disruption of Kir6.2, the Pore-Forming Subunit of ATP-Sensitive K⁺ Channel, Predisposes to Catecholamine-Induced Ventricular Dysrhythmia

ATP-Sensitive K⁺ Channel Knockout Compromises the Metabolic Benefit of Exercise Training, Resulting in Cardiac Deficits

ATP-Sensitive K⁺ Channel–Dependent Regulation of Glucagon Release and Electrical Activity by Glucose in Wild-Type and SUR1^−/− Mouse α-Cells