Deficiency of Subsarcolemmal Mitochondria in Obesity and Type 2 Diabetes

TABLE 3

Electron transport chain activity in subsarcolemmal and intermyofibrillar mitochondria fractions of human skeletal muscle

Lean Obese Type 2 diabetes
n 8 12 11
Subsarcolemmal mitochondria fraction 0.121 ± 0.022 0.034 ± 0.007 0.017 ± 0.003*
Intermyofibrillar mitochondria-1 fraction 0.130 ± 0.018 0.065 ± 0.014 0.040 ± 0.008
Intermyofibrillar mitochondria-2 fraction 0.138 ± 0.016 0.051 ± 0.008 0.068 ± 0.008
Total electron transport chain activity 0.389 ± 0.050 0.150 ± 0.024 0.125 ± 0.013
  • Succinate oxidase (units/mU CK).

  • *

    * P < 0.01, type 2 diabetes vs. obese;

  • P < 0.01, type 2 diabetes or obese vs. lean.

This Article

  1. Diabetes vol. 54 no. 1 8-14