The Fatty Acid–Binding Protein-2 A54T Polymorphism Is Associated With Renal Disease in Patients With Type 2 Diabetes

  1. Luis H. Canani1,
  2. Clarissa Capp12,
  3. Daniel P.K. Ng345,
  4. Serena G.L. Choo4,
  5. Ana Luiza Maia1,
  6. Gustavo B. Nabinger1,
  7. Kátia Santos6,
  8. Daisy Crispim6,
  9. Israel Roisemberg6,
  10. Andrzej S. Krolewski5 and
  11. Jorge L. Gross1
  1. 1Endocrine Division, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
  2. 2Department of Physiology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
  3. 3Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore
  4. 4Centre for Molecular Epidemiology, National University of Singapore, Singapore
  5. 5Section on Genetics and Epidemiology, Joslin Diabetes Center, Boston, Massachusetts
  6. 6Department of Genetics, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
  1. Address correspondence and reprint requests to Jorge Luiz Gross, Serviço de Endocrinologia, Hospital de Clínicas de Porto Alegre, RS, Brazil, Rua Ramiro Barcelos 2350-Prédio 12-4° andar 90035-003 Porto Alegre, RS–Brazil. E-mail: jorgegross{at}terra.com.br

Abstract

The intestinal fatty–acid binding protein-2 (FABP2) gene codes a protein responsible for the absorption of long-chain fatty acids. To test whether FABP2 is a candidate gene for renal disease in patients with type 2 diabetes, a functional A54T polymorphism was genotyped in 1,042 Brazilians with type 2 diabetes. Patients were classified as having normoalbuminuria (urinary albumin excretion [UAE] <20 μg/min; n = 529), microalbuminuria (UAE 20–199 μg/min; n = 217), or proteinuria (UAE >199 μg/min; n = 160). Patients with end-stage renal disease (ESRD) (n = 136) were also included. The prevalence of the TT genotype was higher in patients with renal involvement compared with those with normoalbuminuria (odds ratio [95% CI] 2.4 [1.1–5.4]) following adjustment for type 2 diabetes duration, BMI, hypertension, A1C, and cholesterol levels. The risk was similar considering different stages of renal involvement. In a second independent patient sample (483 type 2 diabetic Caucasians residing in Massachusetts), a significant association was also observed between the TT genotype and proteinuria or ESRD (2.7 [1.0–7.3]; P = 0.048). This study thus provides evidence that FABP2 confers susceptibility to renal disease in type 2 diabetic patients.

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  1. doi: 10.2337/diabetes.54.11.3326 Diabetes November 2005 vol. 54 no. 11 3326-3330
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