Deficiency of Subsarcolemmal Mitochondria in Obesity and Type 2 Diabetes

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

FIG. 2.
FIG. 2.

The distribution of overall succinate oxidase activity (complex II-IV) among subsarcolemmal and intermyofibrillar mitochondrial (IFM) fractions, as a percentage of overall succinate oxidase activity, is shown for skeletal muscle from lean, obese, and type 2 diabetic (T2DM) research volunteers. *Lean vs. obese or type 2 diabetic subjects, P < 0.01; **type 2 diabetic vs. obese subjects, P < 0.05. ETC, electron transport chain; SSM, subsarcolemmal mitochondria.

This Article

  1. Diabetes vol. 54 no. 1 8-14