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Table of Contents

October 2005; 54 (10)

Metabolism

    • Simone Baltrusch,
    • Flavio Francini,
    • Sigurd Lenzen,
    • and Markus Tiedge

    Interaction of Glucokinase With the Liver Regulatory Protein Is Conferred by Leucine-Asparagine Motifs of the Enzyme

    Diabetes October 2005 54:2829-2837; doi:10.2337/diabetes.54.10.2829

Obesity Studies

    • Stefan Engeli,
    • Jana Böhnke,
    • Mareike Feldpausch,
    • Kerstin Gorzelniak,
    • Jürgen Janke,
    • Sándor Bátkai,
    • Pál Pacher,
    • Judy Harvey-White,
    • Friedrich C. Luft,
    • Arya M. Sharma,
    • and Jens Jordan

    Activation of the Peripheral Endocannabinoid System in Human Obesity

    Diabetes October 2005 54:2838-2843; doi:10.2337/diabetes.54.10.2838
    • Janin Berndt,
    • Nora Klöting,
    • Susan Kralisch,
    • Peter Kovacs,
    • Mathias Fasshauer,
    • Michael R. Schön,
    • Michael Stumvoll,
    • and Matthias Blüher

    Plasma Visfatin Concentrations and Fat Depot–Specific mRNA Expression in Humans

    Diabetes October 2005 54:2911-2916; doi:10.2337/diabetes.54.10.2911

Islet Studies

    • Stella Papadopoulou and
    • Helena Edlund

    Attenuated Wnt Signaling Perturbs Pancreatic Growth but Not Pancreatic Function

    Diabetes October 2005 54:2844-2851; doi:10.2337/diabetes.54.10.2844
    • Chia-Wei Lin,
    • Feifei Yan,
    • Satoko Shimamura,
    • Sebastian Barg,
    • and Show-Ling Shyng

    Membrane Phosphoinositides Control Insulin Secretion Through Their Effects on ATP-Sensitive K+ Channel Activity

    Diabetes October 2005 54:2852-2858; doi:10.2337/diabetes.54.10.2852
    • Hirofumi Noguchi,
    • Susan Bonner-Weir,
    • Fan-Yan Wei,
    • Masayuki Matsushita,
    • and Shinichi Matsumoto

    BETA2/NeuroD Protein Can Be Transduced Into Cells Due to an Arginine- and Lysine-Rich Sequence

    Diabetes October 2005 54:2859-2866; doi:10.2337/diabetes.54.10.2859
    • Gabriella K.C. Brolén,
    • Nico Heins,
    • Josefina Edsbagge,
    • and Henrik Semb

    Signals From the Embryonic Mouse Pancreas Induce Differentiation of Human Embryonic Stem Cells Into Insulin-Producing β-Cell–Like Cells

    Diabetes October 2005 54:2867-2874; doi:10.2337/diabetes.54.10.2867
    • Anna K. Busch,
    • Ebru Gurisik,
    • Damien V. Cordery,
    • Michelle Sudlow,
    • Gareth S. Denyer,
    • D. Ross Laybutt,
    • William E. Hughes,
    • and Trevor J. Biden

    Increased Fatty Acid Desaturation and Enhanced Expression of Stearoyl Coenzyme A Desaturase Protects Pancreatic β-Cells from Lipoapoptosis

    Diabetes October 2005 54:2917-2924; doi:10.2337/diabetes.54.10.2917
    • Maria S. Remedi,
    • Joseph C. Koster,
    • Brian L. Patton,
    • and Colin G. Nichols

    ATP-Sensitive K+ Channel Signaling in Glucokinase-Deficient Diabetes

    Diabetes October 2005 54:2925-2931; doi:10.2337/diabetes.54.10.2925

Pathophysiology

    • Kathryn M. Thrailkill,
    • Lichu Liu,
    • Elizabeth C. Wahl,
    • Robert C. Bunn,
    • Daniel S. Perrien,
    • Gael E. Cockrell,
    • Robert A. Skinner,
    • William R. Hogue,
    • Adam A. Carver,
    • John L. Fowlkes,
    • James Aronson,
    • and Charles K. Lumpkin

    Bone Formation Is Impaired in a Model of Type 1 Diabetes

    Diabetes October 2005 54:2875-2881; doi:10.2337/diabetes.54.10.2875
    • Barbara Thorand,
    • Hubert Kolb,
    • Jens Baumert,
    • Wolfgang Koenig,
    • Lloyd Chambless,
    • Christa Meisinger,
    • Thomas Illig,
    • Stephan Martin,
    • and Christian Herder

    Elevated Levels of Interleukin-18 Predict the Development of Type 2 Diabetes: Results From the MONICA/KORA Augsburg Study, 1984–2002

    Diabetes October 2005 54:2932-2938; doi:10.2337/diabetes.54.10.2932
    • Peter Plomgaard,
    • Karim Bouzakri,
    • Rikke Krogh-Madsen,
    • Bettina Mittendorfer,
    • Juleen R. Zierath,
    • and Bente K. Pedersen

    Tumor Necrosis Factor-α Induces Skeletal Muscle Insulin Resistance in Healthy Human Subjects via Inhibition of Akt Substrate 160 Phosphorylation

    Diabetes October 2005 54:2939-2945; doi:10.2337/diabetes.54.10.2939
    • Khalid Hussain,
    • Joseph Bryan,
    • Henrick T. Christesen,
    • Klaus Brusgaard,
    • and Lydia Aguilar-Bryan

    Serum Glucagon Counterregulatory Hormonal Response to Hypoglycemia Is Blunted in Congenital Hyperinsulinism

    Diabetes October 2005 54:2946-2951; doi:10.2337/diabetes.54.10.2946

Complications

    • Takashi Matsuoka,
    • Jun Wada,
    • Izumi Hashimoto,
    • Yanling Zhang,
    • Jun Eguchi,
    • Norio Ogawa,
    • Kenichi Shikata,
    • Yashpal S. Kanwar,
    • and Hirofumi Makino

    Gene Delivery of Tim44 Reduces Mitochondrial Superoxide Production and Ameliorates Neointimal Proliferation of Injured Carotid Artery in Diabetic Rats

    Diabetes October 2005 54:2882-2890; doi:10.2337/diabetes.54.10.2882
    • Kunihiro Ichinose,
    • Yohei Maeshima,
    • Yoshihiko Yamamoto,
    • Hiroyuki Kitayama,
    • Yuki Takazawa,
    • Kumiko Hirokoshi,
    • Hitoshi Sugiyama,
    • Yasushi Yamasaki,
    • Katsumi Eguchi,
    • and Hirofumi Makino

    Antiangiogenic Endostatin Peptide Ameliorates Renal Alterations in the Early Stage of a Type 1 Diabetic Nephropathy Model

    Diabetes October 2005 54:2891-2903; doi:10.2337/diabetes.54.10.2891
    • Jeremy Rich and
    • Jean C. Lee

    The Pathogenesis of Staphylococcus aureus Infection in the Diabetic NOD Mouse

    Diabetes October 2005 54:2904-2910; doi:10.2337/diabetes.54.10.2904
    • Vadim K. Pedchenko,
    • Sergei V. Chetyrkin,
    • Peale Chuang,
    • Amy-Joan L. Ham,
    • Moin A. Saleem,
    • Peter W. Mathieson,
    • Billy G. Hudson,
    • and Paul A. Voziyan

    Mechanism of Perturbation of Integrin-Mediated Cell-Matrix Interactions by Reactive Carbonyl Compounds and Its Implication for Pathogenesis of Diabetic Nephropathy

    Diabetes October 2005 54:2952-2960; doi:10.2337/diabetes.54.10.2952
    • Laurent Weekers,
    • Béatrice Bouhanick,
    • Samy Hadjadj,
    • Yves Gallois,
    • Ronen Roussel,
    • Franck Pean,
    • Amos Ankotche,
    • Gilles Chatellier,
    • François Alhenc-Gelas,
    • Pierre J. Lefebvre,
    • and Michel Marre

    Modulation of the Renal Response to ACE Inhibition by ACE Insertion/Deletion Polymorphism During Hyperglycemia in Normotensive, Normoalbuminuric Type 1 Diabetic Patients

    Diabetes October 2005 54:2961-2967; doi:10.2337/diabetes.54.10.2961
    • Paolo Tessari,
    • Anna Coracina,
    • Edward Kiwanuka,
    • Monica Vedovato,
    • Monica Vettore,
    • Anna Valerio,
    • Michela Zaramella,
    • and Giacomo Garibotto

    Effects of Insulin on Methionine and Homocysteine Kinetics in Type 2 Diabetes With Nephropathy

    Diabetes October 2005 54:2968-2976; doi:10.2337/diabetes.54.10.2968
    • Arshag D. Mooradian,
    • Michael J. Haas,
    • Oksana Batejko,
    • Meri Hovsepyan,
    • and Stephen S. Feman

    Statins Ameliorate Endothelial Barrier Permeability Changes in the Cerebral Tissue of Streptozotocin-Induced Diabetic Rats

    Diabetes October 2005 54:2977-2982; doi:10.2337/diabetes.54.10.2977
    • Shin-ichi Araki,
    • Masakazu Haneda,
    • Toshiro Sugimoto,
    • Motohide Isono,
    • Keiji Isshiki,
    • Atsunori Kashiwagi,
    • and Daisuke Koya

    Factors Associated With Frequent Remission of Microalbuminuria in Patients With Type 2 Diabetes

    Diabetes October 2005 54:2983-2987; doi:10.2337/diabetes.54.10.2983

Pharmacology & Therapeutics

    • George R. Lankas,
    • Barbara Leiting,
    • Ranabir Sinha Roy,
    • George J. Eiermann,
    • Maria G. Beconi,
    • Tesfaye Biftu,
    • Chi-Chung Chan,
    • Scott Edmondson,
    • William P. Feeney,
    • Huaibing He,
    • Dawn E. Ippolito,
    • Dooseop Kim,
    • Kathryn A. Lyons,
    • Hyun O. Ok,
    • Reshma A. Patel,
    • Aleksandr N. Petrov,
    • Kelly Ann Pryor,
    • Xiaoxia Qian,
    • Leah Reigle,
    • Andrea Woods,
    • Joseph K. Wu,
    • Dennis Zaller,
    • Xiaoping Zhang,
    • Lan Zhu,
    • Ann E. Weber,
    • and Nancy A. Thornberry

    Dipeptidyl Peptidase IV Inhibition for the Treatment of Type 2 Diabetes: Potential Importance of Selectivity Over Dipeptidyl Peptidases 8 and 9

    Diabetes October 2005 54:2988-2994; doi:10.2337/diabetes.54.10.2988

Genetics

    • Patrick Concannon,
    • Henry A. Erlich,
    • Cecile Julier,
    • Grant Morahan,
    • Jørn Nerup,
    • Flemming Pociot,
    • John A. Todd,
    • Stephen S. Rich,
    • and the Type 1 Diabetes Genetics Consortium

    Type 1 Diabetes: Evidence for Susceptibility Loci from Four Genome-Wide Linkage Scans in 1,435 Multiplex Families

    Diabetes October 2005 54:2995-3001; doi:10.2337/diabetes.54.10.2995
    • Lee H. Bouwman,
    • Peter Eerligh,
    • Onno T. Terpstra,
    • Mohamed R. Daha,
    • Peter de Knijff,
    • Bart E.P.B. Ballieux,
    • G. Jan Bruining,
    • Arno R. van der Slik,
    • Anja Roos,
    • and Bart O. Roep

    Elevated Levels of Mannose-Binding Lectin at Clinical Manifestation of Type 1 Diabetes in Juveniles

    Diabetes October 2005 54:3002-3006; doi:10.2337/diabetes.54.10.3002
    • Alka Malhotra,
    • Johanna K. Wolford,
    • and the American Diabetes Association GENNID Study Group

    Analysis of Quantitative Lipid Traits in the Genetics of NIDDM (GENNID) Study

    Diabetes October 2005 54:3007-3014; doi:10.2337/diabetes.54.10.3007
    • Emma Carlsson,
    • Pernille Poulsen,
    • Heidi Storgaard,
    • Peter Almgren,
    • Charlotte Ling,
    • Christine Bjørn Jensen,
    • Sten Madsbad,
    • Leif Groop,
    • Allan Vaag,
    • and Martin Ridderstråle

    Genetic and Nongenetic Regulation of CAPN10 mRNA Expression in Skeletal Muscle

    Diabetes October 2005 54:3015-3020; doi:10.2337/diabetes.54.10.3015

Brief Genetics Reports

    • Simonetta Bacci,
    • Ornella Ludovico,
    • Sabrina Prudente,
    • Yuan-Yuan Zhang,
    • Rosa Di Paola,
    • Davide Mangiacotti,
    • Anna Rauseo,
    • David Nolan,
    • Jill Duffy,
    • Grazia Fini,
    • Lucia Salvemini,
    • Cesare Amico,
    • Carlo Vigna,
    • Fabio Pellegrini,
    • Claudia Menzaghi,
    • Alessandro Doria,
    • and Vincenzo Trischitta

    The K121Q Polymorphism of the ENPP1/PC-1 Gene Is Associated With Insulin Resistance/Atherogenic Phenotypes, Including Earlier Onset of Type 2 Diabetes and Myocardial Infarction

    Diabetes October 2005 54:3021-3025; doi:10.2337/diabetes.54.10.3021
    • Christian S. Rose,
    • Jakob Ek,
    • Søren A. Urhammer,
    • Charlotte Glümer,
    • Knut Borch-Johnsen,
    • Torben Jørgensen,
    • Oluf Pedersen,
    • and Torben Hansen

    A −30G>A Polymorphism of the β-Cell–Specific Glucokinase Promoter Associates With Hyperglycemia in the General Population of Whites

    Diabetes October 2005 54:3026-3031; doi:10.2337/diabetes.54.10.3026
    • Ingrid Dahlman,
    • Maria Kaaman,
    • Hong Jiao,
    • Juha Kere,
    • Markku Laakso,
    • and Peter Arner

    The CIDEA Gene V115F Polymorphism Is Associated With Obesity in Swedish Subjects

    Diabetes October 2005 54:3032-3034; doi:10.2337/diabetes.54.10.3032
    • Yunhua Li Muller,
    • Aniello M. Infante,
    • Robert L. Hanson,
    • Latisha Love-Gregory,
    • William Knowler,
    • Clifton Bogardus,
    • and Leslie J. Baier

    Variants in Hepatocyte Nuclear Factor 4α Are Modestly Associated With Type 2 Diabetes in Pima Indians

    Diabetes October 2005 54:3035-3039; doi:10.2337/diabetes.54.10.3035
    • Fernando Gibson,
    • Serge Hercberg,
    • and Philippe Froguel

    Common Polymorphisms in the USF1 Gene Are Not Associated With Type 2 Diabetes in French Caucasians

    Diabetes October 2005 54:3040-3042; doi:10.2337/diabetes.54.10.3040
    • Aline Meirhaeghe,
    • Dominique Cottel,
    • Philippe Amouyel,
    • and Jean Dallongeville

    Association Between Peroxisome Proliferator–Activated Receptor γ Haplotypes and the Metabolic Syndrome in French Men and Women

    Diabetes October 2005 54:3043-3048; doi:10.2337/diabetes.54.10.3043
    • Christopher G. Bell,
    • David Meyre,
    • Chantal Samson,
    • Cliona Boyle,
    • Cécile Lecoeur,
    • Maïte Tauber,
    • Béatrice Jouret,
    • Delphine Jaquet,
    • Claire Levy-Marchal,
    • Marie Aline Charles,
    • Jacques Weill,
    • Fernando Gibson,
    • Charles A. Mein,
    • Philippe Froguel,
    • and Andrew J. Walley

    Association of Melanin-Concentrating Hormone Receptor 1 5′ Polymorphism With Early-Onset Extreme Obesity

    Diabetes October 2005 54:3049-3055; doi:10.2337/diabetes.54.10.3049

Perspectives in Diabetes

    • George L. Kellett and
    • Edith Brot-Laroche

    Apical GLUT2: A Major Pathway of Intestinal Sugar Absorption

    Diabetes October 2005 54:3056-3062; doi:10.2337/diabetes.54.10.3056
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This Issue

October 2005; 54 (10)
  1. Metabolism
  2. Obesity Studies
  3. Islet Studies
  4. Pathophysiology
  5. Complications
  6. Pharmacology & Therapeutics
  7. Genetics
  8. Brief Genetics Reports
  9. Perspectives in Diabetes

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