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Table of Contents

April 2005; 54 (4)

Perspectives in Diabetes

    • Pietro A. Tataranni and
    • Emilio Ortega

    A Burning Question: Does an Adipokine-Induced Activation of the Immune System Mediate the Effect of Overnutrition on Type 2 Diabetes?

    Diabetes April 2005 54:917-927; doi:10.2337/diabetes.54.4.917

Metabolism

    • Rasmus Pold,
    • Lasse S. Jensen,
    • Niels Jessen,
    • Esben S. Buhl,
    • Ole Schmitz,
    • Allan Flyvbjerg,
    • Nobuharu Fujii,
    • Laurie J. Goodyear,
    • Carsten F. Gotfredsen,
    • Christian L. Brand,
    • and Sten Lund

    Long-Term AICAR Administration and Exercise Prevents Diabetes in ZDF Rats

    Diabetes April 2005 54:928-934; doi:10.2337/diabetes.54.4.928
    • Mollie Ranalletta,
    • Hua Jiang,
    • Jing Li,
    • T.S. Tsao,
    • Antine E. Stenbit,
    • Masayoshi Yokoyama,
    • Ellen B. Katz,
    • and Maureen J. Charron

    Altered Hepatic and Muscle Substrate Utilization Provoked by GLUT4 Ablation

    Diabetes April 2005 54:935-943; doi:10.2337/diabetes.54.4.935
    • Jolita Ciapaite,
    • Gerco Van Eikenhorst,
    • Stephan J.L. Bakker,
    • Michaela Diamant,
    • Robert J. Heine,
    • Marijke J. Wagner,
    • Hans V. Westerhoff,
    • and Klaas Krab

    Modular Kinetic Analysis of the Adenine Nucleotide Translocator–Mediated Effects of Palmitoyl-CoA on the Oxidative Phosphorylation in Isolated Rat Liver Mitochondria

    Diabetes April 2005 54:944-951; doi:10.2337/diabetes.54.4.944
    • Jason W. Mastaitis,
    • Elisa Wurmbach,
    • Hui Cheng,
    • Stuart C. Sealfon,
    • and Charles V. Mobbs

    Acute Induction of Gene Expression in Brain and Liver by Insulin-Induced Hypoglycemia

    Diabetes April 2005 54:952-958; doi:10.2337/diabetes.54.4.952

Signal Transduction

    • Marco A. Carvalho-Filho,
    • Mirian Ueno,
    • Sandro M. Hirabara,
    • Amedea B. Seabra,
    • José B.C. Carvalheira,
    • Marcelo G. de Oliveira,
    • Lício A. Velloso,
    • Rui Curi,
    • and Mario J.A. Saad

    S-Nitrosation of the Insulin Receptor, Insulin Receptor Substrate 1, and Protein Kinase B/Akt: A Novel Mechanism of Insulin Resistance

    Diabetes April 2005 54:959-967; doi:10.2337/diabetes.54.4.959
    • Shanthi Srinivasan,
    • Mitsuru Ohsugi,
    • Zhonghao Liu,
    • Szabolcs Fatrai,
    • Ernesto Bernal-Mizrachi,
    • and M. Alan Permutt

    Endoplasmic Reticulum Stress–Induced Apoptosis Is Partly Mediated by Reduced Insulin Signaling Through Phosphatidylinositol 3-Kinase/Akt and Increased Glycogen Synthase Kinase-3β in Mouse Insulinoma Cells

    Diabetes April 2005 54:968-975; doi:10.2337/diabetes.54.4.968
    • Jianhua Shao,
    • Liping Qiao,
    • Rachel C. Janssen,
    • Michael Pagliassotti,
    • and Jacob E. Friedman

    Chronic Hyperglycemia Enhances PEPCK Gene Expression and Hepatocellular Glucose Production Via Elevated Liver Activating Protein/Liver Inhibitory Protein Ratio

    Diabetes April 2005 54:976-984; doi:10.2337/diabetes.54.4.976

Obesity Studies

    • Jenny Tong,
    • Wilfred Y. Fujimoto,
    • Steven E. Kahn,
    • David S. Weigle,
    • Marguerite J. McNeely,
    • Donna L. Leonetti,
    • Jane B. Shofer,
    • and Edward J. Boyko

    Insulin, C-Peptide, and Leptin Concentrations Predict Increased Visceral Adiposity at 5- and 10-Year Follow-Ups in Nondiabetic Japanese Americans

    Diabetes April 2005 54:985-990; doi:10.2337/diabetes.54.4.985
    • Laurent Yvan-Charvet,
    • Patrick Even,
    • May Bloch-Faure,
    • Michèle Guerre-Millo,
    • Naima Moustaid-Moussa,
    • Pascal Ferre,
    • and Annie Quignard-Boulange

    Deletion of the Angiotensin Type 2 Receptor (AT2R) Reduces Adipose Cell Size and Protects From Diet-Induced Obesity and Insulin Resistance

    Diabetes April 2005 54:991-999; doi:10.2337/diabetes.54.4.991
    • WuQiang Fan,
    • Toshihiko Yanase,
    • Masatoshi Nomura,
    • Taijiro Okabe,
    • Kiminobu Goto,
    • Takashi Sato,
    • Hirotaka Kawano,
    • Shigeaki Kato,
    • and Hajime Nawata

    Androgen Receptor Null Male Mice Develop Late-Onset Obesity Caused by Decreased Energy Expenditure and Lipolytic Activity but Show Normal Insulin Sensitivity With High Adiponectin Secretion

    Diabetes April 2005 54:1000-1008; doi:10.2337/diabetes.54.4.1000
    • Hideaki Kaneto,
    • Yoshihisa Nakatani,
    • Takeshi Miyatsuka,
    • Taka-aki Matsuoka,
    • Munehide Matsuhisa,
    • Masatsugu Hori,
    • and Yoshimitsu Yamasaki

    PDX-1/VP16 Fusion Protein, Together With NeuroD or Ngn3, Markedly Induces Insulin Gene Transcription and Ameliorates Glucose Tolerance

    Diabetes April 2005 54:1009-1022; doi:10.2337/diabetes.54.4.1009
    • Erin E. Kershaw,
    • Nicholas M. Morton,
    • Harveen Dhillon,
    • Lynne Ramage,
    • Jonathan R. Seckl,
    • and Jeffrey S. Flier

    Adipocyte-Specific Glucocorticoid Inactivation Protects Against Diet-Induced Obesity

    Diabetes April 2005 54:1023-1031; doi:10.2337/diabetes.54.4.1023

Immunology and Transplantation

    • Tatsuya Kin,
    • Gregory S. Korbutt,
    • Tsunehiro Kobayashi,
    • Jannette M. Dufour,
    • and Ray V. Rajotte

    Reversal of Diabetes in Pancreatectomized Pigs After Transplantation of Neonatal Porcine Islets

    Diabetes April 2005 54:1032-1039; doi:10.2337/diabetes.54.4.1032
    • Dorthe Lundsgaard,
    • Thomas Lindebo Holm,
    • Lars Hornum,
    • and Helle Markholst

    In Vivo Control of Diabetogenic T-Cells by Regulatory CD4+CD25+ T-Cells Expressing Foxp3

    Diabetes April 2005 54:1040-1047; doi:10.2337/diabetes.54.4.1040
    • Vincenzo Mirenda,
    • Dela Golshayan,
    • Joseph Read,
    • Ivan Berton,
    • Anthony N. Warrens,
    • Anthony Dorling,
    • and Robert I. Lechler

    Achieving Permanent Survival of Islet Xenografts by Independent Manipulation of Direct and Indirect T-Cell Responses

    Diabetes April 2005 54:1048-1055; doi:10.2337/diabetes.54.4.1048

Islet Studies

    • Takashi Miki,
    • Kohtaro Minami,
    • Hidehiro Shinozaki,
    • Kimio Matsumura,
    • Atsunori Saraya,
    • Hiroki Ikeda,
    • Yuichiro Yamada,
    • Jens Juul Holst,
    • and Susumu Seino

    Distinct Effects of Glucose-Dependent Insulinotropic Polypeptide and Glucagon-Like Peptide-1 on Insulin Secretion and Gut Motility

    Diabetes April 2005 54:1056-1063; doi:10.2337/diabetes.54.4.1056
    • Khoi Chu and
    • Ming-Jer Tsai

    Neuronatin, a Downstream Target of BETA2/NeuroD1 in the Pancreas, Is Involved in Glucose-Mediated Insulin Secretion

    Diabetes April 2005 54:1064-1073; doi:10.2337/diabetes.54.4.1064
    • Warren C. Ladiges,
    • Sue E. Knoblaugh,
    • John F. Morton,
    • Marcus J. Korth,
    • Bryce L. Sopher,
    • Carole R. Baskin,
    • Alasdair MacAuley,
    • Alan G. Goodman,
    • Renee C. LeBoeuf,
    • and Michael G. Katze

    Pancreatic β-Cell Failure and Diabetes in Mice With a Deletion Mutation of the Endoplasmic Reticulum Molecular Chaperone Gene P58IPK

    Diabetes April 2005 54:1074-1081; doi:10.2337/diabetes.54.4.1074
    • Brian T. Noronha,
    • Jian-Mei Li,
    • Stephen B. Wheatcroft,
    • Ajay M. Shah,
    • and Mark T. Kearney

    Inducible Nitric Oxide Synthase Has Divergent Effects on Vascular and Metabolic Function in Obesity

    Diabetes April 2005 54:1082-1089; doi:10.2337/diabetes.54.4.1082
    • Susanne Ullrich,
    • Susanne Berchtold,
    • Felicia Ranta,
    • Guiscard Seebohm,
    • Guido Henke,
    • Adrian Lupescu,
    • Andreas F. Mack,
    • Cho-Ming Chao,
    • Jiping Su,
    • Roland Nitschke,
    • Dorothea Alexander,
    • Björn Friedrich,
    • Peer Wulff,
    • Dietmar Kuhl,
    • and Florian Lang

    Serum- and Glucocorticoid-Inducible Kinase 1 (SGK1) Mediates Glucocorticoid-Induced Inhibition of Insulin Secretion

    Diabetes April 2005 54:1090-1099; doi:10.2337/diabetes.54.4.1090

Pathophysiology

    • Rubina A. Heptulla,
    • Luisa M. Rodriguez,
    • Lisa Bomgaars,
    • and Morey W. Haymond

    The Role of Amylin and Glucagon in the Dampening of Glycemic Excursions in Children With Type 1 Diabetes

    Diabetes April 2005 54:1100-1107; doi:10.2337/diabetes.54.4.1100
    • Eili T. Kase,
    • Andreas J. Wensaas,
    • Vigdis Aas,
    • Kurt Højlund,
    • Klaus Levin,
    • G. Hege Thoresen,
    • Henning Beck-Nielsen,
    • Arild C. Rustan,
    • and Michael Gaster

    Skeletal Muscle Lipid Accumulation in Type 2 Diabetes May Involve the Liver X Receptor Pathway

    Diabetes April 2005 54:1108-1115; doi:10.2337/diabetes.54.4.1108

Complications

    • Kevin Jon Williams,
    • Ming-Lin Liu,
    • Yanqing Zhu,
    • Xiangsheng Xu,
    • William R. Davidson,
    • Peter McCue,
    • and Kumar Sharma

    Loss of Heparan N-Sulfotransferase in Diabetic Liver: Role of Angiotensin II

    Diabetes April 2005 54:1116-1122; doi:10.2337/diabetes.54.4.1116
    • Alessandra Gallo,
    • Giulio Ceolotto,
    • Paolo Pinton,
    • Elisabetta Iori,
    • Ellen Murphy,
    • Guy A. Rutter,
    • Rosario Rizzuto,
    • Andrea Semplicini,
    • and Angelo Avogaro

    Metformin Prevents Glucose-Induced Protein Kinase C-β2 Activation in Human Umbilical Vein Endothelial Cells Through an Antioxidant Mechanism

    Diabetes April 2005 54:1123-1131; doi:10.2337/diabetes.54.4.1123
    • Timothy J. Stalker,
    • Yulan Gong,
    • and Rosario Scalia

    The Calcium-Dependent Protease Calpain Causes Endothelial Dysfunction in Type 2 Diabetes

    Diabetes April 2005 54:1132-1140; doi:10.2337/diabetes.54.4.1132
    • Corinna Lebherz,
    • Albert M. Maguire,
    • Alberto Auricchio,
    • Waixing Tang,
    • Tomas S. Aleman,
    • Zhangyong Wei,
    • Rebecca Grant,
    • Artur V. Cideciyan,
    • Samuel G. Jacobson,
    • James M. Wilson,
    • and Jean Bennett

    Nonhuman Primate Models for Diabetic Ocular Neovascularization Using AAV2-Mediated Overexpression of Vascular Endothelial Growth Factor

    Diabetes April 2005 54:1141-1149; doi:10.2337/diabetes.54.4.1141

Pharmacology & Therapeutics

  • Prevention of Type 2 Diabetes With Troglitazone in the Diabetes Prevention Program

    Diabetes April 2005 54:1150-1156; doi:10.2337/diabetes.54.4.1150
    • David Kitz Krämer,
    • Lubna Al-Khalili,
    • Sebastio Perrini,
    • Josefin Skogsberg,
    • Per Wretenberg,
    • Katja Kannisto,
    • Harriet Wallberg-Henriksson,
    • Ewa Ehrenborg,
    • Juleen R. Zierath,
    • and Anna Krook

    Direct Activation of Glucose Transport in Primary Human Myotubes After Activation of Peroxisome Proliferator–Activated Receptor δ

    Diabetes April 2005 54:1157-1163; doi:10.2337/diabetes.54.4.1157
    • Dale S. Edgerton,
    • Doss W. Neal,
    • Melanie Scott,
    • Larry Bowen,
    • Warren Wilson,
    • Charles H. Hobbs,
    • Chet Leach,
    • Shantha Sivakumaran,
    • Thomas R. Strack,
    • and Alan D. Cherrington

    Inhalation of Insulin (Exubera) Is Associated With Augmented Disposal of Portally Infused Glucose in Dogs

    Diabetes April 2005 54:1164-1170; doi:10.2337/diabetes.54.4.1164

Genetics

    • Atsuyuki Shimazaki,
    • Yoshihiro Kawamura,
    • Akio Kanazawa,
    • Akihiro Sekine,
    • Susumu Saito,
    • Tatsuhiko Tsunoda,
    • Daisuke Koya,
    • Tetsuya Babazono,
    • Yasushi Tanaka,
    • Masafumi Matsuda,
    • Koichi Kawai,
    • Tomohiro Iiizumi,
    • Masahito Imanishi,
    • Toshihiro Shinosaki,
    • Toru Yanagimoto,
    • Minoru Ikeda,
    • Shigeki Omachi,
    • Atsunori Kashiwagi,
    • Kohei Kaku,
    • Yasuhiko Iwamoto,
    • Ryuzou Kawamori,
    • Ryuichi Kikkawa,
    • Masatoshi Nakajima,
    • Yusuke Nakamura,
    • and Shiro Maeda

    Genetic Variations in the Gene Encoding ELMO1 Are Associated With Susceptibility to Diabetic Nephropathy

    Diabetes April 2005 54:1171-1178; doi:10.2337/diabetes.54.4.1171
    • Kristi Silver,
    • Magdalena Tolea,
    • Jian Wang,
    • Toni I. Pollin,
    • Flora Yao,
    • and Braxton D. Mitchell

    The Exon 1 Cys7Gly Polymorphism Within the Betacellulin Gene Is Associated With Type 2 Diabetes in African Americans

    Diabetes April 2005 54:1179-1184; doi:10.2337/diabetes.54.4.1179
    • Allison M. Bagwell,
    • Jennifer L. Bento,
    • Josyf C. Mychaleckyj,
    • Barry I. Freedman,
    • Carl D. Langefeld,
    • and Donald W. Bowden

    Genetic Analysis of HNF4A Polymorphisms in Caucasian-American Type 2 Diabetes

    Diabetes April 2005 54:1185-1190; doi:10.2337/diabetes.54.4.1185
    • Richard C. Davis,
    • Eric E. Schadt,
    • Alessandra C.L. Cervino,
    • Miklós Péterfy,
    • and Aldons J. Lusis

    Ultrafine Mapping of SNPs From Mouse Strains C57BL/6J, DBA/2J, and C57BLKS/J for Loci Contributing to Diabetes and Atherosclerosis Susceptibility

    Diabetes April 2005 54:1191-1199; doi:10.2337/diabetes.54.4.1191
    • Yen-Feng Chiu,
    • Lee-Ming Chuang,
    • Chin-Fu Hsiao,
    • Yi-Jen Hung,
    • Ming-Wei Lin,
    • Ying-Tsung Chen,
    • John Grove,
    • Eric Jorgenson,
    • Thomas Quertermous,
    • Neil Risch,
    • and Chao A. Hsiung

    An Autosomal Genome-wide Scan for Loci Linked to Pre-Diabetic Phenotypes in Nondiabetic Chinese Subjects From the Stanford Asia-Pacific Program of Hypertension and Insulin Resistance Family Study

    Diabetes April 2005 54:1200-1206; doi:10.2337/diabetes.54.4.1200
    • Nicola Abate,
    • Manisha Chandalia,
    • Pankaj Satija,
    • Beverley Adams-Huet,
    • Scott M. Grundy,
    • Sreedharan Sandeep,
    • Venkatesan Radha,
    • Raj Deepa,
    • and Viswanathan Mohan

    ENPP1/PC-1 K121Q Polymorphism and Genetic Susceptibility to Type 2 Diabetes

    Diabetes April 2005 54:1207-1213; doi:10.2337/diabetes.54.4.1207
    • Donna M. Lehman,
    • Dong-Jing Fu,
    • Angela B. Freeman,
    • Kelly J. Hunt,
    • Robin J. Leach,
    • Teresa Johnson-Pais,
    • Jeanette Hamlington,
    • Thomas D. Dyer,
    • Rector Arya,
    • Hanna Abboud,
    • Harald H.H. Göring,
    • Ravindranath Duggirala,
    • John Blangero,
    • Robert J. Konrad,
    • and Michael P. Stern

    A Single Nucleotide Polymorphism in MGEA5 Encoding O-GlcNAc–selective N-Acetyl-β-d Glucosaminidase Is Associated With Type 2 Diabetes in Mexican Americans

    Diabetes April 2005 54:1214-1221; doi:10.2337/diabetes.54.4.1214
    • Mark O. Goodarzi,
    • Kent D. Taylor,
    • Xiuqing Guo,
    • Manuel J. Quiñones,
    • Jinrui Cui,
    • Xiaohui Li,
    • Tieu Hang,
    • Huiying Yang,
    • Edward Holmes,
    • Willa A. Hsueh,
    • Jerrold Olefsky,
    • and Jerome I. Rotter

    Variation in the Gene for Muscle-Specific AMP Deaminase Is Associated With Insulin Clearance, a Highly Heritable Trait

    Diabetes April 2005 54:1222-1227; doi:10.2337/diabetes.54.4.1222

Brief Genetics Report

    • Mark O. Goodarzi,
    • Kent D. Taylor,
    • Xiuqing Guo,
    • Manuel J. Quiñones,
    • Jinrui Cui,
    • Yanjie Li,
    • Mohammad F. Saad,
    • Huiying Yang,
    • Willa A. Hsueh,
    • Howard N. Hodis,
    • and Jerome I. Rotter

    Association of the Diabetes Gene Calpain-10 With Subclinical Atherosclerosis: The Mexican-American Coronary Artery Disease Study

    Diabetes April 2005 54:1228-1232; doi:10.2337/diabetes.54.4.1228
    • Elizabeth P. Blankenhorn,
    • Lucy Rodemich,
    • Cristina Martin-Fernandez,
    • Jean Leif,
    • Dale L. Greiner,
    • and John P. Mordes

    The Rat Diabetes Susceptibility Locus Iddm4 and at Least One Additional Gene Are Required for Autoimmune Diabetes Induced by Viral Infection

    Diabetes April 2005 54:1233-1237; doi:10.2337/diabetes.54.4.1233
    • Andrew P. Boright,
    • Andrew D. Paterson,
    • Lucia Mirea,
    • Shelley B. Bull,
    • Alireza Mowjoodi,
    • Stephen W. Scherer,
    • and Bernard Zinman

    Genetic Variation at the ACE Gene Is Associated With Persistent Microalbuminuria and Severe Nephropathy in Type 1 Diabetes: The DCCT/EDIC Genetics Study

    Diabetes April 2005 54:1238-1244; doi:10.2337/diabetes.54.4.1238
    • Kathleen M. Gillespie,
    • Runa Nolsøe,
    • Virginie M. Betin,
    • Ole P. Kristiansen,
    • Polly J. Bingley,
    • Thomas Mandrup-Poulsen,
    • and Edwin A.M. Gale

    Is Puberty an Accelerator of Type 1 Diabetes in IL6-174CC Females?

    Diabetes April 2005 54:1245-1248; doi:10.2337/diabetes.54.4.1245

Errata

  • Errata

    Diabetes April 2005 54:1249; doi:10.2337/diabetes.54.4.1249
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This Issue

April 2005; 54 (4)
  1. Perspectives in Diabetes
  2. Metabolism
  3. Signal Transduction
  4. Obesity Studies
  5. Immunology and Transplantation
  6. Islet Studies
  7. Pathophysiology
  8. Complications
  9. Pharmacology & Therapeutics
  10. Genetics
  11. Brief Genetics Report
  12. Errata

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