Table of Contents

Perspectives in Diabetes

Select this article
- Joseph C. Koster,
- M. Alan Permutt,
- and Colin G. Nichols
Diabetes and Insulin Secretion: The ATP-Sensitive K⁺ Channel (K_ATP) Connection
Diabetes November 2005 54:3065-3072; doi:10.2337/diabetes.54.11.3065

Islet Studies

Select this article
- Natalia A. Tamarina,
- Andrey Kuznetsov,
- Christopher J. Rhodes,
- Vytautas P. Bindokas,
- and Louis H. Philipson
Inositol (1,4,5)-Trisphosphate Dynamics and Intracellular Calcium Oscillations in Pancreatic β-Cells
Diabetes November 2005 54:3073-3081; doi:10.2337/diabetes.54.11.3073
Select this article
- Jichun Yang,
- Claudia E. Robert,
- Brant R. Burkhardt,
- Robert A. Young,
- Jianmei Wu,
- Zhiyong Gao,
- and Bryan A. Wolf
Mechanisms of Glucose-Induced Secretion of Pancreatic-Derived Factor (PANDER or FAM3B) in Pancreatic β-Cells
Diabetes November 2005 54:3217-3228; doi:10.2337/diabetes.54.11.3217
Select this article
- Manuel Dolz,
- Danielle Bailbé,
- Marie-Hélène Giroix,
- Sophie Calderari,
- Marie-Noelle Gangnerau,
- Patricia Serradas,
- Katharina Rickenbach,
- Jean-Claude Irminger,
- and Bernard Portha
Restitution of Defective Glucose-Stimulated Insulin Secretion in Diabetic GK Rat by Acetylcholine Uncovers Paradoxical Stimulatory Effect of β-Cell Muscarinic Receptor Activation on cAMP Production
Diabetes November 2005 54:3229-3237; doi:10.2337/diabetes.54.11.3229

Pathophysiology

Select this article
- Nazmi Yaras,
- Mehmet Ugur,
- Semir Ozdemir,
- Hakan Gurdal,
- Nuhan Purali,
- Alain Lacampagne,
- Guy Vassort,
- and Belma Turan
Effects of Diabetes on Ryanodine Receptor Ca Release Channel (RyR2) and Ca²⁺ Homeostasis in Rat Heart
Diabetes November 2005 54:3082-3088; doi:10.2337/diabetes.54.11.3082
Select this article
- Celena Scheede-Bergdahl,
- Milena Penkowa,
- Juan Hidalgo,
- David B. Olsen,
- Peter Schjerling,
- Clara Prats,
- Robert Boushel,
- and Flemming Dela
Metallothionein-Mediated Antioxidant Defense System and Its Response to Exercise Training Are Impaired in Human Type 2 Diabetes
Diabetes November 2005 54:3089-3094; doi:10.2337/diabetes.54.11.3089
Select this article
- Nils Welsh,
- Miriam Cnop,
- Ilham Kharroubi,
- Marco Bugliani,
- Roberto Lupi,
- Piero Marchetti,
- and Décio L. Eizirik
Is There a Role for Locally Produced Interleukin-1 in the Deleterious Effects of High Glucose or the Type 2 Diabetes Milieu to Human Pancreatic Islets?
Diabetes November 2005 54:3238-3244; doi:10.2337/diabetes.54.11.3238
Select this article
- Enoka P. Wijekoon,
- Beatrice Hall,
- Shobhitha Ratnam,
- Margaret E. Brosnan,
- Steven H. Zeisel,
- and John T. Brosnan
Homocysteine Metabolism in ZDF (Type 2) Diabetic Rats
Diabetes November 2005 54:3245-3251; doi:10.2337/diabetes.54.11.3245
Select this article
- Martin K. Rutter,
- James B. Meigs,
- Lisa M. Sullivan,
- Ralph B. D’Agostino, Sr,
- and Peter W. Wilson
Insulin Resistance, the Metabolic Syndrome, and Incident Cardiovascular Events in the Framingham Offspring Study
Diabetes November 2005 54:3252-3257; doi:10.2337/diabetes.54.11.3252
Select this article
- Satoshi Fujita and
- Casey M. Donovan
Celiac-Superior Mesenteric Ganglionectomy, but Not Vagotomy, Suppresses the Sympathoadrenal Response to Insulin-Induced Hypoglycemia
Diabetes November 2005 54:3258-3264; doi:10.2337/diabetes.54.11.3258
Select this article
- Chiara Dalla Man,
- Marco Campioni,
- Kenneth S. Polonsky,
- Rita Basu,
- Robert A. Rizza,
- Gianna Toffolo,
- and Claudio Cobelli
Two-Hour Seven-Sample Oral Glucose Tolerance Test and Meal Protocol: Minimal Model Assessment of β-Cell Responsivity and Insulin Sensitivity in Nondiabetic Individuals
Diabetes November 2005 54:3265-3273; doi:10.2337/diabetes.54.11.3265

Complications

Select this article
- Richard J.M. Coward,
- Gavin I. Welsh,
- Jing Yang,
- Candida Tasman,
- Rachel Lennon,
- Ania Koziell,
- Simon Satchell,
- Geoffrey D. Holman,
- Dontscho Kerjaschki,
- Jeremy M. Tavaré,
- Peter W. Mathieson,
- and Moin A. Saleem
The Human Glomerular Podocyte Is a Novel Target for Insulin Action
Diabetes November 2005 54:3095-3102; doi:10.2337/diabetes.54.11.3095
Select this article
- Saul Genuth,
- Wanjie Sun,
- Patricia Cleary,
- David R. Sell,
- William Dahms,
- John Malone,
- William Sivitz,
- Vincent M. Monnier,
- and for the DCCT Skin Collagen Ancillary Study Group
Glycation and Carboxymethyllysine Levels in Skin Collagen Predict the Risk of Future 10-Year Progression of Diabetic Retinopathy and Nephropathy in the Diabetes Control and Complications Trial and Epidemiology of Diabetes Interventions and Complications Participants With Type 1 Diabetes
Diabetes November 2005 54:3103-3111; doi:10.2337/diabetes.54.11.3103
Select this article
- Yuk Shan Chen,
- Stephen S.M. Chung,
- and Sookja K. Chung
Noninvasive Monitoring of Diabetes-Induced Cutaneous Nerve Fiber Loss and Hypoalgesia in thy1-YFP Transgenic Mice
Diabetes November 2005 54:3112-3118; doi:10.2337/diabetes.54.11.3112
Select this article
- Alvin K.H. Cheung,
- Maggie K.L. Fung,
- Amy C.Y. Lo,
- Terence T.L. Lam,
- Kwok Fai So,
- Stephen S.M. Chung,
- and Sookja K. Chung
Aldose Reductase Deficiency Prevents Diabetes-Induced Blood-Retinal Barrier Breakdown, Apoptosis, and Glial Reactivation in the Retina of db/db Mice
Diabetes November 2005 54:3119-3125; doi:10.2337/diabetes.54.11.3119
Select this article
- Paul J. Beisswenger,
- Keith S. Drummond,
- Robert G. Nelson,
- Scott K. Howell,
- Benjamin S. Szwergold,
- and Michael Mauer
Susceptibility to Diabetic Nephropathy Is Related to Dicarbonyl and Oxidative Stress
Diabetes November 2005 54:3274-3281; doi:10.2337/diabetes.54.11.3274
Select this article
- Fredrik Palm,
- Donald G. Buerk,
- Per-Ola Carlsson,
- Peter Hansell,
- and Per Liss
Reduced Nitric Oxide Concentration in the Renal Cortex of Streptozotocin-Induced Diabetic Rats: Effects on Renal Oxygenation and Microcirculation
Diabetes November 2005 54:3282-3287; doi:10.2337/diabetes.54.11.3282
Select this article
- Hideki Kamiya,
- Weixian Zhangm,
- and Anders A.F. Sima
Apoptotic Stress Is Counterbalanced by Survival Elements Preventing Programmed Cell Death of Dorsal Root Ganglions in Subacute Type 1 Diabetic BB/Wor Rats
Diabetes November 2005 54:3288-3295; doi:10.2337/diabetes.54.11.3288

Genetics

Select this article
- Christine Bellanné-Chantelot,
- Séverine Clauin,
- Dominique Chauveau,
- Philippe Collin,
- Michèle Daumont,
- Claire Douillard,
- Danièle Dubois-Laforgue,
- Laurent Dusselier,
- Jean-François Gautier,
- Michel Jadoul,
- Marie Laloi-Michelin,
- Laetitia Jacquesson,
- Etienne Larger,
- Jacques Louis,
- Marc Nicolino,
- Jean-François Subra,
- Jean-Marie Wilhem,
- Jacques Young,
- Gilberto Velho,
- and José Timsit
Large Genomic Rearrangements in the Hepatocyte Nuclear Factor-1β (TCF2) Gene Are the Most Frequent Cause of Maturity-Onset Diabetes of the Young Type 5
Diabetes November 2005 54:3126-3132; doi:10.2337/diabetes.54.11.3126
Select this article
- Nicola J. Spencer-Jones,
- Xiaoling Wang,
- Harold Snieder,
- Tim D. Spector,
- Nicholas D. Carter,
- and Sandra D. O’Dell
Protein Tyrosine Phosphatase-1B Gene PTPN1: Selection of Tagging Single Nucleotide Polymorphisms and Association With Body Fat, Insulin Sensitivity, and the Metabolic Syndrome in a Normal Female Population
Diabetes November 2005 54:3296-3304; doi:10.2337/diabetes.54.11.3296
Select this article
- Kathryn Gogolin Ewens,
- Roberta Ann George,
- Kumar Sharma,
- Fuad N. Ziyadeh,
- and Richard S. Spielman
Assessment of 115 Candidate Genes for Diabetic Nephropathy by Transmission/Disequilibrium Test
Diabetes November 2005 54:3305-3318; doi:10.2337/diabetes.54.11.3305
Select this article
- Johanna K. Wolford,
- Kimberly A. Yeatts,
- Sharanjeet K. Dhanjal,
- Mary Helen Black,
- Anny H. Xiang,
- Thomas A. Buchanan,
- and Richard M. Watanabe
Sequence Variation in PPARG May Underlie Differential Response to Troglitazone
Diabetes November 2005 54:3319-3325; doi:10.2337/diabetes.54.11.3319

Metabolism

Select this article
- Jane Shearer,
- Patrick T. Fueger,
- Deanna P. Bracy,
- David H. Wasserman,
- and Jeffrey N. Rottman
Partial Gene Deletion of Heart-Type Fatty Acid–Binding Protein Limits the Severity of Dietary-Induced Insulin Resistance
Diabetes November 2005 54:3133-3139; doi:10.2337/diabetes.54.11.3133
Select this article
- Anthony J.G. Hanley,
- Ken Williams,
- Andreas Festa,
- Lynne E. Wagenknecht,
- Ralph B. D’Agostino, Jr,
- and Steven M. Haffner
Liver Markers and Development of the Metabolic Syndrome: The Insulin Resistance Atherosclerosis Study
Diabetes November 2005 54:3140-3147; doi:10.2337/diabetes.54.11.3140
Select this article
- Mandeep Bajaj,
- Swangjit Suraamornkul,
- Anthony Romanelli,
- Gary W. Cline,
- Lawrence J. Mandarino,
- Gerald I. Shulman,
- and Ralph A. DeFronzo
Effect of a Sustained Reduction in Plasma Free Fatty Acid Concentration on Intramuscular Long-Chain Fatty Acyl-CoAs and Insulin Action in Type 2 Diabetic Patients
Diabetes November 2005 54:3148-3153; doi:10.2337/diabetes.54.11.3148
Select this article
- Clinton R. Bruce,
- Valerie A. Mertz,
- George J.F. Heigenhauser,
- and David J. Dyck
The Stimulatory Effect of Globular Adiponectin on Insulin-Stimulated Glucose Uptake and Fatty Acid Oxidation Is Impaired in Skeletal Muscle From Obese Subjects
Diabetes November 2005 54:3154-3160; doi:10.2337/diabetes.54.11.3154

Signal Transduction

Select this article
- Sophie Turban,
- Victoria A. Beardmore,
- Julia M. Carr,
- Kei Sakamoto,
- Eric Hajduch,
- J. Simon C. Arthur,
- and Harinder S. Hundal
Insulin-Stimulated Glucose Uptake Does Not Require p38 Mitogen-Activated Protein Kinase in Adipose Tissue or Skeletal Muscle
Diabetes November 2005 54:3161-3168; doi:10.2337/diabetes.54.11.3161
Select this article
- Rory J. McCrimmon,
- Mark L. Evans,
- Xiaoning Fan,
- Ewan C. McNay,
- Owen Chan,
- Yuyan Ding,
- Wanling Zhu,
- Dorte X. Gram,
- and Robert S. Sherwin
Activation of ATP-Sensitive K⁺ Channels in the Ventromedial Hypothalamus Amplifies Counterregulatory Hormone Responses to Hypoglycemia in Normal and Recurrently Hypoglycemic Rats
Diabetes November 2005 54:3169-3174; doi:10.2337/diabetes.54.11.3169
Select this article
- Hye Sun Park,
- Dong Kyu Jin,
- Sang Min Shin,
- Mi Kyung Jang,
- Nicholas Longo,
- Ji Won Park,
- Duk Soo Bae,
- and Yun Soo Bae
Impaired Generation of Reactive Oxygen Species in Leprechaunism Through Downregulation of Nox4
Diabetes November 2005 54:3175-3181; doi:10.2337/diabetes.54.11.3175

Obesity Studies

Select this article
- Alessandro Pocai,
- Kimyata Morgan,
- Christoph Buettner,
- Roger Gutierrez-Juarez,
- Silvana Obici,
- and Luciano Rossetti
Central Leptin Acutely Reverses Diet-Induced Hepatic Insulin Resistance
Diabetes November 2005 54:3182-3189; doi:10.2337/diabetes.54.11.3182
Select this article
- Dominique Langin,
- Andrea Dicker,
- Geneviève Tavernier,
- Johan Hoffstedt,
- Aline Mairal,
- Mikael Rydén,
- Erik Arner,
- Audrey Sicard,
- Christopher M. Jenkins,
- Nathalie Viguerie,
- Vanessa van Harmelen,
- Richard W. Gross,
- Cecilia Holm,
- and Peter Arner
Adipocyte Lipases and Defect of Lipolysis in Human Obesity
Diabetes November 2005 54:3190-3197; doi:10.2337/diabetes.54.11.3190
Select this article
- Frank H. Koegler,
- Pablo J. Enriori,
- Sonja K. Billes,
- Diana L. Takahashi,
- Meghan S. Martin,
- Randall L. Clark,
- Anne E. Evans,
- Kevin L. Grove,
- Judy L. Cameron,
- and Michael A. Cowley
Peptide YY_(3–36) Inhibits Morning, but Not Evening, Food Intake and Decreases Body Weight in Rhesus Macaques
Diabetes November 2005 54:3198-3204; doi:10.2337/diabetes.54.11.3198

Immunology and Transplantation

Select this article
- Michael R. Rickels,
- Mark H. Schutta,
- Rebecca Mueller,
- James F. Markmann,
- Clyde F. Barker,
- Ali Naji,
- and Karen L. Teff
Islet Cell Hormonal Responses to Hypoglycemia After Human Islet Transplantation for Type 1 Diabetes
Diabetes November 2005 54:3205-3211; doi:10.2337/diabetes.54.11.3205
Select this article
- Katja Radon,
- Doris Windstetter,
- Susanne Solfrank,
- Erika von Mutius,
- Dennis Nowak,
- Hans-Peter Schwarz,
- and for the Chronic Autoimmune Disease and Contact to Animals (CAT) Study Group
Exposure to Farming Environments in Early Life and Type 1 Diabetes: A Case-Control Study
Diabetes November 2005 54:3212-3216; doi:10.2337/diabetes.54.11.3212

Brief Genetics Reports

Select this article
- Luis H. Canani,
- Clarissa Capp,
- Daniel P.K. Ng,
- Serena G.L. Choo,
- Ana Luiza Maia,
- Gustavo B. Nabinger,
- Kátia Santos,
- Daisy Crispim,
- Israel Roisemberg,
- Andrzej S. Krolewski,
- and Jorge L. Gross
The Fatty Acid–Binding Protein-2 A54T Polymorphism Is Associated With Renal Disease in Patients With Type 2 Diabetes
Diabetes November 2005 54:3326-3330; doi:10.2337/diabetes.54.11.3326
Select this article
- Wojciech M. Mlynarski,
- Grzegorz P. Placha,
- Pawel P. Wolkow,
- Jacek P. Bochenski,
- James H. Warram,
- and Andrzej S. Krolewski
Risk of Diabetic Nephropathy in Type 1 Diabetes Is Associated With Functional Polymorphisms in RANTES Receptor Gene (CCR5): A Sex-Specific Effect
Diabetes November 2005 54:3331-3335; doi:10.2337/diabetes.54.11.3331
Select this article
- Guang Sun,
- Sudesh Vasdev,
- Glynn R. Martin,
- Veeresh Gadag,
- and Hongwei Zhang
Altered Calcium Homeostasis Is Correlated With Abnormalities of Fasting Serum Glucose, Insulin Resistance, and β-Cell Function in the Newfoundland Population
Diabetes November 2005 54:3336-3339; doi:10.2337/diabetes.54.11.3336

Erratum

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Erratum
Diabetes November 2005 54:3340; doi:10.2337/diabetes.54.11.3340

Diabetes

Perspectives in Diabetes

Diabetes and Insulin Secretion: The ATP-Sensitive K+ Channel (KATP) Connection

Islet Studies

Inositol (1,4,5)-Trisphosphate Dynamics and Intracellular Calcium Oscillations in Pancreatic β-Cells

Mechanisms of Glucose-Induced Secretion of Pancreatic-Derived Factor (PANDER or FAM3B) in Pancreatic β-Cells

Restitution of Defective Glucose-Stimulated Insulin Secretion in Diabetic GK Rat by Acetylcholine Uncovers Paradoxical Stimulatory Effect of β-Cell Muscarinic Receptor Activation on cAMP Production

Pathophysiology

Effects of Diabetes on Ryanodine Receptor Ca Release Channel (RyR2) and Ca2+ Homeostasis in Rat Heart

Metallothionein-Mediated Antioxidant Defense System and Its Response to Exercise Training Are Impaired in Human Type 2 Diabetes

Is There a Role for Locally Produced Interleukin-1 in the Deleterious Effects of High Glucose or the Type 2 Diabetes Milieu to Human Pancreatic Islets?

Homocysteine Metabolism in ZDF (Type 2) Diabetic Rats

Insulin Resistance, the Metabolic Syndrome, and Incident Cardiovascular Events in the Framingham Offspring Study

Celiac-Superior Mesenteric Ganglionectomy, but Not Vagotomy, Suppresses the Sympathoadrenal Response to Insulin-Induced Hypoglycemia

Two-Hour Seven-Sample Oral Glucose Tolerance Test and Meal Protocol: Minimal Model Assessment of β-Cell Responsivity and Insulin Sensitivity in Nondiabetic Individuals

Complications

The Human Glomerular Podocyte Is a Novel Target for Insulin Action

Glycation and Carboxymethyllysine Levels in Skin Collagen Predict the Risk of Future 10-Year Progression of Diabetic Retinopathy and Nephropathy in the Diabetes Control and Complications Trial and Epidemiology of Diabetes Interventions and Complications Participants With Type 1 Diabetes

Noninvasive Monitoring of Diabetes-Induced Cutaneous Nerve Fiber Loss and Hypoalgesia in thy1-YFP Transgenic Mice

Aldose Reductase Deficiency Prevents Diabetes-Induced Blood-Retinal Barrier Breakdown, Apoptosis, and Glial Reactivation in the Retina of db/db Mice

Susceptibility to Diabetic Nephropathy Is Related to Dicarbonyl and Oxidative Stress

Reduced Nitric Oxide Concentration in the Renal Cortex of Streptozotocin-Induced Diabetic Rats: Effects on Renal Oxygenation and Microcirculation

Apoptotic Stress Is Counterbalanced by Survival Elements Preventing Programmed Cell Death of Dorsal Root Ganglions in Subacute Type 1 Diabetic BB/Wor Rats

Genetics

Large Genomic Rearrangements in the Hepatocyte Nuclear Factor-1β (TCF2) Gene Are the Most Frequent Cause of Maturity-Onset Diabetes of the Young Type 5

Protein Tyrosine Phosphatase-1B Gene PTPN1: Selection of Tagging Single Nucleotide Polymorphisms and Association With Body Fat, Insulin Sensitivity, and the Metabolic Syndrome in a Normal Female Population

Assessment of 115 Candidate Genes for Diabetic Nephropathy by Transmission/Disequilibrium Test

Sequence Variation in PPARG May Underlie Differential Response to Troglitazone

Metabolism

Partial Gene Deletion of Heart-Type Fatty Acid–Binding Protein Limits the Severity of Dietary-Induced Insulin Resistance

Liver Markers and Development of the Metabolic Syndrome: The Insulin Resistance Atherosclerosis Study

Effect of a Sustained Reduction in Plasma Free Fatty Acid Concentration on Intramuscular Long-Chain Fatty Acyl-CoAs and Insulin Action in Type 2 Diabetic Patients

The Stimulatory Effect of Globular Adiponectin on Insulin-Stimulated Glucose Uptake and Fatty Acid Oxidation Is Impaired in Skeletal Muscle From Obese Subjects

Signal Transduction

Insulin-Stimulated Glucose Uptake Does Not Require p38 Mitogen-Activated Protein Kinase in Adipose Tissue or Skeletal Muscle

Activation of ATP-Sensitive K+ Channels in the Ventromedial Hypothalamus Amplifies Counterregulatory Hormone Responses to Hypoglycemia in Normal and Recurrently Hypoglycemic Rats

Impaired Generation of Reactive Oxygen Species in Leprechaunism Through Downregulation of Nox4

Obesity Studies

Central Leptin Acutely Reverses Diet-Induced Hepatic Insulin Resistance

Adipocyte Lipases and Defect of Lipolysis in Human Obesity

Peptide YY(3–36) Inhibits Morning, but Not Evening, Food Intake and Decreases Body Weight in Rhesus Macaques

Immunology and Transplantation

Islet Cell Hormonal Responses to Hypoglycemia After Human Islet Transplantation for Type 1 Diabetes

Exposure to Farming Environments in Early Life and Type 1 Diabetes: A Case-Control Study

Brief Genetics Reports

The Fatty Acid–Binding Protein-2 A54T Polymorphism Is Associated With Renal Disease in Patients With Type 2 Diabetes

Risk of Diabetic Nephropathy in Type 1 Diabetes Is Associated With Functional Polymorphisms in RANTES Receptor Gene (CCR5): A Sex-Specific Effect

Altered Calcium Homeostasis Is Correlated With Abnormalities of Fasting Serum Glucose, Insulin Resistance, and β-Cell Function in the Newfoundland Population

Erratum

Erratum

This Issue

Current Issue

Diabetes and Insulin Secretion: The ATP-Sensitive K⁺ Channel (K_ATP) Connection

Effects of Diabetes on Ryanodine Receptor Ca Release Channel (RyR2) and Ca²⁺ Homeostasis in Rat Heart

Activation of ATP-Sensitive K⁺ Channels in the Ventromedial Hypothalamus Amplifies Counterregulatory Hormone Responses to Hypoglycemia in Normal and Recurrently Hypoglycemic Rats

Peptide YY_(3–36) Inhibits Morning, but Not Evening, Food Intake and Decreases Body Weight in Rhesus Macaques