Table of Contents

Banting Lecture 2004

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- Michael Brownlee
The Pathobiology of Diabetic Complications: A Unifying Mechanism
Diabetes June 2005 54:1615-1625; doi:10.2337/diabetes.54.6.1615

Perspectives in Diabetes

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- Gunter Wolf,
- Sheldon Chen,
- and Fuad N. Ziyadeh
From the Periphery of the Glomerular Capillary Wall Toward the Center of Disease: Podocyte Injury Comes of Age in Diabetic Nephropathy
Diabetes June 2005 54:1626-1634; doi:10.2337/diabetes.54.6.1626

Metabolism

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- Jannik Kruse Nielsen,
- Christian Born Djurhuus,
- Claus Højbjerg Gravholt,
- Andreas Christiansen Carus,
- Jacob Granild-Jensen,
- Hans Ørskov,
- and Jens Sandahl Christiansen
Continuous Glucose Monitoring in Interstitial Subcutaneous Adipose Tissue and Skeletal Muscle Reflects Excursions in Cerebral Cortex
Diabetes June 2005 54:1635-1639; doi:10.2337/diabetes.54.6.1635
Select this article
- Renata Belfort,
- Lawrence Mandarino,
- Sangeeta Kashyap,
- Kelly Wirfel,
- Thongchai Pratipanawatr,
- Rachele Berria,
- Ralph A. DeFronzo,
- and Kenneth Cusi
Dose-Response Effect of Elevated Plasma Free Fatty Acid on Insulin Signaling
Diabetes June 2005 54:1640-1648; doi:10.2337/diabetes.54.6.1640
Select this article
- Juris J. Meier,
- Johannes D. Veldhuis,
- and Peter C. Butler
Pulsatile Insulin Secretion Dictates Systemic Insulin Delivery by Regulating Hepatic Insulin Extraction In Humans
Diabetes June 2005 54:1649-1656; doi:10.2337/diabetes.54.6.1649
Select this article
- Jason K. Kim,
- Hyo-Jeong Kim,
- So-Young Park,
- Anna Cederberg,
- Rickard Westergren,
- Daniel Nilsson,
- Takamasa Higashimori,
- You-Ree Cho,
- Zhen-Xiang Liu,
- Jianying Dong,
- Gary W. Cline,
- Sven Enerback,
- and Gerald I. Shulman
Adipocyte-Specific Overexpression of FOXC2 Prevents Diet-Induced Increases in Intramuscular Fatty Acyl CoA and Insulin Resistance
Diabetes June 2005 54:1657-1663; doi:10.2337/diabetes.54.6.1657

Signal Transduction

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- Poornima Rao,
- Jennifer Roccisana,
- Karen K. Takane,
- Rita Bottino,
- Allan Zhao,
- Massimo Trucco,
- and Adolfo García-Ocaña
Gene Transfer of Constitutively Active Akt Markedly Improves Human Islet Transplant Outcomes in Diabetic Severe Combined Immunodeficient Mice
Diabetes June 2005 54:1664-1675; doi:10.2337/diabetes.54.6.1664
Select this article
- Emma M. Allister,
- Nica M. Borradaile,
- Jane Y. Edwards,
- and Murray W. Huff
Inhibition of Microsomal Triglyceride Transfer Protein Expression and Apolipoprotein B100 Secretion by the Citrus Flavonoid Naringenin and by Insulin Involves Activation of the Mitogen-Activated Protein Kinase Pathway in Hepatocytes
Diabetes June 2005 54:1676-1683; doi:10.2337/diabetes.54.6.1676
Select this article
- Seung-Soon Im,
- Seung-Youn Kang,
- So-Youn Kim,
- Ha-il Kim,
- Jae-Woo Kim,
- Kyung-Sup Kim,
- and Yong-Ho Ahn
Glucose-Stimulated Upregulation of GLUT2 Gene Is Mediated by Sterol Response Element–Binding Protein-1c in the Hepatocytes
Diabetes June 2005 54:1684-1691; doi:10.2337/diabetes.54.6.1684
Select this article
- Håkan K.R. Karlsson,
- Juleen R. Zierath,
- Susan Kane,
- Anna Krook,
- Gustav E. Lienhard,
- and Harriet Wallberg-Henriksson
Insulin-Stimulated Phosphorylation of the Akt Substrate AS160 Is Impaired in Skeletal Muscle of Type 2 Diabetic Subjects
Diabetes June 2005 54:1692-1697; doi:10.2337/diabetes.54.6.1692
Select this article
- Andrew B. Strawbridge and
- Jeffrey S. Elmendorf
Phosphatidylinositol 4,5-Bisphosphate Reverses Endothelin-1–Induced Insulin Resistance via an Actin-Dependent Mechanism
Diabetes June 2005 54:1698-1705; doi:10.2337/diabetes.54.6.1698

Obesity Studies

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- Gema Medina-Gomez,
- Sam Virtue,
- Christopher Lelliott,
- Romina Boiani,
- Mark Campbell,
- Constantinos Christodoulides,
- Christophe Perrin,
- Mercedes Jimenez-Linan,
- Margaret Blount,
- John Dixon,
- Dirk Zahn,
- Rosemary R. Thresher,
- Sam Aparicio,
- Mark Carlton,
- William H. Colledge,
- Mikko I. Kettunen,
- Tuulikki Seppänen-Laakso,
- Jaswinder K. Sethi,
- Stephen O’Rahilly,
- Kevin Brindle,
- Saverio Cinti,
- Matej Orešič,
- Remy Burcelin,
- and Antonio Vidal-Puig
The Link Between Nutritional Status and Insulin Sensitivity Is Dependent on the Adipocyte-Specific Peroxisome Proliferator–Activated Receptor-γ2 Isoform
Diabetes June 2005 54:1706-1716; doi:10.2337/diabetes.54.6.1706
Select this article
- Hung-Yun Lin,
- Qingquan Xu,
- Shuyuan Yeh,
- Ruey-Sheng Wang,
- Janet D. Sparks,
- and Chawnshang Chang
Insulin and Leptin Resistance With Hyperleptinemia in Mice Lacking Androgen Receptor
Diabetes June 2005 54:1717-1725; doi:10.2337/diabetes.54.6.1717
Select this article
- Elisabet Arvidsson Nordström,
- Mikael Rydén,
- Emma C. Backlund,
- Ingrid Dahlman,
- Maria Kaaman,
- Lennart Blomqvist,
- Barbara Cannon,
- Jan Nedergaard,
- and Peter Arner
A Human-Specific Role of Cell Death-Inducing DFFA (DNA Fragmentation Factor-α)-Like Effector A (CIDEA) in Adipocyte Lipolysis and Obesity
Diabetes June 2005 54:1726-1734; doi:10.2337/diabetes.54.6.1726
Select this article
- Ram Weiss,
- Sonia Caprio,
- Maddalena Trombetta,
- Sara E. Taksali,
- William V. Tamborlane,
- and Riccardo Bonadonna
β-Cell Function Across the Spectrum of Glucose Tolerance in Obese Youth
Diabetes June 2005 54:1735-1743; doi:10.2337/diabetes.54.6.1735
Select this article
- Liping Qiao,
- Paul S. MacLean,
- Jerome Schaack,
- David J. Orlicky,
- Christian Darimont,
- Michael Pagliassotti,
- Jacob E. Friedman,
- and Jianhua Shao
C/EBPα Regulates Human Adiponectin Gene Transcription Through an Intronic Enhancer
Diabetes June 2005 54:1744-1754; doi:10.2337/diabetes.54.6.1744

Immunology and Transplantation

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- Helena Johansson,
- Agneta Lukinius,
- Lisa Moberg,
- Torbjörn Lundgren,
- Christian Berne,
- Aksel Foss,
- Marie Felldin,
- Ragnar Källen,
- Kaija Salmela,
- Annika Tibell,
- Gunnar Tufveson,
- Kristina Nilsson Ekdahl,
- Graciela Elgue,
- Olle Korsgren,
- and Bo Nilsson
Tissue Factor Produced by the Endocrine Cells of the Islets of Langerhans Is Associated With a Negative Outcome of Clinical Islet Transplantation
Diabetes June 2005 54:1755-1762; doi:10.2337/diabetes.54.6.1755
Select this article
- Kevan C. Herold,
- Stephen E. Gitelman,
- Umesh Masharani,
- William Hagopian,
- Brygida Bisikirska,
- David Donaldson,
- Kristina Rother,
- Beverly Diamond,
- David M. Harlan,
- and Jeffrey A. Bluestone
A Single Course of Anti-CD3 Monoclonal Antibody hOKT3γ1(Ala-Ala) Results in Improvement in C-Peptide Responses and Clinical Parameters for at Least 2 Years after Onset of Type 1 Diabetes
Diabetes June 2005 54:1763-1769; doi:10.2337/diabetes.54.6.1763
Select this article
- Georg F. Beilhack,
- Rosa R. Landa,
- Marilyn A. Masek,
- and Judith A. Shizuru
Prevention of Type 1 Diabetes with Major Histocompatibility Complex–Compatible and Nonmarrow Ablative Hematopoietic Stem Cell Transplants
Diabetes June 2005 54:1770-1779; doi:10.2337/diabetes.54.6.1770

Islet Studies

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- Zdravka Medarova,
- Susan Bonner-Weir,
- Myra Lipes,
- and Anna Moore
Imaging β-Cell Death With a Near-Infrared Probe
Diabetes June 2005 54:1780-1788; doi:10.2337/diabetes.54.6.1780
Select this article
- Magalie A. Ravier and
- Guy A. Rutter
Glucose or Insulin, but not Zinc Ions, Inhibit Glucagon Secretion From Mouse Pancreatic α-Cells
Diabetes June 2005 54:1789-1797; doi:10.2337/diabetes.54.6.1789
Select this article
- Magalie A. Ravier,
- Martin Güldenagel,
- Anne Charollais,
- Asllan Gjinovci,
- Dorothée Caille,
- Goran Söhl,
- Claes B. Wollheim,
- Klaus Willecke,
- Jean-Claude Henquin,
- and Paolo Meda
Loss of Connexin36 Channels Alters β-Cell Coupling, Islet Synchronization of Glucose-Induced Ca²⁺ and Insulin Oscillations, and Basal Insulin Release
Diabetes June 2005 54:1798-1807; doi:10.2337/diabetes.54.6.1798
Select this article
- Isobel Franklin,
- Jesper Gromada,
- Asllan Gjinovci,
- Sten Theander,
- and Claes B. Wollheim
β-Cell Secretory Products Activate α-Cell ATP-Dependent Potassium Channels to Inhibit Glucagon Release
Diabetes June 2005 54:1808-1815; doi:10.2337/diabetes.54.6.1808

Complications

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- W. David Strain,
- Nish Chaturvedi,
- Christopher J. Bulpitt,
- Chakravarthi Rajkumar,
- and Angela C. Shore
Albumin Excretion Rate and Cardiovascular Risk: Could the Association Be Explained by Early Microvascular Dysfunction?
Diabetes June 2005 54:1816-1822; doi:10.2337/diabetes.54.6.1816
Select this article
- Keiko Naruse,
- Yoji Hamada,
- Eitaro Nakashima,
- Koichi Kato,
- Ryuichi Mizubayashi,
- Hideki Kamiya,
- Yukio Yuzawa,
- Seiichi Matsuo,
- Toyoaki Murohara,
- Tatsuaki Matsubara,
- Yutaka Oiso,
- and Jiro Nakamura
Therapeutic Neovascularization Using Cord Blood–Derived Endothelial Progenitor Cells for Diabetic Neuropathy
Diabetes June 2005 54:1823-1828; doi:10.2337/diabetes.54.6.1823
Select this article
- Lu Cai,
- Jianxun Wang,
- Yan Li,
- Xuihua Sun,
- Lipeng Wang,
- Zhanxiang Zhou,
- and Y. James Kang
Inhibition of Superoxide Generation and Associated Nitrosative Damage Is Involved in Metallothionein Prevention of Diabetic Cardiomyopathy
Diabetes June 2005 54:1829-1837; doi:10.2337/diabetes.54.6.1829
Select this article
- Jose M. Cacicedo,
- Sunun Benjachareowong,
- Eva Chou,
- Neil B. Ruderman,
- and Yasuo Ido
Palmitate-Induced Apoptosis in Cultured Bovine Retinal Pericytes: Roles of NAD(P)H Oxidase, Oxidant Stress, and Ceramide
Diabetes June 2005 54:1838-1845; doi:10.2337/diabetes.54.6.1838

Pharmacology & Therapeutics

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- Lynnetta M. Watts,
- Vara Prasad Manchem,
- Thomas A. Leedom,
- Amber L. Rivard,
- Robert A. McKay,
- Dingjiu Bao,
- Teri Neroladakis,
- Brett P. Monia,
- Diane M. Bodenmiller,
- Julia Xiao-Chun Cao,
- Hong Yan Zhang,
- Amy L. Cox,
- Steven J. Jacobs,
- M. Dodson Michael,
- Kyle W. Sloop,
- and Sanjay Bhanot
Reduction of Hepatic and Adipose Tissue Glucocorticoid Receptor Expression With Antisense Oligonucleotides Improves Hyperglycemia and Hyperlipidemia in Diabetic Rodents Without Causing Systemic Glucocorticoid Antagonism
Diabetes June 2005 54:1846-1853; doi:10.2337/diabetes.54.6.1846

Genetics

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- Huei-Ju Pan,
- Peter Reifsnyder,
- Dennis E. Vance,
- Qiang Xiao,
- and Edward H. Leiter
Pharmacogenetic Analysis of Rosiglitazone-Induced Hepatosteatosis in New Mouse Models of Type 2 Diabetes
Diabetes June 2005 54:1854-1862; doi:10.2337/diabetes.54.6.1854

Brief Genetics Reports

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- Thomas H. Ehrich,
- Tomas Hrbek,
- Jane P. Kenney-Hunt,
- L. Susan Pletscher,
- Bing Wang,
- Clay F. Semenkovich,
- and James M. Cheverud
Fine-Mapping Gene-by-Diet Interactions on Chromosome 13 in a LG/J × SM/J Murine Model of Obesity
Diabetes June 2005 54:1863-1872; doi:10.2337/diabetes.54.6.1863
Select this article
- Jacques Young,
- Louise Morbois-Trabut,
- Béatrice Couzinet,
- Olivier Lascols,
- Elisabeth Dion,
- Véronique Béréziat,
- Bruno Fève,
- Isabelle Richard,
- Jacqueline Capeau,
- Philippe Chanson,
- and Corinne Vigouroux
Type A Insulin Resistance Syndrome Revealing a Novel Lamin A Mutation
Diabetes June 2005 54:1873-1878; doi:10.2337/diabetes.54.6.1873
Select this article
- Akane Ide,
- Sunanda R. Babu,
- David T. Robles,
- Tianbao Wang,
- Henry A. Erlich,
- Teodorica L. Bugawan,
- Marian Rewers,
- Pamela R. Fain,
- and George S. Eisenbarth
“Extended” A1, B8, DR3 Haplotype Shows Remarkable Linkage Disequilibrium but Is Similar to Nonextended Haplotypes in Terms of Diabetes Risk
Diabetes June 2005 54:1879-1883; doi:10.2337/diabetes.54.6.1879
Select this article
- Jose C. Florez,
- Christina M. Agapakis,
- Noël P. Burtt,
- Maria Sun,
- Peter Almgren,
- Lennart Råstam,
- Tiinamaija Tuomi,
- Daniel Gaudet,
- Thomas J. Hudson,
- Mark J. Daly,
- Kristin G. Ardlie,
- Joel N. Hirschhorn,
- Leif Groop,
- and David Altshuler
Association Testing of the Protein Tyrosine Phosphatase 1B Gene (PTPN1) With Type 2 Diabetes in 7,883 People
Diabetes June 2005 54:1884-1891; doi:10.2337/diabetes.54.6.1884
Select this article
- Leen M. ‘t Hart,
- Torben Hansen,
- Ingrid Rietveld,
- Jacqueline M. Dekker,
- Giel Nijpels,
- George M.C. Janssen,
- Pascal A. Arp,
- André G. Uitterlinden,
- Torben Jørgensen,
- Knut Borch-Johnsen,
- Huibert A.P. Pols,
- Oluf Pedersen,
- Cornelia M. van Duijn,
- Robert J. Heine,
- and J. Antonie Maassen
Evidence that the Mitochondrial Leucyl tRNA Synthetase (LARS2) Gene Represents a Novel Type 2 Diabetes Susceptibility Gene
Diabetes June 2005 54:1892-1895; doi:10.2337/diabetes.54.6.1892

Diabetes

Banting Lecture 2004

The Pathobiology of Diabetic Complications: A Unifying Mechanism

Perspectives in Diabetes

From the Periphery of the Glomerular Capillary Wall Toward the Center of Disease: Podocyte Injury Comes of Age in Diabetic Nephropathy

Metabolism

Continuous Glucose Monitoring in Interstitial Subcutaneous Adipose Tissue and Skeletal Muscle Reflects Excursions in Cerebral Cortex

Dose-Response Effect of Elevated Plasma Free Fatty Acid on Insulin Signaling

Pulsatile Insulin Secretion Dictates Systemic Insulin Delivery by Regulating Hepatic Insulin Extraction In Humans

Adipocyte-Specific Overexpression of FOXC2 Prevents Diet-Induced Increases in Intramuscular Fatty Acyl CoA and Insulin Resistance

Signal Transduction

Gene Transfer of Constitutively Active Akt Markedly Improves Human Islet Transplant Outcomes in Diabetic Severe Combined Immunodeficient Mice

Inhibition of Microsomal Triglyceride Transfer Protein Expression and Apolipoprotein B100 Secretion by the Citrus Flavonoid Naringenin and by Insulin Involves Activation of the Mitogen-Activated Protein Kinase Pathway in Hepatocytes

Glucose-Stimulated Upregulation of GLUT2 Gene Is Mediated by Sterol Response Element–Binding Protein-1c in the Hepatocytes

Insulin-Stimulated Phosphorylation of the Akt Substrate AS160 Is Impaired in Skeletal Muscle of Type 2 Diabetic Subjects

Phosphatidylinositol 4,5-Bisphosphate Reverses Endothelin-1–Induced Insulin Resistance via an Actin-Dependent Mechanism

Obesity Studies

The Link Between Nutritional Status and Insulin Sensitivity Is Dependent on the Adipocyte-Specific Peroxisome Proliferator–Activated Receptor-γ2 Isoform

Insulin and Leptin Resistance With Hyperleptinemia in Mice Lacking Androgen Receptor

A Human-Specific Role of Cell Death-Inducing DFFA (DNA Fragmentation Factor-α)-Like Effector A (CIDEA) in Adipocyte Lipolysis and Obesity

β-Cell Function Across the Spectrum of Glucose Tolerance in Obese Youth

C/EBPα Regulates Human Adiponectin Gene Transcription Through an Intronic Enhancer

Immunology and Transplantation

Tissue Factor Produced by the Endocrine Cells of the Islets of Langerhans Is Associated With a Negative Outcome of Clinical Islet Transplantation

A Single Course of Anti-CD3 Monoclonal Antibody hOKT3γ1(Ala-Ala) Results in Improvement in C-Peptide Responses and Clinical Parameters for at Least 2 Years after Onset of Type 1 Diabetes

Prevention of Type 1 Diabetes with Major Histocompatibility Complex–Compatible and Nonmarrow Ablative Hematopoietic Stem Cell Transplants

Islet Studies

Imaging β-Cell Death With a Near-Infrared Probe

Glucose or Insulin, but not Zinc Ions, Inhibit Glucagon Secretion From Mouse Pancreatic α-Cells

Loss of Connexin36 Channels Alters β-Cell Coupling, Islet Synchronization of Glucose-Induced Ca2+ and Insulin Oscillations, and Basal Insulin Release

β-Cell Secretory Products Activate α-Cell ATP-Dependent Potassium Channels to Inhibit Glucagon Release

Complications

Albumin Excretion Rate and Cardiovascular Risk: Could the Association Be Explained by Early Microvascular Dysfunction?

Therapeutic Neovascularization Using Cord Blood–Derived Endothelial Progenitor Cells for Diabetic Neuropathy

Inhibition of Superoxide Generation and Associated Nitrosative Damage Is Involved in Metallothionein Prevention of Diabetic Cardiomyopathy

Palmitate-Induced Apoptosis in Cultured Bovine Retinal Pericytes: Roles of NAD(P)H Oxidase, Oxidant Stress, and Ceramide

Pharmacology & Therapeutics

Reduction of Hepatic and Adipose Tissue Glucocorticoid Receptor Expression With Antisense Oligonucleotides Improves Hyperglycemia and Hyperlipidemia in Diabetic Rodents Without Causing Systemic Glucocorticoid Antagonism

Genetics

Pharmacogenetic Analysis of Rosiglitazone-Induced Hepatosteatosis in New Mouse Models of Type 2 Diabetes

Brief Genetics Reports

Fine-Mapping Gene-by-Diet Interactions on Chromosome 13 in a LG/J × SM/J Murine Model of Obesity

Type A Insulin Resistance Syndrome Revealing a Novel Lamin A Mutation

“Extended” A1, B8, DR3 Haplotype Shows Remarkable Linkage Disequilibrium but Is Similar to Nonextended Haplotypes in Terms of Diabetes Risk

Association Testing of the Protein Tyrosine Phosphatase 1B Gene (PTPN1) With Type 2 Diabetes in 7,883 People

Evidence that the Mitochondrial Leucyl tRNA Synthetase (LARS2) Gene Represents a Novel Type 2 Diabetes Susceptibility Gene

This Issue

Current Issue

Loss of Connexin36 Channels Alters β-Cell Coupling, Islet Synchronization of Glucose-Induced Ca²⁺ and Insulin Oscillations, and Basal Insulin Release