Deficiency of Subsarcolemmal Mitochondria in Obesity and Type 2 Diabetes

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FIG. 3.
FIG. 3.

Representative transmission electron microscopy of longitudinal sections of human skeletal muscle from a lean (T) and a type 2 diabetic (DM) research volunteer are shown (bar = 2.5 μm). The thickness of the perinuclear distribution of subsarcolemmal mitochondria was measured using image analysis (National Institutes of Health image 1.61) and can be observed to be substantially depleted in type 2 diabetes.

This Article

  1. Diabetes vol. 54 no. 1 8-14