The distribution of overall succinate oxidase activity (complex II-IV) among subsarcolemmal and intermyofibrillar mitochondrial
(IFM) fractions, as a percentage of overall succinate oxidase activity, is shown for skeletal muscle from lean, obese, and
type 2 diabetic (T2DM) research volunteers. *Lean vs. obese or type 2 diabetic subjects, P < 0.01; **type 2 diabetic vs. obese subjects, P < 0.05. ETC, electron transport chain; SSM, subsarcolemmal mitochondria.