Table of Contents

Signal Transduction

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- Susanna Freude,
- Leona Plum,
- Jessika Schnitker,
- Uschi Leeser,
- Michael Udelhoven,
- Wilhelm Krone,
- Jens C. Bruning,
- and Markus Schubert
Peripheral Hyperinsulinemia Promotes Tau Phosphorylation In Vivo
Diabetes December 2005 54:3343-3348; doi:10.2337/diabetes.54.12.3343
Select this article
- Steen B. Haugaard,
- Ove Andersen,
- Sten Madsbad,
- Christian Frøsig,
- Johan Iversen,
- Jens Ole Nielsen,
- and Jørgen F.P. Wojtaszewski
Skeletal Muscle Insulin Signaling Defects Downstream of Phosphatidylinositol 3-Kinase at the Level of Akt Are Associated With Impaired Nonoxidative Glucose Disposal in HIV Lipodystrophy
Diabetes December 2005 54:3474-3483; doi:10.2337/diabetes.54.12.3474
Select this article
- Brian R. Barnes,
- Yun Chau Long,
- Tatiana L. Steiler,
- Ying Leng,
- Dana Galuska,
- Jørgen F.P. Wojtaszewski,
- Leif Andersson,
- and Juleen R. Zierath
Changes in Exercise-Induced Gene Expression in 5′-AMP–Activated Protein Kinase γ3–Null and γ3 R225Q Transgenic Mice
Diabetes December 2005 54:3484-3489; doi:10.2337/diabetes.54.12.3484
Select this article
- Cédric Asensio,
- Maria Jimenez,
- Françoise Kühne,
- Françoise Rohner-Jeanrenaud,
- and Patrick Muzzin
The Lack of β-Adrenoceptors Results in Enhanced Insulin Sensitivity in Mice Exhibiting Increased Adiposity and Glucose Intolerance
Diabetes December 2005 54:3490-3495; doi:10.2337/diabetes.54.12.3490
Select this article
- Andrew J. Murray,
- Marcello Panagia,
- David Hauton,
- Geoffrey F. Gibbons,
- and Kieran Clarke
Plasma Free Fatty Acids and Peroxisome Proliferator–Activated Receptor α in the Control of Myocardial Uncoupling Protein Levels
Diabetes December 2005 54:3496-3502; doi:10.2337/diabetes.54.12.3496

Obesity Studies

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- Toshiya Atsumi,
- Taro Nishio,
- Hirokatsu Niwa,
- Jun Takeuchi,
- Hidenori Bando,
- Chikara Shimizu,
- Narihito Yoshioka,
- Richard Bucala,
- and Takao Koike
Expression of Inducible 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase/PFKFB3 Isoforms in Adipocytes and Their Potential Role in Glycolytic Regulation
Diabetes December 2005 54:3349-3357; doi:10.2337/diabetes.54.12.3349
Select this article
- Atsushi Tsuchida,
- Toshimasa Yamauchi,
- Sato Takekawa,
- Yusuke Hada,
- Yusuke Ito,
- Toshiyuki Maki,
- and Takashi Kadowaki
Peroxisome Proliferator–Activated Receptor (PPAR)α Activation Increases Adiponectin Receptors and Reduces Obesity-Related Inflammation in Adipose Tissue: Comparison of Activation of PPARα, PPARγ, and Their Combination
Diabetes December 2005 54:3358-3370; doi:10.2337/diabetes.54.12.3358
Select this article
- Nicholas M. Morton,
- Valerie Densmore,
- Malgorzata Wamil,
- Lynne Ramage,
- Katherine Nichol,
- Lutz Bünger,
- Jonathan R. Seckl,
- and Christopher J. Kenyon
A Polygenic Model of the Metabolic Syndrome With Reduced Circulating and Intra-Adipose Glucocorticoid Action
Diabetes December 2005 54:3371-3378; doi:10.2337/diabetes.54.12.3371
Select this article
- Nancy Chen,
- Li Liu,
- Yiying Zhang,
- Henry N. Ginsberg,
- and Yi-Hao Yu
Whole-body Insulin Resistance in the Absence of Obesity in FVB Mice With Overexpression of Dgat1 in Adipose Tissue
Diabetes December 2005 54:3379-3386; doi:10.2337/diabetes.54.12.3379
Select this article
- Emmanuel Somm,
- Elvire Henrichot,
- Agnès Pernin,
- Cristiana E. Juge-Aubry,
- Patrick Muzzin,
- Jean-Michel Dayer,
- Martin J.H. Nicklin,
- and Christoph A. Meier
Decreased Fat Mass in Interleukin-1 Receptor Antagonist–Deficient Mice: Impact on Adipogenesis, Food Intake, and Energy Expenditure
Diabetes December 2005 54:3503-3509; doi:10.2337/diabetes.54.12.3503
Select this article
- Antoine Tabarin,
- Yolanda Diz-Chaves,
- Maria del Carmen Carmona,
- Bogdan Catargi,
- Eric P. Zorrilla,
- Amanda J. Roberts,
- Donald V. Coscina,
- Sophie Rousset,
- Anabelle Redonnet,
- Graham C. Parker,
- Koki Inoue,
- Daniel Ricquier,
- Luc Pénicaud,
- Brigitte L. Kieffer,
- and Georges F. Koob
Resistance to Diet-Induced Obesity in μ-Opioid Receptor–Deficient Mice: Evidence for a “Thrifty Gene”
Diabetes December 2005 54:3510-3516; doi:10.2337/diabetes.54.12.3510

Immunology and Transplantation

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- Marika Bogdani,
- Krista Suenens,
- Troels Bock,
- Miriam Pipeleers-Marichal,
- Peter In’t Veld,
- and Daniel Pipeleers
Growth and Functional Maturation of β-Cells in Implants of Endocrine Cells Purified From Prenatal Porcine Pancreas
Diabetes December 2005 54:3387-3394; doi:10.2337/diabetes.54.12.3387
Select this article
- Dunja Bruder,
- Astrid M. Westendorf,
- Wiebke Hansen,
- Silvia Prettin,
- Achim D. Gruber,
- Yingjie Qian,
- Harald von Boehmer,
- Karsten Mahnke,
- and Jan Buer
On the Edge of Autoimmunity: T-Cell Stimulation by Steady-State Dendritic Cells Prevents Autoimmune Diabetes
Diabetes December 2005 54:3395-3401; doi:10.2337/diabetes.54.12.3395

Islet Studies

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- Maria E. Wilson,
- Katherine Y. Yang,
- Anna Kalousova,
- Janet Lau,
- Yasuhiro Kosaka,
- Francis C. Lynn,
- Juehu Wang,
- Caroline Mrejen,
- Vasso Episkopou,
- Hans C. Clevers,
- and Michael S. German
The HMG Box Transcription Factor Sox4 Contributes to the Development of the Endocrine Pancreas
Diabetes December 2005 54:3402-3409; doi:10.2337/diabetes.54.12.3402
Select this article
- Katharina Laubner,
- Timothy J. Kieffer,
- Ni T. Lam,
- Xinjie Niu,
- Franz Jakob,
- and Jochen Seufert
Inhibition of Preproinsulin Gene Expression by Leptin Induction of Suppressor of Cytokine Signaling 3 in Pancreatic β-Cells
Diabetes December 2005 54:3410-3417; doi:10.2337/diabetes.54.12.3410
Select this article
- Craig S. Nunemaker,
- Min Zhang,
- David H. Wasserman,
- Owen P. McGuinness,
- Alvin C. Powers,
- Richard Bertram,
- Arthur Sherman,
- and Leslie S. Satin
Individual Mice Can Be Distinguished by the Period of Their Islet Calcium Oscillations: Is There an Intrinsic Islet Period That Is Imprinted In Vivo?
Diabetes December 2005 54:3517-3522; doi:10.2337/diabetes.54.12.3517
Select this article
- Anjaneyulu Kowluru and
- Rajakrishnan Veluthakal
Rho Guanosine Diphosphate–Dissociation Inhibitor Plays a Negative Modulatory Role in Glucose-Stimulated Insulin Secretion
Diabetes December 2005 54:3523-3529; doi:10.2337/diabetes.54.12.3523

Complications

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- Wei Sun,
- Chiara Gerhardinger,
- Zeina Dagher,
- Todd Hoehn,
- and Mara Lorenzi
Aspirin at Low-Intermediate Concentrations Protects Retinal Vessels in Experimental Diabetic Retinopathy Through Non–Platelet-Mediated Effects
Diabetes December 2005 54:3418-3426; doi:10.2337/diabetes.54.12.3418
Select this article
- Hassan Rahmoune,
- Paul W. Thompson,
- Joanna M. Ward,
- Chari D. Smith,
- Guizhu Hong,
- and John Brown
Glucose Transporters in Human Renal Proximal Tubular Cells Isolated From the Urine of Patients With Non–Insulin-Dependent Diabetes
Diabetes December 2005 54:3427-3434; doi:10.2337/diabetes.54.12.3427
Select this article
- Irina G. Obrosova,
- Viktor R. Drel,
- Pal Pacher,
- Olga Ilnytska,
- Zhong Q. Wang,
- Martin J. Stevens,
- and Mark A. Yorek
Oxidative-Nitrosative Stress and Poly(ADP-Ribose) Polymerase (PARP) Activation in Experimental Diabetic Neuropathy: The Relation Is Revisited
Diabetes December 2005 54:3435-3441; doi:10.2337/diabetes.54.12.3435
Select this article
- Richard H. Stephens,
- Patrick McElduff,
- Adrian H. Heald,
- John P. New,
- Jane Worthington,
- William E. Ollier,
- and J. Martin Gibson
Polymorphisms in igf-Binding Protein 1 Are Associated With Impaired Renal Function in Type 2 Diabetes
Diabetes December 2005 54:3547-3553; doi:10.2337/diabetes.54.12.3547
Select this article
- Rindert de Vries,
- Frank G. Perton,
- Geesje M. Dallinga-Thie,
- Arie M. van Roon,
- Bruce H.R. Wolffenbuttel,
- Arie van Tol,
- and Robin P.F. Dullaart
Plasma Cholesteryl Ester Transfer Is a Determinant of Intima-Media Thickness in Type 2 Diabetic and Nondiabetic Subjects: Role of cetp and Triglycerides
Diabetes December 2005 54:3554-3559; doi:10.2337/diabetes.54.12.3554

Pharmacology and Therapeutics

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- Michael Schupp,
- Markus Clemenz,
- Romain Gineste,
- Henning Witt,
- Jürgen Janke,
- Stephane Helleboid,
- Nathalie Hennuyer,
- Patricia Ruiz,
- Thomas Unger,
- Bart Staels,
- and Ulrich Kintscher
Molecular Characterization of New Selective Peroxisome Proliferator–Activated Receptor γ Modulators With Angiotensin Receptor Blocking Activity
Diabetes December 2005 54:3442-3452; doi:10.2337/diabetes.54.12.3442

Brief Genetics Reports

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- Thomas C. Brodnicki,
- Anne L. Fletcher,
- Daniel G. Pellicci,
- Stuart P. Berzins,
- Peter McClive,
- Fiona Quirk,
- Kylie E. Webster,
- Hamish S. Scott,
- Richard L. Boyd,
- Dale I. Godfrey,
- and Grant Morahan
Localization of Idd11 Is Not Associated With Thymus and NKT Cell Abnormalities in NOD Mice
Diabetes December 2005 54:3453-3457; doi:10.2337/diabetes.54.12.3453
Select this article
- M. Geoffrey Hayes,
- Laura del Bosque-Plata,
- Takafumi Tsuchiya,
- Craig L. Hanis,
- Graeme I. Bell,
- and Nancy J. Cox
Patterns of Linkage Disequilibrium in the Type 2 Diabetes Gene Calpain-10
Diabetes December 2005 54:3573-3576; doi:10.2337/diabetes.54.12.3573
Select this article
- Niklas Karlberg,
- Hannu Jalanko,
- Jukka Kallijärvi,
- Anna-Elina Lehesjoki,
- and Marita Lipsanen-Nyman
Insulin Resistance Syndrome in Subjects With Mutated RING Finger Protein TRIM37
Diabetes December 2005 54:3577-3581; doi:10.2337/diabetes.54.12.3577
Select this article
- Shinsuke Noso,
- Hiroshi Ikegami,
- Tomomi Fujisawa,
- Yumiko Kawabata,
- Katsuaki Asano,
- Yoshihisa Hiromine,
- Masako Tsurumaru,
- Shigetaka Sugihara,
- Inkyu Lee,
- Eiji Kawasaki,
- Takuya Awata,
- and Toshio Ogihara
Genetic Heterogeneity in Association of the SUMO4 M55V Variant With Susceptibility to Type 1 Diabetes
Diabetes December 2005 54:3582-3586; doi:10.2337/diabetes.54.12.3582
Select this article
- Markku Vänttinen,
- Pirjo Nuutila,
- Teemu Kuulasmaa,
- Jussi Pihlajamäki,
- Kirsti Hällsten,
- Kirsi A. Virtanen,
- Riikka Lautamäki,
- Pauliina Peltoniemi,
- Teemu Takala,
- Antti P.M. Viljanen,
- Juhani Knuuti,
- and Markku Laakso
Single Nucleotide Polymorphisms in the Peroxisome Proliferator–Activated Receptor δ Gene Are Associated With Skeletal Muscle Glucose Uptake
Diabetes December 2005 54:3587-3591; doi:10.2337/diabetes.54.12.3587

Metabolism

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- Guenther Boden,
- Pengxiang She,
- Maria Mozzoli,
- Peter Cheung,
- Kiranmai Gumireddy,
- Prekumar Reddy,
- Xiaqin Xiang,
- Zhijan Luo,
- and Neil Ruderman
Free Fatty Acids Produce Insulin Resistance and Activate the Proinflammatory Nuclear Factor-κB Pathway in Rat Liver
Diabetes December 2005 54:3458-3465; doi:10.2337/diabetes.54.12.3458
Select this article
- Bartholomew A. Pederson,
- Jill M. Schroeder,
- Gretchen E. Parker,
- Micah W. Smith,
- Anna A. DePaoli-Roach,
- and Peter J. Roach
Glucose Metabolism in Mice Lacking Muscle Glycogen Synthase
Diabetes December 2005 54:3466-3473; doi:10.2337/diabetes.54.12.3466

Pathophysiology

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- So-Young Park,
- You-Ree Cho,
- Hyo-Jeong Kim,
- Takamasa Higashimori,
- Cheryl Danton,
- Mi-Kyung Lee,
- Asim Dey,
- Beverly Rothermel,
- Young-Bum Kim,
- April Kalinowski,
- Kerry S. Russell,
- and Jason K. Kim
Unraveling the Temporal Pattern of Diet-Induced Insulin Resistance in Individual Organs and Cardiac Dysfunction in c57bl/6 Mice
Diabetes December 2005 54:3530-3540; doi:10.2337/diabetes.54.12.3530
Select this article
- Giovanni Targher,
- Lorenzo Bertolini,
- Felice Poli,
- Stefano Rodella,
- Luca Scala,
- Roberto Tessari,
- Luciano Zenari,
- and Giancarlo Falezza
Nonalcoholic Fatty Liver Disease and Risk of Future Cardiovascular Events Among Type 2 Diabetic Patients
Diabetes December 2005 54:3541-3546; doi:10.2337/diabetes.54.12.3541

Genetics

Select this article
- Yoshio Nakano,
- Hiroto Furuta,
- Asako Doi,
- Shohei Matsuno,
- Takayuki Nakagawa,
- Hiroko Shimomura,
- Setsuya Sakagashira,
- Yukio Horikawa,
- Masahiro Nishi,
- Hideyuki Sasaki,
- Tokio Sanke,
- and Kishio Nanjo
A Functional Variant in the Human Betacellulin Gene Promoter Is Associated With Type 2 Diabetes
Diabetes December 2005 54:3560-3566; doi:10.2337/diabetes.54.12.3560
Select this article
- Lu Qi,
- James Meigs,
- JoAnn E. Manson,
- Jing Ma,
- David Hunter,
- Nader Rifai,
- and Frank B. Hu
HFE Genetic Variability, Body Iron Stores, and the Risk of Type 2 Diabetes in U.S. Women
Diabetes December 2005 54:3567-3572; doi:10.2337/diabetes.54.12.3567

Perspectives in Diabetes

Select this article
- Philip E. Cryer
Mechanisms of Hypoglycemia-Associated Autonomic Failure and Its Component Syndromes in Diabetes
Diabetes December 2005 54:3592-3601; doi:10.2337/diabetes.54.12.3592

Diabetes

Signal Transduction

Peripheral Hyperinsulinemia Promotes Tau Phosphorylation In Vivo

Skeletal Muscle Insulin Signaling Defects Downstream of Phosphatidylinositol 3-Kinase at the Level of Akt Are Associated With Impaired Nonoxidative Glucose Disposal in HIV Lipodystrophy

Changes in Exercise-Induced Gene Expression in 5′-AMP–Activated Protein Kinase γ3–Null and γ3 R225Q Transgenic Mice

The Lack of β-Adrenoceptors Results in Enhanced Insulin Sensitivity in Mice Exhibiting Increased Adiposity and Glucose Intolerance

Plasma Free Fatty Acids and Peroxisome Proliferator–Activated Receptor α in the Control of Myocardial Uncoupling Protein Levels

Obesity Studies

Expression of Inducible 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase/PFKFB3 Isoforms in Adipocytes and Their Potential Role in Glycolytic Regulation

Peroxisome Proliferator–Activated Receptor (PPAR)α Activation Increases Adiponectin Receptors and Reduces Obesity-Related Inflammation in Adipose Tissue: Comparison of Activation of PPARα, PPARγ, and Their Combination

A Polygenic Model of the Metabolic Syndrome With Reduced Circulating and Intra-Adipose Glucocorticoid Action

Whole-body Insulin Resistance in the Absence of Obesity in FVB Mice With Overexpression of Dgat1 in Adipose Tissue

Decreased Fat Mass in Interleukin-1 Receptor Antagonist–Deficient Mice: Impact on Adipogenesis, Food Intake, and Energy Expenditure

Resistance to Diet-Induced Obesity in μ-Opioid Receptor–Deficient Mice: Evidence for a “Thrifty Gene”

Immunology and Transplantation

Growth and Functional Maturation of β-Cells in Implants of Endocrine Cells Purified From Prenatal Porcine Pancreas

On the Edge of Autoimmunity: T-Cell Stimulation by Steady-State Dendritic Cells Prevents Autoimmune Diabetes

Islet Studies

The HMG Box Transcription Factor Sox4 Contributes to the Development of the Endocrine Pancreas

Inhibition of Preproinsulin Gene Expression by Leptin Induction of Suppressor of Cytokine Signaling 3 in Pancreatic β-Cells

Individual Mice Can Be Distinguished by the Period of Their Islet Calcium Oscillations: Is There an Intrinsic Islet Period That Is Imprinted In Vivo?

Rho Guanosine Diphosphate–Dissociation Inhibitor Plays a Negative Modulatory Role in Glucose-Stimulated Insulin Secretion

Complications

Aspirin at Low-Intermediate Concentrations Protects Retinal Vessels in Experimental Diabetic Retinopathy Through Non–Platelet-Mediated Effects

Glucose Transporters in Human Renal Proximal Tubular Cells Isolated From the Urine of Patients With Non–Insulin-Dependent Diabetes

Oxidative-Nitrosative Stress and Poly(ADP-Ribose) Polymerase (PARP) Activation in Experimental Diabetic Neuropathy: The Relation Is Revisited

Polymorphisms in igf-Binding Protein 1 Are Associated With Impaired Renal Function in Type 2 Diabetes

Plasma Cholesteryl Ester Transfer Is a Determinant of Intima-Media Thickness in Type 2 Diabetic and Nondiabetic Subjects: Role of cetp and Triglycerides

Pharmacology and Therapeutics

Molecular Characterization of New Selective Peroxisome Proliferator–Activated Receptor γ Modulators With Angiotensin Receptor Blocking Activity

Brief Genetics Reports

Localization of Idd11 Is Not Associated With Thymus and NKT Cell Abnormalities in NOD Mice

Patterns of Linkage Disequilibrium in the Type 2 Diabetes Gene Calpain-10

Insulin Resistance Syndrome in Subjects With Mutated RING Finger Protein TRIM37

Genetic Heterogeneity in Association of the SUMO4 M55V Variant With Susceptibility to Type 1 Diabetes

Single Nucleotide Polymorphisms in the Peroxisome Proliferator–Activated Receptor δ Gene Are Associated With Skeletal Muscle Glucose Uptake

Metabolism

Free Fatty Acids Produce Insulin Resistance and Activate the Proinflammatory Nuclear Factor-κB Pathway in Rat Liver

Glucose Metabolism in Mice Lacking Muscle Glycogen Synthase

Pathophysiology

Unraveling the Temporal Pattern of Diet-Induced Insulin Resistance in Individual Organs and Cardiac Dysfunction in c57bl/6 Mice

Nonalcoholic Fatty Liver Disease and Risk of Future Cardiovascular Events Among Type 2 Diabetic Patients

Genetics

A Functional Variant in the Human Betacellulin Gene Promoter Is Associated With Type 2 Diabetes

HFE Genetic Variability, Body Iron Stores, and the Risk of Type 2 Diabetes in U.S. Women

Perspectives in Diabetes

Mechanisms of Hypoglycemia-Associated Autonomic Failure and Its Component Syndromes in Diabetes

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