Table of Contents

Perspectives in Diabetes

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- Antonio Ceriello
Postprandial Hyperglycemia and Diabetes Complications: Is It Time to Treat?
Diabetes January 2005 54:1-7; doi:10.2337/diabetes.54.1.1

Metabolism

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- Vladimir B. Ritov,
- Elizabeth V. Menshikova,
- Jing He,
- Robert E. Ferrell,
- Bret H. Goodpaster,
- and David E. Kelley
Deficiency of Subsarcolemmal Mitochondria in Obesity and Type 2 Diabetes
Diabetes January 2005 54:8-14; doi:10.2337/diabetes.54.1.8

Signal Transduction

Select this article
- Z. Song and
- V.H. Routh
Differential Effects of Glucose and Lactate on Glucosensing Neurons in the Ventromedial Hypothalamic Nucleus
Diabetes January 2005 54:15-22; doi:10.2337/diabetes.54.1.15
Select this article
- Tomoshige Kino,
- Massimo U. De Martino,
- Evangelia Charmandari,
- Takamasa Ichijo,
- Taoufik Outas,
- and George P. Chrousos
HIV-1 Accessory Protein Vpr Inhibits the Effect of Insulin on the Foxo Subfamily of Forkhead Transcription Factors by Interfering With Their Binding to 14-3-3 Proteins: Potential Clinical Implications Regarding the Insulin Resistance of HIV-1–Infected Patients
Diabetes January 2005 54:23-31; doi:10.2337/diabetes.54.1.23
Select this article
- Yanjun Liu,
- Yuichi Nakagawa,
- Ying Wang,
- Reiko Sakurai,
- Pinky V. Tripathi,
- Kabirullah Lutfy,
- and Theodore C. Friedman
Increased Glucocorticoid Receptor and 11β-Hydroxysteroid Dehydrogenase Type 1 Expression in Hepatocytes May Contribute to the Phenotype of Type 2 Diabetes in db/db Mice
Diabetes January 2005 54:32-40; doi:10.2337/diabetes.54.1.32
Select this article
- Matthew D. Bruss,
- Edward B. Arias,
- Gustav E. Lienhard,
- and Gregory D. Cartee
Increased Phosphorylation of Akt Substrate of 160 kDa (AS160) in Rat Skeletal Muscle in Response to Insulin or Contractile Activity
Diabetes January 2005 54:41-50; doi:10.2337/diabetes.54.1.41

Obesity Studies

Select this article
- Mohammad Bohlooly-Y,
- Bob Olsson,
- Carl E.G. Bruder,
- Daniel Lindén,
- Klara Sjögren,
- Mikael Bjursell,
- Emil Egecioglu,
- Lennart Svensson,
- Peter Brodin,
- John C. Waterton,
- Olle G.P. Isaksson,
- Frank Sundler,
- Bo Ahrén,
- Claes Ohlsson,
- Jan Oscarsson,
- and Jan Törnell
Growth Hormone Overexpression in the Central Nervous System Results in Hyperphagia-Induced Obesity Associated With Insulin Resistance and Dyslipidemia
Diabetes January 2005 54:51-62; doi:10.2337/diabetes.54.1.51
Select this article
- Churl Namkoong,
- Min Seon Kim,
- Pil Geum Jang,
- Sung Min Han,
- Hye Sun Park,
- Eun Hee Koh,
- Woo Je Lee,
- Jong Yeon Kim,
- In Sun Park,
- Joong Yeol Park,
- and Ki Up Lee
Enhanced Hypothalamic AMP-Activated Protein Kinase Activity Contributes to Hyperphagia in Diabetic Rats
Diabetes January 2005 54:63-68; doi:10.2337/diabetes.54.1.63

Immunology and Transplantation

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- Jorge Carrillo,
- Maria Carmen Puertas,
- Aurora Alba,
- Rosa Maria Ampudia,
- Xavier Pastor,
- Raquel Planas,
- Nadal Riutort,
- Nuria Alonso,
- Ricardo Pujol-Borrell,
- Pere Santamaria,
- Marta Vives-Pi,
- and Joan Verdaguer
Islet-infiltrating B-Cells in Nonobese Diabetic Mice Predominantly Target Nervous System Elements
Diabetes January 2005 54:69-77; doi:10.2337/diabetes.54.1.69
Select this article
- Hassen Kared,
- Annie Masson,
- Homa Adle-Biassette,
- Jean-François Bach,
- Lucienne Chatenoud,
- and Flora Zavala
Treatment With Granulocyte Colony−Stimulating Factor Prevents Diabetes in NOD Mice by Recruiting Plasmacytoid Dendritic Cells and Functional CD4⁺CD25⁺ Regulatory T-Cells
Diabetes January 2005 54:78-84; doi:10.2337/diabetes.54.1.78
Select this article
- Sridevi Devaraj,
- Senthil K. Venugopal,
- Uma Singh,
- and Ishwarlal Jialal
Hyperglycemia Induces Monocytic Release of Interleukin-6 via Induction of Protein Kinase C-α and -β
Diabetes January 2005 54:85-91; doi:10.2337/diabetes.54.1.85
Select this article
- Shelley Lindley,
- Colin M. Dayan,
- Amanda Bishop,
- Bart O. Roep,
- Mark Peakman,
- and Timothy I.M. Tree
Defective Suppressor Function in CD4⁺CD25⁺ T-Cells From Patients With Type 1 Diabetes
Diabetes January 2005 54:92-99; doi:10.2337/diabetes.54.1.92
Select this article
- Michael R. Rickels,
- Mark H. Schutta,
- James F. Markmann,
- Clyde F. Barker,
- Ali Naji,
- and Karen L. Teff
β-Cell Function Following Human Islet Transplantation for Type 1 Diabetes
Diabetes January 2005 54:100-106; doi:10.2337/diabetes.54.1.100
Select this article
- Ethel J. Gordon,
- Linda S. Wicker,
- Laurence B. Peterson,
- David V. Serreze,
- Thomas G. Markees,
- Leonard D. Shultz,
- Aldo A. Rossini,
- Dale L. Greiner,
- and John P. Mordes
Autoimmune Diabetes and Resistance to Xenograft Transplantation Tolerance in NOD Mice
Diabetes January 2005 54:107-115; doi:10.2337/diabetes.54.1.107

Islet Studies

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- Helen M. Milne,
- Chris J. Burns,
- Paul E. Squires,
- Nicholas D. Evans,
- John Pickup,
- Peter M. Jones,
- and Shanta J. Persaud
Uncoupling of Nutrient Metabolism From Insulin Secretion by Overexpression of Cytosolic Phospholipase A₂
Diabetes January 2005 54:116-124; doi:10.2337/diabetes.54.1.116
Select this article
- Stefan Norlin,
- Ulf Ahlgren,
- and Helena Edlund
Nuclear Factor-κB Activity in β-Cells Is Required for Glucose-Stimulated Insulin Secretion
Diabetes January 2005 54:125-132; doi:10.2337/diabetes.54.1.125
Select this article
- Troels Bock,
- Bente Pakkenberg,
- and Karsten Buschard
Genetic Background Determines the Size and Structure of the Endocrine Pancreas
Diabetes January 2005 54:133-137; doi:10.2337/diabetes.54.1.133
Select this article
- Nurit Kaiser,
- Michal Yuli,
- Gökhan Üçkaya,
- Andrei I. Oprescu,
- Marie-France Berthault,
- Catherine Kargar,
- Marc Y. Donath,
- Erol Cerasi,
- and Alain Ktorza
Dynamic Changes in β-Cell Mass and Pancreatic Insulin During the Evolution of Nutrition-Dependent Diabetes in Psammomys obesus: Impact of Glycemic Control
Diabetes January 2005 54:138-145; doi:10.2337/diabetes.54.1.138

Pathophysiology

Select this article
- Amal K. Bose,
- Mihaela M. Mocanu,
- Richard D. Carr,
- Christian L. Brand,
- and Derek M. Yellon
Glucagon-like Peptide 1 Can Directly Protect the Heart Against Ischemia/Reperfusion Injury
Diabetes January 2005 54:146-151; doi:10.2337/diabetes.54.1.146
Select this article
- Mikaela Sjöstrand,
- Soffia Gudbjörnsdottir,
- Lena Strindberg,
- and Peter Lönnroth
Delayed Transcapillary Delivery of Insulin to Muscle Interstitial Fluid After Oral Glucose Load in Obese Subjects
Diabetes January 2005 54:152-157; doi:10.2337/diabetes.54.1.152
Select this article
- David E. Laaksonen,
- Jaana Lindström,
- Timo A. Lakka,
- Johan G. Eriksson,
- Leo Niskanen,
- Katja Wikström,
- Sirkka Aunola,
- Sirkka Keinänen-Kiukaanniemi,
- Mauri Laakso,
- Timo T. Valle,
- Pirjo Ilanne-Parikka,
- Anne Louheranta,
- Helena Hämäläinen,
- Merja Rastas,
- Virpi Salminen,
- Zygimantas Cepaitis,
- Martti Hakumäki,
- Hannu Kaikkonen,
- Pirjo Härkönen,
- Jouko Sundvall,
- Jaakko Tuomilehto,
- and Matti Uusitupa
Physical Activity in the Prevention of Type 2 Diabetes: The Finnish Diabetes Prevention Study
Diabetes January 2005 54:158-165; doi:10.2337/diabetes.54.1.158
Select this article
- Valeriya Lyssenko,
- Peter Almgren,
- Dragi Anevski,
- Roland Perfekt,
- Kaj Lahti,
- Michael Nissén,
- Bo Isomaa,
- Björn Forsen,
- Nils Homström,
- Carola Saloranta,
- Marja-Riitta Taskinen,
- Leif Groop,
- and Tiinamaija Tuomi
Predictors of and Longitudinal Changes in Insulin Sensitivity and Secretion Preceding Onset of Type 2 Diabetes
Diabetes January 2005 54:166-174; doi:10.2337/diabetes.54.1.166
Select this article
- Harn-Shen Chen,
- Yue-Xin Shan,
- Tung-Lin Yang,
- Hong-Da Lin,
- Jaw-Wen Chen,
- Shing-Jong Lin,
- and Ping H. Wang
Insulin Deficiency Downregulated Heat Shock Protein 60 and IGF-1 Receptor Signaling in Diabetic Myocardium
Diabetes January 2005 54:175-181; doi:10.2337/diabetes.54.1.175
Select this article
- Shin Ikejima,
- Sanae Sasaki,
- Hiroshi Sashinami,
- Fumiaki Mori,
- Yoshiji Ogawa,
- Teruo Nakamura,
- Yoshinao Abe,
- Koichi Wakabayashi,
- Toshihiro Suda,
- and Akio Nakane
Impairment of Host Resistance to Listeria monocytogenes Infection in Liver of db/db and ob/ob Mice
Diabetes January 2005 54:182-189; doi:10.2337/diabetes.54.1.182
Select this article
- Dominique Darmaun,
- Shiela D. Smith,
- Shawn Sweeten,
- Brenda K. Sager,
- Susan Welch,
- and Nelly Mauras
Evidence for Accelerated Rates of Glutathione Utilization and Glutathione Depletion in Adolescents With Poorly Controlled Type 1 Diabetes
Diabetes January 2005 54:190-196; doi:10.2337/diabetes.54.1.190
Select this article
- Sandrine Boullu-Ciocca,
- Anne Dutour,
- Viviane Guillaume,
- Vincent Achard,
- Charles Oliver,
- and Michel Grino
Postnatal Diet-Induced Obesity in Rats Upregulates Systemic and Adipose Tissue Glucocorticoid Metabolism During Development and in Adulthood: Its Relationship With the Metabolic Syndrome
Diabetes January 2005 54:197-203; doi:10.2337/diabetes.54.1.197

Complications

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- Panayiotis A. Economides,
- Lalita Khaodhiar,
- Antonella Caselli,
- A. Enrique Caballero,
- Hillary Keenan,
- Sven-Erik Bursell,
- George L. King,
- Michael T. Johnstone,
- Edward S. Horton,
- and Aristidis Veves
The Effect of Vitamin E on Endothelial Function of Micro- and Macrocirculation and Left Ventricular Function in Type 1 and Type 2 Diabetic Patients
Diabetes January 2005 54:204-211; doi:10.2337/diabetes.54.1.204
Select this article
- Selim Cellek,
- Patrick N. Anderson,
- and Neale A. Foxwell
Nitrergic Neurodegeneration in Cerebral Arteries of Streptozotocin-Induced Diabetic Rats: A New Insight into Diabetic Stroke
Diabetes January 2005 54:212-219; doi:10.2337/diabetes.54.1.212
Select this article
- Elodie Masson,
- Lysiane Troncy,
- Daniel Ruggiero,
- Nicolas Wiernsperger,
- Michel Lagarde,
- and Samer El Bawab
a-Series Gangliosides Mediate the Effects of Advanced Glycation End Products on Pericyte and Mesangial Cell Proliferation: A Common Mediator for Retinal and Renal Microangiopathy?
Diabetes January 2005 54:220-227; doi:10.2337/diabetes.54.1.220
Select this article
- Romano Nosadini,
- Mario Velussi,
- Enrico Brocco,
- Cataldo Abaterusso,
- Francesco Piarulli,
- Giuseppe Morgia,
- Andrea Satta,
- Rossana Faedda,
- Avinash Abhyankar,
- Holger Luthman,
- and Giancarlo Tonolo
Altered Transcapillary Escape of Albumin and Microalbuminuria Reflects Two Different Pathogenetic Mechanisms
Diabetes January 2005 54:228-233; doi:10.2337/diabetes.54.1.228
Select this article
- Irina G. Obrosova,
- Pal Pacher,
- Csaba Szabó,
- Zsuzsanna Zsengeller,
- Hiroko Hirooka,
- Martin J. Stevens,
- and Mark A. Yorek
Aldose Reductase Inhibition Counteracts Oxidative-Nitrosative Stress and Poly(ADP-Ribose) Polymerase Activation in Tissue Sites for Diabetes Complications
Diabetes January 2005 54:234-242; doi:10.2337/diabetes.54.1.234
Select this article
- Joshua J. Wang,
- Sarah X. Zhang,
- Kangmo Lu,
- Ying Chen,
- Robert Mott,
- Sanai Sato,
- and Jian-xing Ma
Decreased Expression of Pigment Epithelium-Derived Factor Is Involved in the Pathogenesis of Diabetic Nephropathy
Diabetes January 2005 54:243-250; doi:10.2337/diabetes.54.1.243

Pharmacology and Therapeutics

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- Alokesh Duttaroy,
- Palanisamy Kanakaraj,
- Blaire L. Osborn,
- Helmut Schneider,
- Oxana K. Pickeral,
- Cecil Chen,
- Guiyi Zhang,
- Shashi Kaithamana,
- Mallika Singh,
- Robert Schulingkamp,
- Dan Crossan,
- Jason Bock,
- Thomas E. Kaufman,
- Peter Reavey,
- Melisa Carey-Barber,
- Surekha R. Krishnan,
- Andy Garcia,
- Kelly Murphy,
- Jana K. Siskind,
- Malia A. McLean,
- Susan Cheng,
- Steve Ruben,
- Charles E. Birse,
- and Olivier Blondel
Development of a Long-Acting Insulin Analog Using Albumin Fusion Technology
Diabetes January 2005 54:251-258; doi:10.2337/diabetes.54.1.251

Genetics

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- Andrea Baessler,
- Michael J. Hasinoff,
- Marcus Fischer,
- Wibke Reinhard,
- Gabriele E. Sonnenberg,
- Michael Olivier,
- Jeanette Erdmann,
- Heribert Schunkert,
- Angela Doering,
- Howard J. Jacob,
- Anthony G. Comuzzie,
- Ahmed H. Kissebah,
- and Anne E. Kwitek
Genetic Linkage and Association of the Growth Hormone Secretagogue Receptor (Ghrelin Receptor) Gene in Human Obesity
Diabetes January 2005 54:259-267; doi:10.2337/diabetes.54.1.259
Select this article
- Toni I. Pollin,
- Keith Tanner,
- Jeffrey R. O’Connell,
- Sandra H. Ott,
- Coleen M. Damcott,
- Alan R. Shuldiner,
- John C. McLenithan,
- and Braxton D. Mitchell
Linkage of Plasma Adiponectin Levels to 3q27 Explained by Association With Variation in the APM1 Gene
Diabetes January 2005 54:268-274; doi:10.2337/diabetes.54.1.268
Select this article
- Pernille Poulsen,
- Klaus Levin,
- Inge Petersen,
- Kaare Christensen,
- Henning Beck-Nielsen,
- and Allan Vaag
Heritability of Insulin Secretion, Peripheral and Hepatic Insulin Action, and Intracellular Glucose Partitioning in Young and Old Danish Twins
Diabetes January 2005 54:275-283; doi:10.2337/diabetes.54.1.275

Brief Genetics Reports

Select this article
- Barbora Vozarova de Courten,
- Robert L. Hanson,
- Tohru Funahashi,
- Robert S. Lindsay,
- Yuji Matsuzawa,
- Sachiyo Tanaka,
- Farook Thameem,
- Jonathan D. Gruber,
- Philippe Froguel,
- and Johanna K. Wolford
Common Polymorphisms in the Adiponectin Gene ACDC Are Not Associated With Diabetes in Pima Indians
Diabetes January 2005 54:284-289; doi:10.2337/diabetes.54.1.284
Select this article
- Stephen S. Rich,
- Donald W. Bowden,
- Steven M. Haffner,
- Jill M. Norris,
- Mohammed F. Saad,
- Braxton D. Mitchell,
- Jerome I. Rotter,
- Carl D. Langefeld,
- Catherine C. Hedrick,
- Lynne E. Wagenknecht,
- and Richard N. Bergman
A Genome Scan for Fasting Insulin and Fasting Glucose Identifies a Quantitative Trait Locus on Chromosome 17p: The Insulin Resistance Atherosclerosis Study (IRAS) Family Study
Diabetes January 2005 54:290-295; doi:10.2337/diabetes.54.1.290

Erratum

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Erratum
Diabetes January 2005 54:296; doi:10.2337/diabetes.54.1.296
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Erratum
Diabetes January 2005 54:296; doi:10.2337/diabetes.54.1.296-a

Diabetes

Perspectives in Diabetes

Postprandial Hyperglycemia and Diabetes Complications: Is It Time to Treat?

Metabolism

Deficiency of Subsarcolemmal Mitochondria in Obesity and Type 2 Diabetes

Signal Transduction

Differential Effects of Glucose and Lactate on Glucosensing Neurons in the Ventromedial Hypothalamic Nucleus

HIV-1 Accessory Protein Vpr Inhibits the Effect of Insulin on the Foxo Subfamily of Forkhead Transcription Factors by Interfering With Their Binding to 14-3-3 Proteins: Potential Clinical Implications Regarding the Insulin Resistance of HIV-1–Infected Patients

Increased Glucocorticoid Receptor and 11β-Hydroxysteroid Dehydrogenase Type 1 Expression in Hepatocytes May Contribute to the Phenotype of Type 2 Diabetes in db/db Mice

Increased Phosphorylation of Akt Substrate of 160 kDa (AS160) in Rat Skeletal Muscle in Response to Insulin or Contractile Activity

Obesity Studies

Growth Hormone Overexpression in the Central Nervous System Results in Hyperphagia-Induced Obesity Associated With Insulin Resistance and Dyslipidemia

Enhanced Hypothalamic AMP-Activated Protein Kinase Activity Contributes to Hyperphagia in Diabetic Rats

Immunology and Transplantation

Islet-infiltrating B-Cells in Nonobese Diabetic Mice Predominantly Target Nervous System Elements

Treatment With Granulocyte Colony−Stimulating Factor Prevents Diabetes in NOD Mice by Recruiting Plasmacytoid Dendritic Cells and Functional CD4+CD25+ Regulatory T-Cells

Hyperglycemia Induces Monocytic Release of Interleukin-6 via Induction of Protein Kinase C-α and -β

Defective Suppressor Function in CD4+CD25+ T-Cells From Patients With Type 1 Diabetes

β-Cell Function Following Human Islet Transplantation for Type 1 Diabetes

Autoimmune Diabetes and Resistance to Xenograft Transplantation Tolerance in NOD Mice

Islet Studies

Uncoupling of Nutrient Metabolism From Insulin Secretion by Overexpression of Cytosolic Phospholipase A2

Nuclear Factor-κB Activity in β-Cells Is Required for Glucose-Stimulated Insulin Secretion

Genetic Background Determines the Size and Structure of the Endocrine Pancreas

Dynamic Changes in β-Cell Mass and Pancreatic Insulin During the Evolution of Nutrition-Dependent Diabetes in Psammomys obesus: Impact of Glycemic Control

Pathophysiology

Glucagon-like Peptide 1 Can Directly Protect the Heart Against Ischemia/Reperfusion Injury

Delayed Transcapillary Delivery of Insulin to Muscle Interstitial Fluid After Oral Glucose Load in Obese Subjects

Physical Activity in the Prevention of Type 2 Diabetes: The Finnish Diabetes Prevention Study

Predictors of and Longitudinal Changes in Insulin Sensitivity and Secretion Preceding Onset of Type 2 Diabetes

Insulin Deficiency Downregulated Heat Shock Protein 60 and IGF-1 Receptor Signaling in Diabetic Myocardium

Impairment of Host Resistance to Listeria monocytogenes Infection in Liver of db/db and ob/ob Mice

Evidence for Accelerated Rates of Glutathione Utilization and Glutathione Depletion in Adolescents With Poorly Controlled Type 1 Diabetes

Postnatal Diet-Induced Obesity in Rats Upregulates Systemic and Adipose Tissue Glucocorticoid Metabolism During Development and in Adulthood: Its Relationship With the Metabolic Syndrome

Complications

The Effect of Vitamin E on Endothelial Function of Micro- and Macrocirculation and Left Ventricular Function in Type 1 and Type 2 Diabetic Patients

Nitrergic Neurodegeneration in Cerebral Arteries of Streptozotocin-Induced Diabetic Rats: A New Insight into Diabetic Stroke

a-Series Gangliosides Mediate the Effects of Advanced Glycation End Products on Pericyte and Mesangial Cell Proliferation: A Common Mediator for Retinal and Renal Microangiopathy?

Altered Transcapillary Escape of Albumin and Microalbuminuria Reflects Two Different Pathogenetic Mechanisms

Aldose Reductase Inhibition Counteracts Oxidative-Nitrosative Stress and Poly(ADP-Ribose) Polymerase Activation in Tissue Sites for Diabetes Complications

Decreased Expression of Pigment Epithelium-Derived Factor Is Involved in the Pathogenesis of Diabetic Nephropathy

Pharmacology and Therapeutics

Development of a Long-Acting Insulin Analog Using Albumin Fusion Technology

Genetics

Genetic Linkage and Association of the Growth Hormone Secretagogue Receptor (Ghrelin Receptor) Gene in Human Obesity

Linkage of Plasma Adiponectin Levels to 3q27 Explained by Association With Variation in the APM1 Gene

Heritability of Insulin Secretion, Peripheral and Hepatic Insulin Action, and Intracellular Glucose Partitioning in Young and Old Danish Twins

Brief Genetics Reports

Common Polymorphisms in the Adiponectin Gene ACDC Are Not Associated With Diabetes in Pima Indians

A Genome Scan for Fasting Insulin and Fasting Glucose Identifies a Quantitative Trait Locus on Chromosome 17p: The Insulin Resistance Atherosclerosis Study (IRAS) Family Study

Erratum

Erratum

Erratum

This Issue

Current Issue

Treatment With Granulocyte Colony−Stimulating Factor Prevents Diabetes in NOD Mice by Recruiting Plasmacytoid Dendritic Cells and Functional CD4⁺CD25⁺ Regulatory T-Cells

Defective Suppressor Function in CD4⁺CD25⁺ T-Cells From Patients With Type 1 Diabetes

Uncoupling of Nutrient Metabolism From Insulin Secretion by Overexpression of Cytosolic Phospholipase A₂