Patterns of Linkage Disequilibrium in the Type 2 Diabetes Gene Calpain-10
- M. Geoffrey Hayes12,
- Laura del Bosque-Plata3,
- Takafumi Tsuchiya3,
- Craig L. Hanis4,
- Graeme I. Bell123 and
- Nancy J. Cox12
- 1Department of Medicine, University of Chicago, Chicago, Illinois
- 2Department of Human Genetics, University of Chicago, Chicago, Illinois
- 3Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois
- 4Human Genetics Center, University of Texas Health Sciences Center, Houston, Texas
- Address correspondence and reprint requests to Dr. Nancy J. Cox, Department of Human Genetics, University of Chicago, 920 E. 58th St., CLSC 507, Chicago, IL 60637. E-mail: ncox{at}bsd.uchicago.edu
Abstract
We investigated the patterns and extent of linkage disequilibrium (LD) in the vicinity of the type 2 diabetes gene calapin-10 (CAPN10) in Mexican Americans, European Americans, African Americans, and Chinese Americans. We found that CAPN10 occurs within a single block of high LD and that LD decays rapidly outside of the gene. This reduces the likelihood that associations between CAPN10 polymorphisms and type 2 diabetes could be attributed to variation at some distance from CAPN10. We also consistently observed that cases have more extensive LD than control subjects and that cases from families with evidence for linkage have more extensive LD than cases from families without evidence for linkage. These observations further suggest that there are one or more relatively common alleles increasing risk of type 2 diabetes in this local region.
Footnotes
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L.D.B.-P. is currently affiliated with the Instituto Nacional de Medicina Genómica, Mexico, D.F., Mexico. T.T. is currently affiliated with the Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
Additional information for this article can be found in an online appendix at http://diabetes.diabetesjournal.org.
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- Accepted August 26, 2005.
- Received June 5, 2005.
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